Impact of Phytochemicals and Dietary Patterns on Epigenome and Cancer

References

• Waddington CH: The epigenotype. Int J Epidemiol 41, 10–13, 2012.
   PubMed Web of Science ®Google Scholar
• Herceg Z: Epigenetics and cancer: towards an evaluation of the impact of environmental and dietary factors. Mutagenesis 22, 91–103, 2007.
   PubMed Web of Science ®Google Scholar
• Choi JD and Lee JS: Interplay between epigenetics and genetics in cancer. Genomics Inform 11, 164–173, 2013.
   PubMedGoogle Scholar
• Knorre DG, Kudryashova NV, and Godovikova TS: Chemical and functional aspects of posttranslational modification of proteins. Acta Naturae 1, 29–51, 2009.
   PubMed Web of Science ®Google Scholar
• Stallcup MR: Role of protein methylation in chromatin remodeling and transcriptional regulation. Oncogene 20, 3014–3020, 2001.
   PubMed Web of Science ®Google Scholar
• Freeman WH: Covalent modification is a means of regulating enzyme activity. In: Biochemistry, 5th edition, Berg JM, Tymoczko JL, and Stryer L (eds.). New York: Freeman and Company, 2002.
   Google Scholar
• Strahl BD and Allis CD: The language of covalent histone modifications. Nature 403, 41–45, 2000.
   PubMed Web of Science ®Google Scholar
• Kouzarides T: Chromatin modifications and their function. Cell 128, 693–705, 2007.
   PubMed Web of Science ®Google Scholar
• Spange S, Wagner T, Heinzel, T and Krämer OH: Acetylation of non-histone proteins modulates cellular signalling at multiple levels. Int J Biochem Cell Biol 41, 185–198, 2009.
   PubMed Web of Science ®Google Scholar
• Das C and Kundu TK: Transcriptional regulation by the acetylation of nonhistone proteins in humans – a new target for therapeutics. IUBMB Life 57, 137–149, 2005.
   PubMed Web of Science ®Google Scholar
• Woo JH, Kim YH, Choi YJ, Kim DG, Lee KS, et al.: Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt. Carcinogenesis 24, 1199–208, 2003.
   PubMed Web of Science ®Google Scholar
• Ropero S and Esteller M: The role of histone deacetylases (HDACs) in human cancer. Mol Oncology 1, 19–25, 2007.
   PubMed Web of Science ®Google Scholar
• Minucci S and Pelicci PG: Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat Rev Cancer 6, 38–51, 2006.
   PubMed Web of Science ®Google Scholar
• Lin HY, Chen CS, Lin SP, Weng JR, and Chen CS: Targeting histone deacetylase in cancer therapy. Med Res Rev 26, 397–413, 2006.
   PubMed Web of Science ®Google Scholar
• Schwartz C, Beck K, and Mink S: Recruitment of p300 by C/EBPbeta triggers phosphorylation of p300 and modulates coactivator activity. EMBO J 22, 882–892, 2003.
   PubMed Web of Science ®Google Scholar
• Matsuzaki H, Daitoku H, Hatta M, Aoyama H, Yoshimochi K, et al.: Acetylation of FoxO1 alters its DNA-binding ability and sensitivity to phosphorylation. Proc Natl Acad Sci USA 102, 11278–11283, 2005.
   PubMed Web of Science ®Google Scholar
• Yang WM, Yao YL, Sun JM, Davie JR, and Seto E: Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family. J Biol Chem 272, 28001–28007, 1997.
   PubMed Web of Science ®Google Scholar
• Galasinski SC, Resing KA, Goodrich JA, and Ahn NG: Phosphatase inhibition leads to histone deacetylases 1 and 2 phosphorylation and disruption of corepressor interactions. J Biol Chem 277, 19618–19626, 2002.
   PubMed Web of Science ®Google Scholar
• http://www.who.int/mediacentre/factsheets/fs297/en/
   Google Scholar
• Wang J, Wu Z, Li D, Li N, Dindot SV, et al.: Nutrition, epigenetics, and metabolic syndrome. Antioxid Redox Signal 17, 282–301, 2012.
   PubMed Web of Science ®Google Scholar
• Bianchini F and Vainio H: Allium vegetables and organosulfur compounds: do they help prevent cancer? Environ Health Perspect 109, 893–902, 2001.
   PubMed Web of Science ®Google Scholar
• Druesne-Pecollo N and Latino-Martel P: Modulation of histone acetylation by garlic sulfur compounds. Anticancer Agents Med Chem 11, 254–259, 2011.
   PubMed Web of Science ®Google Scholar
• Lea MA and Randolph VM: Induction of histone acetylation in rat liver and hepatoma by organosulfur compounds including diallyl disulfide. Anticancer Res 21, 2841–2845, 2001.
   PubMed Web of Science ®Google Scholar
• Lea MA, Randolph VM, Lee JE, and desBordes C: Induction of histone acetylation in mouse erythroleukemia cells by some organosulfur compounds including allyl isothiocyanate. Int J Cancer 92, 784–789, 2001.
   PubMed Web of Science ®Google Scholar
• Wallace GC, Haar CP, Vandergrift WA, Giglio P, Dixon-Mah YN, et al.: Multi-targeted DATS prevents tumor progression and promotes apoptosis in ectopic glioblastoma xenografts in SCID mice via HDAC inhibition. J Neurooncol 114, 43–50, 2013.
   PubMed Web of Science ®Google Scholar
• Chandra-Kuntal K and Singh SV: Diallyl trisulfide inhibits activation of signal transducer and activator of transcription 3 in prostate cancer cells in culture and in vivo. Cancer Prev Res (Phila) 3, 1473–1483, 2010.
   PubMed Web of Science ®Google Scholar
• Wang YB, Qin J, Zheng XY, Bai Y, Yang K, et al.: Diallyl trisulfide induces Bcl-2 and caspase-3-dependent apoptosis via downregulation of Akt phosphorylation in human T24 bladder cancer cells. Phytomedicine 17, 363–368, 2010.
   PubMed Web of Science ®Google Scholar
• McKay DL and Blumberg JB: A review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.). Phytother Res 20, 519–530, 2006.
   PubMed Web of Science ®Google Scholar
• Pandey M, Kaur P, Shukla S, Abbas A, Fu P, et al.: Plant flavone apigenin inhibits HDAC and remodels chromatin to induce growth arrest and apoptosis in human prostate cancer cells: In vitro and in vivo study. Mol Carcinog 51, 952–962, 2012.
   PubMed Web of Science ®Google Scholar
• Kaur P, Shukla S and Gupta S: Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study. Carcinogenesis 29, 2210–2217, 2008.
   PubMed Web of Science ®Google Scholar
• Shukla S and Gupta S: Apigenin suppresses insulin-like growth factor I receptor signaling in human prostate cancer: an in vitro and in vivo study. Mol Carcinog 48, 243–252, 2009.
   PubMed Web of Science ®Google Scholar
• King JC, Lu QY, Li G, Moro A, Takahashi H, et al.: Evidence for activation of mutated p53 by apigenin in human pancreatic cancer. Biochim Biophys Acta 1823, 593–604, 2012.
   PubMed Web of Science ®Google Scholar
• Ujiki MB, Ding XZ, Salabat MR, Bentrem DJ, Golkar L, et al.: Apigenin inhibits pancreatic cancer cell proliferation through G2/M cell cycle arrest. Mol Cancer 5, 76, 2006.
   PubMed Web of Science ®Google Scholar
• Wu DG, Yu P, Li JW, Jiang P, Sun J, et al.: Apigenin potentiates the growth inhibitory effects by IKK-β-mediated NF-κB activation in pancreatic cancer cells. Toxicol Lett 224, 157–164, 2014.
   PubMed Web of Science ®Google Scholar
• Yin F, Giuliano AE, and Van Herle AJ: Signal pathways involved in apigenin inhibition of growth and induction of apoptosis of human anaplastic thyroid cancer cells (ARO). Anticancer Res 19, 4297–4303, 1999.
   PubMed Web of Science ®Google Scholar
• Harrison ME, Power Coombs MR, Delaney LM, and Hoskin DW: Exposure of breast cancer cells to a subcytotoxic dose of apigenin causes growth inhibition, oxidative stress, and hypophosphorylation of Akt. Exp Mol Pathol 97, 211–217, 2014.
   PubMed Web of Science ®Google Scholar
• Yin F, Giuliano AE, Law RE, and Van Herle AJ: Apigenin inhibits growth and induces G2/M arrest by modulating cyclin-CDK regulators and ERK MAP kinase activation in breast carcinoma cells. Anticancer Res 21, 413–420, 2001.
   PubMed Web of Science ®Google Scholar
• Tseng TH, Chien MH, Lin WL, Wen YC, Chow JM, et al.: Inhibition of MDA-MB-231 breast cancer cell proliferation and tumor growth by apigenin through induction of G2/M arrest and histone H3 acetylation-mediated p21WAF1/CIP1 expression. Environ Toxicol 2016.
   Google Scholar
• Lee WJ, Chen WK, Wang CJ, Lin WL, and Tseng TH: Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and beta 4 integrin function in MDA-MB-231 breast cancer cells. Toxicol Appl Pharmacol 226, 178–191, 2008.
   PubMed Web of Science ®Google Scholar
• Lu HF, Chie YJ, Yang MS, Lee CS, Fu JJ, et al.: Apigenin induces caspase-dependent apoptosis in human lung cancer A549 cells through Bax- and Bcl-2-triggered mitochondrial pathway. Int J Oncol 36, 1477–1484, 2010.
   PubMed Web of Science ®Google Scholar
• Zhao M, Ma J, Zhu HY, Zhang XH, Du ZY, et al.: Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90. Mol Cancer 10, 104, 2011.
   PubMed Web of Science ®Google Scholar
• Chunhua L, Donglan L, Xiuqiong F, Lihua Z, Qin F, et al.: Apigenin up-regulates transgelin and inhibits invasion and migration of colorectal cancer through decreased phosphorylation of AKT. J Nutr Biochem 24, 1766–1775, 2013.
   PubMed Web of Science ®Google Scholar
• Middleton E Jr, Kandaswami C, and Theoharides TC: The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 52, 673–751, 2000.
   PubMed Web of Science ®Google Scholar
• Chang H, Mi M, Ling W, Zhu J, Zhang Q, et al.: Structurally related cytotoxic effects of flavonoids on human cancer cells in vitro. Arch Pharm Res 31, 1137–1144, 2008.
   PubMed Web of Science ®Google Scholar
• Pal-Bhadra M, Ramaiah MJ, Reddy TL, Krishnan A, Pushpavalli SNCVL, et al.: Plant HDAC inhibitor chrysin arrest cell growth and induce p21WAF1 by altering chromatin of STAT response element in A375 cells. BMC Cancer 12, 180, 2012.
   PubMed Web of Science ®Google Scholar
• Lirdprapamongkol K, Sakurai H, Abdelhamed S, Yokoyama S, Athikomkulchai S, et al.: Chrysin overcomes TRAIL resistance of cancer cells through Mcl-1 downregulation by inhibiting STAT3 phosphorylation. Int J Oncol 43, 329–337, 2013.
   PubMed Web of Science ®Google Scholar
• Xia Y, Lian S, Khoi PN, Yoon HJ, Joo YE, et al.: Chrysin inhibits tumor promoter-induced MMP-9 expression by blocking AP-1 via suppression of ERK and JNK pathways in gastric cancer cells. PLoS One 10, e0124007, 2015.
   PubMed Web of Science ®Google Scholar
• Woo KJ, Jeong YJ, Park JW, and Kwon TK: Chrysin-induced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells. Biochem Biophys Res Commun 325, 1215–1222, 2004.
   PubMed Web of Science ®Google Scholar
• Liu H, Hwang JS, Li W, Choi TW, Liu K, et al.: A derivative of chrysin suppresses two-stage skin carcinogenesis by inhibiting mitogen- and stress-activated kinase 1. Cancer Prev Res (Phila) 7, 74–85, 2014.
   PubMed Web of Science ®Google Scholar
• Kristal AR and Lampe JW: Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence. Nutr Cancer 42, 1–9, 2002.
   PubMed Web of Science ®Google Scholar
• Murillo G and Mehta RG: Cruciferous vegetables and cancer prevention. Nutr Cancer 41, 17–28, 2001.
   PubMed Web of Science ®Google Scholar
• Higdon JV, Delage B, Williams DE, and Dashwood RH: Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. Pharmacol Res 55, 224–236, 2007.
   PubMed Web of Science ®Google Scholar
• Tang L, Zirpoli GR, Guru K, Moysich KB, Zhang Y, et al.: Consumption of raw cruciferous vegetables is inversely associated with bladder cancer risk. Cancer Epidemiol Biomarkers Prev 17, 938–944, 2008.
   PubMed Web of Science ®Google Scholar
• Hecht SS: Inhibition of carcinogenesis by isothiocyanates. Drug Metab Rev 32, 395–411, 2000.
   PubMed Web of Science ®Google Scholar
• Emily Ho, John D., Clarke,  , and Roderick H: Dashwood. Dietary Sulforaphane, a Histone Deacetylase Inhibitor for Cancer Prevention. J Nutr 139, 2393–2396, 2009.
   PubMed Web of Science ®Google Scholar
• Myzak MC, Karplus PA, Chung FL, and Dashwood RH: A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. Cancer Res 64, 5767–5774, 2004.
   PubMed Web of Science ®Google Scholar
• Navarro SL, Li F, and Lampe JW: Mechanisms of action of isothiocyanates in cancer chemoprevention: an update. Food Funct 2, 579–587, 2011.
   PubMed Web of Science ®Google Scholar
• Su Z-Y, Zhang C, Lee JH, Shu L, Wu TY, et al.: Requirement and epigenetics reprogramming of Nrf2 in suppression of tumor promoter TPA-induced mouse skin cell transformation by sulforaphane. Cancer Prev Res (Phila) 7, 319–329, 2014.
   PubMed Web of Science ®Google Scholar
• Wiczk A, Hofman D, Konopa G, Herman-Antosiewicz A: Sulforaphane, a cruciferous vegetable-derived isothiocyanate, inhibits protein synthesis in human prostate cancer cells. Biochim Biophys Acta 1823, 1295–1305, 2012.
   PubMed Web of Science ®Google Scholar
• Choi S, Lew KL, Xiao H, Herman-Antosiewicz A, Xiao D, et al.: D,L-Sulforaphane-induced cell death in human prostate cancer cells is regulated by inhibitor of apoptosis family proteins and Apaf-1. Carcinogenesis 28, 151–162, 2007.
   PubMed Web of Science ®Google Scholar
• Stehlik C, de Martin R, Kumabashiri I, Schmid JA, Binder BR, et al.: Nuclear factor (NF)-kappaB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis. J Exp Med 188, 211–216, 1998.
   PubMed Web of Science ®Google Scholar
• Xu C, Shen G, Chen C, Gélinas C, and Kong AN: Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells. Oncogene 24, 4486–4495, 2005.
   PubMed Web of Science ®Google Scholar
• Jeong WS, Kim IW, Hu R, and Kong AN: Modulatory properties of various natural chemopreventive agents on the activation of NF-kappaB signaling pathway. Pharm Res 21, 661–670, 2004.
   PubMed Web of Science ®Google Scholar
• Chinni SR, Li Y, Upadhyay S, Koppolu PK, and Sarkar FH: Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells. Oncogene 20, 2927–2936, 2001.
   PubMed Web of Science ®Google Scholar
• Yan Chen, Wenxiu Shu, Weihua Chen, Qing Wu, Hongli Liu, et al.: Curcumin, both histone deacetylase and p300/CBP-specific inhibitor, represses the activity of nuclear factor kappa B and notch 1 in Raji cells. Basic Clin Pharmacol Toxicol 101, 427–433, 2007.
   PubMed Web of Science ®Google Scholar
• Swamy MV, Citineni B, Patlolla JM, Mohammed A, Zhang Y, et al.: Prevention and treatment of pancreatic cancer by curcumin in combination with omega-3 fatty acids. Nutr Cancer 60, 81–89, 2008.
   PubMed Web of Science ®Google Scholar
• Jiao Y, Wilkinson J 4th, Di X, Wang W, Hatcher H, et al.: Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator. Blood 113, 462–469, 2009.
   PubMed Web of Science ®Google Scholar
• Half E and Arber N: Colon cancer: preventive agents and the present status of chemoprevention. Expert Opin Pharmacother 10, 211–219, 2009.
   PubMed Web of Science ®Google Scholar
• Lv BH, Zhang L, Zhu CC, and Liu J: Inhibition of curcumin on histone deacetylase and expression promotion of P21 (WAF1/CIP1) in HepG2 cells. Zhongguo Zhong Yao Za Zhi 32, 2051–2055, 2007.
   PubMedGoogle Scholar
• Liu HL, Chen Y, Cui GH, and Zhou JF: Curcumin, a potent anti-tumor reagent, is a novel histone deacetylase inhibitor regulating B-NHL cell line Raji proliferation. Acta Pharmacol Sin 26, 603–609, 2005.
   PubMed Web of Science ®Google Scholar
• Wang L, Shen Y, Song R, Sun Y, Xu J, et al.: An anticancer effect of curcumin mediated by down-regulating phosphatase of regenerating liver-3 expression on highly metastatic melanoma cells. Mol Pharmacol 76, 1238–1245, 2009.
   PubMed Web of Science ®Google Scholar
• Lee SJ, Krauthauser C, Maduskuie V, Fawcett PT, Olson JM, et al.: Curcumin-induced HDAC inhibition and attenuation of medulloblastoma growth in vitro and in vivo. BMC Cancer 11, 144, 2011.
   PubMed Web of Science ®Google Scholar
• Qian Y, Ma J, Guo X, Sun J, Yu Y, et al.: Curcumin Enhances the Radiosensitivity of U87 Cells by Inducing DUSP-2 Up-Regulation. Cell Physiol Biochem 35, 1381–1393, 2015.
   PubMed Web of Science ®Google Scholar
• Wang SH, Lin PY, Chiu YC, Huang JS, Kuo YT, et al.: Curcumin-Mediated HDAC Inhibition Suppresses the DNA Damage Response and Contributes to Increased DNA Damage Sensitivity. PLoS One 10, e0134110, 2015.
   PubMed Web of Science ®Google Scholar
• Yu S, Shen G, Khor TO, Kim JH, and Kong AN: Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism. Mol Cancer Ther 7, 2609–2620, 2008.
   PubMed Web of Science ®Google Scholar
• Squires MS, Hudson EA, Howells L, Sale S, Houghton CE, et al.: Relevance of mitogen activated protein kinase (MAPK) and phosphotidylinositol-3-kinase/protein kinase B (PI3K/PKB) pathways to induction of apoptosis by curcumin in breast cells. Biochem Pharmacol 65, 361–376, 2003.
   PubMed Web of Science ®Google Scholar
• Liu HS, Ke CS, Cheng HC, Huang CY, and Su CL: Curcumin-induced mitotic spindle defect and cell cycle arrest in human bladder cancer cells occurs partly through inhibition of aurora A. Mol Pharmacol 80, 638–646, 2011.
   PubMed Web of Science ®Google Scholar
• Tao Y, Zhang P, Frascogna V, Lecluse Y, Auperin A, et al.: Enhancement of radiation response by inhibition of Aurora A kinase using siRNA or a selective Aurora kinase inhibitor PHA680632 in p53-deficient cancer cells. Br J Cancer 97, 1664–1672, 2007.
   PubMed Web of Science ®Google Scholar
• Kundu JK, Na HK, and Surh YJ: Ginger-derived phenolic substances with cancer preventive and therapeutic potential. Forum Nutr 61, 182–192, 2009.
   PubMed Web of Science ®Google Scholar
• Jolad SD, Lantz RC, Chen GJ, Bates RB, and Timmermann BN: Commercially processed dry ginger (Zingiber officinale): composition and effects on LPS-stimulated PGE2 production. Phytochemistry 66, 1614–1635, 2005.
   PubMed Web of Science ®Google Scholar
• Shim S, Kim S, Choi DS, Kwon YB, and Kwon J: Anti-inflammatory effects of [6]-shogaol: potential roles of HDAC inhibition and HSP70 induction. Food Chem Toxicol 49, 2734–2740, 2011.
   PubMed Web of Science ®Google Scholar
• Ling H, Yang H, Tan SH, Chui WK, and Chew EH: 6-Shogaol, an active constituent of ginger, inhibits breast cancer cell invasion by reducing matrix metalloproteinase-9 expression via blockade of nuclear factor-κB activation. Br J Pharmacol 161, 1763–1777, 2010.
   PubMed Web of Science ®Google Scholar
• Kim SO, Kundu JK, Shin YK, Park JH, Cho MH, et al.: [6]-gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin. Oncogene 24, 2558–2567, 2005.
   PubMed Web of Science ®Google Scholar
• Park YJ, Wen J, Bang S, Park SW, and Song SY: [6]-Gingerol induces cell cycle arrest and cell death of mutant p53-expressing pancreatic cancer cells. Yonsei Med J 47, 688–697, 2006.
   PubMed Web of Science ®Google Scholar
• Sung B, Murakami A, Oyajobi BO, and Aggarwal BB: Zerumbone abolishes RANKL-induced NF-kappaB activation, inhibits osteoclastogenesis, and suppresses human breast cancer-induced bone loss in athymic nude mice. Cancer Res 69, 1477–1484, 2009.
   PubMed Web of Science ®Google Scholar
• Takada Y, Murakami A, and Aggarwal BB: Zerumbone abolishes NF-kappaB and IkappaBalpha kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion. Oncogene 24, 6957–6969, 2005.
   PubMed Web of Science ®Google Scholar
• Chung IM, Kim MY, Park WH, and Moon HI: Histone deacetylase inhibitors from the rhizomes of Zingiber zerumbet. Pharmazie 63, 774–776, 2008.
   PubMed Web of Science ®Google Scholar
• Martín AR, Villegas I, La Casa C, and de la Lastra CA: Resveratrol, a polyphenol found in grapes, suppresses oxidative damage and stimulates apoptosis during early colonic inflammation in rats. Biochem Pharmacol 67, 1399–1410, 2004.
   PubMed Web of Science ®Google Scholar
• Venturelli S, Berger A, Böcker A, Busch C, Weiland T, et al.: Resveratrol as a pan-HDAC inhibitor alters the acetylation status of histone [corrected] proteins in human-derived hepatoblastoma cells. PLoS One 8, e73097, 2013.
   PubMed Web of Science ®Google Scholar
• Kai L, Samuel SK, and Levenson AS: Resveratrol enhances p53 acetylation and apoptosis in prostate cancer by inhibiting MTA1/NuRD complex. Int J Cancer 126, 1538–1548, 2010.
   PubMed Web of Science ®Google Scholar
• Ai Z, Li C, Li L, and He G: Resveratrol inhibits β-amyloid-induced neuronal apoptosis via regulation of p53 acetylation in PC12 cells. Mol Med Rep 11, 2429–2434, 2015.
   PubMed Web of Science ®Google Scholar
• Wang Y, Romigh T, He X, Orloff MS, Silverman RH, et al.: Resveratrol regulates the PTEN/AKT pathway through androgen receptor-dependent and -independent mechanisms in prostate cancer cell lines. Hum Mol Genet 19, 4319–4329, 2010.
   PubMed Web of Science ®Google Scholar
• Chen Q, Ganapathy S, Singh KP, Shankar S, and Srivastava RK: Resveratrol induces growth arrest and apoptosis through activation of FOXO transcription factors in prostate cancer cells. PLoS One 5, e15288, 2010.
   PubMed Web of Science ®Google Scholar
• Frazzi R, Valli R, Tamagnini I, Casali B, Latruffe N, et al.: Resveratrol-mediated apoptosis of hodgkin lymphoma cells involves SIRT1 inhibition and FOXO3a hyperacetylation. Int J Cancer 132, 1013–1021, 2013.
   PubMed Web of Science ®Google Scholar
• He X, Wang Y, Zhu J, Orloff M, and Eng C: Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast cancer cell lines mainly by suppressing rapamycin-induced AKT signaling. Cancer Lett 301, 168–176, 2011.
   PubMed Web of Science ®Google Scholar
• Li W, Ma J, Ma Q, Li B, Han L, et al.: Resveratrol inhibits the epithelial-mesenchymal transition of pancreatic cancer cells via suppression of the PI-3K/Akt/NF-κB pathway. Curr Med Chem 20, 4185–4194, 2013.
   PubMed Web of Science ®Google Scholar
• Jiang H, Shang X, Wu H, Gautam SC, Al-Holou S, et al.: Resveratrol downregulates PI3K/Akt/mTOR signaling pathways in human U251 glioma cells. J Exp Ther Oncol 8, 25–33, 2009.
   PubMedGoogle Scholar
• Zhang P, Li H, Yang B, Yang F, Zhang LL, et al.: Biological significance and therapeutic implication of resveratrol-inhibited Wnt, Notch and STAT3 signaling in cervical cancer cells. Genes Cancer 5, 154–164, 2014.
   PubMedGoogle Scholar
• Liu X, Zhang DY, Zhang W, Zhao X, Yuan C, et al.: The effect of green tea extract and EGCG on the signaling network in squamous cell carcinoma. Nutr Cancer 63, 466–475, 2011.
   PubMed Web of Science ®Google Scholar
• Hu Q, Chang X, Yan R, Rong C, Yang C, et al.: (2)-Epigallocatechin-3-gallate induces cancer cell apoptosis via acetylation of amyloid precursor protein. Med Oncol 32, 390, 2015.
   PubMed Web of Science ®Google Scholar
• Pandey M, Shukla S, and Gupta S: Promoter demethylation and chromatin remodeling by green tea polyphenols leads to re-expression of GSTP1 in human prostate cancer cells. Int J Cancer 126, 2520–2533, 2010.
   PubMed Web of Science ®Google Scholar
• Adhami VM, Siddiqui IA, Ahmad N, Gupta S, and Mukhtar H: Oral consumption of green tea polyphenols inhibits insulin-like growth factor-I-induced signaling in an autochthonous mouse model of prostate cancer. Cancer Res 64, 8715–8722, 2004.
   PubMed Web of Science ®Google Scholar
• Klein RD and Fischer SM: Black tea polyphenols inhibit IGF-I-induced signaling through Akt in normal prostate epithelial cells and Du145 prostate carcinoma cells. Carcinogenesis 23, 217–221, 2002.
   PubMed Web of Science ®Google Scholar
• Kiss AK, Granica S, Stolarczyk M, and Melzig MF: Epigenetic modulation of mechanisms involved in inflammation: Influence of selected polyphenolic substances on histone acetylation state. Food Chem 131, 1015–1020, 2012.
   Web of Science ®Google Scholar
• Nandakumar V, Vaid M, and Katiyar SK: (-)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1/p21 and p16INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells. Carcinogenesis 32, 537–544, 2011.
   PubMed Web of Science ®Google Scholar
• Roy SK, Srivastava RK, and Shankar S: Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer. J Mol Signal 5, 10, 2010.
   PubMedGoogle Scholar
• Shimizu M, Deguchi A, Hara Y, Moriwaki H, and Weinstein IB: EGCG inhibits activation of the insulin-like growth factor-1 receptor in human colon cancer cells. Biochem Biophys Res Commun 334, 947–953, 2005.
   PubMed Web of Science ®Google Scholar
• Milligan SA, Burke P, Coleman DT, Bigelow RL, Steffan JJ, et al.: The green tea polyphenol EGCG potentiates the antiproliferative activity of c-Met and epidermal growth factor receptor inhibitors in non-small cell lung cancer cells. Clin Cancer Res 15, 4885–4894, 2009.
   PubMed Web of Science ®Google Scholar
• Kim SO and Kim MR: (-)-Epigallocatechin 3-gallate inhibits invasion by inducing the expression of Raf kinase inhibitor protein in AsPC-1 human pancreatic adenocarcinoma cells through the modulation of histone deacetylase activity. Int J Oncol 42, 349–358, 2013.
   PubMed Web of Science ®Google Scholar
• Masuda M, Suzui M, Lim JT, and Weinstein IB: Epigallocatechin-3-gallate inhibits activation of HER-2/neu and downstream signaling pathways in human head and neck and breast carcinoma cells. Clin Cancer Res 9, 3486–3491, 2003.
   PubMed Web of Science ®Google Scholar
• Pan MH, Lin CC, Lin JK, and Chen WJ: Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling. J Agric Food Chem 55, 5030–5037, 2007.
   PubMed Web of Science ®Google Scholar
• Liang YC, Lin-Shiau SY, Chen CF, and Lin JK: Inhibition of cyclin-dependent kinases 2 and 4 activities as well as induction of Cdk inhibitors p21 and p27 during growth arrest of human breast carcinoma cells by (-)-epigallocatechin-3-gallate. J Cell Biochem 75, 1–12, 1999.
   PubMed Web of Science ®Google Scholar
• Tang Y, Zhao DY, Elliott S, Zhao W, Curiel TJ, et al.: Epigallocatechin-3 gallate induces growth inhibition and apoptosis in human breast cancer cells through survivin suppression. Int J Oncol 31, 705–711, 2007.
   PubMed Web of Science ®Google Scholar
• Qin J, Xie LP, Zheng XY, Wang YB, Bai Y, et al.: A component of green tea, (-)-epigallocatechin-3-gallate, promotes apoptosis in T24 human bladder cancer cells via modulation of the PI3K/Akt pathway and Bcl-2 family proteins. Biochem Biophys Res Commun 354, 852–857, 2007.
   PubMed Web of Science ®Google Scholar
• Noguchi M, Yokoyama M, Watanabe S, Uchiyama M, Nakao Y, et al.: Inhibitory effect of the tea polyphenol, (-)-epigallocatechin gallate, on growth of cervical adenocarcinoma cell lines. Cancer Lett 234, 135–142, 2006.
   PubMed Web of Science ®Google Scholar
• Lee JI, Nian H, Cooper AJ, Sinha R, Dai J, et al.: Alpha-keto acid metabolites of naturally occurring organoselenium compounds as inhibitors of histone deacetylase in human prostate cancer cells. Cancer Prev Res (Phila) 2, 683–693, 2009.
   PubMed Web of Science ®Google Scholar
• Suzana S, Cham BG, Ahmad Rohi G, Mohd Rizal R, Fairulnizal MN, et al.: Relationship between selenium and breast cancer: a case-control study in the Klang Valley. Singapore Med J 50, 265–269, 2009.
   PubMed Web of Science ®Google Scholar
• Suzuki M, Endo M, Shinohara F, Echigo S, and Rikiishi H: Differential apoptotic response of human cancer cells to organoselenium compounds. Cancer Chemother Pharmacol 66, 475–484, 2010.
   PubMed Web of Science ®Google Scholar
• Hu H, Jiang C, Li G, and Lu J: PKB/AKT and ERK regulation of caspase-mediated apoptosis by methylseleninic acid in LNCaP prostate cancer cells. Carcinogenesis 26, 1374–1381, 2005.
   PubMed Web of Science ®Google Scholar
• Nian H, Bisson WH, Dashwood WM, Pinto JT, and Dashwood RH: Alpha-keto acid metabolites of organoselenium compounds inhibit histone deacetylase activity in human colon cancer cells. Carcinogenesis 30, 1416–1423, 2009.
   PubMed Web of Science ®Google Scholar
• Vanommeslaeghe K, Loverix S, Geerlings P, and Tourwé D: DFT-based ranking of zinc-binding groups in histone deacetylase inhibitors. Bioorg Med Chem 13, 6070–6082, 2005.
   PubMed Web of Science ®Google Scholar
• Gasparian AV, Yao YJ, Lü J, Yemelyanov AY, Lyakh LA, et al.: Selenium compounds inhibit I kappa B kinase (IKK) and nuclear factor-kappa B (NF-kappa B) in prostate cancer cells. Mol Cancer Ther 1, 1079–1087, 2002.
   PubMed Web of Science ®Google Scholar
• Facompre ND, Sinha I, El-Bayoumy K, Pinto JT, and Sinha R: Remarkable inhibition of mTOR signaling by the combination of rapamycin and 1,4-phenylenebis(methylene)selenocyanate in human prostate cancer cells. Int J Cancer 131, 2134–2142, 2012.
   PubMed Web of Science ®Google Scholar
• Wang L, Hu H, Wang Z, Xiong H, Cheng Y, et al.: Methylseleninic acid suppresses pancreatic cancer growth involving multiple pathways. Nutr Cancer 66, 295–307, 2014.
   PubMed Web of Science ®Google Scholar
• Khanduja KL, Gandhi RK, Pathania V, and Syal N: Prevention of N-nitrosodiethylamine-induced lung tumorigenesis by ellagic acid and quercetin in mice. Food Chem Toxicol 37, 313–318, 1999.
   PubMed Web of Science ®Google Scholar
• Devipriya S, Ganapathy V, and Shyamaladevi CS: Suppression of tumour growth and invasion in 9,10-dimethylbenz[a]anthracene induced mammary carcinoma by the plant bioflavonoid quercetin. Chem Biol Interact 162, 106–113, 2006.
   PubMed Web of Science ®Google Scholar
• Shan BE, Wang MX, and Li RQ: Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D(1) and surviving expression through Wnt/beta-catenin signaling pathway. Cancer Invest 27, 604–612, 2009.
   PubMed Web of Science ®Google Scholar
• Jeong JH, An JY, Kwon YT, Rhee JG, and Lee YJ: Effects of low dose quercetin: Cancer cell-specific inhibition of cell cycle progression. J Cell Biochem 106, 73–82, 2009.
   PubMed Web of Science ®Google Scholar
• Notoya M, Tsukamoto Y, Nishimura H, Woo JT, Nagai K, et al.: Quercetin, a flavonoid, inhibits the proliferation, differentiation, and mineralization of osteoblasts in vitro. Eur J Pharmacol 485, 89–96, 2004.
   PubMed Web of Science ®Google Scholar
• Bishayee K, Khuda-Bukhsh AR, and Huh SO: PLGA-loaded gold-nanoparticles precipitated with quercetin downregulate HDAC-Akt activities controlling proliferation and activate p53-ROS crosstalk to induce apoptosis in hepatocarcinoma cells. Mol Cells 38, 518–527, 2015.
   PubMed Web of Science ®Google Scholar
• Priyadarsini RV, Vinothini G, Murugan RS, Manikandan P, and Nagini S: The flavonoid quercetin modulates the hallmark capabilities of hamster buccal pouch tumors. Nutr Cancer 63, 218–226, 2011.
   PubMed Web of Science ®Google Scholar
• Kim YH, Lee DH, Jeong JH, Guo ZS, and Lee YJ: Quercetin augments TRAIL-induced apoptotic death: involvement of the ERK signal transduction pathway. Biochem Pharmacol 75, 1946–1958, 2008.
   PubMed Web of Science ®Google Scholar
• Lee WJ, Chen YR, and Tseng TH: Quercetin induces FasL-related apoptosis, in part, through promotion of histone H3 acetylation in human leukemia HL-60 cells. Oncol Rep 25, 583–591, 2011.
   PubMed Web of Science ®Google Scholar
• Wang Y, Han A, Chen E, Singh RK, Chichester CO, et al.: The cranberry flavonoids PAC DP-9 and quercetin aglycone induce cytotoxicity and cell cycle arrest and increase cisplatin sensitivity in ovarian cancer cells. Int J Oncol 46, 1924–1934, 2015.
   PubMed Web of Science ®Google Scholar
• Delmonte P, Perry J, and Rader JI: Determination of isoflavones in dietary supplements containing soy, Red Clover and kudzu: extraction followed by basic or acid. J Chromatogr A 1107, 59–69, 2006.
   PubMed Web of Science ®Google Scholar
• Kikuno N, Shiina H, Urakami S, Kawamoto K, Hirata H, et al.: Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells. Int J Cancer 123, 552–560, 2008.
   PubMed Web of Science ®Google Scholar
• Majid S, Dar AA, Ahmad AE, Hirata H, Kawakami K, et al.: BTG3 tumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer. Carcinogenesis 30, 662–670, 2009.
   PubMed Web of Science ®Google Scholar
• Majid S, Dar AA, Shahryari V, Hirata H, Ahmad A, et al.: Genistein reverses hypermethylation and induces active histone modifications in tumor suppressor gene B-Cell translocation gene 3 in prostate cancer. Cancer 116, 66–76, 2010.
   PubMed Web of Science ®Google Scholar
• Phillip CJ, Giardina CK, Bilir B, et al.: Genistein cooperates with the histone deacetylase inhibitor vorinostat to induce cell death in prostate cancer cells. BMC Cancer 12, 145, 2012.
   PubMed Web of Science ®Google Scholar
• Wang H, Li Q, and Chen H: Genistein affects histone modifications on Dickkopf-Related Protein 1 (DKK1) gene in SW480 human colon cancer cell line. PLoS One 7, e40955, 2012.
   PubMed Web of Science ®Google Scholar
• Li Y and Sarkar FH: Inhibition of nuclear factor kappaB activation in PC3 cells by genistein is mediated via Akt signaling pathway. Clin Cancer Res 8, 2369–2377, 2002.
   PubMed Web of Science ®Google Scholar
• Ferenc P, Solár P, Kleban J, Mikes J, and Fedorocko P: Down-regulation of Bcl-2 and Akt induced by combination of photoactivated hypericin and genistein in human breast cancer cells. J Photochem Photobiol B 98, 25–34, 2010.
   PubMed Web of Science ®Google Scholar
• Nakamura Y, Yogosawa S, Izutani Y, Watanabe H, Otsuji E, et al.: A combination of indol-3-carbinol and genistein synergistically induces apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and progression of autophagy. Mol Cancer 8, 100, 2009.
   PubMed Web of Science ®Google Scholar
• Sakla MS, Shenouda NS, Ansell PJ, Macdonald RS, and Lubahn DB: Genistein affects HER2 protein concentration, activation, and promoter regulation in BT-474 human breast cancer cells. Endocrine 32, 69–78, 2007.
   PubMed Web of Science ®Google Scholar
• Messing E, Gee JR, Saltzstein DR, Kim K, diSant'Agnese A, et al.: A phase 2 cancer chemoprevention biomarker trial of isoflavone G-2535 (genistein) in presurgical bladder cancer patients. Cancer Prev Res (Phila) 5, 621–630, 2012.
   PubMed Web of Science ®Google Scholar
• Basak S, Pookot D, Noonan EJ, and Dahiya R: Genistein down-regulates androgen receptor by modulating HDAC6-Hsp90 chaperone function. Mol Cancer Ther 7, 3195–3202, 2008.
   PubMed Web of Science ®Google Scholar
• Renehan AG, Zwahlen M, Minder C, O'Dwyer ST, Shalet SM, et al.: Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis. Lancet 363, 1346–1353, 2004.
   PubMed Web of Science ®Google Scholar
• Lee J, Ju J, Park S, Hong SJ, and Yoon S: Inhibition of IGF-1 signaling by genistein: modulation of E-cadherin expression and downregulation of β-catenin signaling in hormone refractory PC-3 prostate cancer cells. Nutr Cancer 64, 153–162, 2012.
   PubMed Web of Science ®Google Scholar
• Li Y, Wang Z, Kong D, Li R, Sarkar SH, et al.: Regulation of Akt/FOXO3a/GSK-3beta/AR signaling network by isoflavone in prostate cancer cells. J Biol Chem 283, 27707–27716, 2008.
   PubMed Web of Science ®Google Scholar
• Singh-Gupta V, Zhang H, Banerjee S, Kong D, Raffoul JJ, et al.: Radiation-induced HIF-1α cell survival pathway is inhibited by soy isoflavones in prostate cancer cells. Int J Cancer 124, 1675–1684, 2009.
   PubMed Web of Science ®Google Scholar
• Trujillo E, Davis C, and Milner J: Nutrigenomics, proteomics, metabolomics, and the practice of dietetics. J Am Diet Assoc 106, 403–413, 2006.
   PubMed Web of Science ®Google Scholar
• Venkateswaran V, Haddad AQ, Fleshner NE, Fan R, Sugar LM, et al.: Association of diet-induced hyperinsulinemia with accelerated growth of prostate cancer (LNCaP) xenografts. J Natl Cancer Inst 99, 1793–1800, 2007.
   PubMed Web of Science ®Google Scholar
• Honma K, Mochizuki K, and Goda T: Carbohydrate/fat ratio in the diet alters histone acetylation on the sucrase-isomaltase gene and its expression in mouse small intestine. Biochem Biophys Res Commun 357, 1124–1129, 2007.
   PubMed Web of Science ®Google Scholar
• Honma K, Mochizuki K, and Goda T: Inductions of histone H3 acetylation at lysine 9 on SGLT1 gene and its expression by feeding mice a high carbohydrate/fat ratio diet. Nutrition 25, 40–44, 2009.
   PubMed Web of Science ®Google Scholar
• Inoue S, Mochizuki K, and Goda T: Jejunal induction of SI and SGLT1 genes in rats by high-starch/low-fat diet is associated with histone acetylation and binding of GCN5 on the genes. J Nutr Sci Vitaminol (Tokyo) 57, 162–169, 2011.
   PubMed Web of Science ®Google Scholar
• Kitada M, Kume S, Takeda-Watanabe A, Tsuda S, Kanasaki K, et al.: Calorie restriction in overweight males ameliorates obesity-related metabolic alterations and cellular adaptations through anti-aging effects, possibly including AMPK and SIRT1 activation. Biochim Biophys Acta 1830, 4820–4827, 2013.
   PubMed Web of Science ®Google Scholar
• Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, et al.: Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science 339, 211–214, 2013.
   PubMed Web of Science ®Google Scholar
• Draznin B, Wang C, Adochio R, Leitner JW, and Cornier MA: Effect of dietary macronutrient composition on AMPK and SIRT1 expression and activity in human skeletal muscle. Horm Metab Res 44, 650–655, 2012.
   PubMed Web of Science ®Google Scholar
• Bergouignan A, Gozansky WS, Barry DW, Leitner W, MacLean PS, et al.: Increasing dietary fat elicits similar changes in fat oxidation and markers of muscle oxidative capacity in lean and obese humans. PLoS One 7, e30164, 2012.
   PubMed Web of Science ®Google Scholar
• Fontana L, Adelaiye RM, Rastelli AL, Miles KM, Ciamporcero E, et al.: Dietary protein restriction inhibits tumor growth in human xenograft models of prostate and breast cancer. Oncotarget 4, 2451–2461, 2013.
   PubMed Web of Science ®Google Scholar
• Zheng S, Rollet M, Yang K, and Pan YX: A gestational low-protein diet represses p21(WAF1/Cip1) expression in the mammary gland of offspring rats through promoter histone modifications. Br J Nutr 108, 998–1007, 2012.
   PubMed Web of Science ®Google Scholar
• Kobayashi N, Barnard RJ, Said J, Hong-Gonzalez J, Corman DM, et al.: Effect of low-fat diet on development of prostate cancer and Akt phosphorylation in the Hi-Myc transgenic mouse model. Cancer Res 68, 3066–3073, 2008.
   PubMed Web of Science ®Google Scholar
• Bassett JK, Severi G, Hodge AM, MacInnis RJ, Gibson RA, et al.: Plasma phospholipid fatty acids, dietary fatty acids and prostate cancer risk. Int J Cancer 133, 1882–1891, 2013.
   PubMed Web of Science ®Google Scholar
• Cummings JH and Englyst HN: Fermentation in the human large intestine and the available substrates. Am J Clin Nutr 45, 1243–1255, 1987.
   PubMed Web of Science ®Google Scholar
• Wong JM, de Souza R, Kendall CW, Emam A, and Jenkins DJ: Colonic health: fermentation and short chain fatty acids. J Clin Gastroenterol 40, 235–243, 2006.
   PubMed Web of Science ®Google Scholar
• Sekhavat A, Sun JM, and Davie JR: Competitive inhibition of histone deacetylase activity by trichostatin A and butyrate. Biochem Cell Biol 85, 751–758, 2007.
   PubMed Web of Science ®Google Scholar
• Blottière HM, Buecher B, Galmiche JP, and Cherbut C: Molecular analysis of the effect of short-chain fatty acids on intestinal cell proliferation. Proc Nutr Soc 62, 101–106, 2003.
   PubMed Web of Science ®Google Scholar
• Hassig CA, Tong JK, and Schreiber SL: Fiber-derived butyrate and the prevention of colon cancer. Chem Biol 4, 783–789, 1997.
   PubMed Web of Science ®Google Scholar
• Li GX, Lee MJ, Liu AB, Yang Z, Lin Y, et al.: δ-tocopherol is more active than α - or γ -tocopherol in inhibiting lung tumorigenesis in vivo. Cancer Prev Res (Phila) 4, 404–413, 2011.
   PubMed Web of Science ®Google Scholar
• Wang H, Hong J, and Yang CS: δ-Tocopherol inhibits receptor tyrosine kinase-induced AKT activation in prostate cancer cells. Mol Carcinog 2015.
   Web of Science ®Google Scholar
• Lee HJ, Ju J, Paul S, So JY, DeCastro A, et al.: Mixed tocopherols prevent mammary tumorigenesis by inhibiting estrogen action and activating PPAR-γ. Clin Cancer Res 15, 4242–4249, 2009.
   PubMed Web of Science ®Google Scholar
• Ahn KS, Sethi G, Krishnan K, and Aggarwal BB: Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis. J Biol Chem 282, 809–820, 2007.
   PubMed Web of Science ®Google Scholar
• Kunnumakkara AB, Sung B, Ravindran J, Diagaradjane P, Deorukhkar A, et al.: {Gamma}-tocotrienol inhibits pancreatic tumors and sensitizes them to gemcitabine treatment by modulating the inflammatory microenvironment. Cancer Res 70, 8695–8705, 2010.
   PubMed Web of Science ®Google Scholar
• Samant GV and Sylvester PW: Gamma-Tocotrienol inhibits ErbB3-dependent PI3K/Akt mitogenic signalling in neoplastic mammary epithelial cells. Cell Prolif 39, 563–574, 2006.
   PubMed Web of Science ®Google Scholar
• Ye C, Zhao W, Li M, Zhuang J, Yan X, et al.: δ-tocotrienol induces human bladder cancer cell growth arrest, apoptosis and chemosensitization through inhibitionof STAT3 pathway. PLoS One 10, e0122712, 2015.
   PubMed Web of Science ®Google Scholar
• Birringer M, Pfluger P, Kluth D, Landes N, and Brigelius-Flohé R: Identities and differences in the metabolism of tocotrienols and tocopherols in HepG2 cells. J Nutr 132, 3113–3118, 2002.
   PubMed Web of Science ®Google Scholar
• Majumdar AP, Banerjee S, Nautiyal J, Patel BB, Patel V, et al.: Curcumin synergizes with resveratrol to inhibit colon cancer. Nutr Cancer 61(4), 544–553, 2009.
   PubMed Web of Science ®Google Scholar
• Verma SP, Salamone E, and Goldin B: Curcumin and genistein, plant natural products, show synergistic inhibitory effects on the growth of human breast cancer MCF-7 cells induced by estrogenic pesticides. Biochem Biophys Res Commun 233, 692–696, 1997.
   PubMed Web of Science ®Google Scholar
• Khafif A, Schantz SP, Chou TC, Edelstein D, and Sacks PG: Quantitation of chemopreventive synergism between (−)-epigallocatechin-3-gallate and curcumin in not normal, premalignant and malignant human oral epithelial cells. Carcinogenesis 19, 419–424, 1998.
   PubMed Web of Science ®Google Scholar
• Cruz-Correa M, Shoskes DA, Sanchez P, Zhao R, Hylind LM, et al.: Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis. Clin Gastroenterol Hepatol 4(8), 1035–1038, 2006.
   Google Scholar
• Mertens-Talcott SU and Percival SS: Ellagic acid and quercetin interact synergistically with resveratrol in the induction of apoptosis and cause transient cell cycle arrest in human leukemia cells. Cancer Lett 218(2), 141–151, 2005.
   PubMed Web of Science ®Google Scholar
• Kowalczyk MC, Kowalczyk P, Tolstykh O, Hanausek M, and Walaszek Z: Synergistic effects of combined phytochemicals and skin cancer prevention in SENCAR mice. Cancer Prev Res (Phila) 3(2), 170–178, 2010.
   PubMed Web of Science ®Google Scholar
• Pappa G, Strathmann J, Löwinger M, Bartsch H, and Gerhäuser C: Quantitative combination effects between sulforaphane and 3,3′-diindolylmethane on proliferation of human colon cancer cells in vitro. Carcinogenesis 28, 1471–1477, 2007.
   PubMed Web of Science ®Google Scholar
• Hsieh TC and Wu JM: Suppression of cell proliferation and gene expression by combinatorial synergy of EGCG, resveratrol and gamma-tocotrienol in estrogen receptor-positive MCF-7 breast cancer cells. Int J Oncol 33(4), 851–859, 2008.
   PubMed Web of Science ®Google Scholar
• Russo GL: Ins and outs of dietary phytochemicals in cancer chemoprevention. Biochem Pharmacol 74, 533–544, 2007.
   PubMed Web of Science ®Google Scholar
• Gupta S, Hastak K, Ahmad N, Lewin JS, and Mukhtar H: Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols. Proc Natl Acad Sci USA 98(18), 10350–10355, 2001.
   PubMed Web of Science ®Google Scholar
• Shanafelt TD, Lee YK, Call TG, Nowakowski GS, Dingli D, et al.: Clinical effects of oral green tea extracts in four patients with low grade B-cell malignancies. Leuk Res 30(6), 707–712, 2006.
   PubMed Web of Science ®Google Scholar
• hang SM, Hunter DJ, Rosner BA, Giovannucci EL, Colditz GA, et al.: Intakes of fruits, vegetables, and related nutrients and the risk of non-Hodgkin's lymphoma among women. Cancer Epidemiol Biomarkers Prev 9, 477–485, 2000.
   PubMed Web of Science ®Google Scholar
• Michaud DS, Spiegelman D, Clinton SK, Rimm EB, Willett WC, et al.: Fruit and vegetable intake and incidence of bladder cancer in a male prospective cohort. J Natl Cancer Inst 91, 605–613, 1999.
   PubMed Web of Science ®Google Scholar
• Cohen JH, Kristal AR, and Stanford JL: Fruit and vegetable intakes and prostate cancer risk. J Natl Cancer Inst 92, 61–68, 2000.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Zhuang W, Hu W, Liu GJ, Wu TX, et al.: Consumption of large amounts of Allium vegetables reduces risk for gastric cancer in a meta-analysis. Gastroenterology 141, 80–89, 2011.
   PubMed Web of Science ®Google Scholar
• Galeone C, Pelucchi C, Levi F, Negri E, Franceschi S, Talamini R, et al.: Onion and garlic use and human cancer. Am J Clin Nutr 84, 1027–1032, 2006.
   PubMed Web of Science ®Google Scholar