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Review Article

Application of Probabilistic Modeling to Quantify the Reduction Levels of Hepatocellular Carcinoma Risk Attributable to Chronic Aflatoxins Exposure

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Pages 1-13 | Received 09 Dec 2015, Accepted 26 Aug 2016, Published online: 05 Dec 2016

References

  • Ngindu A, Johnson BK, Kenya PR, Ngira JA, Ocheng DM, et al.: Outbreak of acute hepatitis caused by aflatoxin poisoning in Kenya. Lancet 12, 1346–1348, 1982.
  • Nyikal J, Misore A, Nzioka C, Njuguna C, Muchiri E, et al.: Outbreak of aflatoxin poisoning—Eastern and Central Provinces, Kenya, January-July 2004. Morb Mortal Wkly Rep 53, 790–793, 2004.
  • Azziz-Baumgartner E, Lindblade K, Gieseker K, Rogers HS, Kieszak S, et al.: Case-control study of an acute aflatoxicosis outbreak, Kenya, 2004. Environ Health Perspect 113, 1779–1783, 2005.
  • Lewis L, Onsongo M, Njapau H, Schurz-Rogers H, Luber G, et al.: Aflatoxin contamination of commercial maize products during an outbreak of acute aflatoxicosis in eastern and central Kenya. Environ Health Perspect 113, 1763–1767, 2005.
  • Wagacha JM and Muthomi JW: Mycotoxin problem in Africa: current status, implications to food safety and health and possible management strategies. Int J Food Microbiol 10, 124, 1–12, 2008.
  • Unnevehr L and Grace D (eds.): Aflatoxins: Finding Solutions for Improved Food Safety. Washington, DC, International Food Policy Research Institute, 2013.
  • Szymañska K, Chen J-G, Cui Y, Gong YY, Turner PC, et al.: TP53 R249S mutations, exposure to aflatoxin, and occurrence of hepatocellular carcinoma in a cohort of chronic hepatitis B virus carriers from Qidong, China. Cancer Epidemiol biomarkers Prev 18, 1638–1643, 2009.
  • Groopman JD, Kensler TW, and Wild CP: Protective interventions to prevent aflatoxin-induced carcinogenesis in developing countries. Annu Rev Public Health 29, 187–203, 2008.
  • Liao C-D, Wong JW, Zhang K, Hayward DG, Lee NS, et al.: Multi-mycotoxin analysis of finished grain and nut products using high-performance liquid chromatography-triple-quadrupole mass spectrometry. J Agric Food Chem 61, 4771–4782, 2013.
  • Rawal S and Coulombe RA: Metabolism of aflatoxin B1 in turkey liver microsomes: the relative roles of cytochromes P450 1A5 and 3A37. Toxicol Appl Pharmacol 254, 349–354, 2011.
  • Cousin MA, Riley RT, and Pestka JJ: Foodborne mycotoxins: chemistry, biology, ecology, and toxicology. In: Foodborne pathogens: microbiology and molecular biology. Fratamico PM, Bhunia AK, and Smith JL (eds). Norfolk: Caister Academic Press, 2006, 163–226.
  • Skipper PL and Tannenbaum SR: Protein adducts in the molecular dosimetry of chemical carcinogens. Carcinogenesis 11, 507–518, 1990.
  • Hollinger FB: Hepatitis B virus infection and transfusion medicine: science and the occult. Transfusion 48, 1001–1026, 2008.
  • Mahoney FJ: Update on diagnosis, management, and prevention of hepatitis B virus infection. Clin Microbiol Rev 12, 351–366, 1999.
  • Wild CP and Gong YY: Mycotoxins and human disease: a largely ignored global health issue. Carcinogenesis 31, 71–82, 2010.
  • Wu F, Stacy SL, and Kensler TW: Global risk assessment of aflatoxins in maize and peanuts: Are regulatory standards adequately protective? Toxicol Sci 135, 251–259, 2013.
  • Mutuma G, Mbuchi M, and Zeyhle E: Prevalence of Hepatitis B Virus (HBV) surface antigen and HBV-associated hepatocellular carcinoma in Kenyans of various ages. Afr J Heal Sci 18, 53–61, 2011.
  • Government of Kenya: National cancer control strategy. Nairobi, Kenya, 2011. Retrieved from http://www.ipcrc.net/pdfs/Kenya-National-Cancer-Control-strategy.pdf
  • Wild CP and Hall AJ: Primary prevention of hepatocellular carcinoma in developing countries. Mutat Res 462, 381–393, 2000.
  • Owaga E, Muga R, Mumbo H, and Aila F: Chronic dietary aflatoxins exposure in Kenya and emerging public health concerns of impaired growth and immune suppression in children. Int J Biol Chem Sci 5, 1325–1336, 2011.
  • Liu Y and Wu F: Global burden of aflatoxin-induced hepatocellular carcinoma: a risk assessment. Environ Health Perspect 118, 818–824, 2010.
  • Drewnowski A and Popkin BM: The nutrition transition: new trends in the global diet. Nutr Rev 55, 31–43, 1997.
  • Kilonzo RM, Imungi JK, Muiru WM, Lamuka PO, and Njage PMK: Household dietary exposure to aflatoxins from maize and maize products in Kenya. Food Addit Contam Part A 31, 2055–2062, 2014.
  • Mutegi C, Wagacha M, Kimani J, Otieno G, Wanyama R, et al.: Incidence of aflatoxin in peanuts (Arachis hypogaea Linnaeus) from markets in Western, Nyanza and Nairobi Provinces of Kenya and related market traits. J Stored Prod Res 52, 118–127, 2013.
  • Plymoth A, Viviani S, and Hainaut P: Control of hepatocellular carcinoma through hepatitis B vaccination in areas of high endemicity: perspectives for global liver cancer prevention. Cancer Lett 286, 15–21, 2009.
  • Strosnider H, Azziz-Baumgartner E, Banziger M, Bhat R V, Breiman R, et al.: Workgroup report: Public health strategies for reducing aflatoxin exposure in developing countries. Environ Health Perspect 114, 1898–1903, 2006.
  • Daniel JH, Lewis LW, Redwood YA, Kieszak S, Breiman RF, et al.: Comprehensive assessment of maize aflatoxin levels in eastern Kenya, 2005–2007. Environ Health Perspect 119, 1794–1799, 2011.
  • World Health Organization/Food and Agriculture Organization: Food safety risk analysis-a guide for national food safety authorities. Rome, Italy, Food and Agriculture Organization of the United Nations, 2006. Retrieved from http://www.fao.org/docrep/012/a0822e/a0822e00.htm
  • Hoornstra E and Notermans S: Quantitative microbiological risk assessment. Int J Food Microbiol 66, 21–29, 2001.
  • International Agency for Research on Cancer: Some traditional herbal medicines, some mycotoxins, naphthalene and styrene. IARC Monogr Eval Carcinog risks to humans 82, 171–300, 2002.
  • Williams JH, Phillips TD, Jolly PE, Stiles JK, Jolly CM, et al.: Human aflatoxicosis in developing countries: A review of toxicology, exposure, potential health consequences, and interventions. Am J Clin Nutr 80, 1106–2230, 2004.
  • Wild CP and Montesano R: A model of interaction: aflatoxins and hepatitis viruses in liver cancer aetiology and prevention. Cancer Lett 286, 22–28, 2009.
  • Mphahlele JM, Francois G, Kew M, Hoosen AA, and Meheus A (eds.): Hepatitis B virus infection in eastern and southern Africa: epidemiology, clinical aspects and prevention. Southern African Journal of Epidemiology Infection. 2002.
  • Tasheva-petkova YR, Christova-bagdassarian VL, and Kolev A: Harmonize approaches to analysis and risk assessment of mycotoxins in foodstuffs. Int J Adv Res 2, 1097–1106, 2014.
  • Abt E, Rodricks JV, Levy JI, Zeise L, and Burke TA: Science and decisions: advancing risk assessment. Risk Anal 30, 1028–1036, 2010.
  • Yeh FS, Yu MC, Mo CC, Luo S, Tong MJ, et al.: Hepatitis B virus, aflatoxins, and hepatocellular carcinoma in southern Guangxi, China. Cancer Res 49, 2506–2509, 1989.
  • Shephard GS: Risk assessment of aflatoxins in food in Africa. Food Addit Contam Part A 25, 1246–1256, 2008.
  • Wu F and Khlangwiset P: Health economic impacts and cost-effectiveness of aflatoxin-reduction strategies in Africa: case studies in biocontrol and post-harvest interventions. Food Addit Contam Part A 27, 496–509, 2010.
  • Wagacha JM, Mutegi CK, Christie ME, Karanja LW, and Kimani J: Changes in Fungal Population and Aflatoxin Levels and Assessment of Major Aflatoxin Types in Stored Peanuts (Arachis hypogaea Linnaeus). J Food Res 2, 10–23, 2013.
  • Food and Agriculture Organization: Human energy requirements- report of a Joint FAO/WHO/UNU Expert Consultation. Rome, Italy, Food and Agriculture Organization, 2001. Retrieved from http://www.fao.org/docrep/007/y5686e/y5686e00.htm
  • Hansen AW, Christensen DL, Larsson MW, Eis J, Christensen T, et al.: Dietary patterns, food and macronutrient intakes among adults in three ethnic groups in rural Kenya. Public Health Nutr 14, 1671–1679, 2011.
  • United States Agency for International Development: Staple foods value chain analysis. Country report – Kenya, 2010. Retrieved from http://pdf.usaid.gov/pdf_docs/PNADW641.pdf
  • Muthomi JW, Njenga LN, Gathumbi JK, and Chemining'wa GN: The occurrence of aflatoxins in maize and distribution of mycotoxin-producing fungi in Eastern Kenya. Plant Pathol J 8, 113–119, 2009.
  • Nyirahakizimana H, Mwamburi L, Wakhisi J, Mutegi CK, Christie ME, et al.: Occurrence of Aspergillus species and aflatoxin contamination in raw and roasted peanuts from formal and informal markets in Eldoret and Kericho, Kenya. Adv Microbiol 3, 333–342, 2013.
  • Ondieki D, Lutta ST, Okoth MO, and Kering P: Rapid assessment of aflatoxin contamination of groundnuts by thin layer chromatography and competitive enzyme linked immunosorbent assay from selected divisions of Busia County in Kenya. J Food Sci Technol 5, 12–20, 2014.
  • Menza NC, Margaret MW, and Lucy KM: Incidence, types and levels of aflatoxin in different peanuts varieties produced in Busia and Kisii Central Districts, Kenya. Open J Med Microbiol 5, 209–221, 2015.
  • Ndungu JW, Makokha AO, Onyango CA, Mutegi CK, Wagacha JM, and Christie ME: Prevalence and potential for aflatoxin contamination in groundnuts and peanut butter from farmers and traders in Nairobi and Nyanza provinces of Kenya. J Appl Biosci 65, 4922–4934, 2013.
  • Government of Kenya: Population and housing census 2009, 2009. Retrieved from http://www.knbs.or.ke/index.php?option=com_phocadownload&view=category&id=109:population-and-housing-census-2009&Itemid=599
  • El-Serag HB and Mason AC: Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med 340, 745–750, 1999.
  • Yu MC and Yuan J-M: Environmental factors and risk for hepatocellular carcinoma. Gastroenterology 127, S72–S78, 2004.
  • Waliyar F, Osiru M, Ntare BR, Kumar KVK, Sudini H, Traore A, et al.: Post-harvest management of aflatoxin contamination in groundnut. World Mycotoxin J 8, 245–252, 2015.
  • Torres AM, Barros GG, Palacios SA, Chulze SN, and Battilani P: Review on pre- and post-harvest management of peanuts to minimize aflatoxin contamination. Food Res Int 62 11–19, 2014.
  • Dorner JW: Management and prevention of mycotoxins in peanuts. Food Addit Contam Part A 25, 203–208, 2008.
  • Guchi E: Aflatoxin contamination in groundnut (Arachis hypogaea l.) caused by Aspergillus species in Ethiopia. J Appl Environ Microbiol 3, 11–19, 2015.
  • Hell K, Mutegi C, and Fandohan P: Aflatoxin control and prevention strategies in maize for Sub-Saharan Africa. In: 10th International Working Conference on Stored Product Protection. Julius-Kühn-Archiv 534–541, 2010.
  • Choudhary AK and Kumari P: Management of mycotoxin contamination in preharvest and post harvest crops: present status and future prospects. J Phytol 2, 37–52, 2010.
  • Jalili M: A review on aflatoxins reduction in food. Iran J Heal Saf Environ 3, 445–459, 2015.
  • Codex Alimentarius Commission: Code of practice for the prevention and reduction of aflatoxin contamination in peanuts–CAC/RCP 55–2004, 2004. Retrieved from http://www.codexalimentarius.org/input/download/standards/10084/CXP_055e.pdf
  • Ogunsanwo B and Faboya O: Effect of roasting on the aflatoxin contents of Nigerian peanut seeds. African J Biotechnol 3, 451–455.
  • Filbert ME and Brown DL: Aflatoxin contamination in Haitian and Kenyan peanut butter and two solutions for reducing such contamination. J Hunger Environ Nutr 7, 321–232, 2012.
  • Siwela AH, Mukaroa KJ, and Nziramasanga N: Aflatoxin carryover during large scale peanut butter production. Food Nutr Sci 2, 105–108, 2011.
  • Moreira JF, Peluzzio JM, Faraco A, and Prado G: Use of glycerol coating to control aflatoxin production by Aspergillus parasiticus in peanut grains. J Basic Appl Pharm Sci 36, 227–31, 2015.
  • Prado G, Madeira JEGC, Morais VAD, Oliveira MS, Souza RA, et al.: Reduction of aflatoxin B1 in stored peanuts (Arachis hypogaea L.) using Saccharomyces cerevisiae. J Food Prot 74, 1003–1006, 2011.
  • Atehnkeng J, Ojiambo PS, Ikotun T, Sikora RA, Cotty PJ, et al.: Evaluation of atoxigenic isolates of Aspergillus flavus as potential biocontrol agents for aflatoxin in maize. Food Addit Contam Part A 25, 1264–1271, 2008.
  • Afolabi CG, Bandyopadhyay R, Leslie JF, and Ekpo EJA: Effect of sorting on incidence and occurrence of fumonisins and Fusarium verticillioides on maize from Nigeria. J Food Prot 69, 2019–2023, 2006.
  • Fandohan P, Zoumenou D, Hounhouigan DJ, Marasas WFO, Wingfield MJ, et al.: Fate of aflatoxins and fumonisins during the processing of maize into food products in Benin. Int J Food Microbiol 98, 249–259, 2005.
  • Park DL: Effect of processing on aflatoxin. Adv Exp Med Biol 504, 173–179, 2002.
  • Siwela AH, Siwela M, Matindi G, Dube S, and Nziramasanga N: Decontamination of aflatoxin-contaminated maize by dehulling. J Sci Food Agric 85, 2535–2538, 2005.
  • Mutungi C, Lamuka P, Arimi S, Gathumbi J, and Onyango C: The fate of aflatoxins during processing of maize into muthokoi—A traditional Kenyan food. Food Control 19, 714–721, 2008.
  • Shekhar M, Singh S, Ashraf A, Khan A, and Kumar S: Efficacy of inorganic salts and organic acids against colony growth of Aspergillus flavus and their use to control aflatoxin level in post harvest maize. Internet J Food Saf 11, 4–10, 2009.
  • Elias-Orozco R, Castellanos-Nava A, Gaytán-Martínez M, Figueroa-Cárdenas JD, and Loarca-Piña G: Comparison of nixtamalization and extrusion processes for a reduction in aflatoxin content. Food Addit Contam Part A 19, 878–885, 2002.
  • Kroes R, Müller D, Lambe J, Löwik MRH, van Klaveren J, et al.: Assessment of intake from the diet. Food Chem Toxicol 40, 327–385, 2002.
  • Bearer CF: Environmental health hazards: how children are different from adults. Futur Child 5, 11–26, 1995a.
  • Bearer CF: How are children different from adults? Environ Health Perspect 103, 7–12, 1995b.
  • Gong Y, Hounsa A, Egal S, Turner PC, Sutcliffe AE, Hall AJ, et al.: Postweaning exposure to aflatoxin results in impaired child growth: a longitudinal study in Benin, West Africa. Environ Health Perspect 112, 1334–1338, 2004.
  • Gong Y, Turner P, Hounsa A, White K, Cardwell K, et al.: Dietary exposure to human hepatocarcinogens, aflatoxins, micronutrient deficiency, and child growth in Benin, West Africa. J Nutr 134, 3522S–3522S, 2004.
  • Magnussen A and Parsi MA: Aflatoxins, hepatocellular carcinoma and public health. World J Gastroenterol 19, 1508–1512, 2013.
  • Gong Y, Cardwell K, Hounsa A, Egal S, Turner PC, et al.: Dietary aflatoxin exposure and impaired growth in young children from Benin and Togo: cross sectional study. Br Med J 325, 20–21, 2002.
  • World Health Organization: Hepatitis B. World Health Organization, 2015. Retrieved from http://www.who.int/mediacentre/factsheets/fs204/en/
  • Obade M, Andang'o P, Obonyo C, and Lusweti F: Exposure of children 4 to 6 months of age to aflatoxin in Kisumu County, Kenya. African J Food Agric Nutr Dev 15, 9949–9963, 2015.
  • Thun MJ, DeLancey JO, Center MM, Jemal A, and Ward EM: The global burden of cancer: priorities for prevention. Carcinogenesis 31, 100–110, 2010.
  • Bennett JW and Klich M: Mycotoxins. Clin Microbiol Rev 16, 497–516, 2003.
  • Omer RE, Kuijsten A, Kadaru AMY, Kok FJ, Idris MO, et al.: Population-attributable risk of dietary aflatoxins and hepatitis B virus infection with respect to hepatocellular carcinoma. Nutr Cancer 48, 15–21, 2004.
  • Hell K and Mutegi C: Aflatoxin control and prevention strategies in key crops of Sub-Saharan Africa. African J Microbiol Res 5, 459–466, 2011.
  • Bandyopadhyay R, Kumar M, and Leslie JF: Relative severity of aflatoxin contamination of cereal crops in West Africa. Food Addit Contam Part A 24, 1109–1114, 2007;
  • Mulemi BA: Cancer crisis and treatment ambiguity in Kenya. In: Anthropologies of cancer in transnational worlds. Mathews HF, Burke NJ, and Kampriani E (eds). New York and London: Routledge, 2015, 160–175.
  • Jemal A, Bray F, Center MM, Ferlay J, Ward E, et al.: Global cancer statistics. CA Cancer J Clin 61, 69–90, 2011.
  • Guto SN, Pypers P, Vanlauwe B, de Ridder N, and Giller KE: Socio-ecological niches for minimum tillage and crop-residue retention in continuous maize cropping systems in smallholder farms of central Kenya. Agron J 104, 188–198, 2012.
  • Kisinyo PO, Othieno CO, Gudu SO, Okalebo JR, Opala PA, Ng'etich WK, et al.: Immediate and residual effects of lime and phosphorus fertilizer on soil acidity and maize production in Western Kenya. Exp Agric 50, 128–143, 2013.
  • Otinga AN, Pypers P, Okalebo JR, Njoroge R, Emong'ole M, et al.: Partial substitution of phosphorus fertiliser by farmyard manure and its localised application increases agronomic efficiency and profitability of maize production. F Crop Res 140, 32–43, 2013.
  • Saunders M and Kohn LM: Evidence for alteration of fungal endophyte community assembly by host defense compounds. New Phytol 182, 229–238, 2009.
  • Hutchison ML, Walters LD, Avery SM, Munro F, and Moore A: Analyses of livestock production, waste storage, and pathogen levels and prevalences in farm manures. Appl Environ Microbiol 71, 1231–1236, 2005.
  • Youssef K, Ligorio A, Nigro F, and Ippolito A: Activity of salts incorporated in wax in controlling postharvest diseases of citrus fruit. Postharvest Biol Technol 65, 39–43, 2012.
  • Fagundes C, Pérez-Gago MB, Monteiro AR, and Palou L: Antifungal activity of food additives in vitro and as ingredients of hydroxypropyl methylcellulose-lipid edible coatings against Botrytis cinerea and Alternaria alternata on cherry tomato fruit. Int J Food Microbiol 166, 391–398, 2013.
  • Fagundes C, Palou L, Monteiro AR, and Pérez-Gago MB: Effect of antifungal hydroxypropyl methylcellulose-beeswax edible coatings on gray mold development and quality attributes of cold-stored cherry tomato fruit. Postharvest Biol Technol 92, 1–8, 2014.
  • In Y-W, Kim J-J, Kim H-J, and Oh S-W: Antimicrobial activities of acetic acid, citric acid and lactic acid against Shigella species. J Food Saf 33, 79–85, 2013.
  • Rivero S, Giannuzzi L, García MA, and Pinotti A: Controlled delivery of propionic acid from chitosan films for pastry dough conservation. J Food Eng 116, 524–531, 2013.
  • Zhang T, Howell BA, Dumitrascu A, Martin SJ, and Smith PB: Synthesis and characterization of glycerol-adipic acid hyperbranched polyesters. Polymer 55, 5065–5072, 2014.
  • Meireles A, Machado I, Fulgêncio R, Mergulhão F, Melo L, and Simões M: Efficacy of antimicrobial combinations to reduce the use of sodium hypochlorite in the control of planktonic and sessile Escherichia coli. Biochem Eng J 104, 115–122, 2015.

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