225
Views
10
CrossRef citations to date
0
Altmetric
Original Articles

Effect of Glucose on GLUT1-Dependent Intracellular Ascorbate Accumulation and Viability of Thyroid Cancer Cells

, , &
Pages 1335-1343 | Received 22 Dec 2014, Accepted 28 Jul 2015, Published online: 18 Sep 2015

REFERENCES

  • Shaw RJ: Glucose metabolism and cancer. Curr Opin Cell Biol 18, 598–608, 2006.
  • Gillies RJ and Gatenby RA: Adaptive landscapes and emergent phenotypes: why do cancers have high glycolysis? J Bioenerg Biomembr 39, 251–257, 2007.
  • Ganapathy V, Thangaraju M, and Prasad PD: Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond. Pharmacol Ther 121, 29–40, 2009.
  • Bensinger SJ and Christofk HR: New aspects of the Warburg effect in cancer cell biology. Semin Cell Dev Biol 23, 352–361, 2012.
  • Mori Y, Tsukinoki K, Yasuda M, Miyazawa M, Kaneko A, et al.: Glucose transporter type 1 expression are associated with poor prognosis in patients with salivary gland tumors. Oral Oncol 43, 563–569, 2007.
  • Chung FY, Huang MY, Yeh CS, Chang HJ, Cheng TL, et al.: GLUT1 gene is a potential hypoxic marker in colorectal cancer patients. BMC Cancer 9, 241, 2009.
  • Krzeslak A, Wojcik-Krowiranda K, Forma E, Jozwiak P, Romanowicz H, et al.: Expression of GLUT1 and GLUT3 glucose transporters in endometrial and breast cancers. Pathol Oncol Res 18, 721–728, 2012.
  • Sasaki H, Shitara M, Yokota K, Hikosaka Y, Moriyama S, et al.: Overexpression of GLUT1 correlates with Kras mutations in lung carcinomas. Mol Med Rep 5, 599–602, 2012.
  • Cho H, Lee YS, Kim J, Chung JY, and Kim JH: Overexpression of glucose transporter-1 (GLUT-1) predicts poor prognosis in epithelial ovarian cancer. Cancer Invest 31, 607–615, 2013.
  • Jóźwiak P, Krześlak A, Pomorski L, and Lipińska A: Expression of hypoxia-related glucose transporters GLUT1 and GLUT3 in benign, malignant and non-neoplastic thyroid lesions. Mol Med Rep 6, 601–606, 2012.
  • Jóźwiak P and Lipińska A: The role of glucose transporter 1 (GLUT1) in the diagnosis and therapy of tumors. Postepy Hig Med Dosw 66, 165–174, 2012.
  • Liang WJ, Johnson D, and Jarvis SM: Vitamin C transport systems of mammalian cells. Mol Membr Biol 18, 87–95, 2001.
  • Flashman E, Davies SL, Yeoh KK, and Schofield CJ: Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents. Biochem J 427, 135–142, 2010.
  • Kawada H, Kaneko M, Sawanobori M, Uno T, Matsuzawa H, et al.: High concentrations of L-ascorbic acid specifically inhibit the growth of human leukemic cells via downregulation of HIF-1α transcription. PLoS One 8, e62717, 2013.
  • Chen Q, Espey MG, Sun AY, Pooput C, Kirk KL, et al.: Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice. Proc Natl Acad Sci U S A 105, 11105–11109, 2008.
  • Herst PM, Broadley KW, Harper JL, and McConnell MJ: Pharmacological concentrations of ascorbateradiosensitize glioblastoma multiforme primary cells by increasing oxidative DNA damage and inhibiting G2/M arrest. Free Radic Biol Med 52, 1486–1493, 2012.
  • Monti DA, Mitchell E, Bazzan AJ, Littman S, Zabrecky G, et al.: Phase I evaluation of intravenous ascorbic acid in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer. PLoS One 7, e29794, 2012.
  • Stephenson CM, Levin RD, Spector T, and Lis CG: Phase I clinical trial to evaluate the safety, tolerability, and pharmacokinetics of high-dose intravenous ascorbic acid in patients with advanced cancer. Cancer Chemother Pharmacol 72, 139–146, 2013.
  • Tsukaguchi H, Tokui T, Mackenzie B, Berger UV, Chen XZ, et al.: A family of mammalian Na+-dependent L-ascorbic acid transporters. Nature 399, 70–75, 1999.
  • Agus DB, Vera JC, and Golde DW: Stromal cell oxidation: a mechanism by which tumors obtain vitamin C. Cancer Res 59, 4555–4558, 1999.
  • Corpe CP, Lee JH, Kwon O, Eck P, Narayanan J, et al.: 6-Bromo-6-deoxy-L-ascorbic acid: an ascorbate analog specific for Na+-dependent vitamin C transporter but not glucose transporter pathways. J Biol Chem 280, 5211–5220, 2005.
  • Corti A, Raggi C, Franzini M, Paolicchi A, Pompella A, et al.: Plasma membrane gamma-glutamyltransferase activity facilitates the uptake of vitamin C in melanoma cells. Free Radic Biol Med 37, 1906–1915, 2004.
  • Yamada K, Saito M, Matsuoka H, and Inagaki N: A real-time method of imaging glucose uptake in single, living mammalian cells. Nat Protoc 2, 753–762, 2007.
  • Lykkesfeldt J: Determination of ascorbic acid and dehydroascorbic acid in biological samples by high-performance liquid chromatography using subtraction methods: reliable reduction with tris[2-carboxyethyl]phosphine hydrochloride. Anal Biochem 282, 89–93, 2000.
  • Wilson JX: Regulation of vitamin C transport. Annu Rev Nutr 25, 105–125, 2005.
  • Vera JC, Rivas CI, Zhang RH, Farber CM, and Golde DW: Human HL-60 myeloid leukemia cells transport dehydroascorbic acid via the glucose transporters and accumulate reduced ascorbic acid. Blood 84, 1628–1634, 1994.
  • Bode AM, Liang HQ, Green EH, Meyer TE, Buckley DJ, et al.: Ascorbic acid recycling in Nb2 lymphoma cells: implications for tumor progression. Free Radic Biol Med 26, 136–147, 1999.
  • Jóźwiak P, Krześlak A, Bryś M, and Lipińska A: Glucose-dependent glucose transporter 1 expression and its impact on viability of thyroid cancer cells. Oncol Rep 33, 913–920, 2015.
  • Hosoya K, Nakamura G, Akanuma S, Tomi M, and Tachikawa M: Dehydroascorbic acid uptake and intracellular ascorbic acid accumulation in cultured Müller glial cells (TR-MUL). Neurochem Int 52, 1351–1357, 2008.
  • Kuiper C, Molenaar IG, Dachs GU, Currie MJ, Sykes PH, et al.: Low ascorbate levels are associated with increased hypoxia-inducible factor-1 activity and an aggressive tumor phenotype in endometrial cancer. Cancer Res 70, 5749–5758, 2010.
  • Castro MA, Angulo C, Brauchi S, Nualart F, and Concha II: Ascorbic acid participates in a general mechanism for concerted glucose transport inhibition and lactate transport stimulation. Pflugers Arch 457, 519–528, 2008.
  • Beltrán FA, Acuña AI, Miró MP, Angulo C, Concha II, et al.: Ascorbic acid-dependent GLUT3 inhibition is a critical step for switching neuronal metabolism. J Cell Physiol 226, 3286–3294, 2011.
  • Park S, Han SS, Park CH, Hahm ER, Lee SJ, et al.: L-Ascorbic acid induces apoptosis in acute myeloid leukemia cells via hydrogen peroxide-mediated mechanisms. Int J Biochem Cell Biol 36, 2180–2195, 2004.
  • Harakeh S, Diab-Assaf M, Khalife JC, Abu-el-Ardat KA, Baydoun E, et al.: Ascorbic acid induces apoptosis in adult T-cell leukemia. Anticancer Res 27, 289–298, 2007.
  • Hong SW, Jin DH, Hahm ES, Yim SH, Lim JS, et al.: Ascorbate (vitamin C) induces cell death through the apoptosis-inducing factor in human breast cancer cells. Oncol Rep 18, 811–815, 2007.
  • Kim JE, Kang JS, and Lee WJ: Vitamin C induces apoptosis in human colon cancer cell line, HCT-8 via the modulation of calcium influx in endoplasmic reticulum and the dissociation of Bad from 14-3-3β. Immune Netw 12, 189–195, 2012.
  • Chen Q, Espey MG, Krishna MC, Mitchell JB, Corpe CP, et al.: Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues. Proc Natl Acad Sci U S A 102, 13604–13609, 2005.
  • Long LH and Halliwell B: Artefacts in cell culture: pyruvate as a scavenger of hydrogen peroxide generated by ascorbate or epigallocatechingallate in cell culture media. Biochem Biophys Res Commun 388, 700–704, 2009.
  • Shinar E, Rachmilewitz EA, Shifter A, Rahamim E, and Saltman P: Oxidative damage to human red cells induced by copper and iron complexes in the presence of ascorbate. Biochim Biophys Acta 1014, 66–72, 1989.
  • Valko M, Rhodes CJ, Moncol J, Izakovic M, and Mazur M: Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 160, 1–40, 2006.
  • Watson J: Oxidants, antioxidants and the current incurability of metastatic cancers. Open Biol 3, 120144, 2013.
  • Schumacker PT: Reactive oxygen species in cancer: a dance with the devil. Cancer Cell 27, 156–157, 2015.
  • Hanahan D and Weinberg RA: Hallmarks of cancer: the next generation. Cell 144, 646–674, 2011.
  • Boroughs LK and DeBerardinis RJ: Metabolic pathways promoting cancer cell survival and growth. Nat Cell Biol 17, 351–357, 2015.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.