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Review Article

Latest in Vitro and in Vivo Assay, Clinical Trials and Patents in Cancer Treatment using Curcumin: A Literature Review

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Pages 569-578 | Received 27 Oct 2017, Accepted 16 Mar 2018, Published online: 30 Apr 2018

References

  • Aggarwal B, Surh Y, and Shishodia S: The Molecular Targets and Therapeutic uses of Curcumin in Health and Disease. New York, NY: Springer, 2007.
  • Momtazi A and Sahebkar A: Difluorinated curcumin: a promising curcumin analogue with improved anti-tumor activity and pharmacokinetic profile. CPD 22, 4386–4397, 2016.
  • Shoba G, Joy D, Joseph T, Majeed M, Rajedendran R, et al.: Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med 64, 353–356, 1998.
  • Turmeric Uses, Benefits and Dosage-Drugs.com Herbal Database. Drugs.com. 2016. Available from: https://www.drugs.com/npp/turmeric.html
  • Perrone D, Ardito F, Giannatempo G, Dioguardi M, Troiano G, et al.: Biological and therapeutic activities, and anticancer properties of curcumin (Review). Expl Ther Med 10, 1615–1623, 2015.
  • Boominathan L: Curcumin functions as a positive regulator of miRNA processing and a negative regulator of cancer stem cell proliferation. Nat Proced 2010.
  • Ruiz de Porras V, Bystrup S, Martínez-Cardús A, Pluvinet R, Sumoy L, et al.: Curcumin mediates oxaliplatin-acquired resistance reversion in colorectal cancer cell lines through modulation of CXC-Chemokine/NF-κB signalling pathway. Sci Rep 6, 24675, 2016.
  • Sahu B, Hazarika H, Bharadwaj R, Loying P, Baishya R, et al.: Curcumin-docetaxel co-loaded nanosuspension for enhanced anti-breast cancer activity. Expert Opin Drug Deliv 13, 1065–1074, 2016.
  • Rachakonda G, Vu T, Jin L, Samanta D, and Datta P: Role of TGF-β-induced Claudin-4 expression through c-Jun signaling in non-small cell lung cancer. Cell Signal 28, 1537–1544, 2016.
  • Bisht S, Schlesinger M, Rupp A, Schubert R, Nolting J, et al.: A liposomal formulation of the synthetic curcumin analog EF24 (Lipo-EF24) inhibits pancreatic cancer progression: towards future combination therapies. J Nanobiotechnol 14, 57, 2016.
  • Seo J, Kim B, Dhanasekaran D, Tsang B, and Song Y: Curcumin induces apoptosis by inhibiting sarco/endoplasmic reticulum Ca2+ ATPase activity in ovarian cancer cells. Cancer Lett 371, 30–37, 2016.
  • Dricu A, Alexandru O, Georgescu A, Ene L, Purcaru S, et al.: The effect of curcumin on low-passage glioblastoma cells in vitro. J Can Res Ther 12, 1025, 2016.
  • Sharma V, Kumar L, Mohanty S, Maikhuri J, Rajender S, et al.: Sensitization of androgen refractory prostate cancer cells to anti-androgens through re-expression of epigenetically repressed androgen receptor-Synergistic action of quercetin and curcumin. Mol Cell Endocrinol 431, 12–23, 2016.
  • Lee J, Park S, Kim S, Um S, and Moon E: Curcumin hampers the antitumor effect of vinblastine via the inhibition of microtubule dynamics and mitochondrial membrane potential in HeLa cervical cancer cells. Phytomedicine 23, 705–713, 2016.
  • Tung C, Jian Y, Chen J, Wang T, Chen W, et al.: Curcumin downregulates p38 MAPK-dependent X-ray repair cross-complement group 1 (XRCC1) expression to enhance cisplatin-induced cytotoxicity in human lung cancer cells. Naunyn-Schmiedeberg's Arch Pharmacol 389, 657–666, 2016.
  • Zhou X, Wang W, Li P, Zheng Z, Tu Y, et al.: Curcumin enhances the effects of 5-fluorouracil and oxaliplatin in inducing gastric cancer cell apoptosis both in vitro and in vivo. Oncol Res 23, 29–34, 2016.
  • Ooko E, Alsalim T, Saeed B, Saeed M, Kadioglu O, et al.: Modulation of P-glycoprotein activity by novel synthetic curcumin derivatives in sensitive and multidrug-resistant T-cell acute lymphoblastic leukemia cell lines. Toxicol Appl Pharmacol 305, 216–233, 2016.
  • Montgomery A, Adeyeni T, San K, Heuertz R, and Ezekiel U: Curcumin sensitizes silymarin to exert synergistic anticancer activity in colon cancer cells. J Cancer 7, 1250–1257, 2016.
  • Kumar D, Basu S, Parija L, Rout D, Manna S, et al.: Curcumin and Ellagic acid synergistically induce ROS generation, DNA damage, p53 accumulation and apoptosis in HeLa cervical carcinoma cells. Biomed Pharmacother 81, 31–37, 2016.
  • Jayakumar S, Patwardhan R, Pal D, Sharma D, and Sandur S: Dimethoxycurcumin, a metabolically stable analogue of curcumin enhances the radiosensitivity of cancer cells: possible involvement of ROS and thioredoxin reductase. Biochem Biophys Res Commun 478, 446–454, 2016.
  • Lu Y, Wang J, Liu L, Yu L, Zhao N, et al.: Curcumin increases the sensitivity of Paclitaxel-resistant NSCLC cells to Paclitaxel through microRNA-30c-mediated MTA1 reduction. Tumour Biol. 39, 2017.
  • Zhu J, Yang X, Chen Y, Jiang Y, Wang S, et al.: Curcumin suppresses lung cancer stem cells via inhibiting Wnt/β-catenin and sonic hedgehog pathways. Phytother Res 31, 680–688, 2017.
  • Zhou GZ, Cao FK, Chang JM, Sun GC, and Chen XB: Mechanism of curcumin analog MHMD-induced cell death in A549 lung cancer cells. - PubMed - NCBI [Internet]. Ncbi.nlm.nih.gov. 2017 [cited 17 June 2017]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/?term=25392116.
  • Xia Y, Wei X, Li W, Kanchana K, Xu C, et al.: Curcumin Analogue A501 induces G2/M arrest and apoptosis in non-small cell lung cancer cells. Asian Pac J Cancer Prev 15, 6893–6898, 2014.
  • Zhu W, Liu S, Wu L, Xu H, Wang J, et al.: Delivery of curcumin by directed self-assembled micelles enhances therapeutic treatment of non-small-cell lung cancer. Int J Nanomedicine 12, 2621–2634, 2017.
  • Badrzadeh F, Akbarzadeh A, Zarghami N, Yamchi M, Zeighamian V, et al.: Comparison between effects of free curcumin and curcumin loaded NIPAAm-MAA nanoparticles on telomerase and PinX1 gene expression in lung cancer cells. Asian Pac J Cancer Prev 15, 8931–8936, 2017.
  • Ranjan A, Mukerjee A, Gdowski A, Helson L, Bouchard A, et al.: Curcumin-ER prolonged subcutaneous delivery for the treatment of non-small cell lung cancer. J Biomed Nanotechnol. 12, 679–688, 2016.
  • Liang Z, Wu R, Xie W, Zhu M, Xie C, et al.: Curcumin reverses tobacco smoke-induced epithelial-mesenchymal transition by suppressing the MAPK pathway in the lungs of mice. Mol Med Rep 36, 190, 2017.
  • Kumar U, Sharma U, and Rathi G: Reversal of hypermethylation and reactivation of glutathione S-transferase pi 1 gene by curcumin in breast cancer cell line. Tumour Biol 39, 2017.
  • Jia T, Zhang L, Duan Y, Zhang M, Wang G, et al.: The differential susceptibilities of MCF-7 and MDA-MB-231 cells to the cytotoxic effects of curcumin are associated with the PI3K/Akt-SKP2-Cip/Kips pathway. Cancer Cell Int 14, 126, 2014.
  • Gallardo M and Calaf G: Curcumin and epithelial-mesenchymal transition in breast cancer cells transformed by low doses of radiation and estrogen. Int J Oncol 48, 2534–2542, 2016.
  • Rao D, Liu H, Ambudkar S, and Mayer M: A combination of curcumin with either gramicidin or ouabain selectively kills cells that express the multidrug resistance-linked ABCG2 transporter. J Biol Chem 289, 31397–31410, 2014.
  • Guzzarlamudi S, Singh P, Pawar V, Singh Y, Sharma K, et al.: Synergistic chemotherapeutic activity of curcumin bearing methoxypolyethylene glycol-g-linoleic acid based micelles on breast cancer cells. J Nanosci Nanotechnol 16, 4180–4190, 2016.
  • Baek J and Cho C: A multifunctional lipid nanoparticle for co-delivery of paclitaxel and curcumin for targeted delivery and enhanced cytotoxicity in multidrug resistant breast cancer cells. Oncotarget 8, 30369–30382, 2017.
  • Grill A, Shahani K, Koniar B, and Panyam J: Chemopreventive efficacy of curcumin-loaded PLGA microparticles in a transgenic mouse model of HER-2-positive breast cancer. Drug Deliv Trans Res 2017.
  • Sun Q, Zhang W, Guo Y, Li Z, Chen X, et al.: Curcumin inhibits cell growth and induces cell apoptosis through upregulation of miR-33b in gastric cancer. Tumour Biol 37, 13177–13184, 2016.
  • Liu X, Sun K, Chen H, Song A, Zhang X, et al.: Curcumin inhibits proliferation of gastric cancer cells by impairing ATP-sensitive potassium channel opening. World J Surg Oncol 12, 389, 2014.
  • Liang T, Zhang X, Xue W, Zhao S, Zhang X, et al.: Curcumin induced human gastric cancer BGC-823 cells apoptosis by ROS-mediated ASK1-MKK4-JNK stress signaling pathway. Int J Mol Sci 15, 15754–15765, 2014.
  • Tsai W, Yu K, Huang Y, and Lee C: EGFR-targeted photodynamic therapy by curcumin-encapsulated chitosan/TPP nanoparticles. Int J Nanomedicine 13, 903–916, 2018.
  • Tung L, Song S, Chan K, Choi M, Lam H, et al.: Preclinical study of novel curcumin analogue SSC-5 using orthotopic tumor xenograft model for esophageal squamous cell carcinoma. Cancer Res Treat 2018. doi:10.4143/crt.2017.353.
  • Ma J, Fang B, Zeng F, Pang H, Zhang J, et al.: Curcumin inhibits cell growth and invasion through up-regulation of miR-7 in pancreatic cancer cells. Toxicol Lett 231, 82–91, 2014.
  • Huang Y, Zhu D, Chen X, Chen Q, Luo Z, et al.: Curcumin enhances the effects of irinotecan on colorectal cancer cells through the generation of reactive oxygen species and activation of the endoplasmic reticulum stress pathway. Oncotarget 8, 40264–40275, 2017.
  • Buhrmann C, Kraehe P, Lueders C, Shayan P, Goel A, et al.: Curcumin suppresses crosstalk between colon cancer stem cells and stromal fibroblasts in the tumor microenvironment: Potential role of EMT. PLoS ONE 9, e107514, 2014.
  • Montazeri M, Sadeghizadeh M, Pilehvar-Soltanahmadi Y, Zarghami F, Khodi S, et al.: Dendrosomal curcumin nanoformulation modulate apoptosis-related genes and protein expression in hepatocarcinoma cell lines. Int J Pharm 509, 244–254, 2016.
  • Zhang YJ, Xiang H, Liu JS, Li D, Fang ZY, et al.: Study on the mechanism of AMPK signaling pathway and its effect on apoptosis of human hepatocellular carcinoma SMMC-7721 cells by curcumin. [cited 2 June 2017]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/?term=28338175.
  • Zhang S, Tang D, Zang W, Yin G, Dai J, et al.: Synergistic inhibitory effect of traditional Chinese medicine astragaloside IV and curcumin on tumor growth and angiogenesis in an orthotopic nude-mouse model of human hepatocellular carcinoma. Anticancer Res 37, 465–474, 2017.
  • Sesarman A, Tefas L, Sylvester B, Licarete E, Rauca V, et al.: Anti-angiogenic and anti-inflammatory effects of long-circulating liposomes co-encapsulating curcumin and doxorubicin on C26 murine colon cancer cells. Pharmacol Rep 70, 331–339, 2017.
  • Liang Z, Wu R, Xie W, Geng H, Zhao L, et al.: Curcumin Suppresses MAPK pathways to reverse tobacco smoke-induced gastric epithelial-mesenchymal transition in mice. Phytother Res 29, 1665–1671, 2015.
  • Zhang P, Lai ZL, Chen HF, Zhang M, Wang A, Jia T, et al.: Curcumin synergizes with 5-fluorouracil by impairing AMPK/ULK1-dependent autophagy, AKT activity and enhancing apoptosis in colon cancer cells with tumor growth inhibition in xenograft mice. J Exp Clin Cancer Res 36, 190–212, 2017.
  • Wang Y, Ying X, Xu H, Yan H, Li X, et al.: The functional curcumin liposomes induce apoptosis in C6 glioblastoma cells and C6 glioblastoma stem cells in vitro and in animals. Int J Med 12, 1369–1384, 2017.
  • Sidhar H and Giri R: Induction of Bex genes by curcumin is associated with apoptosis and activation of p53 in N2a neuroblastoma cells. Sci Rep 7, 41420, 2017.
  • Picone P, Nuzzo D, Caruana L, Messina E, Scafidi V, et al.: Curcumin induces apoptosis in human neuroblastoma cells via inhibition of AKT and Foxo3a nuclear translocation. Free Radic Res 48, 1397–1408, 2014.
  • Alsaab H, Alzhrani R, Kesharwani P, Sau S, Boddu S, et al.: Folate decorated nanomicelles loaded with a potent curcumin analogue for targeting retinoblastoma. Pharmaceutics 9, 15, 2017.
  • Mukherjee S, Baidoo J, Sampat S, Mancuso A, David L, et al.: Liposomal TriCurin, a synergistic combination of curcumin, epicatechin gallate and resveratrol, repolarizes tumor-associated microglia/macrophages, and eliminates glioblastoma (GBM) and GBM stem cells. Molecules 23, 201, 2018.
  • Maiti P, Al-Gharaibeh A, Kolli N, and Dunbar G: Solid lipid curcumin particles induce more DNA fragmentation and cell death in cultured human glioblastoma cells than does natural curcumin. Oxid Med Cell Longev 2017, 1–17, 2017.
  • Singh R: Combinatorial effect of curcumin with docetaxel modulates apoptotic and cell survival molecules in prostate cancer. Front Biosci 9, 235–245, 2017.
  • Yang J, Wang C, Zhang Z, Chen X, Jia Y, et al.: Curcumin inhibits the survival and metastasis of prostate cancer cells via the Notch-1 signaling pathway. APMIS 125, 134–140, 2017.
  • Zhang H, Xu W, Li B, Zhang K, Wu Y, et al.: Curcumin promotes cell cycle arrest and inhibits survival of human renal cancer cells by negative modulation of the PI3K/AKT signaling pathway. Cell Biochem Biophys 73, 681–686, 2015.
  • Tian B, Zhao Y, Liang T, Ye X, Li Z, et al.: Curcumin inhibits urothelial tumor development by suppressing IGF2 and IGF2-mediated PI3K/AKT/mTOR signaling pathway. J Drug Target 25, 626–636, 2017.
  • Gao Y, Shi Q, Xu S, Du C, Liang L, et al.: Curcumin promotes KLF5 proteasome degradation through downregulating YAP/TAZ in bladder dancer cells. Int J Mol Sci 15, 15173–15187, 2014.
  • Moran J, Rodriguez-Velasco F, Roncero-Martin R, Vera V, and Pedrera-Zamorano J: Cytotoxic effects of curcumin in osteosarcoma cells. Int J Nanomedicine 9, 5273–5275, 2014.
  • Chen P, Wang H, Yang F, Chen H, He W, et al.: Curcumin promotes osteosarcoma cell death by activating miR-125a/ERRα signal pathway. J Cell Biochem 118, 74–81, 2016.
  • Huang L, Cai M, Xie X, Chen Y, and Luo X: Uptake enhancement of curcumin encapsulated into phosphatidylcholine-shielding micelles by cancer cells. J Biomater Sci Polym Ed 25, 1407–1424, 2014.
  • Hu A, Huang JJ, Jin XJ, Li JP, Tang YJ, et al.: Curcumin suppresses invasiveness and vasculogenic mimicry of squamous cell carcinoma of the larynx through the inhibition of JAK-2/STAT-3 signaling. - PubMed - NCBI [Internet]. Ncbi.nlm.nih.gov. 2017 [cited 14 June 2017]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/?term=25628937.
  • Zhen L, Fan D, Yi X, Cao X, Chen D, et al.: Curcumin inhibits oral squamous cell carcinoma proliferation and invasion via EGFR signaling pathways. - PubMed - NCBI [Internet]. Ncbi.nlm.nih.gov. 2017 [cited 17 June 2017]. Available from: https://circumnavigational/pubmed/?term=25400722.
  • Schwertheim S, Wein F, Lennartz K, Worm K, Schmid K, et al.: Curcumin induces G2/M arrest, apoptosis, NF-κB inhibition, and expression of differentiation genes in thyroid carcinoma cells. J Cancer Res Clin Oncol 143, 1143–1154, 2017.
  • Hosseinimehr S and Hosseini S: Radiosensitive effect of curcumin on thyroid cancer cell death induced by radioiodine-131. Interdiscip Toxicol 7, 85–88, 2014.
  • Harati K, Behr B, Daigeler A, Hirsch T, Jacobsen F, et al.: Curcumin and viscum album extract decrease proliferation and cell viability of soft-tissue sarcoma cells: an in vitro analysis of eight cell lines using real-time monitoring and colorimetric assays. Nutr Cancer 69, 340–351, 2017.
  • Orr W, Denbo J, Saab K, Ng C, Wu J, et al.: Curcumin potentiates rhabdomyosarcoma radiosensitivity by suppressing NF-κB activity. PLoS ONE 8, e51309, 2013.
  • Iqbal B: Antiproliferative and apoptotic effect of curcumin and TRAIL (TNF related apoptosis inducing Ligand) in chronic myeloid leukaemic cells. J Clin Diagnos Res 10, XC01–XC05, 2016.
  • Sirohi V, Popli P, Sankhwar P, Kaushal J, Gupta K, et al.: Curcumin exhibits anti-tumor effect and attenuates cellular migration via Slit-2 mediated down-regulation of SDF-1 and CXCR4 in endometrial adenocarcinoma cells. J Nutr Biochem 44, 60–70, 2017.
  • Feng W, Yang CX, Zhang L, Fang Y, and Yan M: Curcumin promotes the apoptosis of human endometrial carcinoma cells by downregulating the expression of androgen receptor through Wnt signal pathway. - PubMed - NCBI [Internet]. Ncbi.nlm.nih.gov. 2017. Available from: https://circumnavigational/pubmed/?term=25556280.
  • Bondì M, Emma M, Botto C, Augello G, Azzolina A, et al.: Biocompatible lipid nanoparticles as carriers to improve curcumin efficacy in ovarian cancer treatment. J Agric Food Chem 65, 1342–1352, 2017.
  • Mukherjee S, Hussaini R, White R, Atwi D, Fried A, et al.: TriCurin, a synergistic formulation of curcumin, resveratrol, and epicatechin gallate, repolarizes tumor-associated macrophages and triggers an immune response to cause suppression of HPV+ tumors. Cancer Immunol Immunother 2018. doi:10.1007/s00262-018-2130-3.

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