Lycopene in the Prevention of Radiation-Induced Esophagitis

References

• Singh AK, Lockett MA, and Bradley JD: Predictors of radiation-induced esophageal toxicity in patients with non-small-cell lung cancer treated with three-dimensional conformal radiotherapy. Int J Radiat Oncol Biol Phys 55, 337–3341, 2003.
   PubMed Web of Science ®Google Scholar
• Choy H, Akerley W, Safran H, Graziano S, Chung C, et al.: Multiinstitutional phase II trial of paclitaxel, carboplatin, and concurrent radiation therapy for locally advanced non-small-cell lung cancer. J Clin Oncol 16, 3316–3322, 1998.
   PubMed Web of Science ®Google Scholar
• Chang JY, Bradley JD, Govindan R, and Komaki R: Lung. In: Principles and Practice of Radiation Oncology, 5th ed. Edward C. Halperin, Carlos A Perez and Luther W. Brady (eds). Philadelphia, PA: Lippincott Williams & Wilkins, 2008, pp. 1076–1108.
   Google Scholar
• Cox JD, Pajak TF, Asbell S, Russell AH, Pederson J, et al.: Interruptions of high-dose radiation therapy decrease long-term survival of favorable patients with unresectable non-small cell carcinoma of the lung: analysis of 1244 cases from 3 Radiation Therapy Oncology Group (RTOG) trials. Int J Radiat Oncol Biol Phys 27, 493–498, 1993.
   PubMed Web of Science ®Google Scholar
• Dillman RO, Seagren SL, Propert KJ, Guerra J, Eaton WL, et al.: A randomized trial of induction chemotherapy plus high-dose radiation versus radiation alone in stage III non-small-cell lung cancer. N Engl J Med 323, 940–945, 1990.
   PubMed Web of Science ®Google Scholar
• Byhardt RW, Scott C, Sause WT, Emami B, Komaki R, et al.: Response, toxicity, failure patterns, and survival in five Radiation Therapy Oncology Group (RTOG) trials of sequential and/or concurrent chemotherapy and radiotherapy for locally advanced non-small-cell carcinoma of the lung. Int J Radiat Oncol Biol Phys 42, 469–78, 1998.
   PubMed Web of Science ®Google Scholar
• Werner-Wasik M, Pequignot E, Leeper D, Hauck W, and Curran W: Predictors of severe esophagitis include use of concurrent chemotherapy, but not the length of irradiated esophagus: a multivariate analysis of patients with lung cancer treated with nonoperative therapy. Int J Radiat Oncol Biol Phys 48, 689–96, 2000.
   PubMed Web of Science ®Google Scholar
• Qiao WB, Zhao YH, Zhao YB, and Wang ZB: Clinical and dosimetric factors of radiation-induced esophageal injury: radiation-induced esophageal toxicity. World J Gastroenterol 11, 2626–2629, 2005.
   PubMed Web of Science ®Google Scholar
• Kim TH, Cho KH, Pyo HR, Lee JS, Han JY, et al.: Dose-volumetric parameters of acute esophageal toxicity in patients with lung cancer treated with three-dimensional conformal radiotherapy. Int J Radiat Oncol Biol Phys 62, 995–1002, 2005.
   PubMed Web of Science ®Google Scholar
• Belderbos J, Heemsbergen W, Hoogeman M, Pengel K, Rossi M, et al.: Acute esophageal toxicity in non-small cell lung cancer patients after high dose conformal radiotherapy. Radiother Oncol 75, 157–164, 2005.
   PubMed Web of Science ®Google Scholar
• Aupérin A, Le Péchoux C, Rolland E, Curran WJ, Furuse K, et al.: Meta-analysis of concomitant versus sequential radiochemotherapy in locally advanced non-small-cell lung cancer. J Clin Oncol 28, 2181–2190, 2010.
   PubMed Web of Science ®Google Scholar
• Komaki R, Seiferheld W, Ettinger D, Lee JS, Movsas B, et al.: Randomized phase II chemotherapy and radiotherapy trial for patients with locally advanced inoperable non-small-cell lung cancer: long-term follow-up of RTOG 92-04. Int J Radiat Oncol Biol Phys 53, 548–557, 2002.
   PubMed Web of Science ®Google Scholar
• Saunders MI, Dische S, Barrett A, Parmar MK, Harvey A, et al.: Randomized multicentre trials of CHART vs. conventional radiotherapy in head and neck and non-small cell lung cancer: An interim report. Br J Cancer 73, 1455–1462, 1996.
   PubMed Web of Science ®Google Scholar
• Maguire PD, Sibley GS, Zhou SM, Jamieson TA, Light KL, et al.: Clinical and dosimetric predictors of radiation-induced esophageal toxicity. Int J Radiat Oncol Biol Phys 45, 97–103, 1999.
   PubMed Web of Science ®Google Scholar
• Ahn SJ, Kahn D, Zhou S, Yu X, Hollis D, et al.: Dosimetric and clinical predictors for radiation-induced esophageal injury. Int J Radiat Oncol Biol Phys 61, 335–347, 2005.
   PubMed Web of Science ®Google Scholar
• Choi GB, Shin JH, Song HY, Lee YS, Cho YK, et al.: Fluoroscopically guided balloon dilation for patients with esophageal stricture after radiation treatment. J Vascular Intervent Radiol 16, 1705–1710, 2005.
   PubMed Web of Science ®Google Scholar
• Abelson JA, Murphy JD, Loo BW Jr, Chang DT, Daly ME, et al.: Esophageal tolerance to high-dose stereotactic ablative radiotherapy. Dis Esophagus 25, 623–629, 2012.
   PubMed Web of Science ®Google Scholar
• Sainathan S, Wu LD, and Andaz S: Delayed esophageal perforation from stereotactic body radiation therapy for locally recurrent central nonsmall cell lung cancer. Lung India 31, 158–160, 2014.
   PubMedGoogle Scholar
• W Dörr: Pathogenesis of normal-tissue side-effects (chapter 13). In: Basic Clinical Radiobiology, 4th ed. Joiner M and van der Kogel A (eds.). London, UK: Hodder Education, Hachette UK Company, 2009, pp. 169–190.
   Google Scholar
• W Dörr: Biological response modifiers: normal tissues (chapter 22). In: Basic Clinical Radiobiology, 4th ed. Joiner M and van der Kogel A (eds.). London, UK: Hodder Education, Hachette UK Company, 2009, pp. 301–315.
   Google Scholar
• Antonadou D, Coliarakis N, Synodinou M, Athanassiou H, Kouveli A, et al.: Clinical Radiation Oncololgy Hellenic Group: Randomized phase III trial of radiation treatment +/− amifostine in patients with advanced-stage lung cancer. Int J Radiat Oncol Biol Phys 51, 915–922, 2001.
   PubMed Web of Science ®Google Scholar
• Movsas B, Scott C, Langer C, Werner-Wasik M, Nicolaou N, et al.: Randomized trial of amifostine in locally advanced non-small-cell lung cancer patients receiving chemotherapy and hyperfractionated radiation: Radiation Therapy Oncology Group Trial 98-01. J Clin Oncol 23, 2145–2154, 2005.
   PubMed Web of Science ®Google Scholar
• Komaki R, Lee JS, Milas L, Lee HK, Fossella FV, et al.: Effects of amifostine on acute toxicity from concurrent chemotherapy and radiotherapy for inoperable non-small-cell lung cancer: report of a randomized comparative trial. Int J Radiat Oncol Biol Phys 58, 1369–1377, 2004.
   PubMed Web of Science ®Google Scholar
• Antonadou D, Throuvalas N, Petridis A, Bolanos N, Sagriotis A, et al.: Effect of amifostine on toxicities associated with radiochemotherapy in patients with locally advanced non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 57, 402–408, 2003.
   PubMed Web of Science ®Google Scholar
• Leong SS, Tan EH, Fong KW, Wilder-Smith E, Ong YK, et al.: Randomized double-blind trial of combined modality treatment with or without amifostine in unresectable stage III non-small cell lung cancer. J Clin Oncol 21, 1767–1774, 2003.
   PubMed Web of Science ®Google Scholar
• Topkan E, Yavuz MN, Onal C, and Yavuz AA: Prevention of acute radiation-induced esophagitis with glutamine in non-small cell lung cancer patients treated with radiotherapy: evaluation of clinical and dosimetric parameters. Lung Cancer 63, 393–399, 2009.
   PubMed Web of Science ®Google Scholar
• Epperly MW, Defilippi S, Sikora C, Gretton J, and Greenberger JS: Radioprotection of lung and esophagus by overexpression of the human manganese superoxide dismutase transgene. Mil Med 167, 71–73, 2002.
   PubMedGoogle Scholar
• Stickle RL, Epperly MW, Klein E, Bray JA, and Greenberger JS: Prevention of irradiation-induced esophagitis by PL delivery of the human MnSOD transgene. Radiat Oncol Invest 7, 204–217, 1999.
   PubMedGoogle Scholar
• Epperly MW, Sikora C, Defilippi S, Bray J, Koe G, et al.: Plasmid/liposome transfer of the human manganese superoxide dismutase transgene prevents ionizing irradiation-induced apoptosis in human esophagus organ explant culture. Int J Cancer 90, 128–137, 2000.
   PubMed Web of Science ®Google Scholar
• Epperly MW, Gretton JA, DeFilippi SJ, Greenberger JS, Sikora CA, et al.: Modulation of radiation-induced cytokine elevation associated with esophagitis and esophageal stricture by MnSOD-PL (SOD2-PL) gene therapy. Radiat Res 155, 2–14, 2001.
   PubMed Web of Science ®Google Scholar
• Epperly MW, Carpenter M, Agarwal A, Mitra P, Nie S, et al.: Intra-oral manganese superoxide dismutase plasmid liposome radioprotective gene therapy decreases ionizing irradiation-induced murine mucosal cell cycling and apoptosis. In Vivo 18, 401–410, 2004.
   PubMed Web of Science ®Google Scholar
• Epperly MW, Kagan VE, Sikora CA, Gretton JE, Defilippi SJ, et al.: Manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) administration protects mice from esophagitis associated with fractionated radiation. Int J Cancer 96, 221–231, 2001.
   PubMed Web of Science ®Google Scholar
• Niu Y, Wang H, Wiktor-Brown D, Rugo R, Shen H, et al.: Irradiated esophageal cells are protected from radiation-induced recombination by MnSOD gene therapy. Radiat Res 173, 453–461, 2010.
   PubMed Web of Science ®Google Scholar
• Epperly MW, Goff JP, Li S, Gao X, Wipf P, et al.: Intraesophageal administration of GS-nitroxide (JP4–039) protects against ionizing irradiation-induced esophagitis. In Vivo 24, 811–819, 2010.
   PubMed Web of Science ®Google Scholar
• Nicolopoulos N, Mantidis A, Stathopoulos E, Papaodysseas S, Kouvaris J, et al.: Prophylactic administration of indomethacin for irradiation esophagitis. Radiother Oncol 3, 23–25, 1985.
   PubMed Web of Science ®Google Scholar
• Tochner Z, Barnes M, Mitchell JB, Orr K, Glatstein E, et al.: Protection by indomethacin against acute radiation esophagitis. Digestion 47, 81–87, 1990.
   PubMed Web of Science ®Google Scholar
• Taal BG, Vales Olmos RA, Boot H, and Hoefnagel CA: Assessment of sucralfate coating by sequential scintigraphic imaging in radiation-induced esophageal lesions. Gastrointest Endosc 41, 109–114, 1995.
   PubMed Web of Science ®Google Scholar
• Rao AV and Agarwal S: Role of lycopene as antioxidant carotenoid in the prevention of chronic diseases: a review. Nutr Res 19, 305–332, 1999.
   Web of Science ®Google Scholar
• Salman H, Bergman M, Djaldetti M, and Bessler H: Lycopene affects proliferation and apoptosis of four malignant cell lines. Biomed Pharmacother 61, 366–369, 2007.
   PubMed Web of Science ®Google Scholar
• Zefferino R, Leone A, Piccaluga S, Cincione R, and Ambrosi L: Mercury modulates interplay between IL-1beta, TNF-alpha, and gap junctional intercellularcommunication in keratinocytes: mitigation by lycopene. J Immunotoxicol 5, 353–360, 2008.
   PubMed Web of Science ®Google Scholar
• Hwang ES and Lee HJ: Inhibitory effects of lycopene on the adhesion, invasion, and migration of SK-Hep1 human hepatoma cells. Exp Biol Med (Maywood) 231, 322–327, 2006.
   PubMed Web of Science ®Google Scholar
• Nahum A, Hirsch K, Danilenko M, Watts CK, Prall OW, et al.: Lycopene inhibition of cell cycle progression in breast and endometrial cancer cells is associated with reduction in cyclin D levels and retention of p27 (Kip1) in the cyclin E-cdk2 complexes. Oncogene 20, 3428–3436, 2001.
   PubMed Web of Science ®Google Scholar
• Di Franco R, Calvanese M, Murino P, Manzo R, Guida C, et al.: Skin toxicity from external beam radiation therapy in breast cancer patients: protective effects of Resveratrol, Lycopene, Vitamin C and anthocianin (Ixor®). Radiat Oncol 7, 12, 2012.
   PubMed Web of Science ®Google Scholar
• Srinivasan M, Devipriya N, Kalpana KB, and Menon VP: Lycopene: an antioxidant and radioprotector against gama-radiation-induced cellular damages in cultured human lymphocytes. Toxicology 262, 43–49, 2009.
   PubMed Web of Science ®Google Scholar
• Srinivasan M, Sudheer AR, Pillai KR, Kumar PR, Sudhakaran PR, et al.: Lycopene as a natural protector against gamma-radiation induced DNA damage, lipid peroxidation and antioxidant status in primary culture of isolated rat hepatocytes in vitro. Biochim Biophys Acta 1770, 659–665, 2007.
   PubMed Web of Science ®Google Scholar
• Dhirhe T, Maheshwari BK, Raut P, and Dhirhe S. Radio-protective effect of lycopersicon esculentum extract against radiation induced chromosomal aberration in swiss albino mice. Int J Pharm Sci Rev Res 7, 97–99, 2011.
   Google Scholar
• Meydan D, Gursel B, Bilgici B, Can B, and Ozbek N: Protective effect of lycopene against radiation-induced hepatic toxicity in rats. J Int Med Res 39, 1239–1252, 2011.
   PubMed Web of Science ®Google Scholar
• Saada HN, Rezk RG, and Eltahawy NA. Lycopene protects the structure of the small intestine against gamma-radiation-induced oxidative stress. Phytother Res 24, 204–208, 2010.
   PubMed Web of Science ®Google Scholar
• Andic F, Garipagaoglu M, Yurdakonar E, Tuncel N, and Kucuk O: Lycopene in the prevention of gastrointestinal toxicity of radiotherapy. Nutr Cancer 61, 784–788, 2009.
   PubMed Web of Science ®Google Scholar
• Liu C, Lian F, Smith DE, Russell RM, and Wang XD: Lycopene supplementation inhibits lung squamous metaplasia and induces apoptosis via up-regulating insulin-like growth factor-binding protein 3 in cigarette smoke-exposed ferrets. Cancer Res 63, 3138–3144, 2003.
   PubMed Web of Science ®Google Scholar
• Pirayesh Islamian J, and Mehrali H. Lycopene as a carotenoid provides radioprotectant and antioxidant effects by quenching radiation-induced free radical singlet oxygen: an overview. Cell J 16, 386–391, 2015.
   PubMed Web of Science ®Google Scholar
• DiMascio P, Kaiser S, and Sies S: Lycopene as the most effective biological carotenoid singlet oxygen quencher. Arch Biochem Biophys 274, 532–538, 1989.
   PubMed Web of Science ®Google Scholar
• Dogukan A, Tuzcu M, Agca CA, Gencoglu H, Sahin N, et al.: A tomato lycopene complex protects the kidney from cisplatin-induced injury via affecting oxidative stress as well as Bax, Bcl-2, and HSPs expression. Nutr Cancer 63, 427–34, 2011.
   PubMed Web of Science ®Google Scholar
• Mathews-Roth MM, Welankiwar S, Sehgal PK, Lausen NC, Russett M, et al.: Distribution of [14C]canthaxanthin and [14C]lycopene in rats and monkeys. J Nutr 120, 1205–1213, 1990.
   PubMed Web of Science ®Google Scholar
• Ferreira AL, Yeum KJ, Liu C, Smith D, Krinsky NI, et al.: Tissue distribution of lycopene in ferrets and rats after lycopene supplementation. J Nutr 130, 1256–1260, 2000.
   PubMed Web of Science ®Google Scholar
• Chapet O, Kong FM, Lee JS, Hayman JA, and Ten Haken RK: Normal tissue complication probability modeling for acute esophagitis in patients treated with conformal radiation therapy for non-small cell lung cancer. Radiother Oncol 77, 176–181, 2005.
   PubMed Web of Science ®Google Scholar
• Rodriguez N, Algara M, Foro P, Lacruz M, Reig A, et al.: Predictors of acute esophagitis in lung cancer patients treated with concurrent three-dimensional conformal radiotherapy and chemotherapy. Int J Radiat Oncol Biol Phys 73, 810–817, 2009.
   PubMed Web of Science ®Google Scholar
• Bradley J, Deasy JO, Bentzen S, and El-Naqa I: Dosimetric correlates for acute esophagitis in patients treated with radiotherapy for lung carcinoma. Int J Radiat Oncol Biol Phys 58, 1108–1113, 2004.
   Web of Science ®Google Scholar
• Werner-Wasik M, Yorke E, Deasy J, Nam J, and Marks LB: Radiation dose-volume effects in the esophagus. Int J Radiat Oncol Biol Phys 76, 86–93, 2010.
   PubMed Web of Science ®Google Scholar
• Dieleman EM, Senan S, Vincent A, Lagerwaard FJ, Slotman BJ, et al.: Four-dimensional computed tomographic analysis of esophageal mobility during normal respiration. Int J Radiat Oncol Biol Phys 67, 775–780, 2007.
   PubMed Web of Science ®Google Scholar