974
Views
73
CrossRef citations to date
0
Altmetric
Review Article

Rosemary (Rosmarinus officinalis L.) Extract as a Potential Complementary Agent in Anticancer Therapy

, &
Pages 1223-1231 | Received 18 Aug 2014, Accepted 28 Jul 2015, Published online: 09 Oct 2015

REFERENCES

  • Kim HK, Wilson EG, Choi YH, and Verpoorte R: Metabolomics: a tool for anticancer lead-finding from natural products. Planta Med 76, 1094–1102, 2010. doi:10.1055/s-0030-1249898
  • Aggarwal BB and Kunnumakkara AB: Molecular Targets and Therapeutic Uses of Spices: Modern Uses for Ancient Medicine: Singapore, World Scientific Publishing Group, 2009.
  • Ulbricht C, Abrams TR, Brigham A, Ceurvels J, Clubb J, et al.: An evidence-based systematic review of rosemary (Rosmarinus officinalis) by the Natural Standard Research Collaboration. J Diet Suppl 7, 351–413, 2010. doi:10.3109/19390211.2010.525049
  • Hanahan D and Weinberg RA: The hallmarks of cancer. Cell 100, 57–70, 2000.
  • Cheung S and Tai J: Anti-proliferative and antioxidant properties of rosemary Rosmarinus officinalis. Oncol Rep 17, 1525–1531, 2007.
  • Yesil-Celiktas O, Sevimli C, Bedir E, and Vardar-Sukan F: Inhibitory effects of rosemary extracts, carnosic acid and rosmarinic acid on the growth of various human cancer cell lines. Plant Foods Hum Nutr 65, 158–163, 2010. doi:10.1007/s11130-010-0166-4
  • Mothana RA, Kriegisch S, Harms M, Wende K, and Lindequist U: Assessment of selected Yemeni medicinal plants for their in vitro antimicrobial, anticancer, and antioxidant activities. Pharm Biol 49, 200–210, 2011. doi:10.3109/13880209.2010.512295
  • Đilas S, Knez Ž, Četojević-Simin D, Tumbas V, Škerget M, et al.: In vitro antioxidant and antiproliferative activity of three rosemary (Rosmarinus officinalis L.) extract formulations. International Journal of Food Science & Technology 47, 2052–2062, 2012.
  • González-Vallinas M, Molina S, Vicente G, Sánchez-Martínez R, Vargas T, et al.: Modulation of estrogen and epidermal growth factor receptors by rosemary extract in breast cancer cells. Electrophoresis 35, 1719–1727, 2014. doi: 10.1002/elps.201400011
  • Valdés A, García-Cañas V, Rocamora-Reverte L, Gómez-Martínez A, Ferragut JA, et al.: Effect of rosemary polyphenols on human colon cancer cells: transcriptomic profiling and functional enrichment analysis. Genes Nutr 8, 43–60, 2013. doi:10.1007/s12263-012-0311-9
  • Peng CH, Su JD, Chyau CC, Sung TY, Ho SS, et al.: Supercritical fluid extracts of rosemary leaves exhibit potent anti-inflammation and anti-tumor effects. Biosci Biotechnol Biochem 71, 2223–2232, 2007.
  • Huang MT, Ho CT, Wang ZY, Ferraro T, Lou YR, et al.: Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid. Cancer Res 54, 701–708, 1994.
  • Singletary K, MacDonald C, and Wallig M: Inhibition by rosemary and carnosol of 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation. Cancer Lett 104, 43–48, 1996.
  • Singletary KW: Rosemary extract and carnosol stimulate rat liver glutathione-S-transferase and quinone reductase activities. Cancer Lett 100, 139–144, 1996.
  • Singletary KW and Rokusek JT: Tissue-specific enhancement of xenobiotic detoxification enzymes in mice by dietary rosemary extract. Plant Foods Hum Nutr 50, 47–53, 1997.
  • Slamenova D, Kuboskova K, Horvathova E, and Robichova S: Rosemary-stimulated reduction of DNA strand breaks and FPG-sensitive sites in mammalian cells treated with H2O2 or visible light-excited Methylene Blue. Cancer Lett 177, 145–153, 2002.
  • Zhu BT, Loder DP, Cai MX, Ho CT, Huang MT, et al.: Dietary administration of an extract from rosemary leaves enhances the liver microsomal metabolism of endogenous estrogens and decreases their uterotropic action in CD-1 mice. Carcinogenesis 19, 1821–1827, 1998.
  • Yi W and Wetzstein HY: Anti-tumorigenic activity of five culinary and medicinal herbs grown under greenhouse conditions and their combination effects. J Sci Food Agric 91, 1849–1854, 2011. doi:10.1002/jsfa.4394
  • Ibáñez C, Simó C, García-Cañas V, Gómez-Martínez A, Ferragut JA, et al.: CE/LC-MS multiplatform for broad metabolomic analysis of dietary polyphenols effect on colon cancer cells proliferation. Electrophoresis 33, 2328–2336, 2012. doi:10.1002/elps.201200143
  • Berrington D and Lall N: Anticancer activity of certain herbs and spices on the cervical epithelial carcinoma (HeLa) cell line. Evid Based Complement Alternat Med 2012, 564927, 2012. doi:10.1155/2012/564927
  • Tai J, Cheung S, Wu M, and Hasman D: Antiproliferation effect of Rosemary (Rosmarinus officinalis) on human ovarian cancer cells in vitro. Phytomedicine 19, 436–443, 2012. doi:10.1016/j.phymed.2011.12.012
  • González-Vallinas M, Molina S, Vicente G, Zarza V, Martín-Hernández R, et al.: Expression of MicroRNA-15b and the glycosyltransferase GCNT3 correlates with antitumor efficacy of rosemary diterpenes in colon and pancreatic cancer. PLoS One 9, e98556, 2014. doi:10.1371/journal.pone.0098556
  • Petiwala SM, Berhe S, Li G, Puthenveetil AG, Rahman O, et al.: Rosemary (Rosmarinus officinalis) extract modulates CHOP/GADD153 to promote androgen receptor degradation and decreases xenograft tumor growth. PLoS One 9, e89772, 2014. doi:10.1371/journal.pone.0089772
  • González-Vallinas M, Molina S, Vicente G, de la Cueva A, Vargas T, et al.: Antitumor effect of 5-fluorouracil is enhanced by rosemary extract in both drug sensitive and resistant colon cancer cells. Pharmacol Res 72, 61–68, 2013. doi:10.1016/j.phrs.2013.03.010
  • Wang W, Li N, Luo M, Zu Y, and Efferth T: Antibacterial activity and anticancer activity of Rosmarinus officinalis L. essential oil compared to that of its main components. Molecules 17, 2704–2713, 2012. doi:10.3390/molecules17032704
  • Vicente G, Molina S, González-Vallinas M, García-Risco MR, Fornari T, et al.: Supercritical rosemary extracts, their antioxidant activity and effect on hepatic tumor progression. The Journal of Supercritical Fluids 79, 101–108, 2013. doi:http://dx.doi.org/10.1016/j.supflu.2012.07.006
  • Kontogianni VG, Tomic G, Nikolic I, Nerantzaki AA, Sayyad N, et al.: Phytochemical profile of Rosmarinus officinalis and Salvia officinalis extracts and correlation to their antioxidant and anti-proliferative activity. Food Chem 136, 120–129, 2013. doi:10.1016/j.foodchem.2012.07.091
  • Sancheti G and Goyal PK: Effect of Rosmarinus officinalis in modulating 7,12-dimethylbenz(a)anthracene induced skin tumorigenesis in mice. Phytother Res 20, 981–986, 2006. doi:10.1002/ptr.1989
  • Petiwala SM, Puthenveetil AG, Johnson JJ: Polyphenols from the Mediterranean herb rosemary (Rosmarinus officinalis) for prostate cancer. Front Pharmacol 4, 29, 2013. doi:10.3389/fphar.2013.00029
  • Ahmad HH, Hamza AH, Hassan AZ, and Sayed AH: Promising therapeutic role of Rosmarinus officinalis successive methanolic fraction against colorectal cancer. International Journal of Pharmacy and Pharmaceutical Sciences 5, 164–170, 2013.
  • Einbond LS, Wu HA, Kashiwazaki R, He K, Roller M, et al.: Carnosic acid inhibits the growth of ER-negative human breast cancer cells and synergizes with curcumin. Fitoterapia 83, 1160–1168, 2012. doi:10.1016/j.fitote.2012.07.006
  • Zhao PW, Lee DY, Ma ZZ, Huang LS, Sun LP, et al.: The antioxidant effect of carnosol in bovine aortic endothelial cells is mainly mediated via estrogen receptor alpha pathway. Biological and Pharmaceutical Bulletin 35, 1947–1955, 2012.
  • Johnson JJ, Syed DN, Suh Y, Heren CR, Saleem M, et al.: Disruption of androgen and estrogen receptor activity in prostate cancer by a novel dietary diterpene carnosol: implications for chemoprevention. Cancer Prev Res (Phila) 3, 1112–1123, 2010. doi:10.1158/1940–6207.CAPR-10-0168
  • Plouzek CA, Ciolino HP, Clarke R, and Yeh GC: Inhibition of P-glycoprotein activity and reversal of multidrug resistance in vitro by rosemary extract. Eur J Cancer 35, 1541–1545, 1999.
  • Rodríguez-Antona C: Pharmacogenomics of paclitaxel. Pharmacogenomics 11, 621–623, 2010. doi:10.2217/pgs.10.32
  • Sharabani H, Izumchenko E, Wang Q, Kreinin R, Steiner M, et al.: Cooperative antitumor effects of vitamin D3 derivatives and rosemary preparations in a mouse model of myeloid leukemia. Int J Cancer 118, 3012–3021, 2006. doi:10.1002/ijc.21736
  • Shabtay A, Sharabani H, Barvish Z, Kafka M, Amichay D, et al.: Synergistic antileukemic activity of carnosic acid-rich rosemary extract and the 19-nor Gemini vitamin D analogue in a mouse model of systemic acute myeloid leukemia. Oncology 75, 203–214, 2008. doi:10.1159/000163849
  • Reverchon E and De Marco I: Supercritical fluid extraction and fractionation of natural matter. The Journal of Supercritical Fluids 38, 146–166, 2006.
  • Pourmortazavi SM and Hajimirsadeghi SS: Supercritical fluid extraction in plant essential and volatile oil analysis. Journal of Chromatography A 1163, 2–24, 2007.
  • Babovic N, Djilas S, Jadranin M, Vajs V, Ivanovic J, et al.: Supercritical carbon dioxide extraction of antioxidant fractions from selected Lamiaceae herbs and their antioxidant capacity. Innovative Food Science & Emerging Technologies 11, 98–107, 2010.
  • Cuvelier M-E, Richard H, and Berset C: Antioxidative activity and phenolic composition of pilot-plant and commercial extracts of sage and rosemary. Journal of the American Oil Chemists' Society 73, 645–652, 1996.
  • Ibáñez C, Valdés A, García-Cañas V, Simó C, Celebier M, et al.: Global Foodomics strategy to investigate the health benefits of dietary constituents. Journal of chromatography A 1248, 139–153, 2012.
  • Baron JA, Cole BF, Mott L, Haile R, Grau M, et al.: Neoplastic and antineoplastic effects of beta-carotene on colorectal adenoma recurrence: results of a randomized trial. J Natl Cancer Inst 95, 717–722, 2003.
  • Greenberg ER, Baron JA, Tosteson TD, Freeman DH, Jr., Beck GJ, et al.: A clinical trial of antioxidant vitamins to prevent colorectal adenoma. Polyp Prevention Study Group. N Engl J Med 331, 141–147, 1994. doi:10.1056/NEJM199407213310301
  • Mooney LA, Madsen AM, Tang D, Orjuela MA, Tsai WY, et al.: Antioxidant vitamin supplementation reduces benzo(a)pyrene-DNA adducts and potential cancer risk in female smokers. Cancer Epidemiol Biomarkers Prev 14, 237–242, 2005.
  • Huang MC, Chen HY, Huang HC, Huang J, Liang JT, et al.: C2GnT-M is downregulated in colorectal cancer and its re-expression causes growth inhibition of colon cancer cells. Oncogene 25, 3267–3276, 2006. doi:10.1038/sj.onc.1209350
  • Giráldez MD, Lozano JJ, Ramírez G, Hijona E, Bujanda L, et al.: Circulating MicroRNAs as biomarkers of colorectal cancer: results from a genome-wide profiling and validation study. Clinical Gastroenterology and Hepatology 11, 681–688, 2012.
  • Johnson JJ: Carnosol: a promising anti-cancer and anti-inflammatory agent. Cancer Lett 305, 1–7, 2011. doi:10.1016/j.canlet.2011.02.005
  • Kapoor S: Carnosic acid and its inhibitory effect on tumor growth in systemic malignancies. Oral Dis 19, 427, 2013. doi:10.1111/odi.12055
  • Novotny L, Vachalkova A, and Biggs D: Ursolic acid: an anti-tumorigenic and chemopreventive activity. Minireview. Neoplasma 48, 241–246, 2001.
  • Zimmermann GR, Lehar J, and Keith CT: Multi-target therapeutics: when the whole is greater than the sum of the parts. Drug Discov Today 12, 34–42, 2007. doi:10.1016/j.drudis.2006.11.008
  • European Commission: Directive 2010/67/EU of 20 October 2010 amending Directive 2008/84/EC laying down specific purity criteria on food additives other than colours and sweeteners. Official Journal of the European Union L277, 17–26, 2010.
  • Jordan MJ, Lax V, Rota MC, Loran S, and Sotomayor JA: Relevance of carnosic acid, carnosol, and rosmarinic acid concentrations in the in vitro antioxidant and antimicrobial activities of Rosmarinus officinalis (L.) methanolic extracts. J Agric Food Chem 60, 9603–9608, 2012. doi:10.1021/jf302881t

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.