Antitumoral Effect of Hibiscus sabdariffa on Human Squamous Cell Carcinoma and Multiple Myeloma Cells

References

• Amin AR, Kucuk O, Khuri FR, and Shin DM: Perspectives for cancer prevention with natural compounds. J Clin Oncol 27, 2712–2725, 2009.
   PubMed Web of Science ®Google Scholar
• Link A, Balaguer F, and Goel A: Cancer chemoprevention by dietary polyphenols: promising role for epigenetics. Biochem Pharmacol 80, 1771–1792, 2010.
   PubMed Web of Science ®Google Scholar
• Ali BH, Al Wabel N, and Blunden G: Phytochemical, pharmacological and toxicological aspects of Hibiscus sabdariffa L.: a review. Phytother Res 19, 369–375, 2005.
   PubMed Web of Science ®Google Scholar
• Lin HH, Chen JH, Kuo WH, and Wang CJ: Chemopreventive properties of Hibiscus sabdariffa L. on human gastric carcinoma cells through apoptosis induction and JNK/p38 MAPK signaling activation. Chem Biol Interact 165, 59–75, 2007.
   PubMed Web of Science ®Google Scholar
• Miloso M, Scuteri A, Foudah D, and Tredici G: MAPKs as mediators of cell fate determination: an approach to neurodegenerative diseases. Curr Med Chem 15, 538–548, 2008.
   PubMed Web of Science ®Google Scholar
• De Luca A, Maiello MR, D'Alessio A, Pergameno M, and Normanno N: The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches. Expert Opin Ther Targets 16, S17–S27, 2012.
   PubMed Web of Science ®Google Scholar
• Koul HK, Pal M, and Koul S: Role of p38 MAP kinase signal transduction in solid tumors. Genes Cancer 4, 342–359, 2013.
   PubMedGoogle Scholar
• Siegel RL, Miller KD, and Jemal A: Cancer statistics. CA Cancer J Clin 65, 5–29, 2015.
   PubMed Web of Science ®Google Scholar
• Maggioni D, Biffi L, Nicolini G, and Garavello W: Flavonoids in oral cancer prevention and therapy. Eur J Cancer Prev 2014.
   Web of Science ®Google Scholar
• Noguti J, De Moura CF, De Jesus GP, Da Silva VH, Hossaka TA, et al: Metastasis from oral cancer: an overview. Cancer Genomics Proteomics 9, 329–335, 2012.
   PubMed Web of Science ®Google Scholar
• Shain K: Metastatic myeloma? Blood 119, 5612–5613, 2012.
   PubMed Web of Science ®Google Scholar
• Ria R, Reale A, and Vacca A: Novel agents and new therapeutic approaches for treatment of multiple myeloma. World J Methodol 4, 73–90, 2014.
   PubMedGoogle Scholar
• Machiels JP, Lambrecht M, Hanin FX, Duprez T, Gregoire V, et al.: Advances in the management of squamous cell carcinoma of the head and neck. F1000Prime Rep 6, 44, 2014.
   PubMedGoogle Scholar
• Lin HH, Huang HP, Huang CC, Chen JH, and Wang CJ: Hibiscus polyphenol-rich extract induces apoptosis in human gastric carcinoma cells via p53 phosporylation and p39 MAPK/FasL cascade pathway. Mol Carcinog 43, 86–99, 2005.
   PubMed Web of Science ®Google Scholar
• Chang YC, Huang HP, Hsu JD, Yang SF, and Wang CJ: Hibiscus anthocyanins rich extract-induced apoptotic cell death in human promyelocitic leukemia cells. Toxicol Appl Pharmacol 205, 201–212, 2005.
   PubMed Web of Science ®Google Scholar
• Hopkins AL, Lamm MG, Funk JL, and Ritenbaugh C: Hibiscus sabdariffa L. in the treatment of hypertension and hyperlipidemia: a comprehensive review of animal and human studies. Fitoterapia 85, 84–94, 2013.
   PubMed Web of Science ®Google Scholar
• Frank T, Netzel G, Kammerer DR, Carle R, Kler A, Kriesl E, Bitsch I, Bitsch R, and Netzel M: Consumption of Hibiscus sabdariffa L. aqueous extract and its impact on systemic antioxidant potential in healthy subjects. J Sci Food Agric 92, 2207–2218, 2012.
   PubMed Web of Science ®Google Scholar
• Frank T, Janssen M, Netzel M, Strass G, Kler A, Kriesl E, and Bitsch I: Pharmacokinetics of anthocyanidin-3-glycosides following consumption of Hibiscus sabdariffa L. extract. J Clin Pharmacol 45, 203–210, 2005.
   PubMed Web of Science ®Google Scholar
• Lo CW, Huang HP, Lin HM, Chien CT, and Wang CJ: Effect of Hibiscus anthocyanins-rich extract induces apoptosis of proliferating smooth muscle cell via activation of P38 MAPK and p53 pathway. Mol Nutr Food Res 51, 1452–1460, 2007.
   PubMed Web of Science ®Google Scholar
• Chiu CT, Hsuan SW, Lin HH, Hsu CC, Chou FP, et al.: Hibiscus sabdariffa leaf polyphenolic extract induces human melanoma cell death, apoptosis, and autophagy. J Food Sci 80, H649–H458, 2015.
   PubMed Web of Science ®Google Scholar
• Tseng TH, Kao TW, Chu CY, Chou FP, Lin WL, et al.: Induction of apoptosis by hibiscus protocatechuic acid in human leukemia cells via reduction of retinoblastoma (RB) phosphorylation and Bcl-2 expression. Biochem Pharmacol 60, 307–315, 2000.
   PubMed Web of Science ®Google Scholar
• Ramirez-Rodrigues MM, Plaza ML, Azeredo A, Balaban MO, and Marshall MR: Physicochemical and phytochemical properties of cold and hot water extraction from Hibiscus sabdariffa. J Food Sci 76, C428–C435, 2011.
   PubMed Web of Science ®Google Scholar
• Teicher BA and Tomaszewski JE: Proteasome inhibitors. Biochem Pharmacol 96, 1–9, 2015.
   PubMed Web of Science ®Google Scholar
• Moucadel V, Prudent R, Sautel CF, Teillet F, Barette C, et al.: Antitumoral activity of allosteric inhibitors of protein kinase CK2. Oncotarget 2, 997–1010, 2011.
   PubMed Web of Science ®Google Scholar
• Akita RW and Sliwkowski MX: Preclinical studies with Erlotinib (Tarceva). Semin Oncol 30, 15–24, 2003.
   PubMed Web of Science ®Google Scholar
• Chiu CT, Chen JH, Chou FP, and Lin HH: Hibiscus sabdariffa leaf extract inhibits human prostate cancer cell invasion via down-regulation of Akt/NF-kB/MMP-9 pathway. Nutrients 7, 5065–5087, 2015.
   PubMed Web of Science ®Google Scholar
• Syed DN, Afaq F, Sarfaraz S, Khan N, Kedlaya R et al.: Delphinidin inhibits cell proliferation and invasion via modulation of Met receptor phosphorylation. Toxicol Appl Pharmacol 231, 52–60, 2008.
   PubMed Web of Science ®Google Scholar
• Chiang WC, Wong YK, Lin SC, Chang KW, and Liu CJ: Increase of MMP-13 expression in multi-stage oral carcinogenesis and epigallocatechin-3-gallate suppress MMP-13 expression. Oral Dis 12, 27–33, 2006.
   PubMed Web of Science ®Google Scholar
• Ho YC, Yang SF, Peng CY, Chou MY, and Chang YC: Epigallocatechin-3-gallate inhibits the invasion of human oral cancer cells and decreases the productions of matrix metalloproteinases and urokinase-plasminogen activator. J Oral Pathol Med 36, 588–593, 2007.
   PubMed Web of Science ®Google Scholar
• Lai WW, Hsu SC, Chueh FS, Chen YY, Yang JS, et al.: Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-κB and matrix metalloproteinase-2/-9 signaling pathways. Anticancer Res 33, 1941–1950, 2013.
   PubMed Web of Science ®Google Scholar
• Burotto M, Chiou VL, Lee JM, and Kohn EC: The MAPK pathway across different malignancies: a new perspective. Cancer 120, 3446–3456, 2014.
   PubMed Web of Science ®Google Scholar
• Kolch W, Calder M and Gilbert D: When kinases meet mathematics: the system biology of MAPK signaling. FEBS Lett 579, 1891–1895, 2005.
   PubMed Web of Science ®Google Scholar
• Chappell WH, Steelman LS, Long JM, Kempf RC, Abrams SL, et al.: Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health. Oncotarget 2, 135–164, 2011.
   PubMed Web of Science ®Google Scholar
• Sever R and Brugge JS: Signal transduction in cancer. Cold Spring Harb Perspect Med 5, pii: a006098. doi: 10.1101/cshperspect.a006098, 2015.
   Web of Science ®Google Scholar
• del Barco Barrantes I, and Nebreda AR: Roles of p38 MAPKs in invasion and metastasis. Biochem Soc Trans 40, 79–84, 2012.
   PubMed Web of Science ®Google Scholar
• Vial E and Pouysségur J: Regulation of tumor cell motility by ERK mitogen-activated protein kinases. Ann N Y Acad Sci 1030, 208–218, 2004.
   PubMed Web of Science ®Google Scholar
• Theocharis S, Kotta-Loizou I, Klijanienko J, Giaginis C, Alexandrou P, et al: Extracellular signal-regulated kinase (ERK) expression and activation in mobile tongue squamous cell carcinoma: associations with clinic pathological parameters and patients survival. Tumour Biol 35, 6455–6465, 2014.
   PubMed Web of Science ®Google Scholar
• Kim JK, So H, Youn MJ, Kim HJ, Kim Y, et al.: Hibiscus sabdariffa L. water extract inhibits the adipocyte differentiation through the PI3-K and MAPK pathway. J Ethnopharmacol 114, 260–267, 2007.
   PubMed Web of Science ®Google Scholar
• Zhong D, Gu C, Shi L, Xun T, Li X, Liu S, and Yu L: Obatoclax induces G1/G0-phase arrest via p38/p21(waf1/Cip1) signaling pathway in human esophageal cancer cells. J Cell Biochem 115, 1624–1635, 2014.
   PubMed Web of Science ®Google Scholar
• Ellinger-Ziegelbauer H, Kelly K, and Siebenlist U: Cell cycle arrest and reversion of Ras-induced transformation by a conditionally activated form of mitogen-activated protein kinase kinase kinase 3. Mol Cell Biol 19, 3857–3868, 1999.
   PubMed Web of Science ®Google Scholar
• Hartung T and Daston G: Are in vitro tests suitable for regulatory use? Toxicol Sci 111, 233–237, 2009.
   PubMed Web of Science ®Google Scholar