197
Views
9
CrossRef citations to date
0
Altmetric
Original Articles

Anticancer Activity and Molecular Mechanism of Polyphenol Rich Calophyllum inophyllum Fruit Extract in MCF-7 Breast Cancer Cells

, , &
Pages 1308-1324 | Received 23 Nov 2016, Accepted 26 Jun 2017, Published online: 25 Oct 2017

References

  • Sun J, and Liu RH: Cranberry phytochemical extracts induce cell cycle arrest and apoptosis in human MCF-7 breast cancer cells. Cancer Let 241, 124–134, 2006.
  • Ramos S: Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention. J Nutr Biochem 18, 427–442, 2007.
  • Kong Q, Beel JA, and Lillehei KO: A threshold concept for cancer therapy. Med Hypotheses 55, 29–35, 2000.
  • Shanmugapriya, Chen Y, Kanwar JR, and Sasidharan S: Effects of Calophyllum inophyllum fruit extract on the proliferation and morphological characteristics of human breast cancer cells MCF-7. Asian Pac J Trop Dis 6, 291–297, 2016.
  • Kathiresan K, Boopathy NS, and Kavitha S: Coastal vegetationo an underexplored source of anticancer drugs. Nat prod Radiance 5, 115–119, 2006.
  • Jaikumar K, Sheik Noor Mohamed M, Anand D, and Saravanan P: Anticancer activity of Calophyllum inophyllum L., ethanolic leaf extract in MCF human breast cell lines. Int J Pharm Sci Res 7, 3330–3335, 2016.
  • Petard P: Raau Tahiti: The Use of Polynesian Medicinal Plants in Tahitian Medicine. Noumea, New Caledonia: South Pacific Commission, 1972.
  • Dweck AC, and Meadows T: Tamanu (Calophyllum inophyllum)-the African, Asian, Polynesian and Pacific Panacea. Int J Cosmet Sci 24, 341–348, 2002.
  • Chevalier J: Study on a New Cicatrizing Agent for Cutaneous and Mucous Wounds, Oil of Calophyllum Inophyllum. Paris, France: Institut de Biologie Normale Superieure, 1951.
  • Singleton VL, Orthofer R, and Lamuela-Raventos RM: Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent. Methods Enzymol 299, 152–178, 1999.
  • van England M, Ramaekers FC, Schutte B, and Ruetelingsperger CP: A novel assay to measure loss of plasma membrane asymmetry during apoptosis of adherent cells in culture. Cytometry 24, 131–139, 1996.
  • Zhang G, Gurtu V, Kavin SR, and Yan G: Early detection of apoptosis using a fluorescent conjugate of Annexin V. Biotechniques 23, 525–531, 1997.
  • Liu JD, et al.: Molecular mechanisms of G0/G1 cell-cycle arrest and apoptosis induced by Terfenadine in human cancer cells. Mol Carcinog 37, 39–50, 2003.
  • Marchetti P, et al.: Mitochondrial permeability transition is a central coordinating event of apoptosis. J Exp Med 184, 1155, 1996.
  • Susin SA, et al.: Bcl-2 inhibits the mitochondrial release of an apoptogenic protease. J Exp Med 184, 1331–1341, 1996.
  • Zhivotovsky B: Caspases: the enzymes of death. Essays Biochem 39, 25–40, 2003.
  • Kampa M, Nifli AP, Notas G, and Castanas E: Polyphenols and cancer cell growth. Rev Physiol Biochem Pharmacol 159, 79–113, 2007.
  • Azmi AS, Bhat SH, Hanif S, and Hadi SM: Plant polyphenols mobilize endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: a putative mechanism for anticancer properties. FEBS Let 580, 533–538, 2006.
  • Sebastian SR, and Britto AJD: Screening for the elite genotype of Calophyllum inophyllum L. based on antioxidant activity and calocoumarin-a content. World J Pharm Pharm Sci 3, 1479–1494, 2014.
  • Dutta S, and Ray S: Evaluations of antioxidant potentials of leaf aqueous and methanolic extracts of C. inophyllum in relation to total phenol and flavonoids contents. Int J Pharm Biol Sci 5, 441–450, 2014.
  • Goh SH, and Jantan I: A xanthone from Calophyllum inophyllum. Phytochemistry 30, 366–367, 1991.
  • Iinuma M, Tosa H, Tanaka T, and Yonemori S: Two new xanthones in the underground part of Calophyllum inophyllum. Heterocycles 37, 833–838, 1994.
  • Fan GJ, Han BH, Kang YH, and Park MK: Evaluation of inhibitory potentials of Chinese medicinal plants on platelet-activating factor (PAF) receptor binding. Nat Prod Sci 7, 33–37, 2001.
  • Spada PDS, De Souza GGN, Bortolini GV, Henriques JAP, and Salvador M: Antioxidant, mutagenic, and antimutagenic activity of frozen fruits. J Med Food 11, 144–151, 2008.
  • Mohsen SM, and Ammar ASM: Total phenolic contents and antioxidant activity of corn tassel extracts. Food Chem 112, 595–598, 2009.
  • Dufour D, et al.: Antioxidant, anti-inflammatory and anticancer activities of methanolic extracts from Ledum groenlandicum Retzius. J Ethnopharmacol 111, 22–28, 2007.
  • Oueslati S, et al.: Phenolic content, antioxidant, anti-inflammatory and anticancer activities of the edible halophyte Suaeda fruticosa Forssk. Food Chem 132, 943–947, 2012.
  • Wlodkowic D, Telford W, Skommer J, and Darzynkiewicz Z: Apoptosis and beyond: cytometry in studies of programmed cell death. Methods Cell Biol 103, 55–98, 2011.
  • Chen C, and Kong AT: Dietary cancer-chemopreventive compounds: from signaling and gene expression to pharmacological effects. Trends Pharmacol Sci 26, 318–326, 2005.
  • Song G, et al.: Effects of oxymatrin on proliferation and apoptosis in human hepatoma cells. Colloids Surf B Biointerfaces 48, 1–5, 2006.
  • Darzynkiewicz Z, et al.: Cytometry in cell necrobiology: analysis of apoptosis and accidental cell death (necrosis). Cytometry 27, 1–20, 1997.
  • Kimura S, et al.: Inhibition of leukemic cell growth by a novel anti-cancer drug (GUT-70) from Calophyllum brasiliense that acts by induction of apoptosis. Int J Cancer 113, 158–165, 2005.
  • Birch-Machin MA: Assessment of mitochondrial respiratory complex function In Vitro and In Vivo. In: Drug-Induced Mitochondrial Dysfunction, Dykens JA and Will Y (eds.). Canada: John Wiley & Sons, Inc., 2008, pp. 383–397.
  • Storz P: Reactive oxygen species in tumor progression. Front Biosci 10, 1881–1896, 2005.
  • Pelicano H, Carney D, and Huang P: ROS stress in cancer cells and therapeutic implications. Drug Resistance Updates 7, 97–110, 2004.
  • Tan S, Sagara Y, Liu Y, Maher P, and Schubert D: The regulation of reactive oxygen species production during programmed cell death. J Cell Biol 141, 1423–1432, 1998.
  • Green DR, and Kroemer G: The pathophysiology of mitochondrial cell death. Science 305, 626–629, 2004.
  • Hara K, et al.: Mitochondria determine the efficacy of anticancer agents that interact with DNA but not the cytoskeleton. J Pharmacol Exp Ther 337, 838–845, 2011.
  • Zamzami N, et al.: Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis. FEBS Let 384, 53–37, 1996.
  • Zamzami N, and Kroemer G: The mitochondrion in apoptosis: how Pandora's Box opens. Nat Rev Mol Cell Biol 2, 67–71, 2001.
  • Gottlieb E, Heiden MGV, and Thompson CB: Bcl-xL prevents the initial decrease in mitochondrial membrane potential and subsequent reactive oxygen species production during tumor necrosis factor alpha-induced apoptosis. Mol Cell Biol 20, 5680–5689, 2000.
  • Herrera B, et al.: Reactive oxygen species (ROS) mediates the mitochondrial-dependent apoptosis induced by transforming growth factor β in fetal hepatocytes. FASEB J 15, 3741–3751, 2001.
  • Wu X, Stahl T, Hu Y, Kassie F, and Mersch-Sundermann V: The production of reactive oxygen species and the mitochondrial membrane potential are modulated during onion oil–induced cell cycle arrest and apoptosis in A549 cells. J Nutr 136, 608–613, 2006.
  • Wang Y, et al.: Arsenic induces mitochondria-dependent apoptosis by reactive oxygen species generation rather than glutathione depletion in Chang human hepatocytes. Arch Toxicol 83, 899–908, 2009.
  • Ly JD, Grubb DR, and Lawen A: The mitochondrial membrane potential (Δψm) in apoptosis: an update. Apoptosis 8, 115–128, 2003.
  • Lamkanfi M, Declercq W, Kalai M, Saelens X, and Vandenabeele P: Alice in caspase land. a phylogenetic analysis of caspases from worm to man. Cell Death Differ 9, 358–361, 2002.
  • Walsh JG, et al.: Executioner caspase-3 and caspase-7 are functionally distinct proteases. Proc Natl Acad Sci U.S.A. 105, 12815–12819, 2008.
  • Lamkanfi M, et al.: Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival. Blood 113, 2742–2745, 2009.
  • Reed JC: Regulation of apoptosis by Bcl-2 family proteins and its role in cancer and chemoresistance. Curr Opin Oncol 7, 541–546, 1995.
  • Elmore S: Apoptosis: a review of programmed cell death. Toxicol Pathol 35, 495–516, 2007.
  • Symonds H, et al.: p53-dependent apoptosis suppresses tumor growth and progression in vivo. Cell 78, 703–711, 1994.
  • Katiyar SK, Roy AM, and Baliga MS: Silymarin induces apoptosis primarily through a p53-dependent pathway involving Bcl-2/Bax, cytochrome c release, and caspase activation. Mol Cancer Ther 4, 207–216, 2005.
  • Collins AR: The comet assay for DNA damage and repair principles, applications, and limitations. Mol Biotechnol 26, 249–261, 2004.
  • Azqueta A, and Collins AR: The essential comet assay: a comprehensive guide to measuring DNA damage and repair. Arch Toxicol 87, 949–968, 2013.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.