Enhancing the Apoptotic Effect of a Low Dose of Paclitaxel on Tumor Cells in Mice by Arabinoxylan Rice Bran (MGN-3/Biobran)Footnote^*

^*Data were partially presented at the 2015 meeting of the American Association for Cancer Research (AACR), April 18–22, in Pennsylvania, Philadelphia, USA.

References

• Cancer Research UK: http://www.cancerresearchuk.org/, accessed August 2015.
   Google Scholar
• The American Society of Health-System Pharmacists. “Paclitaxel” https://www.drugs.com/monograph/paclitaxel.html, accessed June 19, 2016.
   Google Scholar
• McGrogan BT, Gilmartin B, Carney DN, McCann A: Taxanes, microtubules and chemoresistant breast cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1785, 96–132, 2008.
   PubMed Web of Science ®Google Scholar
• Francis PA, Kris MG, Rigas JR, Grant SC, and Miller VA: Paclitaxel (Taxol) and docetaxel (Taxotere): active chemotherapeutic agents in lung cancer. Lung Cancer 12 (Suppl 1), S163–S172, 1995.
   Google Scholar
• Singal PK and Iliskovic N: Doxorubicin-induced cardiomyopathy. The New England J Med 339, 900–905, 1999.
   Web of Science ®Google Scholar
• Lucchetta M, Lonardi S, Bergamo F, Alberti P, Velasco R, et al.: Incidence of atypical acute nerve hyperexcitability symptoms in oxaliplatin-treated patients with colorectal cancer. Cancer Chemother Pharmacol 70, 899–902, 2012.
   PubMed Web of Science ®Google Scholar
• Davis CD: Nutritional interactions: credentialing of molecular targets for cancer prevention. Exper Biol Med 232, 176–183, 2007.
   PubMed Web of Science ®Google Scholar
• Gelsomino G, Corsetto PA, Campia I, Montorfano G, Kopecka J, et al.: Omega 3 fatty acids chemosensitize multidrug resistant colon cancer cells by down-regulating cholesterol synthesis and altering detergent resistant membranes composition. Mol Cancer 12, 137, 2013.
   PubMed Web of Science ®Google Scholar
• Kuan CY, Walker TH, Luo PG, and Chen CF: Long-chain polyunsaturated fatty acids promote paclitaxel cytotoxicity via inhibition of the MDR1 gene in the human colon cancer Caco-2 cell line. J Am Coll Nutr 30, 265–273, 2011.
   PubMed Web of Science ®Google Scholar
• Tolba MF, Esmat A, Al-Abd AM, Azab SS, Khalifa AE, et al.: Caffeic acid phenethyl ester synergistically enhances docetaxel and paclitaxel cytotoxicity in prostate cancer cells. IUBMB Life 65, 716–729, 2013.
   PubMed Web of Science ®Google Scholar
• Pondugula SR, Ferniany G, Ashraf F, Abbott KL, Smith BF, et al.: Stearidonic acid, a plant-based dietary fatty acid, enhances the chemosensitivity of canine lymphoid tumor cells. Biochem Biophys Res Commun 460, 1002–1007, 2015.
   PubMed Web of Science ®Google Scholar
• Kunnumakkara AB, Sung B, Ravindran J, Diagaradjane P, Deorukhkar A, et al.: Zyflamend suppresses growth and sensitizes human pancreatic tumors to gemcitabine in an orthotopic mouse model through modulation of multiple targets. Int J Cancer 131, E292–E303, 2012.
   PubMed Web of Science ®Google Scholar
• Ishijima N, Kanki K, Shimizu H, and Shiota G: Activation of AMP-activated protein kinase by retinoic acid sensitizes hepatocellular carcinoma cells to apoptosis induced by sorafenib. Cancer Sci 106, 567–575, 2015.
   PubMed Web of Science ®Google Scholar
• McCartney L, Marcus SE, and Knox JP: Monoclonal antibodies to plant cell wall xylans and arabinoxylans. J Histochem Cytochem 53, 543–546, 2005.
   PubMed Web of Science ®Google Scholar
• Coelho E, Rocha MA, Moreira AS, Domingues MR, and Coimbra MA: Revisiting the structural features of arabinoxylans from brewers' spent grain. Carbohydr Polym 139, 167–176, 2015.
   PubMed Web of Science ®Google Scholar
• Guillon F and Champ MM: Carbohydrate fractions of legumes: uses in human nutrition and potential for health. Br J Nutr 88 (Suppl 3), S293–306, 2002.
   PubMed Web of Science ®Google Scholar
• Izydorczyk MS, Chornick TL, Paulley FG, Edwards NM, and Dexter JE: Physicochemical properties of hull-less barley fibre-rich fractions varying in particle size and their potential as functional ingredients in two-layer flat bread. Food Chem 108, 561–570, 2008.
   PubMed Web of Science ®Google Scholar
• Noaman E, Badr El-Din NK, Bibars MA, Abou Mossallam AA, and Ghoneum M: Antioxidant potential by arabinoxylan rice bran, MGN-3/biobran, represents a mechanism for its oncostatic effect against murine solid Ehrlich carcinoma. Cancer Lett 268, 348–359, 2008.
   PubMed Web of Science ®Google Scholar
• Rao RS and Muralikrishna G: Water soluble feruloyl arabinoxylans from rice and ragi: changes upon malting and their consequence on antioxidant activity. Phytochemistry 67, 91–99, 2006.
   PubMed Web of Science ®Google Scholar
• Ghoneum M: Anti-HIV activity in vitro of Biobran, an activated arabinoxylan from rice bran. Biochem Biophys Res Commun 243, 25–29, 1998.
   PubMed Web of Science ®Google Scholar
• Gollapudi S and Ghoneum M: MGN-3/BioBran, modified arabinoxylan from rice bran, sensitizes human breast cancer cells to chemotherapeutic agent, daunorubicin. Cancer Detect Prev 32, 1–6, 2008.
   PubMedGoogle Scholar
• Ghoneum M: Wheat and Rice in Disease Prevention and Health (In English). In: Ronald Ross Watson, Victor Preedy, and Sherma Zibadi (editors). Apoptosis and arabinoxylan rice bran. Elsevier Science & Technology Book, March 2014, pp 399–404. ( *book chapter- in English).
   Google Scholar
• Ghoneum M and Gollapudi S: Modified arabinoxylan rice bran (MGN- 3/BioBran) potentiates apoptosis in cancer cells induced by multiple anti-cancer agents in vitro. Nice, France: International Symposium on Predictive Oncology & Intervention Strategies; February 7–10, 2004 Cancer Detect Prev. 41. Persidis A. Cancer Multidrug Resistance.
   Google Scholar
  Nat Biotech 17, 94–95, 1999.
   PubMed Web of Science ®Google Scholar
• Endo Y and Kambayashi H: Modified rice bran beneficial of weight loss of mice as a major and acute adverse effect of Cisplatin. Pharmacol Toxicol 92, 300–303, 2003.
   PubMedGoogle Scholar
• Jacoby HI, Wnorowski G, Sakata K, et al.: The effect of MGN-3 on cisplatin and doxorubicin induced toxicity in the rat. J Nutraceuticals Funct Med Foods 3, 3–11, 2001.
   Google Scholar
• Bang MH, Van Riep T, Thinh NT, et al.: Arabinoxylan rice bran (MGN-3) enhances the effects of interventional therapies for the treatment of hepatocellular carcinoma: a three-year randomized clinical trial. Anticancer Res 30, 5145–5151, 2010.
   PubMed Web of Science ®Google Scholar
• Takahara K and Sano K: The life prolongation and QOL improvement effect of rice bran arabinoxylan derivative (MGN-3. Bio-Bran) for progressive cancer. Clin Pharmacol Therapy 14, 267–271, 2004.
   Google Scholar
• Ghoneum M: Enhancement of human natural killer cell activity by modified arabinoxylan from rice bran (Biobran). Int J Immunother 14, 89–99, 1998.
   Web of Science ®Google Scholar
• Ghoneum M and Jewett A: Production of tumor necrosis factor-alpha and interferon-gamma from human peripheral blood lymphocytes by MGN-3, a modified arabinoxylan from rice bran, and its synergy with interleukin-2 in vitro. Cancer Detect Prev 24, 314–324, 2000.
   PubMedGoogle Scholar
• Ghoneum M and Brown J: NK immunorestoration of cancer patients by Biobran, a modified arabinoxylan rice bran (study of 32 patients followed for up to 4 years). Anti-aging Med Therapeutics 3, 217–226, 1999.
   Google Scholar
• Ghoneum M and Gollapudi S: Modified arabinoxylan rice bran (Biobran/Biobran) sensitizes human T-cell leukemia cells to death receptor (CD95)-induced apoptosis. Cancer Lett 201, 41–49, 2003.
   PubMed Web of Science ®Google Scholar
• Badr El-Din NK, Noaman E, and Ghoneum M: In vivo tumor inhibitory effects of nutritional rice bran supplement MGN-3/Biobran on Ehrlich carcinoma-bearing mice. Nutr Cancer 60, 235–244, 2008.
   PubMed Web of Science ®Google Scholar
• Ghoneum M, Badr El-Din NK, Ali DA: and El-Dein MA: Modified arabinoxylan from rice bran, MGN-3/Biobran, sensitizes metastatic breast cancer cells to paclitaxel in vitro. Anticancer Res 34, 81–87, 2014.
   PubMed Web of Science ®Google Scholar
• Riccardi C and Nicoletti I: Analysis of apoptosis by propidium iodide staining and flow cytometry. Nature Protocols 1, 1458–1461, 2006.
   PubMed Web of Science ®Google Scholar
• Reynolds ES: The use of lead citrate at high pH as an electron microscopy. J Cell Biol 17, 208–212, 1963.
   PubMed Web of Science ®Google Scholar
• Kaleoğlu Ö and İşli N: Ehrlich-Lettre Asit Tümörü. Tıp Fakültesi Mecmuası 40, 978–984, 1977.
   Google Scholar
• D'Amours D, Sallmann FR, Dixit VM, and Poirier GG: Gain-of-function of poly (ADP-ribose) polymerase-1 upon cleavage by apoptotic proteases: implications for apoptosis. J Cell Sci 114, 3771–3778, 2001.
   PubMed Web of Science ®Google Scholar
• Michalakis J, Georgatos SD, de Bree E, Polioudaki H, Romanos J, et al.: Short-term exposure of cancer cells to micromolar doses of paclitaxel, with or without hyperthermia, induces long-term inhibition of cell proliferation and cell death in vitro. Ann Surg Oncol 14, 1220–1228, 2007.
   PubMed Web of Science ®Google Scholar
• Flores ML, Castilla C, Ávila R, Ruiz-Borrego M, Sáez C, et al.: Paclitaxel sensitivity of breast cancer cells requires efficient mitotic arrestand disruption of Bcl-xL/Bak interaction. Breast Cancer Res Treat 133, 917–928, 2012.
   PubMed Web of Science ®Google Scholar
• Kang JX, Liu J, Wang J, He C, and Li FP: The extract of huanglian, a medicinal herb, induces cell growth arrest and apoptosis by upregulation of interferon-beta and TNF-alpha in human breast cancer cells. Carcinogenesis 26, 1934–1939, 2005.
   PubMed Web of Science ®Google Scholar
• Fadlalla K, Watson A, Yehualaeshet T, Turner T, and Samuel T: Ruta graveolens extract induces DNA damage pathways and blocks Akt activation to inhibit cancer cell proliferation and survival. Anticancer Res 31, 233–241, 2011.
   PubMed Web of Science ®Google Scholar
• Saraydin SU, Tuncer E, Tepe B, Karadayi S, Özer H, et al.: Antitumoral effects of Melissa officinalis on breast cancer in vitro and in vivo. Asian Pac J Cancer Prev 13, 2765–2770, 2012.
   PubMedGoogle Scholar
• Ghoneum M and Gollapudi S: Modified arabinoxylan rice bran (MGN-3/Biobran) enhances yeast-induced apoptosis in human breast cancer cells in vitro. Anticancer Res 25, 859–870, 2005.
   PubMed Web of Science ®Google Scholar
• Cholujova D, Jakubikova J, and Sedlak J: BioBran-augmented maturation of human monocyte-derived dendritic cells. Neoplasma 56, 89–95, 2009.
   PubMed Web of Science ®Google Scholar
• Ghoneum M and Agrawal S: Activation of human monocyte derived dendritic cells in vitro by the biological response modifier arabinoxylan rice bran (MGN-3/Biobran). Int J Immunopathol Pharmacol 24, 941–948, 2011.
   PubMed Web of Science ®Google Scholar
• Ghoneum M and Agrawal S: MGN-3/Biobran enhances generation of cytotoxic CD8+ T cells via upregulation of dec-205 expression on dendritic cells. Int J Immunopathol Pharmacol 27, 523–530, 2014.
   PubMed Web of Science ®Google Scholar
• Pérez-Martínez A, Valentín J, Fernández L, Hernández-Jiménez E, López-Collazo E, et al.: Arabinoxylan rice bran (MGN-3/Biobran) enhances natural killer cell-mediated cytotoxicity against neuroblastoma in vitro and in vivo. Cytotherapy 14, S1465–S3249, 2015.
   Google Scholar
• Cholujova D, Jakubikova J, Czako B, Martisova M, Hunakova L, et al.: Biobran arabinoxylan rice bran modulates innate immunity in multiple myeloma patients. Cancer Immunol Immunother 62, 437–445, 2013.
   PubMed Web of Science ®Google Scholar