Visceral Obesity is Associated with Poor Prognosis in Pancreatic Adenocarcinoma

References

• Calle EE, Rodriguez C, Walker-Thurmond K, and Thun MJ: Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 348, 1625–1638, 2003.
   PubMed Web of Science ®Google Scholar
• Renehan AG, Tyson M, Egger M, Heller RF, and Zwahlen M: Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 371, 569–578, 2008.
   PubMed Web of Science ®Google Scholar
• Arslan AA, Helzlsouer KJ, Kooperberg C, Shu XO, Steplowski E, et al.: Anthropometric measures, body mass index, and pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan). Arch Intern Med 170, 791–802, 2010.
   PubMedGoogle Scholar
• Aune D, Greenwood DC, Chan DS, Vieira R, Vieira AR, et al.: Body mass index, abdominal fatness and pancreatic cancer risk: a systematic review and non-linear dose-response meta-analysis of prospective studies. Ann Oncol 23, 843–852, 2012.
   PubMed Web of Science ®Google Scholar
• Gaujoux S, Torres J, Olson S, Winston C, Gonen M, et al.: Impact of obesity and body fat distribution on survival after pancreaticoduodenectomy for pancreatic adenocarcinoma. Ann Surg Oncol 19, 2908–2916, 2012.
   PubMed Web of Science ®Google Scholar
• Balentine CJ, Enriquez J, Fisher W, Hodges S, Bansal V, et al.: Intra-abdominal fat predicts survival in pancreatic cancer. J Gastrointest Surg 14, 1832–1837, 2010.
   PubMed Web of Science ®Google Scholar
• Sledzianowski JF, Duffas JP, Muscari F, Suc B, and Fourtanier F: Risk factors for mortality and intra-abdominal morbidity after distal pancreatectomy. Surgery 137, 180–185, 2005.
   PubMed Web of Science ®Google Scholar
• House MG, Fong Y, Arnaoutakis DJ, Sharma R, Winston CB, et al.: Preoperative predictors for complications after pancreaticoduodenectomy: impact of BMI and body fat distribution. J Gastrointest Surg 12, 270–278, 2008.
   PubMed Web of Science ®Google Scholar
• Bamgbade OA, Rutter TW, Nafiu OO, and Dorje P: Postoperative complications in obese and nonobese patients. World J Surg 31, 556–560; discussion 561, 2007.
   PubMed Web of Science ®Google Scholar
• Shuster A, Patlas M, Pinthus JH, and Mourtzakis M: The clinical importance of visceral adiposity: a critical review of methods for visceral adipose tissue analysis. Br J Radiol 85, 1–10, 2012.
   PubMed Web of Science ®Google Scholar
• Yoshizumi T, Nakamura T, Yamane M, Islam AH, Menju M, et al.: Abdominal fat: standardized technique for measurement at CT. Radiology 211, 283–286, 1999.
   PubMed Web of Science ®Google Scholar
• Kobayashi J, Tadokoro N, Watanabe M, and Shinomiya M: A novel method of measuring intra-abdominal fat volume using helical computed tomography. Int J Obes Relat Metab Disord 26, 398–402, 2002.
   PubMed Web of Science ®Google Scholar
• Sottier D, Petit JM, Guiu S, Hamza S, Benhamiche H, et al.: Quantification of the visceral and subcutaneous fat by computed tomography: interobserver correlation of a single slice technique. Diagn Interv Imaging 94, 879–884, 2013.
   PubMedGoogle Scholar
• Shen W, Punyanitya M, Wang Z, Gallagher D, St-Onge MP, et al.: Visceral adipose tissue: relations between single-slice areas and total volume. Am J Clin Nutr 80, 271–278, 2004.
   PubMed Web of Science ®Google Scholar
• Kvist H, Chowdhury B, Sjostrom L, Tylen U, and Cederblad A: Adipose tissue volume determination in males by computed tomography and 40K. Int J Obes 12, 249–266, 1988.
   PubMed Web of Science ®Google Scholar
• Sjostrom L, Kvist H, Cederblad A, and Tylen U: Determination of total adipose tissue and body fat in women by computed tomography, 40K, and tritium. Am J Physiol 250, E736–E745, 1986.
   PubMed Web of Science ®Google Scholar
• Donohoe CL, Doyle SL, and Reynolds JV: Visceral adiposity, insulin resistance and cancer risk. Diabetol Metab Syndr 3, 12, 2011.
   PubMed Web of Science ®Google Scholar
• Despres JP and Lemieux I: Abdominal obesity and metabolic syndrome. Nature 444, 881–887, 2006.
   PubMed Web of Science ®Google Scholar
• Doyle SL, Donohoe CL, Lysaght J, and Reynolds JV: Visceral obesity, metabolic syndrome, insulin resistance and cancer. Proc Nutr Soc 71, 181–189, 2012.
   PubMed Web of Science ®Google Scholar
• Guiu B, Petit JM, Bonnetain F, Ladoire S, Guiu S, et al.: Visceral fat area is an independent predictive biomarker of outcome after first-line bevacizumab-based treatment in metastatic colorectal cancer. Gut 59, 341–347, 2010.
   PubMed Web of Science ®Google Scholar
• Moon HG, Ju YT, Jeong CY, Jung EJ, Lee YJ, et al.: Visceral obesity may affect oncologic outcome in patients with colorectal cancer. Ann Surg Oncol 15, 1918–1922, 2008.
   PubMed Web of Science ®Google Scholar
• Ohki T, Tateishi R, Shiina S, Goto E, Sato T, et al.: Visceral fat accumulation is an independent risk factor for hepatocellular carcinoma recurrence after curative treatment in patients with suspected NASH. Gut 58, 839–844, 2009.
   PubMed Web of Science ®Google Scholar
• Mathur A, Hernandez J, Shaheen F, Shroff M, Dahal S, et al.: Preoperative computed tomography measurements of pancreatic steatosis and visceral fat: prognostic markers for dissemination and lethality of pancreatic adenocarcinoma. HPB (Oxford) 13, 404–410, 2011.
   PubMed Web of Science ®Google Scholar
• Demerath EW, Reed D, Rogers N, Sun SS, Lee M, et al.: Visceral adiposity and its anatomical distribution as predictors of the metabolic syndrome and cardiometabolic risk factor levels. Am J Clin Nutr 88, 1263–1271, 2008.
   PubMed Web of Science ®Google Scholar
• Fox CS, Massaro JM, Hoffmann U, Pou KM, Maurovich-Horvat P, et al.: Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study. Circulation 116, 39–48, 2007.
   PubMed Web of Science ®Google Scholar
• Pou KM, Massaro JM, Hoffmann U, Vasan RS, Maurovich-Horvat P, et al.: Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study. Circulation 116, 1234–1241, 2007.
   PubMed Web of Science ®Google Scholar
• Giovannucci E and Michaud D: The role of obesity and related metabolic disturbances in cancers of the colon, prostate, and pancreas. Gastroenterology 132, 2208–2225, 2007.
   PubMed Web of Science ®Google Scholar
• Deglise C, Bouchardy C, Burri M, Usel M, Neyroud-Caspar I, et al.: Impact of obesity on diagnosis and treatment of breast cancer. Breast Cancer Res Treat 120, 185–193, 2010.
   PubMed Web of Science ®Google Scholar
• Porter GA, Inglis KM, Wood LA, and Veugelers PJ: Effect of obesity on presentation of breast cancer. Ann Surg Oncol 13, 327–332, 2006.
   PubMed Web of Science ®Google Scholar