Emu Oil Combined with Lyprinol™ Reduces Small Intestinal Damage in a Rat Model of Chemotherapy-Induced Mucositis

References

• Longley DB, Harkin DP, and Johnston PG: 5-Fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer 3, 330–338, 2003.
   PubMed Web of Science ®Google Scholar
• Lundqvist EÅ: Principles of chemotherapy. Int J Gynecol Obstet 119 (Suppl 2), S151–S154, 2012.
   PubMed Web of Science ®Google Scholar
• Di Fiore F, and Van Cutsem E: Acute and long-term gastrointestinal consequences of chemotherapy. Best Pract Res Clin Gastroenterol 23, 113–124, 2009.
   PubMed Web of Science ®Google Scholar
• Elting LS, Cooksley C, Chambers M, and Cantor SB: The burdens of cancer therapy - clinical and economic outcomes of chemotherapy-induced mucositis. Cancer 98, 1531–1539, 2003.
   PubMed Web of Science ®Google Scholar
• Bowen JM, Gibson RJ, and Keefe DMK: Animal models of mucositis: implications for therapy. J Support Oncol 9, 161–168, 2011.
   PubMedGoogle Scholar
• Rosenthal DI: Consequences of mucositis-induced treatment breaks and dose reductions on head and neck cancer treatment outcomes. J Support Oncol 5, 23–31, 2007.
   PubMedGoogle Scholar
• Rubenstein EB, Peterson DE, Schubert M, Keefe D, McGuire D, Epstein J, Elting LS, Fox PC, Cooksley C, and Sonis ST: Clinical practice guidelines for the prevention and treatment of cancer therapy-induced oral and gastrointestinal mucositis. Cancer 100, 2026–2046, 2004.
   PubMed Web of Science ®Google Scholar
• Lalla RV, Sonis ST, and Peterson DE: Management of oral mucositis in patients who have cancer. Dent Clin North Am 52, 61–77, 2008.
   PubMedGoogle Scholar
• Yasuda M, Kato S, Yamanaka N, Iimori M, Utsumi D, Kitahara Y, Iwata K, Matsuno K, Amagase K, Yabe-Nishimura C, and Takeuchi K: Potential role of the NADPH oxidase NOX1 in the pathogenesis of 5-Fluorouracil-induced intestinal mucositis in mice. Am J Physiol-Gastrointest Liver Physiol 302, G1133–G1142, 2012.
   PubMed Web of Science ®Google Scholar
• Pinedo HM, and Peters GF: Fluorouracil: biochemistry and pharmacology. J Clin Oncol 6, 1653–1664, 1988.
   PubMed Web of Science ®Google Scholar
• McCarthy GM, Awde JD, Ghandi H, Vincent M, and Kocha WI: Risk factors associated with mucositis in cancer patients receiving 5-fluorouracil. Oral Oncol 34, 484–490, 1998.
   PubMed Web of Science ®Google Scholar
• Sonis ST: A biological approach to mucositis. J Support Oncol 2, 21–32, discussion 5–6, 2004.
   PubMedGoogle Scholar
• Keefe D, Lees J, and Horvath N: Palifermin for oral mucositis in the high-dose chemotherapy and stem cell transplant setting: the Royal Adelaide Hospital Cancer Centre experience. Support Care Cancer 14, 580–582, 2006.
   PubMed Web of Science ®Google Scholar
• Cheah KY, Howarth GS, and Bastian SE: Grape seed extract dose-responsively decreases disease severity in a rat model of mucositis; concomitantly enhancing chemotherapeutic effectiveness in colon cancer cells. PloS one 9, e85184, 2014.
   PubMed Web of Science ®Google Scholar
• Smith CL, Geier MS, Yazbeck R, Torres DM, Butler RN, and Howarth GS: Lactobacillus fermentum BR11 and fructo-oligosaccharide partially reduce jejunal inflammation in a model of intestinal mucositis in rats. Nutr Cancer Int J 60, 757–767, 2008.
   PubMed Web of Science ®Google Scholar
• Lindsay RJ, Geier MS, Yazbeck R, Butler RN, and Howarth GS: Orally administered emu oil decreases acute inflammation and alters selected small intestinal parameters in a rat model of mucositis. Br J Nutr 104, 513–519, 2010.
   PubMed Web of Science ®Google Scholar
• Torres DM, Tooley KL, Butler RN, Smith CL, Geier MS, and Howarth GS: Lyprinol (TM) only partially improves indicators of small intestinal integrity in a rat model of 5-fluorouracil-induced mucositis. Cancer Biol Ther 7, 295–302, 2008.
   PubMed Web of Science ®Google Scholar
• Mashtoub S, Tran CD, and Howarth GS: Emu oil expedites small intestinal repair following 5-fluorouracil-induced mucositis in rats. Exp Biol Med 238, 1305–1317, 2013.
   PubMed Web of Science ®Google Scholar
• Lee C-H, Lum JH-K, Ng CK-C, McKay J, Butt YK-C, Wong M-S, and Lo SC-L: Pain controlling and cytokine-regulating effects of Lyprinol, a lipid extract of Perna canaliculus, in a rat adjuvant-induced arthritis model. Evid Based Complement Alternat Med 6, 239–245, 2009.
   PubMed Web of Science ®Google Scholar
• Emelyanov A, Fedoseev G, Krasnoschekova O, Abulimity A, Trendeleva T, and Barnes PJ: Treatment of asthma with lipid extract of New Zealand green-lipped mussel: a randomised clinical trial. Eur Respir J 20, 596–600, 2002.
   PubMed Web of Science ®Google Scholar
• Tenikoff D, Murphy KJ, Le M, Howe PR, and Howarth GS: Lyprinol (stabilised lipid extract of New Zealand green-lipped mussel): a potential preventative treatment modality for inflammatory bowel disease. J Gastroenterol 40, 361–365, 2005.
   PubMed Web of Science ®Google Scholar
• Murphy KJ, Mooney BD, Mann NJ, Nichols PD, and Sinclair AJ: Lipid, FA, and sterol composition of New Zealand green lipped mussel (Perna canaliculus) and Tasmanian blue mussel (Mytilus edulis). Lipids 37, 587–595, 2002.
   PubMed Web of Science ®Google Scholar
• Treschow AP, Hodges LD, Wright PF, Wynne PM, Kalafatis N, and Macrides TA: Novel anti-inflammatory omega-3 PUFAs from the New Zealand green-lipped mussel, Perna canaliculus. Comp Biochem Physiol B Biochem Mol Biol 147, 645–656, 2007.
   PubMed Web of Science ®Google Scholar
• Calder PC: n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am J Clin Nutr 83, 1505S–1519S, 2006.
   PubMed Web of Science ®Google Scholar
• Beckerbauer LM, Thiel-Cooper R, Ahn DU, Sell JL, Parrish FC, and Beitz DC: Influence of two dietary fats on the composition of emu oil and meat. Poult Sci 80, 187–194, 2001.
   PubMed Web of Science ®Google Scholar
• Snowden JM, and Whitehouse MW: Anti-inflammatory activity of emu oils in rats. Inflammopharmacology 5, 127–132, 1997.
   PubMedGoogle Scholar
• Whitehouse MW, Turner AG, Davis CKC, and Roberts MS: Emu oil(s): a source of non-toxic transdermal anti-inflammatory agents in Aboriginal medicine. Inflammopharmacology 6, 1–8, 1998.
   PubMedGoogle Scholar
• Abimosleh SM, Lindsay RJ, Butler RN, Cummins AG, and Howarth GS: Emu oil increases colonic crypt depth in a rat model of ulcerative colitis. Digest Dis Sci 57, 887–896, 2012.
   PubMed Web of Science ®Google Scholar
• Abimosleh SM, Tran CD, and Howarth GS: Emu oil reduces small intestinal inflammation in the absence of clinical improvement in a rat model of indomethacin-induced enteropathy. Evid Based Complement Alternat Med 429706, 2013.
   PubMed Web of Science ®Google Scholar
• Lee CH, Butt YKC, Wong MS, and Lo SCL: A lipid extract of Perna canaliculus affects the expression of pro-inflammatory cytokines in a rat adjuvant-induced arthritis model. Eur Ann Allergy Clin Immunol 40, 148–153, 2008.
   PubMedGoogle Scholar
• Whitehouse MW, Macrides TA, Kalafatis N, Betts WH, Haynes DR, and Broadbent J: Anti-inflammatory activity of a lipid fraction (Lyprinol) from the New Zealand green-lipped mussel. Inflammopharmacology 5, 237–246, 1997.
   PubMedGoogle Scholar
• Tomas FM, Murray AJ, and Jones LM: Modification of glucocorticoid-induced changes in myofibrillar protein turnover in rats by protein and energy deficiency as assessed by urinary excretion of N-methylhistidine. Br J Nutr 51, 323–337, 1984.
   PubMed Web of Science ®Google Scholar
• Makrides M, Neumann MA, and Gibson RA: Effect of maternal docosahexaenoic acid (DHA) supplementation on breast milk composition. Eur J Clin Nutr 50, 352–357, 1996.
   PubMed Web of Science ®Google Scholar
• Howarth GS, Francis GL, Cool JC, Xu X, Byard RW, and Read LC: Milk growth factors enriched from cheese whey ameliorate intestinal damage by methotrexate when administered orally to rats. J Nutr 126, 2519–2530, 1996.
   PubMed Web of Science ®Google Scholar
• Santucci L, Fiorucci S, Di Matteo FM, and Morelli A: Role of tumor necrosis factor α release and leukocyte margination in indomethacin-induced gastric injury in rats. Gastroenterology 108, 393–401, 1995.
   PubMed Web of Science ®Google Scholar
• Suzuki K, Ota H, Sasagawa S, Sakatani T, and Fujikura T: Assay method for myeloperoxidase in human polymorphonuclear leukocytes. Analyt Biochem 132, 345–352, 1983.
   PubMed Web of Science ®Google Scholar
• Owen RW, Giacosa A, Hull WE, Haubner R, Spiegelhalder B, and Bartsch H: The antioxidant/anticancer potential of phenolic compounds isolated from olive oil. Eur J Cancer 36, 1235–1247, 2000.
   PubMed Web of Science ®Google Scholar
• Sánchez-Fidalgo S, Cárdeno A, Sánchez-Hidalgo M, Aparicio-Soto M, and de la Lastra CA: Dietary extra virgin olive oil polyphenols supplementation modulates DSS-induced chronic colitis in mice. J Nutr Biochem 24, 1401–1413, 2013.
   PubMed Web of Science ®Google Scholar
• Haxhija EQ, Yang H, Spencer AU, Sun X, and Teitelbaum DH: Intestinal epithelial cell proliferation is dependent on the site of massive small bowel resection. Pediatr Surg Int 23, 379–390, 2007.
   PubMed Web of Science ®Google Scholar
• Drozdowski L, and Thomson ABR: Intestinal mucosal adaptation. World J Gastroenterol 12, 4614–4627, 2006.
   PubMed Web of Science ®Google Scholar
• Shaw D, Gohil K, and Basson MD: Intestinal mucosal atrophy and adaptation. World J Gastroenterol 18, 6357–6375, 2012.
   PubMed Web of Science ®Google Scholar
• Mashtoub S, Feo B, Whittaker AL, Lymn KA, Martinez-Puig D, and Howarth GS: Oral nucleotides only minimally improve 5-fluorouracil-induced mucositis in rats. Nutr Cancer 67, 994–1000, 2015.
   PubMed Web of Science ®Google Scholar