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Original Articles

Andrographolide Exhibits Anticancer Potential Against Human Colon Cancer Cells by Inducing Cell Cycle Arrest and Programmed Cell Death via Augmentation of Intracellular Reactive Oxygen Species Level

, , & , PhD
Pages 787-803 | Received 05 Jul 2017, Accepted 22 Feb 2018, Published online: 21 May 2018

References

  • Siegel RL, Miller KD, Fedewa SA, Ahnen DJ, Meester RGS, et al.: Colorectal cancer statistics, 2017. CA Cancer J Clin 67(3), 177–193, 2017.
  • Ferlay J, Soerjomataram II, Dikshit R, Eser S, and Mathers C, et al.: Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2014. doi:10.1002/ijc.29210.
  • Center MM, Jemal A, and Ward E: International trends in colorectal cancer incidence rates. Cancer Epidemiol Biomarkers Prev 18, 1688–1694, 2009. doi:10.1158/1055-9965.EPI-09-0090.
  • NCRP: Three-Year Report of the Population Based Cancer Registries 2009–2011. National Cancer Registry Programme, Indian Council of Medical Research (ICMR), Bangalore, India, 2013.
  • Norwati D, Harmy MY, Norhayati MN, and Amry AR: Colorectal cancer screening practices of primary care providers: results of a national survey in Malaysia. Asian Pacific J Cancer Prev 15(6), 2901–2904, 2014. doi:10.7314/APJCP.2014.15.6.2901.
  • Rabik CA and Dolan ME: Molecular mechanisms of resistance and toxicity associated with platinating agents. Cancer Treat Rev 33, 9–23, 2007. doi:10.1016/j.ctrv.2006.09.006.
  • Hosseini A and Ghorbani A: Cancer therapy with phytochemicals: evidence from clinical studies. Avicenna J Phytomed 5(2), 84–97, 2015.
  • Samy RP, Thwin MM, Gopalakrishnakone P, and Ignacimuthu S: Ethnobotanical survey of folk plants for the treatment of snakebites in Southern part of Tamilnadu, India. J. Ethnopharmacol 115, 302–312, 2008. doi:10.1016/j.jep.2007.10.006.
  • Hossain M, Urbi Z, Sule A, and Rahman KMH: Andrographis paniculata (Burm. f.) Wall. ex Nees: a review of ethnobotany, phytochemistry, and pharmacology. Sci World J 2014, 274905, 2014.
  • Wasman S, Mahmood A, Chua LS, Alshawsh MA, and Hamdan S: Antioxidant and gastroprotective activities of Andrographis paniculata (Hempedu Bumi) in Sprague Dawley rat. Indian J Exp Biol 49, 767–772, 2011.
  • Al- Bayaty FH, Abdulla MA, Hassan MIA, and Ali HM: Effect of Andrographis paniculata leaf extract on wound healing in rats. Nat Prod Res 26, 423–429, 2012. doi:10.1080/14786419.2010.496114.
  • Xia YF, Ye BQ, Li YD, Wang JG, He XJ, et al.: Andrographolide attenuates inflammation by inhibition of NF-kappaB activation through covalent modification of reduced cysteine 62 of p50. J. Immunol 173, 4207–4217, 2004. doi:10.4049/jimmunol.173.6.4207.
  • Reddy VL, Reddy SM, Ravikanth V, Krishnaiah P, and Goud TV, et al.: A new bis-andrographolide ether from Andrographis paniculata Nees and evaluation of anti-HIV activity. Nat Prod Res 19, 223–230, 2005. doi:10.1080/14786410410001709197.
  • Varma A, Padh H, and Shrivastava N: Andrographolide: A new plant-derived antineoplastic entity on horizon. Evid Based Complement Alternat Med 2011, 815390, 2011.
  • Yang S, Evens AM, Prachand S, Singh ATK, Bhalla S, et al.: Mitochondrial-Mediated apoptosis in lymphoma cells by the diterpenoid lactone andrographolide, the active component of Andrographis paniculata. Clin Cancer Res 16(19), 4755–4768, 2010. doi:10.1158/1078-0432.CCR-10-0883.
  • Chen CC, Wu ML, Doerksen RJ, Ho CT, and Huang TC: Andrographolide induces apoptosis via down-regulation of glyoxalase 1 and HMG-CoA reductase in HL-60 cells. J funct foods 14, 226–235, 2015. doi:10.1016/j.jff.2015.01.048.
  • Lee YC, Lin HH, Hsu CH, Wang CJ, Chiang TA, et al.: Inhibitory effects of andrographolide on migration and invasion in human non-small cell lung cancer A549 cells via down-regulation of PI3K/Akt signaling pathway. Eur J Pharmacol 632, 23–32, 2010. doi:10.1016/j.ejphar.2010.01.009.
  • Cheng X, Xiao Y, Wang X, Wang P, Li H, et al.: Anti-tumor and proapoptotic activity of ethanolic extract and its various fractions from Polytrichum commune L.ex Hedw in L1210 cells. J Ethnopharmacol 143, 49–56, 2012. doi:10.1016/j.jep.2012.05.054.
  • Johnson S, Nguyen V, and Coder D: Assessment of cell viability. Current Protoc Cytometry 65, 9.2.1–9.2.26, 2013.
  • Liu B, Ordonez-Ercan D, Fan Z, Edgerton SM, Yang X, et al.: Downregulation of ErbB3 aborgates ErbB2-mediated tamoxifen resistance in breast cancer cells. Int J Cancer 120, 1874–1882, 2007. doi:10.1002/ijc.22423.
  • Chen HM, Wua YC, Chia YC, Chang FR, Hsu HK, et al.: Gallic acid, a major component of Toona sinensis leaf extracts, contains a ROS-mediated anti-cancer activity in human prostate cancer cells. Cancer Lett 286, 161–171, 2009. doi:10.1016/j.canlet.2009.05.040.
  • Fadok VA, Voelker DR, Campbell PA, Cohen J, Bratton DL, et al.: Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J Immunol 148, 2207–2216, 1992.
  • Green DR and Reed JC: Mitochondria and apoptosis. Science 281, 1309–1312, 1998. doi:10.1126/science.281.5381.1309.
  • Chazotte B: Labeling mitochondria with mitotracker dyes. Cold Spring Harb Protoc 2011(8), 990–992, 2011.
  • Danial NN and Korsmeyer SJ: Cell death: critical control points. Cell 116, 205–219, 2004. doi:10.1016/S0092-8674(04)00046-7.
  • Wenzel U, Nickel A, and Daniel H: alpha-Lipoic acid induces apoptosis in human colon cancer cells by increasing mitochondrial respiration with a concomitant O2-*-generation. Apoptosis 10(2), 359–368, 2005. doi:10.1007/s10495-005-0810-x.
  • Chung KY and Saltz LB: Adjuvant therapy of colon cancer: Current status and future directions. Cancer J 13, 192–197, 2007. doi:10.1097/PPO.0b013e318074d26e.
  • Weijl N, Cleton F, and Osanto S: Free radicals and antioxidants in hemotherapy-induced toxicity. Cancer Treat Rev 23, 209–240, 1997. doi:10.1016/S0305-7372(97)90012-8.
  • Satyanarayana C, Deevi DS, Rajagopalan R, Srinivas N, and Rajagopal S: DRF 3188 a novel semi-synthetic analog of andrographolide: cellular response to MCF 7 breast cancer cells. BMC Cancer 4, 26–33, 2004. doi:10.1186/1471-2407-4-26.
  • Wong HC, Sagineedu SR, Lajis NH, Loke SC, and Stanslas J: Andrographolide induces cell cycle arrest and apoptosis in PC-3 prostate cancer cells. AJPP 5(2), 225–233, 2011.
  • Yang S, Evens AM, Prachand S, Singh ATK, Bhalla S, et al.: Mitochondrial-mediated apoptosis in lymphoma cells by the diterpenoid lactone andrographolide, the active component of Andrographis paniculata. Clin Cancer Res 16(19), 4755–4768, 2010. doi:10.1158/1078-0432.CCR-10-0883.
  • Yang SH, Wang SM, Syu JP, Chen Y, Wang SD, et al.: Andrographolide induces apoptosis of C6 Glioma Cells via the ERK-p53-Caspase 7-PARP pathway. Biomed Res Int 2014, 312847, 2014.
  • Li W, Lam M, Choy D, Birkeland A, Sullivan ME, et al.: Human primary renal cells as a model for toxicity assessment of chemo-therapeutic drugs. Toxicol In Vitro 20, 669–676, 2006. doi:10.1016/j.tiv.2005.09.016.
  • Green DR and Kroemer G: The pathophysiology of mitochondrial cell death. Science 305, 626–629, 2004. doi:10.1126/science.1099320.
  • Savill J and Fadok V: Corpse clearance defines the meaning of cell death. Nature 407, 784–788, 2000. doi:10.1038/35037722.
  • Manikam SD and Stanslas J: Andrographolide inhibits growth of promyelocytic leukemia cells by inducing retinoic acid receptor independent cell differentiation and apoptosis. J Pharm Pharmacol 61, 78–79, 2009. doi:10.1211/jpp.61.01.0010.
  • Bortner CD, Oldenburg NBE, and Cidlowski JA: The role of DNA fragmentation in apoptosis. Trends Cell Biol 5(1), 21–26, 1995. doi:10.1016/S0962-8924(00)88932-1.
  • Yunos NM, Mutalip SSM, Jauri MH, Yu JQ, and Huq F: Anti-proliferative and pro-apoptotic effects from sequenced combinations of andrographolide and cisplatin on ovarian cancer cell lines. Anticancer Res 33, 4365–4372, 2013.
  • Cohen JJ: Programmed cell death in the immune system. Adv Immunol 50, 55–85, 1991. doi:10.1016/S0065-2776(08)60822-6.
  • Inoue S, Browne G, Melino G, and Cohen GM: Ordering of caspases in cells undergoing apoptosis by the intrinsic pathway. Cell Death Differ 16, 1053–1061, 2009. doi:10.1038/cdd.2009.29.
  • Ly JD, Grubb DR, and Lawen A: The mitochondrial membrane potential (deltapsi(m)) in apoptosis; an update. Apoptosis 8, 115–128, 2003. doi:10.1023/A:1022945107762.
  • Valko M, Leibfritz D, Moncola J, Cronin MTD, Mazura M, et al.: Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biology 39, 44–84, 2007. doi:10.1016/j.biocel.2006.07.001.
  • Ott M, Gogvadze V, Orrenius S, and Zhivotovsky B: Mitochondria, oxidative stress and cell death. Apoptosis 12, 913–922, 2007. doi:10.1007/s10495-007-0756-2.
  • Yang L, Wu D, Luo K, Wu S, and Wu P: Andrographolide enhances 5-fluorouracil-induced apoptosis via caspase-8-dependent mitochondrial pathway involving p53 participation in hepatocellular carcinoma (SMMC-7721) cells. Cancer Lett 276, 180–188, 2009. doi:10.1016/j.canlet.2008.11.015.
  • Weinberg RA: The retinoblastoma protein and cell cycle control. Cell 81, 323–330, 1995. doi:10.1016/0092-8674(95)90385-2.
  • Hall M, Bates S, and Peters G: Evidence for different modes of action of Cyclin-dependent kinase inhibitors p15 and p16 that bind to kinases p21, and p27 bind to Cyclins. Oncogene 11, 1581–1588, 1995.
  • Li Y, Zhang P, Qiu F, Chen L, Miao C, et al.: Inactivation of PI3K/Akt signaling mediates proliferation inhibition and G2/M phase arrest induced by andrographolide in human glioblastoma cells. Life Sci 90, 962–967, 2012. doi:10.1016/j.lfs.2012.04.044.
  • Vermeulen K, Bockstaele DRV, and Berneman ZN: The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer. Cell Prolif 36, 131–149, 2003. doi:10.1046/j.1365-2184.2003.00266.x.
  • Li J, Cheung HY, Zhang Z, Chan GK, and Fong WF: Andrographolide induces cell cycle arrest at G2/M phase and cell death in HepG2 cells via alteration of reactive oxygen species. Eur J Pharmacol 568, 31–44, 2007. doi:10.1016/j.ejphar.2007.04.027.

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