Effectiveness of Parenteral Glutamine on Methotrexate-induced Oral Mucositis in Children with Acute Lymphoblastic Leukemia

References

• Keefe DM, Brealey J, Goland GJ, and Cummins AG: Chemotherapy for cancer causes apoptosis that precedes hypoplasia in crypts of the small intestine in humans. Gut 47, 632–637, 2000.
   PubMed Web of Science ®Google Scholar
• Pico JL, Avila-Garavito A, and Naccache P: Mucositis: its occurrence, consequences, and treatment in the oncology setting. Oncologist 3, 446–451, 1998.
   PubMedGoogle Scholar
• Wu KH, Tsai C, Wu HP, Sieber M, Peng CT, et al.: Human application of ex vivo expanded umbilical cord-derived mesenchymal stem cells: enhance hematopoiesis after cord blood transplantation. Cell Transpl 22, 2041–2051, 2013.
   PubMed Web of Science ®Google Scholar
• Sonis ST: The pathobiology of mucositis. Nat Rev Cancer 4, 277–284, 2004.
   PubMed Web of Science ®Google Scholar
• Yarom N, Ariyawardana A, Hovan A, Barasch A, Jarvis V, et al.: Systematic review of natural agents for the management of oral mucositis in cancer patients. Support Care Cancer 21, 3209–3221, 2013.
   PubMed Web of Science ®Google Scholar
• Chaveli-Lopez B and Bagan-Sebastian JV: Treatment of oral mucositis due to chemotherapy. J Clin Exp Dent 8, e201–209, 2016.
   PubMedGoogle Scholar
• Gibson RJ, Keefe DM, Lalla RV, Bateman E, Blijlevens N, et al.: Systematic review of agents for the management of gastrointestinal mucositis in cancer patients. Support Care Cancer 21, 313–326, 2013.
   PubMed Web of Science ®Google Scholar
• Keefe DM, Sonis ST, and Bowen JM: Emerging drugs for chemotherapy-induced mucositis. Expert Opin Emerg Drugs 13, 511–522, 2008.
   PubMed Web of Science ®Google Scholar
• Duncan M and Grant G: Oral and intestinal mucositis-causes and possible treatments. Aliment Pharm Ther 18, 853–874, 2003.
   PubMed Web of Science ®Google Scholar
• Hall JC, Heel K, and McCauley R: Glutamine. Brit J Surg 83, 305–312, 1996.
   PubMed Web of Science ®Google Scholar
• Miller AL: Therapeutic considerations of L-glutamine: A review of the literature. Altern Med Rev 4, 239–248, 1999.
   PubMedGoogle Scholar
• Leung HWC and Chan ALF: Glutamine in alleviation of radiation-induced severe oral mucositis: A meta-analysis. Nutr Cancer 68, 734–742, 2016.
   PubMed Web of Science ®Google Scholar
• Sayles C, Hickerson SC, Bhat RR, Hall J, Garey KW, et al.: Oral glutamine in preventing treatment-related mucositis in adult patients with cancer: a systematic review. Nutr Clin Pract 31, 171–179, 2016.
   PubMed Web of Science ®Google Scholar
• Tsujimoto T, Yamamoto Y, Wasa M, Takenaka Y, Nakahara S, et al.: L-glutamine decreases the severity of mucositis induced by chemoradiotherapy in patients with locally advanced head and neck cancer: a double-blind, randomized, placebo-controlled trial. Oncol Rep 33, 33–39, 2015.
   PubMed Web of Science ®Google Scholar
• Gaurav K, Goel RK, Shukla M, and Pandey M: Glutamine: a novel approach to chemotherapy-induced toxicity. Indian J Med Pediatr Oncol 33, 13–20, 2012.
   PubMedGoogle Scholar
• Choi K, Lee SS, Oh SJ, Lim SY, Jeon WK, et al.: The effect of oral glutamine on 5-fluorouracil/leucovorin-induced mucositis/stomatitis assessed by intestinal permeability test. Clin Nutr 26, 57–62, 2007.
   PubMed Web of Science ®Google Scholar
• Peterson DE: New strategies for management of oral mucositis in cancer patients. J Support Oncol 4, 9–13, 2006.
   PubMedGoogle Scholar
• Anderson PM, Schroeder G, and Skubitz KM: Oral glutamine reduces the duration and severity of stomatitis after cytotoxic cancer chemotherapy. Cancer 83, 1433–1439, 1998.
   PubMed Web of Science ®Google Scholar
• Qutob AF, Gue S, Revesz T, Logan RM, and Keefe D: Prevention of oral mucositis in children receiving cancer therapy: a systematic review and evidence-based analysis. Oral Oncol 49, 102–107, 2013.
   PubMed Web of Science ®Google Scholar
• Ward E, Smith M, Henderson M, Reid U, Lewis I, et al.: The effect of high-dose enteral glutamine on the incidence and severity of mucositis in paediatric oncology patients. Eur J Clin Nutr 63, 134–140, 2009.
   PubMed Web of Science ®Google Scholar
• Kuskonmaz B, Yalcin S, Kucukbayrak O, Cetin N, Cetin M, et al.: The effect of glutamine supplementation on hematopoietic stem cell transplant outcome in children: a case-control study. Pediatr Transpl 12, 47–51, 2008.
   PubMed Web of Science ®Google Scholar
• Storey B: The role of oral glutamine in pediatric bone marrow transplant. J Pediatr Oncol Nurs 24, 41–45, 2007.
   PubMed Web of Science ®Google Scholar
• Aquino VM, Harvey AR, Garvin JH, Godder KT, Nieder ML, et al.: A double-blind randomized placebo-controlled study of oral glutamine in the prevention of mucositis in children undergoing hematopoietic stem cell transplantation: a pediatric blood and marrow transplant consortium study. Bone Marrow Transpl 36, 611–616, 2005.
   PubMed Web of Science ®Google Scholar
• Melis GC, Boelens PG, van der Sijp JRM, Popovici T, De Bandt J-P, et al.: The feeding route (enteral or parenteral) affects the plasma response of the dipetide Ala-Gln and the amino acids glutamine, citrulline and arginine, with the administration of Ala-Gln in preoperative patients. Br J Nutr 94, 19–26, 2005.
   PubMed Web of Science ®Google Scholar
• Buijs N, Brinkmann SJH, Oosterink JE, Luttikhold J, Schierbeek H, et al.: Intravenous glutamine supplementation enhances renal de novo arginine synthesis in humans: a stable isotope study. Am J Clin Nutr 100, 1385–1391, 2014.
   PubMed Web of Science ®Google Scholar
• Kuhn KS, Muscaritoli M, Wischmeyer P, and Stehle P: Glutamine as indispensable nutrient in oncology: experimental and clinical evidence. Eur J Nutr 49, 197–210, 2010.
   PubMed Web of Science ®Google Scholar
• Cerchietti LC, Navigante AH, Lutteral MA, Castro MA, Kirchuk R, et al.: Double-blinded, placebo-controlled trial on intravenous L-alanyl-L-glutamine in the incidence of oral mucositis following chemoradiotherapy in patients with head-and-neck cancer. Int J Radiat Oncol Biol Phys 65, 1330–1337, 2006.
   PubMed Web of Science ®Google Scholar
• Li MJ, Liu HC, Yen HJ, Jaing TH, Lin DT, et al.: Treatment for childhood acute lymphoblastic leukemia in Taiwan: Taiwan Pediatric Oncology Group ALL-2002 study emphasizing optimal reinduction therapy and central nervous system preventive therapy without cranial radiation. Pediatr Blood Cancer 64, 234–241, 2017.
   PubMed Web of Science ®Google Scholar
• Yen HJ, Chang WH, Liu HC, Yeh TC, Hung GY, et al.: Outcomes following discontinuation of E. coli l-asparaginase upon severe allergic reactions in children with acute lymphoblastic leukemia. Pediatr Blood Cancer 63, 665–670, 2016.
   PubMed Web of Science ®Google Scholar
• Yildirim ZK, Bidev D, and Buyukavci M: Parenteral glutamine supplementation has no effect on chemotherapy-induced toxicity in children with non-Hodgkin lymphoma. J Pediatr Hematol Oncol 35, 371–376, 2013.
   PubMed Web of Science ®Google Scholar
• Uderzo C, Rebora P, Marrocco E, Varotto S, Cichello F, et al.: Glutamine-enriched nutrition does not reduce mucosal morbidity or complications after stem-cell transplantation for childhood malignancies: a prospective randomized study. Transplantation 91, 1321–1325, 2011.
   PubMed Web of Science ®Google Scholar
• Miller AB, Hoogstraten B, Staquet M, and Winkler A: Reporting results of cancer treatment. Cancer 47, 207–214, 1981.
   PubMed Web of Science ®Google Scholar
• Beutheu S, Ouelaa W, Guerin C, Belmonte L, Aziz M, et al.: Glutamine supplementation, but not combined glutamine and arginine supplementation, improves gut barrier function during chemotherapy-induced intestinal mucositis in rats. Clin Nutr 33, 694–701, 2014.
   PubMed Web of Science ®Google Scholar
• Sukhotnik I, Mogilner JG, Karry R, Shamian B, Lurie M, et al.: Effect of oral glutamine on enterocyte turnover during methotrexate-induced mucositis in rats. Digestion 79, 5–13, 2009.
   PubMed Web of Science ®Google Scholar
• Harsha WT, Kalandarova E, McNutt P, Irwin R, Noel J, et al.: Nutritional supplementation with transforming growth factor-beta, glutamine, and short chain fatty acids minimizes methotrexate-induced injury. J Pediatr Gastroenterol Nutr 42, 53–58, 2006.
   PubMed Web of Science ®Google Scholar
• Souba WW: Glutamine and cancer. Ann Surg 218, 715–728, 1993.
   PubMed Web of Science ®Google Scholar
• Tsubuku S, Hatayama K, Mawatari K, Smriga M, and Kimura T: Thirteen-week oral toxicity study of L-glutamine in rats. Int J Toxicol 23, 107–112, 2004.
   PubMed Web of Science ®Google Scholar
• Klimberg VS, Pappas AA, Nwokedi E, Jensen JC, Broadwater JR, et al.: Effect of supplemental dietary glutamine on methotrexate concentrations in tumors. Arch Surg 127, 1317–1320, 1992.
   PubMedGoogle Scholar
• Rubio IT, Cao Y, Hutchins LF, Westbrook KC, and Klimberg VS: Effect of glutamine on methotrexate efficacy and toxicity. Ann Surg 227, 772–780, 1998.
   PubMed Web of Science ®Google Scholar
• Klimberg VS, Nwokedi E, Hutchins LF, Pappas AA, Lang NP, et al.: Glutamine facilitates chemotherapy while reducing toxicity. J Parenter Enter Nutr 16, 83S–87S, 1992.
   PubMed Web of Science ®Google Scholar
• Charland SL, Bartlett DL, and Torosian MH: A significant methotrexate-glutamine pharmacokinetic interaction. Nutrition 11, 154–158, 1995.
   PubMed Web of Science ®Google Scholar