Black Raspberries and Their Anthocyanin and Fiber Fractions Alter the Composition and Diversity of Gut Microbiota in F-344 Rats

References

• Ley RE, Peterson DA, Gordon JI: Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell 124, 837–848, 2006.
   PubMed Web of Science ®Google Scholar
• Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, et al.: A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464, 59–65, 2010.
   PubMed Web of Science ®Google Scholar
• Guinane CM, Cotter PD: Role of the gut microbiota in health and chronic gastrointestinal disease: understanding a hidden metabolic organ. Therap Adv Gastroenterol 6, 295–308, 2013.
   PubMed Web of Science ®Google Scholar
• Zhang H, DiBaise JK, Zuccolo A, Kudrna D, Braidotti M, et al.: Human gut microbiota in obesity and after gastric bypass. Proc Natl Acad Sci U S A 106, 2365–2370, 2009.
   PubMed Web of Science ®Google Scholar
• Qin J, Li Y, Cai Z, Li S, Zhu J, et al.: A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 490, 55–60, 2012.
   PubMed Web of Science ®Google Scholar
• Kau AL, Ahern PP, Griffin NW, Goodman AL, Gordon JI: Human nutrition, the gut microbiome and the immune system. Nature 474, 327–336, 2011.
   PubMed Web of Science ®Google Scholar
• Frank DN, St Amand AL, Feldman RA, Boedeker EC, Harpaz N, et al.: Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci U S A 104, 13780–13785, 2007.
   PubMed Web of Science ®Google Scholar
• Claesson MJ, Jeffery IB, Conde S, Power SE, O'Connor EM, et al.: Gut microbiota composition correlates with diet and health in the elderly. Nature 488, 178–184, 2012.
   PubMed Web of Science ®Google Scholar
• O'Keefe SJ, Li JV, Lahti L, Ou J, Carbonero F, et al.: Fat, fibre and cancer risk in African Americans and rural Africans. Nat Commun 6, 6342, 2015.
   PubMed Web of Science ®Google Scholar
• Kresty LA, Morse MA, Morgan C, Carlton PS, Lu J, et al.: Chemoprevention of esophageal tumorigenesis by dietary administration of lyophilized black raspberries. Cancer Res 61, 6112–6119, 2001.
   PubMed Web of Science ®Google Scholar
• Wang LS, Hecht SS, Carmella SG, Yu N, Larue B, et al.: Anthocyanins in black raspberries prevent esophageal tumors in rats. Cancer Prev Res (Phila) 2, 84–93, 2009.
   PubMed Web of Science ®Google Scholar
• Voragen FGJ, Timmers JPJ, Linssen JPH, Schols HA, Pilnik W: Methods of analysis for cell-wall polysaccharides of fruit and vegetables. Z Lebensm Unters Forsch 177, 251–256, 1983.
   Google Scholar
• Ross HA, McDougall GJ, Stewart D: Antiproliferative activity is predominantly associated with ellagitannins in raspberry extracts. Phytochemistry 68, 218–228, 2007.
   PubMed Web of Science ®Google Scholar
• Stoner GD: Foodstuffs for preventing cancer: the preclinical and clinical development of berries. Cancer Prev Res 2, 187–194, 2009.
   PubMed Web of Science ®Google Scholar
• McKenna P, Hoffmann C, Minkah N, Aye PP, Lackner A, et al.: The macaque gut microbiome in health, lentiviral infection, and chronic enterocolitis. PLoS Pathog 4, e20, 2008.
   PubMed Web of Science ®Google Scholar
• Dethlefsen L, Huse S, Sogin ML, Relman DA: The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing. PLoS Biol 6, e280, 2008.
   PubMed Web of Science ®Google Scholar
• Ohtani N: Microbiome and cancer. Semin Immunopathol 37, 65–72, 2015.
   PubMed Web of Science ®Google Scholar
• Greiner AK, Papineni RV, Umar S: Chemoprevention in gastrointestinal physiology and disease. Natural products and microbiome. Am J Physiol Gastrointest Liver Physiol 307, G1–G15, 2014.
   PubMed Web of Science ®Google Scholar
• Frank DN, Zhu W, Sartor RB, Li E: Investigating the biological and clinical significance of human dysbioses. Trends Microbiol 19, 427–434, 2011.
   PubMed Web of Science ®Google Scholar
• Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal WZ, et al.: Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 482, 179–185, 2012.
   PubMed Web of Science ®Google Scholar
• Ley RE, Turnbaugh PJ, Klein S, Gordon JI: Microbial ecology: human gut microbes associated with obesity. Nature 444, 1022–1023, 2006.
   PubMed Web of Science ®Google Scholar
• Wen L, Ley RE, Volchkov PY, Stranges PB, Avanesyan L, et al.: Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature 455, 1109–1113, 2008.
   PubMed Web of Science ®Google Scholar
• Vijay-Kumar M, Aitken JD, Carvalho FA, Cullender TC, Mwangi S, et al.: Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science 328, 228–231, 2010.
   PubMed Web of Science ®Google Scholar
• Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, et al.: Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature 472, 57–63, 2011.
   PubMed Web of Science ®Google Scholar
• Miyoshi J, Chang EB: The gut microbiota and inflammatory bowel diseases. Transl Res 2016.
   PubMed Web of Science ®Google Scholar
• Akin H, Tozun N: Diet, microbiota, and colorectal cancer. J Clin Gastroenterol 48(Suppl 1), S67–S69, 2014.
   PubMed Web of Science ®Google Scholar
• Vendrame S, Guglielmetti S, Riso P, Arioli S, Klimis-Zacas D, et al.: Six-week consumption of a wild blueberry powder drink increases bifidobacteria in the human gut. J Agric Food Chem 59, 12815–12820, 2011.
   PubMed Web of Science ®Google Scholar
• Paturi G, Butts CA, Bentley-Hewitt KL, Ansell J: Influence of green and gold kiwifruit on indices of large bowel function in healthy rats. J Food Sci 79, H1611–H1620, 2014.
   PubMed Web of Science ®Google Scholar
• Wang LS, Arnold M, Huang YW, Sardo C, Seguin C, et al.: Modulation of genetic and epigenetic biomarkers of colorectal cancer in humans by black raspberries: a phase I pilot study. Clin Cancer Res 17, 598–610, 2011.
   PubMed Web of Science ®Google Scholar
• Wang LS, Burke CA, Hasson H, Kuo CT, Molmenti CL, et al.: A phase Ib study of the effects of black raspberries on rectal polyps in patients with familial adenomatous polyposis. Cancer Prev Res (Phila) 7, 666–674, 2014.
   PubMed Web of Science ®Google Scholar
• Pan P, Skaer CW, Stirdivant SM, Young MR, Stoner GD, et al.: Beneficial regulation of metabolic profiles by black raspberries in human colorectal cancer patients. Cancer Prev Res (Phila) 8, 743–750, 2015.
   PubMed Web of Science ®Google Scholar
• Pan P, Skaer CW, Wang HT, Stirdivant SM, Young MR, et al.: Black raspberries suppress colonic adenoma development in ApcMin/+ mice: relation to metabolite profiles. Carcinogenesis 36, 1245–1253, 2015.
   PubMed Web of Science ®Google Scholar
• Wang LS, Kuo CT, Huang TH, Yearsley M, Oshima K, et al.: Black raspberries protectively regulate methylation of Wnt pathway genes in precancerous colon tissue. Cancer Prev Res (Phila) 6, 1317–1327, 2013.
   PubMed Web of Science ®Google Scholar
• Wang LS, Kuo CT, Stoner K, Yearsley M, Oshima K, et al.: Dietary black raspberries modulate DNA methylation in dextran sodium sulfate (DSS)-induced ulcerative colitis. Carcinogenesis 34, 2842–2850, 2013.
   PubMed Web of Science ®Google Scholar
• Pan P, C WS, Wang HT, Oshima K, Huang YW, et al.: Loss of free fatty acid receptor 2 enhances colonic adenoma development and reduces the chemopreventive effects of black raspberries in ApcMin/+ mice. Carcinogenesis 38, 86–93, 2017.
   PubMed Web of Science ®Google Scholar
• Pan P, Skaer CW, Wang HT, Kreiser MA, Stirdivant SM, et al.: Systemic metabolite changes in wild-type C57BL/6 mice fed black raspberries. Nutr Cancer 69, 299–306, 2017.
   PubMed Web of Science ®Google Scholar
• Sobhani I, Tap J, Roudot-Thoraval F, Roperch JP, Letulle S, et al.: Microbial dysbiosis in colorectal cancer (CRC) patients. PLoS ONE 6, e16393, 2011.
   PubMed Web of Science ®Google Scholar
• Shen XJ, Rawls JF, Randall T, Burcal L, Mpande CN, et al.: Molecular characterization of mucosal adherent bacteria and associations with colorectal adenomas. Gut Microbes 1, 138–147, 2010.
   PubMed Web of Science ®Google Scholar
• Derrien M, Belzer C, de Vos WM: Akkermansia muciniphila and its role in regulating host functions. Microb Pathog 2016.
   PubMed Web of Science ®Google Scholar
• Zhao S, Liu W, Wang J, Shi J, Sun Y, et al.: Akkermansia muciniphila improves metabolic profiles by reducing inflammation in chow diet-fed mice. J Mol Endocrinol 2016.
   Web of Science ®Google Scholar
• Song H, Chu Q, Yan F, Yang Y, Han W, et al.: Red pitaya betacyanins protects from diet-induced obesity, liver steatosis and insulin resistance in association with modulation of gut microbiota in mice. J Gastroenterol Hepatol 31, 1462–1469, 2016.
   PubMed Web of Science ®Google Scholar
• Liu W, Crott JW, Lyu L, Pfalzer AC, Li J, et al.: Diet- and genetically-induced obesity produces alterations in the microbiome, inflammation and Wnt pathway in the intestine of Apc+/1638N mice: comparisons and contrasts. J Cancer 7, 1780–1790, 2016.
   PubMed Web of Science ®Google Scholar
• Peiffer DS, Zimmerman NP, Wang LS, Ransom BW, Carmella SG, et al.: Chemoprevention of esophageal cancer with black raspberries, their component anthocyanins, and a major anthocyanin metabolite, protocatechuic acid. Cancer Prev Res (Phila) 7, 574–584, 2014.
   PubMed Web of Science ®Google Scholar
• Peiffer DS, Wang LS, Zimmerman NP, Ransom BW, Carmella SG, et al.: Dietary consumption of black raspberries or their anthocyanin constituents alters innate immune cell trafficking in esophageal cancer. Cancer Immunol Res 4, 72–82, 2016.
   PubMed Web of Science ®Google Scholar
• Riviere A, Selak M, Lantin D, Leroy F, De Vuyst L: Bifidobacteria and butyrate-producing colon bacteria: importance and strategies for their stimulation in the human gut. Front Microbiol 7, 979, 2016.
   PubMed Web of Science ®Google Scholar
• Elli M, Cattivelli D, Soldi S, Bonatti M, Morelli L: Evaluation of prebiotic potential of refined psyllium (Plantago ovata) fiber in healthy women. J Clin Gastroenterol 42(Suppl 3 Pt 2), S174–S176, 2008.
   PubMed Web of Science ®Google Scholar
• David LA, Maurice CF, Carmody RN, Gootenberg DB, Button JE, et al.: Diet rapidly and reproducibly alters the human gut microbiome. Nature 505, 559–563, 2014.
   PubMed Web of Science ®Google Scholar
• Duncan SH, Louis P, Thomson JM, Flint HJ: The role of pH in determining the species composition of the human colonic microbiota. Environ Microbiol 11, 2112–2122, 2009.
   PubMed Web of Science ®Google Scholar
• De Filippo C, Cavalieri D, Di Paola M, Ramazzotti M, Poullet JB, et al.: Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci U S A 107, 14691–14696, 2010.
   PubMed Web of Science ®Google Scholar