Young Barley Indicates Antitumor Effects in Experimental Breast Cancer In Vivo and In Vitro

References

• Yiannakopoulou ECh: Effect of green tea catechins on breast carcinogenesis: a systematic review of in-vitro and in-vivo experimental studies. Eur J Cancer Prev 3, 84–89, 2014.
   Google Scholar
• Cutler GJ, Nettleton JA, Ross JA, Harnack LJ, Jacobs DR Jr, et al.: Dietary flavonoid intake and risk of cancer in postmenopausal women: The Iowa Women's Health Study. Int J Cancer 123, 664–671, 2008.
   PubMed Web of Science ®Google Scholar
• Fink N, Steck SE, Wolff MS, Britton JA, Kabat GC, et al.: Dietary flavonoid intake and breast cancer survival among women on Long Island. Am J Epidemiol 163, S96, 2006.
   Web of Science ®Google Scholar
• Neuhouser ML: Dietary flavonoids and cancer risk: evidence from human population studies. Nutr Cancer 50, 1–7, 2004.
   PubMed Web of Science ®Google Scholar
• Sun M, Nie S, Pan X, Zhang R, Fan Z, and Wang S: Quercetin-nanostructured lipid carriers: Characteristics and anti-breast cancer activities in vitro. Col Surf B 113, 15–24, 2014.
   PubMed Web of Science ®Google Scholar
• Purushothaman A, Nandhakumar E, and Sachdanandam P: Phytochemical analysis and anticancer capacity of Shemamruthaa, a herbal formulation against DMBA-induced mammary carcinoma in rats. Asian Pac J Trop Med 6, 925–933, 2013.
   PubMed Web of Science ®Google Scholar
• Geethangilil M, Rao YK, Fang SH, and Tzeng YM: Cytotoxic constituents from Andrographis paniculata induce cell cycle arrest in Jurkat cells. Phytother Res 22, 1336–1341, 2008.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Li Q, Ge Y, Chen J, Dong Y, and Shi W: Silibinin triggers apoptosis and cell-cycle arrest of SGC7901 cells. Phytother Res 27, 397–403, 2013.
   PubMed Web of Science ®Google Scholar
• Ma H, Lai F, Xie H, Wang J, and Wang H: Involvement of the Bcl-2 family members in Pinus massoniana bark extract induced apoptosis in HeLa cells. Phytother Res 22, 1472–1476, 2008.
   PubMed Web of Science ®Google Scholar
• Garvin S, Ollinger K, and Dabrosin C: Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo. Cancer Lett 231, 113–122, 2006.
   PubMed Web of Science ®Google Scholar
• Ferreres F, Andrade PB, Valentao P, and Gil-Izquierdo A: Further knowledge on barley (Hordeum vulgare L.) leaves O-glycosyl-C-glycosyl flavones by liquid chromatography-UV diode-array detection-electrospray ionisation mass spectrometry. J Chromatogr A 1182, 56–64, 2008.
   PubMed Web of Science ®Google Scholar
• Kamiyama M and Shibamoto T: Flavonoids with potent antioxidant activity found in young green barley leaves. J Agric Food Chem 60, 6260–6267, 2012.
   PubMed Web of Science ®Google Scholar
• Benedet JA, Umeda H, Shibamoto T: Antioxidant activity of flavonoids isolated from young green barley leaves toward biological lipid samples. J Agric Food Chem 55, 5499–5504, 2007.
   PubMed Web of Science ®Google Scholar
• Nishiyama T, Hagiwara Y, Hagiwara H, and Shibamoto T: Inhibition of malonaldehyde formation from lipids by an isoflavonoid isolated from young green barley leaves. J. Am Oil Chem Soc 70, 1811–1813, 1993.
   Web of Science ®Google Scholar
• Liu RH: Dietary bioactive compounds and their health implications. J Food Sci 78, A18–A25, 2013.
   PubMed Web of Science ®Google Scholar
• Gottardis MM and Jordan VC: Antitumor actions of keoxifene and tamoxifen in the N-nitrosomethylurea-induced rat mammary carcinoma model. Cancer Res 47, 4020–4024, 1987.
   PubMed Web of Science ®Google Scholar
• Yu YM, Chang WC, Liu CS, and Tsai CM: Effect of young barley leaf extract and adlay on plasma lipids and LDL oxidation in hyperlipidemic smokers. Biol Pharm Bull 27, 802–805, 2004.
   PubMed Web of Science ®Google Scholar
• Koga R, Tsubata M, Ikeguchi M, Takagaki K, Irino N, and Kondo R: Hypercholesterolemia-reducing effect of young barley leaf powder. J Jap Soc Food Sci Technol 60, 19–24, 2013.
   Web of Science ®Google Scholar
• Russo J and Russo IH: Atlas and histologic classification of tumors of the rat mammary gland. J Mammary Gland Biol Neoplasia 5, 187–200, 2000.
   PubMed Web of Science ®Google Scholar
• Mylona E, Nomikos A, Alexandrou P, Giannopoulou I, Keramopoulos A, and Nakopoulou L: Lymphatic and blood vessel morphometry in invasive breast carcinomas: relation with proliferation and VEGF-C and -D proteins expression. Histol Histopathol 22, 825–835, 2007.
   PubMed Web of Science ®Google Scholar
• Murín R, Drgová A, Kaplán P, Dobrota D, and Lehotský J: Ischemia/Reperfusion-induced oxidative stress causes structural changes of brain membrane proteins and lipids. Gen Physiol Biophys 20, 431–438, 2001.
   PubMed Web of Science ®Google Scholar
• Mosmann T: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65, 55–63, 1983.
   PubMed Web of Science ®Google Scholar
• Muir D, Varon S, and Manthorpe M: An enzyme-linked immunosorbent assay for bromodeoxyuridine incorporation using fixed microcultures. Anal Biochem 185, 377–382, 1990.
   PubMed Web of Science ®Google Scholar
• Vermes I, Haanen C, Steffens-Nakken H, and Reutellingsperger C: A novel assay for apoptosis flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled annexin V. J Immunol Methods 184, 39–51, 1995.
   PubMed Web of Science ®Google Scholar
• Gray JW and Coffino P: Cell cycle analysis by flow cytometry. Method Enzymol 58, 233–248, 1979.
   PubMedGoogle Scholar
• Kubatka P, Kapinová A, Kruzliak P, Kello M, Výbohová D, et al.: Antineoplastic effects of Chlorella pyrenoidosa in the breast cancer model. Nutrition 31, 560–569, 2015.
   PubMed Web of Science ®Google Scholar
• Kubatka P, Kapinová A, Kello M, Kruzliak P, Kajo K, et al.: Fruit peel polyphenols demonstrate substantial anti-tumour effects in the model of breast cancer. Eur J Nutr 2015.
   PubMed Web of Science ®Google Scholar
• Kisková T, Jendželovský R, Rentsen E, Maier-Salamon A, Kokošová N, et al.: Resveratrol enhances the chemopreventive effect of celecoxib in chemically induced breast cancer in rats. Eur J Cancer Prev 23, 506–513, 2014.
   PubMed Web of Science ®Google Scholar
• Kisková T, Ekmekcioglu C, Garajová M, Orendas P, Bojková B, et al.: A combination of resveratrol and melatonin exerts chemopreventive effects in N-methyl-N-nitrosourea-induced rat mammary carcinogenesis. Eur J Cancer Prev 21, 163–170, 2012.
   PubMed Web of Science ®Google Scholar
• Ziegler CC, Rainwater L, Whelan J, and McEntee MF: Dietary resveratrol does not affect intestinal tumorigenesis in Apc(Min/+) mice. J Nutr 134, 5–10, 2004.
   PubMed Web of Science ®Google Scholar
• Zhang J, Park HS, Kim JA, Hong GE, Nagappan A, et al.: Flavonoids identified from korean Scutellaria baicalensis induce apoptosis by ROS generation and caspase activation on human fibrosarcoma cells. Am J Chinese Med 42, 465–483, 2014.
   PubMed Web of Science ®Google Scholar
• Yang PM, Tseng HH, Peng ChW, Chen WS, and Chiu SJ: Dietary flavonoid fisetin targets caspase-3-deficient human breast cancer MCF-7 cells by induction of caspase-7-associated apoptosis and inhibition of autophagy. Int J Oncol 40, 469–478, 2012.
   PubMed Web of Science ®Google Scholar
• Clurman BE, Sheaff RJ, Thress K, Groudine M, and Roberts JM: Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by Cdk2 binding and cyclin phosphorylation. Genes Dev 10, 1979–90, 1996.
   PubMed Web of Science ®Google Scholar
• Mailand N, Falck J, Lukas C, Syljuâsen RG, Welcker M, et al.: Rapid destruction of human Cdc25A in response to DNA damage. Science 288, 1425–1429, 2000.
   PubMed Web of Science ®Google Scholar
• Kim JA, Kim DH, Hossain MA, Kim MY, Sung B, et al.: HS-1793, a resveratrol analogue, induces cell cycle arrest and apoptotic cell death in human breast cancer cells. Int J Oncol 44, 473–480, 2014.
   PubMed Web of Science ®Google Scholar
• Chen ZT, Tao ZZ, Chen SM, Chen C, Li F, and Xiao BK: Indole-3-carbinol inhibits nasopharyngeal carcinoma growth through cell cycle arrest in vivo and in vitro. PLoS One 8, e82288, 2013.
   PubMed Web of Science ®Google Scholar
• Cserni G, Voeroes A, Liepniece-Karele I, Bianchi S, Vezzosi V, et al.: Distribution pattern of the Ki67 labelling index in breast cancer and its implications for choosing cut-off values. Breast 23, 259–63, 2014.
   PubMed Web of Science ®Google Scholar
• Tan HL, Elsen AC, Erdman JW Jr, Thomas-Ahner JM, and Clinton SK: Bioactive tomato components inhibit cancer promoting activity of testosterone in the mouse prostate epithelium. Faseb J 26, 1023, 2012.
   Web of Science ®Google Scholar
• Ronis MJ, Blackburn M, Shankar K, Gomez-Acevedo H, Singhal R, et al.: Uterine physiological responses and global gene expression in ovariectomized (OVX) rats treated with soy protein isolate (SPI) or 17-beta estradiol. Faseb J 26, 243, 2012.
   Web of Science ®Google Scholar
• Petrovic D: The role of vascular endothelial growth factor gene as the genetic marker of atherothrombotic disorders and in the gene therapy of coronary artery disease. Cardiovasc Hematol Agents Med Chem 8, 47–54, 2010.
   PubMedGoogle Scholar
• Urban P, Rabajdova MB, Varga J, Kruzliak P, Fialkovicova V, et al.: Vascular marker expression during the development of various types of gynaecological malignancy. Tumour Biol 35, 11229–11235, 2014.
   PubMed Web of Science ®Google Scholar
• Wang Z, Wang N, Han Sh, Wang D, Mo S, et al.: Dietary compound isoliquiritigenin inhibits breast cancer neoangiogenesis via VEGF/VEGFR-2 signaling pathway. Plos One 8, e68566, 2013.
   PubMed Web of Science ®Google Scholar
• Hussain SP, Lorne J, and Harris CC: Radical causes of cancer. Nature Rev Cancer 3, 276–284, 2003.
   PubMed Web of Science ®Google Scholar
• Malencik DA and Anderson SR: Dityrosine as a product of oxidative stress and fluorescent probe. Amino Acids 25, 233–247, 2003.
   PubMed Web of Science ®Google Scholar