127
Views
7
CrossRef citations to date
0
Altmetric
Original Articles

Anticarcinogenic Effects of Dried Citrus Peel in Colon Carcinogenesis Due to Inhibition of Oxidative Stress

, , , , , , , , , , & show all
Pages 855-861 | Received 04 Aug 2016, Accepted 05 Apr 2017, Published online: 18 Jul 2017

References

  • Tamura M, Mutoh M, Fujii G, and Matsui H: Involvement of mitochondrial reactive oxygen species in gastric carcinogenesis. J Gastroint Dig Syst 3, 150, 2013.
  • Sen CK, and Packer L: Antioxidant and redox regulation of gene transcription. FASEB J 10, 709–720, 1996.
  • Slocum S, and Kensler TW: Nrf2: control of sensitivity to carcinogens. Arch Toxicol 85, 273–284, 2011.
  • Yanaka A: Sulforaphane enhances protection and repair of gastric mucosa against oxidative stress in vitro, and demonstrates anti-inflammatory effects on Helicobacter pylori-infected gastric mucosae in mice and human subjects. Curr Pharm Des 17, 1532–1540, 2011.
  • Cimino F, Cristani M, Saija A, Bonina FP, and Vifgili F: Protective effects of a red orange extract on UV-B induced damage in human keratinocytes. BioFactors 30, 129–138, 2007.
  • Russo A, Bonina F, Acquaviva R, Campisi A, Galvano N, et al.: Red orange extract: effect on DNA cleavage. J Food Sci 67, 2814–2818, 2002.
  • Bonina FP, Leotta C, Scalia G, Puglia C, Trombetta D, et al.: Evaluation of oxidative stress in diabetic patients after supplementation with a standardised red orange extract. Diabetes Nutr Metab 15, 14–19, 2002.
  • Ahmad M, Ansari MN, Alam A, and Khan TH: Oral dose of citrus peel extracts promotes wound repair in diabetic rats. Pak J Biol Sci 16, 1086–1094, 2013.
  • Shimizu S, Miyamoto S, Fujii G, Nakanishi R Onuma W, et al.: Suppression of intestinal carcinogenesis in Apc-mutant mice by limonin. J Clin Biochem Nutr 57, 39–43, 2015.
  • Wang LS, Kuo CT, Huang YW, Stoner GD, and Lechner JF: Gene-diet interactions on colorectal cancer risk. Curr Nutr Rep 1, 132–141, 2012.
  • Akakabe Y, and Nyuugaku T: An efficient conversion of carboxylic acids to one-carbon degraded aldehydes via 2-hydroperoxy acids. Biosci Biotechnol Biochem 71, 1370–1371, 2007.
  • Hamberg M, Sanz A, and Castresana C: Alpha-oxidation of fatty acids in higher plants. Identification of a pathogen-inducible oxygenase (piox) as an alpha-dioxygenase and biosynthesis of 2-hydroperoxylinolenic acid. J Biol Chem 274, 24503–24513, 1999.
  • Wentworth P Jr, McDunn JE, Wentworth AD, Takeuchi C, Nieva J, et al.: Evidence for antibody-catalyzed ozone formation in bacterial killing and inflammation. Science 298, 2195–2199, 2002.
  • Mutoh M, Watanabe K, Kitamura T, Shoji T, Takahashi M, et al.: Involvement of prostaglandin E receptor Subtype EP4 in colon carcinogenesis. Cancer Res 62, 28–32, 2002.
  • Tomono S, Miyoshi N, and Ohshima H: Comprehensive analysis of the lipophilic reactive carbonyls present in biological specimens by LC/ESI-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci 988, 149–156, 2015.
  • Onuma W, Tomono S, Shinngo M, Fujii G, Hamoya T, et al.: Irsogladine maleate, a gastric mucosal protectant, suppresses intestinal polyp development in Apc-mutant mice. Oncotarget 7, 8640–8652, 2016.
  • Izumi Y, Matsumura A, Wakaita S, Akagi K, Fukuda H, et al.: Isolation, identification, and biological evaluation of Nrf2-ARE activator from the leaves of green perilla (Perilla frutescens var. crispa f. viridis). Free Radical Bio Med 53, 669–679, 2012.
  • Di Donato JA, Mercurio F, and Karin M: NF-κB and the link between inflammation and cancer. Immunol Rev 246, 379–400, 2012.
  • Jeong WS, Jun M, and Kong AN: Nrf2: a potential molecular target for cancer chemoprevention by natural compounds Antioxid. Redox Signal 8, 99–106, 2006.
  • Tuzcu M, Aslan A, Tuzcu Z, Yabas M, Bahcecioglu IH, et al.: Tomato powder impedes the development of azoxymethane-induced colorectal cancer in rats through suppression of COX-2 expression via NF-κB and regulating Nrf2/HO-1 pathway. Mol Nutr Food Res 56, 1477–1481, 2012.
  • Chiou YS, Tsai ML, Nagabhushanam K, Wang YJ, Wu CH, et al.: Pterostilbene is more potent than resveratrol in preventing azoxymethane(AOM)-induced colon tumorigenesis via activation of the NF-E2-related factor 2 (Nrf2)-mediated antioxidant signaling pathway. J Agric Food Chem 59, 2725–2733, 2011.
  • Takahashi M, Mutoh M, Kawamori T, Sugimura S, Wakabayashi K: Altered expression of beta-catenin, inducible nitric oxide synthase and cyclooxygenase-2 in azoxymethane-induced rat colon carcinogenesis. Carcinogenesis 21, 1319–1327, 2000.
  • Igarashi M, Hippo Y, Ochiai M, Fukuda H, Nakagama H: AKT is critically involved in cooperation between obesity and the dietary carcinogen amino-1-methyl-6-phenylimidazo [4,5-b] (PhIP) toward colon carcinogenesis in rats. Biochem Biophys Res Commun 443, 852–857, 2014.
  • Niki E: Lipid peroxidation: physiological levels and dual biological effects. Free Radic Biol Med 47, 469–484, 2009.
  • Zarkovic N: 4-Hydroxynonenal as a bioactive marker of pathophysiological processes. Mol Aspects Med 24, 281–291, 2003.
  • Jang EJ, Jeong HO, Park D, Kim DH, Choi YJ, et al.: Src tyrosine kinase activation by 4-Hydroxynonenal upregulates p38, ERK/AP-1 signaling and COX-2 expression in YPEN-1 cells. PLoS ONE 10, e0129244, 2015.
  • Pierre F, Freeman A, Taché S, Van der Meer R, Corpet DE: Beef meat and blood sausage promote the formation of azoxymethane-induced mucin-depleted foci and aberrant crypt foci in rat colons. J Nutr 134, 2711–2716, 2004.
  • Guéraud F, Taché S, Steghens JP, Milkovic L, Borovic-Sunjic S, et al.: Dietary polyunsaturated fatty acids and heme iron induce oxidative stress biomarkers and a cancer promoting environment in the colon of rats. Free Radic Biol Med 83, 192–200, 2015.
  • Kwak MK, Egner PA, Dolan PM, Ramos-Gomez M, Groopman JD, et al.: Role of phase 2 enzyme induction in chemoprotection by dithiolethiones. Mutat Res 480–481, 305–315, 2001.
  • Teraoka N, Mutoh M, Takasu S, Ueno T, Nakano K, et al.: High susceptibility to azoxymethane-induced colorectal carcinogenesis in obese KK-Ay mice. Int J Cancer 129, 528–535, 2011.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.