Sequential Therapy of Breast Cancer Cell Lines with Vitamin C and Quercetin Improves the Efficacy of Chemotherapeutic Drugs

References

• Cancer IAfRo: Breast Cancer. Estimated incidence, mortality and prevalence worldwide in 2012. World Health Organization [ updated 2012] Available from: http://www.globocaniarc fr/Pages/fact_sheets_cancer aspx (accessed 8 January 2015).
   Google Scholar
• Naderimagham S, Alipour S, Djalalinia S, Kasaeian A, Noori A, et al.: National and sub-national burden of breast cancer in Iran; 1990–2013. Arch Iran Med 17(12), 794, 2014.
   PubMed Web of Science ®Google Scholar
• Mocanu MM, Nagy P, and Szollosi J: Chemoprevention of breast cancer by dietary polyphenols. Molecules (Basel, Switzerland) 20(12), 22578–22620, 2015.
   PubMed Web of Science ®Google Scholar
• Abdel-Latif GA, Al-Abd AM, Tadros MG, Al-Abbasi FA, Khalifa AE, et al.: The chemomodulatory effects of resveratrol and didox on herceptin cytotoxicity in breast cancer cell lines. Sci Rep 5, 1–13, 2015.
   Web of Science ®Google Scholar
• Siegel R, Naishadham D, and Jemal A: Cancer statistics, 2013. CA: Cancer J Clin 63(1), 11–30, 2013.
   PubMed Web of Science ®Google Scholar
• Group EBCTC: Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100 000 women in 123 randomised trials. Lancet 379(9814), 432–444, 2012.
   PubMed Web of Science ®Google Scholar
• Zoli W, Ulivi P, Tesei A, Fabbri F, Rosetti M, et al.: Addition of 5-fluorouracil to doxorubicin-paclitaxel sequence increases caspase-dependent apoptosis in breast cancer cell lines. Breast Cancer Res 7(5), R681–R689, 2005.
   PubMed Web of Science ®Google Scholar
• Ren D, Villeneuve NF, Jiang T, Wu T, Lau A, et al.: ?Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Proc Natl Acad Sci 108(4), 1433–1438, 2011.
   PubMed Web of Science ®Google Scholar
• Ramos S: Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention. J Nutr Biochem 18(7), 427–442, 2007.
   PubMed Web of Science ®Google Scholar
• Minaei A, Sabzichi M, Ramezani F, Hamishehkar H, and Samadi N: Co-delivery with nano-quercetin enhances doxorubicin-mediated cytotoxicity against MCF-7 cells. Mol Biol Rep 43(2), 99–105, 2016.
   PubMed Web of Science ®Google Scholar
• Zamani M, Goodarzi MT, Lavasani NS, and Khosravi A: Effects of ascorbic Acid on serum level of unconjugated estriol and its relationship with preterm premature rupture of membrane: a double-blind randomized controlled clinical trial. Iran J Med Sci 38(3), 227, 2013.
   PubMedGoogle Scholar
• Chen M-F, Yang C-M, Su C-M, and Hu M-L: Vitamin C protects against cisplatin-induced nephrotoxicity and damage without reducing its effectiveness in C57BL/6 mice xenografted with Lewis lung carcinoma. Nutr Cancer 66(7), 1085–1091, 2014.
   PubMed Web of Science ®Google Scholar
• Kurbacher CM, Wagner U, Kolster B, Andreotti PE, Krebs D, et al.: Ascorbic acid (vitamin C) improves the antineoplastic activity of doxorubicin, cisplatin, and paclitaxel in human breast carcinoma cells in vitro. Cancer Lett 103(2), 183–189, 1996.
   PubMed Web of Science ®Google Scholar
• Fromberg A, Gutsch D, Schulze D, Vollbracht C, Weiss G, et al.: Ascorbate exerts anti-proliferative effects through cell cycle inhibition and sensitizes tumor cells towards cytostatic drugs. Cancer Chemother Pharmacol 67(5), 1157–1166, 2011.
   PubMed Web of Science ®Google Scholar
• Bądziul D, Jakubowicz-Gil J, Langner E, Rzeski W, Głowniak K, et al.: The effect of quercetin and imperatorin on programmed cell death induction in T98G cells in vitro. Pharmacol Rep 66(2), 292–300, 2014.
   PubMed Web of Science ®Google Scholar
• Staedler D, Idrizi E, Kenzaoui BH, and Juillerat-Jeanneret L: Drug combinations with quercetin: doxorubicin plus quercetin in human breast cancer cells. Cancer Chemother Pharmacol 68(5), 1161–1172, 2011.
   PubMed Web of Science ®Google Scholar
• Mostafavi-Pour Z, Zal F, Monabati A, and Vessal M: Protective effects of a combination of quercetin and vitamin E against cyclosporine A‐induced oxidative stress and hepatotoxicity in rats. Hepatol Res 38(4), 385–392, 2008.
   PubMed Web of Science ®Google Scholar
• Mostafavi-Pour Z, Ramezani F, Keshavarzi F, and Samadi N. Oncol Lett. 2017 Mar; 13(3):1965–1973. doi: 10.3892/ol.2017.5619. Epub 2017 Jan 18.
   Google Scholar
• Chou T-C: Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev 58(3), 621–681, 2006.
   PubMed Web of Science ®Google Scholar
• Miles D, von Minckwitz G, and Seidman AD: Combination versus sequential single-agent therapy in metastatic breast cancer. Oncologist 7(Supplement 6), 13–19, 2002.
   PubMed Web of Science ®Google Scholar
• Vinod BS, Maliekal TT, and Anto RJ: Phytochemicals as chemosensitizers: from molecular mechanism to clinical significance. Antioxidants Redox Signal 18(11), 1307–1348, 2013.
   PubMed Web of Science ®Google Scholar
• Tupal A, Sabzichi M, Ramezani F, Kouhsoltani M, and Hamishehkar H: Dermal delivery of doxorubicin-loaded solid lipid nanoparticles for the treatment of skin cancer. J Microencapsul 33(4), 372–380, 2016.
   PubMed Web of Science ®Google Scholar
• Wu G-S, Lu J-J, Guo J-J, Huang M-Q, Gan L, et al.: Synergistic anti-cancer activity of the combination of dihydroartemisinin and doxorubicin in breast cancer cells. Pharmacol Rep 65(2), 453–459, 2013.
   PubMed Web of Science ®Google Scholar
• Sabzichi M, Samadi N, Mohammadian J, Hamishehkar H, Akbarzadeh M, et al.: Sustained release of melatonin: A novel approach in elevating efficacy of tamoxifen in breast cancer treatment. Colloids Surf B: Biointerfaces 145, 64–71, 2016.
   PubMed Web of Science ®Google Scholar
• Seghatoleslam A, and Zambrano A: Effects of over-expression of LOC92912 gene on cell cycle progression. Iran J Med Sci 34(4), 277–284, 2015.
   Google Scholar
• Weiss RB, Woolf SH, Demakos E, Holland JF, Berry DA, et al.: Natural history of more than 20 years of node-positive primary breast carcinoma treated with cyclophosphamide, methotrexate, and fluorouracil-based adjuvant chemotherapy: A study by the cancer and leukemia Group B. J Clin Oncol 21(9), 1825–1835, 2003.
   PubMed Web of Science ®Google Scholar
• Ma Y, Chapman J, Levine M, Polireddy K, Drisko J, et al.: High-dose parenteral ascorbate enhanced chemosensitivity of ovarian cancer and reduced toxicity of chemotherapy. Sci Transl Med 6(222), 222ra18–ra18, 2014.
   PubMed Web of Science ®Google Scholar
• Wang G, Zhang J, Liu L, Sharma S, and Dong Q: Quercetin potentiates doxorubicin mediated antitumor effects against liver cancer through p53/Bcl-xl. Plos One 7(12), e51764, 2012.
   PubMed Web of Science ®Google Scholar
• Chang Y-F, Chi C-W, and Wang J-J: Reactive oxygen species production is involved in quercetin-induced apoptosis in human hepatoma cells. Nutr Cancer 55(2), 201–209, 2006.
   PubMed Web of Science ®Google Scholar
• Kuo P-C, Liu H-F, and Chao J-I: Survivin and p53 modulate quercetin-induced cell growth inhibition and apoptosis in human lung carcinoma cells. J Biol Chem 279(53), 55875–55885, 2004.
   PubMed Web of Science ®Google Scholar
• Srivastava S, Somasagara RR, Hegde M, Nishana M, Tadi SK, et al.: Quercetin, a natural flavonoid interacts with DNA, arrests cell cycle and causes tumor regression by activating mitochondrial pathway of apoptosis. Sci Rep 6, 1–13, 2016.
   PubMed Web of Science ®Google Scholar
• Zamin LL, Filippi‐Chiela EC, Dillenburg‐Pilla P, Horn F, Salbego C, et al.: Resveratrol and quercetin cooperate to induce senescence‐like growth arrest in C6 rat glioma cells. Cancer Sci 100(9), 1655–1662, 2009.
   PubMed Web of Science ®Google Scholar
• Frajese GV, Benvenuto M, Fantini M, Ambrosin E, Sacchetti P, et al.: Potassium increases the antitumor effects of ascorbic acid in breast cancer cell lines in vitro. Oncol Lett 11(6), 4224–4234, 2016.
   PubMed Web of Science ®Google Scholar
• Balabhadrapathruni S, Thomas T, Yurkow E, Amenta P, and Thomas T: Effects of genistein and structurally related phytoestrogens on cell cycle kinetics and apoptosis in MDA-MB-468 human breast cancer cells. Oncol Rep 7(1), 3–15, 2000.
   PubMed Web of Science ®Google Scholar
• Guerriero E, Sorice A, Capone F, Napolitano V, Colonna G, et al.: Vitamin C effect on mitoxantrone-induced cytotoxicity in human breast cancer cell lines. PloS One 9(12), e115287, 2014.
   PubMed Web of Science ®Google Scholar
• Ranganathan S, Halagowder D, and Sivasithambaram ND: Quercetin suppresses twist to induce apoptosis in MCF-7 breast cancer cells. PloS One 10(10), e0141370, 2015.
   PubMed Web of Science ®Google Scholar
• Lu J, Papp LV, Fang J, Rodriguez-Nieto S, Zhivotovsky B, et al.: Inhibition of mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity. Cancer Res 66(8), 4410–4418, 2006.
   PubMed Web of Science ®Google Scholar
• Demidenko Z, Kalurupalle S, Hanko C, Lim C, Broude E, et al.: Mechanism of G1-like arrest by low concentrations of paclitaxel: next cell cycle p53-dependent arrest with sub G1 DNA content mediated by prolonged mitosis. Oncogene 27(32), 4402–4410, 2008.
   PubMed Web of Science ®Google Scholar
• Rasti M, Arabsolghar R, Khatooni Z, and Mostafavi-Pour Z: p53 binds to estrogen receptor 1 promoter in human breast cancer cells. Pathol Oncol Res 18(2), 169–175, 2012.
   PubMed Web of Science ®Google Scholar
• Jung-Achoi J-YK, Lee J-Y, Kang C-M, and Kwon H-J: Induction of cell cycle arrest and apoptosis in human breast cancer cells by quercetin. Int J Oncol 19, 837–844, 2001.
   PubMed Web of Science ®Google Scholar
• Zhang H, Zhang M, Yu L, Zhao Y, He N, et al.: Antitumor activities of quercetin and quercetin-5′, 8-disulfonate in human colon and breast cancer cell lines. Food Chem Toxicol 50(5), 1589–1599, 2012.
   PubMed Web of Science ®Google Scholar
• Seo HS, Choi HS, Choi HS, Choi YK, Um J-Y, et al.: Phytoestrogens induce apoptosis via extrinsic pathway, inhibiting nuclear factor-κB signaling in HER2-overexpressing breast cancer cells. Anticancer Res 31(10), 3301–3313, 2011.
   PubMed Web of Science ®Google Scholar
• Duo J, Ying G-G, Wang G-W, and Zhang L: Quercetin inhibits human breast cancer cell proliferation and induces apoptosis via Bcl-2 and Bax regulation. Mol Med Rep 5(6), 1453–1456, 2012.
   PubMed Web of Science ®Google Scholar
• Jordan MA, Wendell K, Gardiner S, Derry WB, Copp H, et al.: Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death. Cancer Res 56(4), 816–825, 1996.
   PubMed Web of Science ®Google Scholar