Macranthoside B Induces Apoptosis and Autophagy Via Reactive Oxygen Species Accumulation in Human Ovarian Cancer A2780 Cells

References

• Rapkiewicz AV, Espina V, Petricoin EF 3rd, and Liotta LA: Biomarkers of ovarian tumours. Eur J Cancer 40, 2604–2612, 2004.
   PubMed Web of Science ®Google Scholar
• Ali AY, Farrand L, Kim JY, Byun S, Suh JY, et al.: Molecular determinants of ovarian cancer chemoresistance: new insights into an old conundrum. Ann N Y Acad Sci 1271, 58–67, 2012.
   PubMed Web of Science ®Google Scholar
• Hadaschik BA, Sowery RD, and Gleave ME: Novel targets and approaches in advanced prostate cancer. Curr Opin Urol 17, 182–187, 2007.
   PubMed Web of Science ®Google Scholar
• Chen X, Zhou H, Liu YB, Wang JF, Li H, et al.: Database of traditional Chinese medicine and its application to studies of mechanism and to prescription validation. Br J Pharmacol 149, 1092–1103, 2006.
   PubMed Web of Science ®Google Scholar
• Uezono Y, Miyano K, Sudo Y, Suzuki M, Shiraishi S, et al.: A Review of Traditional Japanese Medicines and their Potential Mechanism of Action. Curr Pharm Des 18, 4839–4853, 2012.
   PubMed Web of Science ®Google Scholar
• Chen Y, Feng X, Jia X, Wang M, Liang J, et al.: Triterpene glycosides from Lonicera. isolation and structural determination of seven glycosides from flower buds of Lonicera macranthoides. Chem Nat Compd 44, 39–43, 2008.
   Web of Science ®Google Scholar
• Chen Y, Feng X, Wang M, Jia X, Zhao Y, et al.: Triterpene glycosides from Lonicera. II isolation and structural determination of glycosides from flower buds of Lonicera macranthoides. Chem Nat Compd 45, 514–518, 2009.
   Web of Science ®Google Scholar
• Hai W, Cheng H, Zhao M, Wang Y, Hong L, et al.: Two new cytotoxic triterpenoid saponins from the roots of Clematis argentilucida. Fitoterapia 83, 759–764, 2012.
   PubMed Web of Science ®Google Scholar
• Hung TM, Jin W, Thuong PT, Song KS, Seong YH, et al.: Cytotoxic saponins from the root of Dipsacus asper Wall. Arch Pharm Res 28, 1053–1056, 2005.
   PubMed Web of Science ®Google Scholar
• Bang SC, Lee JH, Song GY, Kim DH, Yoon MY, et al.: Antitumor activity of Pulsatilla koreana saponins and their structure-activity relationship. Chem Pharm Bull (Tokyo) 53, 1451–1554, 2005.
   PubMed Web of Science ®Google Scholar
• Wang J, Zhao XZ, Qi Q, Tao L, Zhao Q, et al.: Macranthoside B, a hederagenin saponin extracted from Lonicera macranthoides and its anti-tumor activities in vitro and in vivo. Food Chem Toxicol 47, 1716–1721, 2009.
   PubMed Web of Science ®Google Scholar
• Guan F, Shan Y, Zhao X, Zhang D, Wang M, et al.: Apoptosis and membrane permeabilisation induced by macranthoside B on HL-60 cells. Nat Prod Res 25, 332–340, 2011.
   PubMed Web of Science ®Google Scholar
• Mizushima N, Levine B, Cuervo AM, and Klionsky DJ: Autophagy fights disease through cellular self-digestion. Nature 451, 1069–1075, 2008.
   PubMed Web of Science ®Google Scholar
• Levine B, Kroemer G: Autophagy in the pathogenesis of disease. Cell 132, 27–42, 2008.
   PubMed Web of Science ®Google Scholar
• Kaminskyy VO, Piskunova T, Zborovskaya IB, Tchevkina EM, and Zhivotovsky B: Suppression of basal autophagy reduces lung cancer cell proliferation and enhances caspase-dependent and -independent apoptosis by stimulating ROS formation. Autophagy 8, 1032–1044, 2012.
   PubMed Web of Science ®Google Scholar
• Cheng JP, and Lane JD: Organelle dynamics and membrane trafficking in apoptosis and autophagy. Histol Histopathol 25, 1457–1472, 2010.
   PubMed Web of Science ®Google Scholar
• Glick D, Barth S, and Macleod KF: Autophagy: cellular and molecular mechanisms. J Pathol 221, 3–12, 2010.
   PubMed Web of Science ®Google Scholar
• Rosenfeldt MT, and Ryan KM: The multiple roles of autophagy in cancer. Carcinogenesis 32, 955–963, 2011.
   PubMed Web of Science ®Google Scholar
• Wang Q, Liang B, Shirwany NA, and Zou MH: 2-Deoxy-D-glucose treatment of endothelial cells induces autophagy by reactive oxygen species-mediated activation of the AMP-activated protein kinase. PLoS One 6, e17234, 2011.
   PubMed Web of Science ®Google Scholar
• Wong CH, Iskandar KB, Yadav SK, Hirpara JL, Loh T, et al.: Simultaneous induction of non-canonical autophagy and apoptosis in cancer cells by ROS-dependent ERK and JNK activation. PLoS One 5, e9996, 2010.
   PubMed Web of Science ®Google Scholar
• Jia XD, Feng X, Dong YF, Zhao XZ, Wang M, et al.: Saponins from flower buds of Lonicera macranthoides. Chin Tradit Herbal Drugs 38, 1452–1455, 2007.
   Google Scholar
• Levine B: Cell biology: autophagy and cancer. Nature 446, 745–747, 2007.
   PubMed Web of Science ®Google Scholar
• Liu EY, and Ryan KM: Autophagy and cancer–issues we need to digest. J Cell Sci 125, 2349–2358, 2012.
   PubMed Web of Science ®Google Scholar
• Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, et al.: Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 10, 51–64, 2006.
   PubMed Web of Science ®Google Scholar
• Gozuacik D, and Kimchi A: Autophagy and cell death. Curr Top Dev Biol 78, 217–245, 2007.
   PubMed Web of Science ®Google Scholar
• Yang F, Chen WD, Deng R, Li DD, Wu KW, et al.: Hirsutanol A induces apoptosis and autophagy via reactive oxygen species accumulation in breast cancer MCF-7 cells. J Pharmacol Sci 119, 214–220, 2012.
   PubMed Web of Science ®Google Scholar
• Liao A, Hu R, Zhao Q, Li J, Li Y, et al.: Autophagy induced by FTY720 promotes apoptosis in U266 cells. Eur J Pharm Sci 45, 600–605, 2012.
   PubMed Web of Science ®Google Scholar
• Chen ZH, Lam HC, Jin Y, Kim HP, Cao J, et al.: Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema. Proc Natl Acad Sci U S A 107, 18880–18885, 2010.
   PubMed Web of Science ®Google Scholar
• Miki H, Uehara N, Kimura A, Sasaki T, Yuri T, et al.: Resveratrol induces apoptosis via ROS-triggered autophagy in human colon cancer cells. Int J Oncol 40, 1020–1028, 2012.
   PubMed Web of Science ®Google Scholar
• Devasagayam TP, Tilak JC, Boloor KK, Sane KS, Ghaskadbi SS, et al.: Free radicals and antioxidants in human health: current status and future prospects. J Assoc Physicians India 52, 794–804, 2004.
   PubMedGoogle Scholar
• Jiang F, Zhang Y, and Dusting GJ: NADPH oxidase-mediated redox signaling: roles in cellular stress response, stress tolerance, and tissue repair. Pharmacol Rev 63, 218–242, 2011.
   PubMed Web of Science ®Google Scholar
• Hou DX, Tong X, Terahara N, Luo D, and Fujii M: Delphinidin 3-sambubioside, a Hibiscus anthocyanin, induces apoptosis in human leukemia cells through reactive oxygen species-mediated mitochondrial pathway. Arch Biochem Biophys 440, 101–109, 2005.
   PubMed Web of Science ®Google Scholar
• Chipuk JE, Bouchier-Hayes L, and Green DR: Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario. Cell Death Differ 13, 1396–1402, 2006.
   PubMed Web of Science ®Google Scholar
• Chen Y, McMillan-Ward E, Kong J, Israels SJ, and Gibson SB: Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells. Cell Death Differ 15, 171–182, 2008.
   PubMed Web of Science ®Google Scholar
• Suter M, Riek U, Tuerk R, Schlattner U, Wallimann T, et al.: Dissecting the role of 5′-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase. J Biol Chem 281, 32207–32216, 2006.
   PubMed Web of Science ®Google Scholar
• Hardie DG, Scott JW, Pan DA, and Hudson ER: Management of cellular energy by the AMP-activated protein kinase system. FEBS Lett 546, 113–120, 2003.
   PubMed Web of Science ®Google Scholar
• Gleason CE, Lu D, Witters LA, Newgard CB, and Birnbaum MJ: The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells. J Biol Chem 282, 10341–10351, 2007.
   PubMed Web of Science ®Google Scholar
• Chen MB, Shen WX, Yang Y, Wu XY, Gu JH, et al.: Activation of AMP-activated protein kinase is involved in vincristine-induced cell apoptosis in B16 melanoma cell. J Cell Physiol 226, 1915–1925, 2011.
   PubMed Web of Science ®Google Scholar
• Din FV, Valanciute A, Houde VP, Zibrova D, Green KA, et al.: Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells. Gastroenterology 142, 1504–1515 e3, 2012.
   PubMed Web of Science ®Google Scholar