Phellinus Linteus Extract Induces Autophagy and Synergizes With 5-Fluorouracil to Inhibit Breast Cancer Cell Growth

REFERENCES

• Wyatt MD and Wilson DM, III: Participation of DNA repair in the response to 5-fluorouracil. Cell Mol Life Sci 66, 788–799, 2009.
   PubMed Web of Science ®Google Scholar
• Sullivan R, Smith JE, and Rowan NJ: Medicinal mushrooms and cancer therapy: translating a traditional practice into Western medicine. Perspect Biol Med 49, 159–170, 2006.
   PubMed Web of Science ®Google Scholar
• Zhu T, Kim SH, and Chen CY: A medicinal mushroom: Phellinus linteus. Curr Med Chem 15, 1330–1335, 2008.
   PubMed Web of Science ®Google Scholar
• Kim GY, Lee JY, Lee JO, Ryu CH, Choi BT, et al.: Partial characterization and immunostimulatory effect of a novel polysaccharide-protein complex extracted from Phellinus linteus. Biosci Biotechnol Biochem 70, 1218–1226, 2006.
   PubMed Web of Science ®Google Scholar
• Han SB, Lee CW, Kang JS, Yoon YD, Lee KH, et al.: Acidic polysaccharide from Phellinus linteus inhibits melanoma cell metastasis by blocking cell adhesion and invasion. Int Immunopharmacol 6, 697–702, 2006.
   PubMed Web of Science ®Google Scholar
• Han SB, Lee CW, Jeon YJ, Hong ND, Yoo ID, et al.: The inhibitory effect of polysaccharides isolated from Phellinus linteus on tumor growth and metastasis. Immunopharmacology 41, 157–164, 1999.
   PubMed Web of Science ®Google Scholar
• Tsuji T, Du W, Nishioka T, Chen L, Yamamoto D, et al.: Phellinus linteus extract sensitizes advanced prostate cancer cells to apoptosis in athymic nude mice. PLoS One 5, e9885, 2010.
   Google Scholar
• Lee HJ, Lee HJ, Lim ES, Ahn KS, Shim BS, et al.: Cambodian Phellinus linteus inhibits experimental metastasis of melanoma cells in mice via regulation of urokinase type plasminogen activator. Biol Pharm Bull 28, 27–31, 2005.
   PubMed Web of Science ®Google Scholar
• Guo J, Zhu T, Collins L, Xiao ZX, Kim SH, et al.: Modulation of lung cancer growth arrest and apoptosis by Phellinus Linteus. Mol Carcinog 46, 144–154, 2007.
   PubMed Web of Science ®Google Scholar
• Collins L, Zhu T, Guo J, Xiao ZJ, and Chen CY: Phellinus linteus sensitises apoptosis induced by doxorubicin in prostate cancer. Br J Cancer 95, 282–288, 2006.
   PubMed Web of Science ®Google Scholar
• Zhu T, Guo J, Collins L, Kelly J, Xiao ZJ, et al.: Phellinus linteus activates different pathways to induce apoptosis in prostate cancer cells. Br J Cancer 96, 583–590, 2007.
   PubMed Web of Science ®Google Scholar
• Li G, Kim DH, Kim TD, Park BJ, Park HD, et al.: Protein-bound polysaccharide from Phellinus linteus induces G2/M phase arrest and apoptosis in SW480 human colon cancer cells. Cancer Lett 216, 175–181, 2004.
   PubMed Web of Science ®Google Scholar
• Park HJ, Choi SY, Hong SM, Hwang SG, and Park DK: The ethyl acetate extract of Phellinus linteus grown on germinated brown rice induces G0/G1 cell cycle arrest and apoptosis in human colon carcinoma HT29 cells. Phytother Res 24, 1019–1026, 2010.
   PubMed Web of Science ®Google Scholar
• Sliva D, Jedinak A, Kawasaki J, Harvey K, and Slivova V: Phellinus linteus suppresses growth, angiogenesis and invasive behaviour of breast cancer cells through the inhibition of AKT signalling. Br J Cancer 98, 1348–1356, 2008.
   PubMed Web of Science ®Google Scholar
• Song KS, Li G, Kim JS, Jing K, Kim TD, et al.: Protein-bound polysaccharide from Phellinus linteus inhibits tumor growth, invasion, and angiogenesis and alters Wnt/beta-catenin in SW480 human colon cancer cells. BMC Cancer 11, 307, 2011.
   PubMed Web of Science ®Google Scholar
• Shibata Y, Kurita S, Okugi H, and Yamanaka H: Dramatic remission of hormone refractory prostate cancer achieved with extract of the mushroom, Phellinus linteus. Urol Int 73, 188–190, 2004.
   PubMed Web of Science ®Google Scholar
• Nam SW, Han JY, Kim JI, Park SH, Cho SH, et al.: Spontaneous regression of a large hepatocellular carcinoma with skull metastasis. J Gastroenterol Hepatol 20, 488–492, 2005.
   PubMed Web of Science ®Google Scholar
• Kojima H, Tanigawa N, Kariya S, Komemushi A, Shomura Y, et al.: A case of spontaneous regression of hepatocellular carcinoma with multiple lung metastases. Radiat Med 24, 139–142, 2006.
   PubMedGoogle Scholar
• Melet A, Song K, Bucur O, Jagani Z, Grassian AR, et al.: Apoptotic pathways in tumor progression and therapy. Adv Exp Med Biol 615, 47–79, 2008.
   PubMed Web of Science ®Google Scholar
• Johnstone RW, Ruefli AA, and Lowe SW: Apoptosis: a link between cancer genetics and chemotherapy. Cell 108, 153–164, 2002.
   PubMed Web of Science ®Google Scholar
• Kondo Y and Kondo S: Autophagy and cancer therapy. Autophagy 2, 85–90, 2006.
   PubMed Web of Science ®Google Scholar
• Kung CP, Budina A, Balaburski G, Bergenstock MK, and Murphy M: Autophagy in tumor suppression and cancer therapy. Crit Rev Eukaryot Gene Expr 21, 71–100, 2011.
   PubMed Web of Science ®Google Scholar
• Maycotte P and Thorburn A: Autophagy and cancer therapy. Cancer Biol Ther 11, 127–137, 2011.
   PubMed Web of Science ®Google Scholar
• Djavaheri-Mergny M, Maiuri MC, and Kroemer G: Cross talk between apoptosis and autophagy by caspase-mediated cleavage of Beclin 1. Oncogene 29, 1717–1719, 2010.
   PubMed Web of Science ®Google Scholar
• Cui Q, Tashiro S, Onodera S, Minami M, and Ikejima T: Autophagy preceded apoptosis in oridonin-treated human breast cancer MCF-7 cells. Biol Pharm Bull 30, 859–864, 2007.
   PubMed Web of Science ®Google Scholar
• Brenton JD, Carey LA, Ahmed AA, and Caldas C: Molecular classification and molecular forecasting of breast cancer: ready for clinical application? J Clin Oncol 23, 7350–7360, 2005.
   PubMed Web of Science ®Google Scholar
• Chavez KJ, Garimella SV, and Lipkowitz S: Triple negative breast cancer cell lines: One tool in the search for better treatment of triple negative breast cancer. Breast Dis 32, 35–48, 2010.
   PubMedGoogle Scholar
• Song TY, Lin HC, Yang NC, and Hu ML: Antiproliferative and antimetastatic effects of the ethanolic extract of Phellinus igniarius (Linnearus: Fries) Quelet. J Ethnopharmacol 115, 50–56, 2008.
   PubMed Web of Science ®Google Scholar
• Ferraro E and Cecconi F: Autophagic and apoptotic response to stress signals in mammalian cells. Arch Biochem Biophys 462, 210–219, 2007.
   PubMed Web of Science ®Google Scholar
• Paglin S, Hollister T, Delohery T, Hackett N, McMahill M, et al.: A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res 61, 439–444, 2001.
   PubMed Web of Science ®Google Scholar
• Biederbick A, Kern HF, and Elsasser HP: Monodansylcadaverine (MDC) is a specific in vivo marker for autophagic vacuoles. Eur J Cell Biol 66, 3–14, 1995.
   PubMed Web of Science ®Google Scholar
• Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, et al.: LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 19, 5720–5728, 2000.
   PubMed Web of Science ®Google Scholar
• Barth S, Glick D, and Macleod KF: Autophagy: assays and artifacts. J Pathol 221, 117–124, 2010.
   PubMed Web of Science ®Google Scholar
• Park HJ, Han ES, and Park DK: The ethyl acetate extract of PGP (Phellinus linteus grown on Panax ginseng) suppresses B16F10 melanoma cell proliferation through inducing cellular differentiation and apoptosis. J Ethnopharmacol 132, 115–121, 2010.
   PubMed Web of Science ®Google Scholar
• Opipari AW, Jr., Tan L, Boitano AE, Sorenson DR, Aurora A, et al.: Resveratrol-induced autophagocytosis in ovarian cancer cells. Cancer Res 64, 696–703, 2004.
   PubMed Web of Science ®Google Scholar
• Ellington AA, Berhow M, and Singletary KW: Induction of macroautophagy in human colon cancer cells by soybean B-group triterpenoid saponins. Carcinogenesis 26, 159–167, 2005.
   PubMed Web of Science ®Google Scholar
• Meschini S, Condello M, Marra M, Formisano G, Federici E, et al.: Autophagy-mediated chemosensitizing effect of the plant alkaloid voacamine on multidrug resistant cells. Toxicol In Vitro 21, 197–203, 2007.
   PubMed Web of Science ®Google Scholar
• Kuo PL, Hsu YL, and Cho CY: Plumbagin induces G2-M arrest and autophagy by inhibiting the AKT/mammalian target of rapamycin pathway in breast cancer cells. Mol Cancer Ther 5, 3209–3221, 2006.
   PubMed Web of Science ®Google Scholar
• Fazi B, Bursch W, Fimia GM, Nardacci R, Piacentini M, et al.: Fenretinide induces autophagic cell death in caspase-defective breast cancer cells. Autophagy 4, 435–441, 2008.
   PubMed Web of Science ®Google Scholar
• Ko H, Kim YJ, Park JS, Park JH, and Yang HO: Autophagy inhibition enhances apoptosis induced by ginsenoside Rk1 in hepatocellular carcinoma cells. Biosci Biotechnol Biochem 73, 2183–2189, 2009.
   PubMed Web of Science ®Google Scholar
• Chatterjee SJ and Pandey S: Chemo-resistant melanoma sensitized by tamoxifen to low dose curcumin treatment through induction of apoptosis and autophagy. Cancer Biol Ther 11, 216–228, 2011.
   PubMed Web of Science ®Google Scholar
• Lu TL, Huang GJ, Wang HJ, Chen JL, Hsu HP, et al.: Hispolon promotes MDM2 downregulation through chaperone-mediated autophagy. Biochem Biophys Res Commun 398, 26–31, 2010.
   PubMed Web of Science ®Google Scholar
• Zhong S, Ji DF, Li YG, Lin TB, Lv ZQ, et al.: Activation of P27kip1-cyclin D1/E-CDK2 pathway by polysaccharide from Phellinus linteus leads to S-phase arrest in HT-29 cells. Chem Biol Interact 206, 222–229, 2013.
   PubMed Web of Science ®Google Scholar