Next-Gen Therapeutics for Skin Cancer: Nutraceuticals

References

• Kalra EK: Nutraceutical-definition and introduction. AAPS J 5(3), 27–8, 2003. doi:10.1208/ps050325.
   Google Scholar
• Wildman RE, editor: Handbook of nutraceuticals and functional foods. CRC Press, 2016.
   Google Scholar
• Hardy G: Nutraceuticals and functional foods: introduction and meaning. 2000.
   Google Scholar
• Zeisel SH: Regulation of “nutraceuticals”. Science 285, 1853–5, 1999. doi:10.1126/science.285.5435.1853.
   PubMed Web of Science ®Google Scholar
• Baradaran A, Madihi Y, Merrikhi A, Rafieian-Kopaei M, Nasri H: Serum lipoprotein in diabetic patients with various renal function not yet on dialysis. Pak J Med Sci 29(Suppl), 354–7, 2013.
   Google Scholar
• Nasri H: Impact of diabetes mellitus on parathyroid hormone in hemodialysis patients. J Parathyr Dis 1, 9–11, 2013.
   Google Scholar
• Madihi Y, Merrikhi A, Baradaran A, Rafieian-kopaei M, Shahinfard N, et al.: Impact of sumac on postprandial high-fat oxidative stress. Pak J Med Sci 29, 340–5, 2013. doi:10.12669/pjms.291(Suppl).3529.
   Web of Science ®Google Scholar
• Setorki M, Rafieian-Kopaei M, Merikhi A, Heidarian E, Shahinfard N, et al.: Suppressive impact of anethum graveolens consumption on biochemical risk factors of atherosclerosis in hypercholesterolemic rabbits. Int J Prev Med 4, 889–95, 2013.
   PubMedGoogle Scholar
• Khosravi-Boroujeni H, Mohammadifard N, Sarrafzadegan N, Sajjadi F, Maghroun M, et al.: Potato consumption and cardiovascular disease risk factors among Iranian population. Int J Food Sci Nutr 63, 913–20, 2012. doi:10.3109/09637486.2012.690024.
   PubMed Web of Science ®Google Scholar
• Khosravi-Boroujeni H, Sarrafzadegan N, Mohammadifard N, Sajjadi F, Maghroun M, et al.: White rice consumption and CVD risk factors among Iranian population. J Health Popul Nutr 31, 252–61, 2013. doi:10.3329/jhpn.v31i2.16390.
   PubMed Web of Science ®Google Scholar
• Shirzad H, Burton RC, Smart YC, Rafieian-kopaei M, Shirzad M: Natural cytotoxicity of NC-2+cells against the growth and metastasis of WEHI-164 fibrosarcoma. Scand J Immunol 73, 85–90, 2011. doi:10.1111/j.1365-3083.2010.02481.x.
   PubMed Web of Science ®Google Scholar
• Shirzad M, Kordyazdi R, Shahinfard N, Nikokar M: Does royal jelly affect tumor cells? J HerbMed Pharmacol 2, 45–8, 2013.
   Google Scholar
• Krehl WA: The role of nutrition in maintaining health and preventing disease. Health Values 7(2), 9–13, 1983.
   PubMedGoogle Scholar
• Afman L, Müller M: Nutrigenomics: from molecular nutrition to prevention of disease. J Am Diet Assoc 106(4), 56976, 2006. doi:10.1016/j.jada.2006.01.001.
   Google Scholar
• O'neill S, O'driscoll L: Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies. Obes Rev 16(1), 1–2, 2015. doi:10.1111/obr.12229.
   PubMed Web of Science ®Google Scholar
• Popkin BM, Adair LS, Ng SW: Global nutrition transition and the pandemic of obesity in developing countries. Nutr Rev 70(1), 3–21, 2012. doi:10.1111/j.1753-4887.2011.00456.x.
   PubMed Web of Science ®Google Scholar
• Ruiz-Núñez B, Pruimboom L, Dijck-Brouwer DJ, Muskiet FA: Lifestyle and nutritional imbalances associated with Western diseases: causes and consequences of chronic systemic low-grade inflammation in an evolutionary context. J Nutr Biochem 24(7), 1183–201, 2013. doi:10.1016/j.jnutbio.2013.02.009.
   PubMed Web of Science ®Google Scholar
• Booth FW, Roberts CK, Laye MJ: Lack of exercise is a major cause of chronic diseases. Compr Physiol 2012. doi:10.1002/cphy.c110025.
   PubMed Web of Science ®Google Scholar
• Kushi LH, Byers T, Doyle C, Bandera EV, McCullough M, et al.: American Cancer Society Guidelines on Nutrition and Physical Activity for cancer prevention: reducing the risk of cancer with healthy food choices and physical activity. CA: A Cancer J Clin 56(5), 254–81, 2006.
   PubMed Web of Science ®Google Scholar
• Siegel RL, Miller KD, Jemal A: Cancer statistics, 2016. CA: A Cancer J Clin 66(1), 7–30, 2016.
   PubMed Web of Science ®Google Scholar
• McNeil BJ, Pauker SG, Sox Jr HC, Tversky A: On the elicitation of preferences for alternative therapies. New Engl J Med 306(21), 1259–62, 1982. doi:10.1056/NEJM198205273062103.
   PubMed Web of Science ®Google Scholar
• Cassileth BR, Deng G: Complementary and alternative therapies for cancer. Oncologist 9(1), 80–9, 2004. doi:10.1634/theoncologist.9-1-80.
   PubMed Web of Science ®Google Scholar
• Eisenberg DM, Kessler RC, Foster C, Norlock FE, Calkins DR, et al.: Unconventional medicine in the United States: prevalence, costs, and patterns of use. N Engl J Med 328, 246–25, 1993. doi:10.1056/NEJM199301283280406.
   PubMed Web of Science ®Google Scholar
• Service RF: Nanotechnology takes aim at cancer. Science 310, 1132–1134, 2005. doi:10.1126/science.310.5751.1132.
   PubMed Web of Science ®Google Scholar
• Breitbart EW, Greinert R, Volkmer B: Effectiveness of information campaigns. Prog Biophys Mol Biol 92(1), 167–72, 2006. doi:10.1016/j.pbiomolbio.2006.02.023.
   PubMed Web of Science ®Google Scholar
• Suárez B, López-Abente G, Martínez C, Navarro C, Tormo MJ, et al.: Occupation and skin cancer: the results of the HELIOS-I multicenter case-control study. BMC Public Health 7(1), 180, 2007. doi:10.1186/1471-2458-7-180.
   PubMed Web of Science ®Google Scholar
• Glanz K, Buller DB, Saraiya M: Reducing ultraviolet radiation exposure among outdoor workers: state of the evidence and recommendations. Environ Health 6(1), 22, 2007. doi:10.1186/1476-069X-6-22.
   PubMed Web of Science ®Google Scholar
• Hofman M, Ryan JL, Figueroa-Moseley CD, Jean-Pierre P, Morrow GR: Cancer-related fatigue: the scale of the problem. Oncologist 12(Supplement 1), 4–10, 2007. doi:10.1634/theoncologist.12-S1-4.
   PubMed Web of Science ®Google Scholar
• Naidu MU, Ramana GV, Rani PU, Suman A, Roy P: Chemotherapy-induced and/or radiation therapy-induced oral mucositis-complicating the treatment of cancer. Neoplasia 6(5), 423–31, 2004. doi:10.1593/neo.04169.
   PubMed Web of Science ®Google Scholar
• King's Fund, Lennard-Jones JE: A positive approach to nutrition as treatment. King's Fund Centre 1992.
   Google Scholar
• Marventano S, Forjaz MJ, Grosso G, Mistretta A, Giorgianni G, et al.: Health related quality of life in colorectal cancer patients: state of the art. BMC Surg 13(2), S15, 2013. doi:10.1186/1471-2482-13-S2-S15.
   PubMed Web of Science ®Google Scholar
• de Graeff A, de Leeuw RJ, Ros WJ, Hordijk GJ, Battermann JJ, et al.: A prospective study on quality of life of laryngeal cancer patients treated with radiotherapy. Head Neck 21(4), 291–6, 1999. doi:10.1002/(SICI)1097-0347(199907)21:4%3c291::AID-HED1%3e3.0.CO;2-B.
   PubMed Web of Science ®Google Scholar
• Anand P, Kunnumakara AB, Sundaram C, Harikumar KB, Tharakan ST, et al.: Cancer is a preventable disease that requires major lifestyle changes. Pharm Res 25(9), 2097–116, 2008. doi:10.1007/s11095-008-9661-9.
   PubMed Web of Science ®Google Scholar
• Key TJ, Schatzkin A, Willett WC, Allen NE, Spencer EA, et al.: Diet, nutrition and the prevention of cancer. Public Health Nutr 7(1a), 187–200, 2004. doi:10.1079/PHN2003588.
   PubMed Web of Science ®Google Scholar
• Jemal A, Bray F, Center MM, Ferlay J, Ward E, et al.: Global cancer statistics. CA: A Cancer J Clin 61(2), 69–90, 2011.
   PubMed Web of Science ®Google Scholar
• Wujastyk D. G., JAN MEULENBELD: A History of Indian Medical Literature.(Groningen Oriental Studies Volume XV/I–III.) Groningen: Egbert Forsten (Ia and Ib) 1999;(IIa and IIb) 2000;(III) 2002. Ia: 1 frontispiece, xvii, 699 pp.; Ib: 1 frontispiece, vi, 774 pp.; IIa: 1 frontispiece, viii, 839 pp.(in addition: reprint of 19 pages defective in Ia); IIb: 1 frontispiece, viii, 1018 pp.; III (Indexes): 1 frontispiece, ii, 549 pp.€ 600.-. Bull Sch Orient Afr Stud 67(3), 404–7, 2004.
   Web of Science ®Google Scholar
• Yu R, Hong H: Cancer Management with Chinese Medicine. World Scientific, 2012.
   Google Scholar
• Pandey M, Verma RK, Saraf SA: Nutraceuticals: new era of medicine and health. Asian J Pharm Clin Res 3(1), 11–5, 2010.
   Google Scholar
• Kalia AN: New Delhi: CBS Publisher and Distributor. Textbook of industrial pharmacognocy; pp. 204–8. 2005.
   Google Scholar
• Rao R: Encyclopedia of Indian Medicine (2^nd ed.) Dr. P.V. Parameshvara Charitable Trust, Bangalore, India, 1987.
   Google Scholar
• Aggarwal BB, Van Kuiken ME, Iyer LH, Harikumar KB, Sung B: Molecular targets of nutraceuticals derived from dietary spices: potential role in suppression of inflammation and tumorigenesis. Exp Biol Med 234(8), 825–49, 2009. doi:10.3181/0902-MR-78.
   Web of Science ®Google Scholar
• Ali SS, Kasoju N, Luthra A, Singh A, Sharanabasava H, et al.: Indian medicinal herbs as sources of antioxidants. Food Res Int 41(1), 1–5, 2008. doi:10.1016/j.foodres.2007.10.001.
   Web of Science ®Google Scholar
• Atreya, Perfect Balance: Ayurvedic Nutrition for Mind, Body and Soul. Penguin Penguin Putnam Inc, New York, 2002.
   Google Scholar
• Lakhotia SC: Translating Ayurveda's Dosha-Prakriti into objective parameters. J Ayurveda Integr Med 5(3), 176, 2014.
   PubMedGoogle Scholar
• Basham AL: The Practice of Medicine in Ancient and Medieval India. In Asian Medical Systems, Leslie, Charles (eds.). Berkeley: University of California Press, 1976, pp. 18–43.
   Google Scholar
• Nybe E V: Three Decades of Spices Research at KAU. Kerala Agricultural University, Thrissur, India, 2004, pp. 131.
   Google Scholar
• Mashhadi NS, Ghiasvand R, Askari G, Hariri M, Darvishi L, et al.: Anti-oxidative and anti-inflammatory effects of ginger in health and physical activity: review of current evidence. Int J Prev Med 4(Suppl 1), S36, 2013.
   PubMedGoogle Scholar
• Surh YJ: Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: a short review. Food Chem Toxicol 40(8), 1091–7, 2002. doi:10.1016/S0278-6915(02)00037-6.
   PubMed Web of Science ®Google Scholar
• Tripp MK, Watson M, Balk SJ, Swetter SM, Gershenwald JE: State of the science on prevention and screening to reduce melanoma incidence and mortality: the time is now. CA: A Cancer J Clin 66(6), 460–80, 2016.
   PubMed Web of Science ®Google Scholar
• Aggarwal BB, Sundaram C, Nikita M, Ichikawa H: Curcumin, the indian solid gold. Adv Exp Med Biol 595, 1–75, 2007. doi:10.1007/978-0-387-46401-5_1.
   PubMed Web of Science ®Google Scholar
• Huei-Chen H, Tong-Rong J, Sheau-Farn Y: Inhibitory effect of curcumin, an anti-inflammatory agent, on vascular smooth muscle cell proliferation. Eur J Pharmacol 221(2-3), 381–4, 1992. doi:10.1016/0014-2999(92)90727-L.
   PubMed Web of Science ®Google Scholar
• Gupta SC, Patchva S, Aggarwal BB: Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J 1, 1–24, 2013.
   Google Scholar
• Tayyem RF, Heath DD, Al-Delaimy WK, Rock CL: Curcumin content of turmeric and curry powders. Nutr Cancer 55(2), 126–31, 2006. doi:10.1207/s15327914nc5502_2.
   PubMed Web of Science ®Google Scholar
• Menon VP, Sudheer AR: Antioxidant and anti-inflammatory properties of curcumin. In The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease. 2007, pp. 105–125, Springer US.
   Google Scholar
• Lim GP, Chu T, Yang F, Beech W, Frautschy SA, et al.: The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci 21(21), 8370–7, 2001. doi:10.1523/JNEUROSCI.21-21-08370.2001.
   PubMed Web of Science ®Google Scholar
• Jacob A, Wu R, Zhou M, Wang P: Mechanism of the anti-inflammatory effect of curcumin: PPAR-γ activation. PPAR Res 2008.
   Web of Science ®Google Scholar
• Wilken R, Veena MS, Wang MB, Srivatsan ES: Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma. Mol Cancer 10(1), 12, 2011. doi:10.1186/1476-4598-10-12.
   PubMed Web of Science ®Google Scholar
• Singh S, Aggarwal BB: Activation of transcription factor NF-κB is suppressed by curcumin (diferuloylmethane). J Biol Chemi 270(42), 24995–5000, 1995. doi:10.1074/jbc.270.42.24995.
   PubMed Web of Science ®Google Scholar
• Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB: Oxidative stress, inflammation, and cancer: how are they linked? Free Radical Biol Med 49(11), 1603–16, 2010. doi:10.1016/j.freeradbiomed.2010.09.006.
   PubMed Web of Science ®Google Scholar
• Amiri KI, Richmond A: Role of nuclear factor-κ B in melanoma. Cancer Metastasis Rev 24(2), 301–13, 2005. doi:10.1007/s10555-005-1579-7.
   PubMed Web of Science ®Google Scholar
• Kumar A, Dhawan S, Hardegen NJ, Aggarwal BB: Curcumin (diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-κB activation. Biochem Pharmacol 55(6), 775–83, 1998. doi:10.1016/S0006-2952(97)00557-1.
   PubMed Web of Science ®Google Scholar
• Bermudez Y, Stratton SP, Curiel-Lewandrowski C, Warneke J, Hu C, et al.: Activation of the PI3K/Akt/mTOR and MAPK signaling pathways in response to acute solar-simulated light exposure of human skin. Cancer Prev Res 8(8), 720–8, 2015. doi:10.1158/1940-6207.CAPR-14-0407.
   PubMed Web of Science ®Google Scholar
• Kuttan R, Sudheeran PC, Josph CD: Turmeric and curcumin as topical agents in cancer therapy. Tumori 73(1), 29–31, 1987. doi:10.1177/030089168707300105.
   PubMed Web of Science ®Google Scholar
• Sonavane K, Phillips J, Ekshyyan O, Moore-Medlin T, Roberts Gill J, et al.: Topical curcumin-based cream is equivalent to dietary curcumin in a skin cancer model. J Skin Cancer 2012. doi:10.1155/2012/147863.
   PubMedGoogle Scholar
• Cheng AL, Hsu CH, Lin JK, Hsu MM, Ho YF, et al.: Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res 21(4B):2895–900, 2001.
   PubMed Web of Science ®Google Scholar
• Dhillon N, Aggarwal BB, Newman RA, Wolff RA, Kunnumakkara AB, et al.: Phase II trial of curcumin in patients with advanced pancreatic cancer. Clin Cancer Res 14(14), 4491–9, 2008. doi:10.1158/1078-0432.CCR-08-0024.
   PubMed Web of Science ®Google Scholar
• Mahammedi H, Planchat E, Pouget M, Durando X, Curé H, et al.: The new combination docetaxel, prednisone and curcumin in patients with castration-resistant prostate cancer: a pilot phase II study. Oncology 90(2), 69–78, 2016. doi:10.1159/000441148.
   PubMed Web of Science ®Google Scholar
• Ali BH, Blunden G, Tanira MO, Nemmar A: Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): a review of recent research. Food Chem Toxicol 46(2), 409–20, 2008. doi:10.1016/j.fct.2007.09.085.
   PubMed Web of Science ®Google Scholar
• Grzanna R, Lindmark L, Frondoza CG: Ginger—an herbal medicinal product with broad anti-inflammatory actions. J Med Food 8(2), 125–132, 2005. doi:10.1089/jmf.2005.8.125.
   PubMed Web of Science ®Google Scholar
• Demin G, Yingying Z: Comparative antibacterial activities of crude polysaccharides and flavonoids from Zingiber officinale and their extraction. Am J Trop Med 5, 235–238, 2010.
   Google Scholar
• Shukla Y, Singh M: Cancer preventive properties of ginger: a brief review. Food Chem Toxicol 45(5):683–90, 2007. doi:10.1016/j.fct.2006.11.002.
   PubMed Web of Science ®Google Scholar
• Peng F, Tao Q, Wu X, Dou H, Spencer S, et al.: Cytotoxic, cytoprotective and antioxidant effects of isolated phenolic compounds from fresh ginger. Fitoterapia 83(3), 568–85, 2012. doi:10.1016/j.fitote.2011.12.028.
   PubMed Web of Science ®Google Scholar
• Ryan JL, Heckler CE, Roscoe JA, Dakhil SR, Kirshner J, et al.: Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients. Support Care Cancer 20(7), 1479–89, 2012. doi:10.1007/s00520-011-1236-3.
   PubMed Web of Science ®Google Scholar
• Hu R, Zhou P, Peng YB, et al.: 6-shogaol induces apoptosis in human hepatocellular carcinoma cells and exhibits anti-tumor activity in vivo through endoplasmic reticulum stress. PLoS ONE 7(6), Article ID e39664, 2012. doi:10.1371/journal.pone.0039664.
   Web of Science ®Google Scholar
• Weng CJ, Wu CF, Huang HW, Ho CT, Yen GC: Anti-invasion effects of 6-shogaol and 6-gingerol, two active components in ginger, on human hepatocarcinoma cells. Mol Nutr Food Res 54(11), 1618–1627, 2010. doi:10.1002/mnfr.201000108.
   PubMed Web of Science ®Google Scholar
• Zhou L, Qi L, Jiang L, et al.: Antitumor activity of gemcitabine can be potentiated in pancreatic cancer through modulation of TLR4/NF-κB signaling by 6-shogaol. AAPS J 16(2), 246–257, 2014. doi:10.1208/s12248-013-9558-3.
   PubMed Web of Science ®Google Scholar
• Ray A, Vasudevan S, Sengupta S: 6-Shogaol inhibits breast cancer cells and stem cell-like spheroids by modulation of Notch signaling pathway and induction of autophagic cell death. PloS one 10(9), e0137614, 2015. doi:10.1371/journal.pone.0137614.
   PubMed Web of Science ®Google Scholar
• Ishiguro K, Ando T, Maeda O, Ohmiya N, Niwa Y, et al.: Ginger ingredients reduce viability of gastric cancer cells via distinct mechanisms. Biochem Biophys Res Commun 362(1), 218–23, 2007. doi:10.1016/j.bbrc.2007.08.012.
   PubMed Web of Science ®Google Scholar
• Rhode J, Fogoros S, Zick S, Wahl H, Griffith KA, et al.: Ginger inhibits cell growth and modulates angiogenic factors in ovarian cancer cells. BMC Complement Altern Med 7(1), 44, 2007. doi:10.1186/1472-6882-7-44.
   PubMedGoogle Scholar
• Nigam N, Bhui K, Prasad S, George J, Shukla Y: [6]-Gingerol induces reactive oxygen species regulated mitochondrial cell death pathway in human epidermoid carcinoma A431 cells. Chem-Biol Int 181(1), 77–84, 2009. doi:10.1016/j.cbi.2009.05.012.
   PubMed Web of Science ®Google Scholar
• Bhagavathula N, Warner RL, DaSilva M, McClintock SD, Barron A, et al.: A combination of curcumin and ginger extract improves abrasion wound healing in corticosteroid‐impaired hairless rat skin. Wound Repair Regen 17(3), 360–6, 2009. doi:10.1111/j.1524-475X.2009.00483.x.
   PubMed Web of Science ®Google Scholar
• Kim JK, Kim Y, Na KM, Surh YJ, Kim TY: [6]-Gingerol prevents UVB-induced ROS production and COX-2 expression in vitro and in vivo. Free Radical Res 41(5), 603–14, 2007. doi:10.1080/10715760701209896.
   PubMed Web of Science ®Google Scholar
• Bode AM, Ma WY, Surh YJ, Dong Z: Inhibition of epidermal growth factor-induced cell transformation and activator protein 1 activation by [6]-gingerol. Cancer Res 61(3), 850–3, 2001.
   PubMed Web of Science ®Google Scholar
• Katiyar SK, Agarwal R, Mukhtar H: Inhibition of tumor promotion in SENCAR mouse skin by ethanol extract of Zingiber officinale rhizome. Cancer Res 56(5), 1023–30, 1996.
   PubMed Web of Science ®Google Scholar
• Danwilai K, Konmun J, Sripanidkulchai BO, Subongkot S: Antioxidant activity of ginger extract as a daily supplement in cancer patients receiving adjuvant chemotherapy: a pilot study. Cancer Manage Res 9, 11, 2017. doi:10.2147/CMAR.S124016.
   PubMed Web of Science ®Google Scholar
• Rahman K: Historical perspective on garlic and cardiovascular disease. J Nutr 131(3), 977S–9S, 2001. doi:10.1093/jn/131.3.977S.
   PubMed Web of Science ®Google Scholar
• Fenwick GR, Hanley AB, Whitaker JR: The genus Allium—part 1. Crit Rev Food Sci Nutr 22(3), 199–271, 1985. doi:10.1080/10408398509527415.
   PubMed Web of Science ®Google Scholar
• Corzo-Martínez M, Corzo N, Villamiel M: Biological properties of onions and garlic. Trends Food Sci Technol 18(12), 609–25, 2007. doi:10.1016/j.tifs.2007.07.011.
   Web of Science ®Google Scholar
• Block E: Garlic and other Alliums: the lore and the science. Royal Soc Chem 2010.
   Google Scholar
• Jin ZY, Wu M, Han RQ, Zhang XF, Wang XS, et al.: Raw garlic consumption as a protective factor for lung cancer, a population-based case–control study in a Chinese population. Cancer Prev Res 2013.
   Web of Science ®Google Scholar
• Fleischauer AT, Poole C, Arab L: Garlic consumption and cancer prevention: meta-analyses of colorectal and stomach cancers. Am J Clin Nutr 72(4), 1047–52, 2000. doi:10.1093/ajcn/72.4.1047.
   PubMed Web of Science ®Google Scholar
• Pazyar N, Feily A: Garlic in dermatology. Dermatol Rep 3(1), 2011. doi:10.4081/dr.2011.e4.
   PubMedGoogle Scholar
• Das I, Acharya A, Saha T: Protective effect of garlic in skin cancer. In Handbook of Diet, Nutrition and the Skin, 2012, pp. 300–17.
   Google Scholar
• Taylor P, Noriega R, Farah C, Abad MJ, Arsenak M, et al.: Ajoene inhibits both primary tumor growth and metastasis of B16/BL6 melanoma cells in C57BL/6 mice. Cancer Lett 239(2), 298–304, 2006. doi:10.1016/j.canlet.2005.08.022.
   PubMed Web of Science ®Google Scholar
• Shan Y, Wei Z, Tao L, Wang S, Zhang F, et al.: Prophylaxis of diallyl disulfide on skin carcinogenic model via p21-dependent Nrf2 stabilization. Sci Rep 6, 35676, 2016. doi:10.1038/srep35676.
   PubMed Web of Science ®Google Scholar
• Tilli CM, Stavast-Kooy AJ, Vuerstaek JD, Thissen MR, Krekels GA, et al.: The garlic-derived organosulfur component ajoene decreases basal cell carcinoma tumor size by inducing apoptosis. Arch Dermatol Res 295(3), 117–23, 2003. doi:10.1007/s00403-003-0404-9.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Zhuang W, Hu W, Liu GJ, Wu TX, et al.: Consumption of large amounts of Allium vegetables reduces risk for gastric cancer in a meta-analysis. Gastroenterology 141(1), 80–9, 2011. doi:10.1053/j.gastro.2011.03.057.
   PubMed Web of Science ®Google Scholar
• Hajheydari Z, Jamshidi M, Akbari J, Mohammadpour R: Combination of topical garlic gel and betamethasone valerate cream in the treatment of localized alopecia areata: a double-blind randomized controlled study. Indian J Dermatol, Venereol Leprology 73(1), 29, 2007. doi:10.4103/0378-6323.30648.
   PubMed Web of Science ®Google Scholar
• Nzeako BC, Al-Kharousi ZS, Al-Mahrooqui Z: Antimicrobial activities of clove and thyme extracts. Sultan Qaboos Univ Med J 6(1), 33, 2006.
   PubMedGoogle Scholar
• Nuñez L, D'Aquino M: Microbicide activity of clove essential oil (Eugenia caryophyllata). Brazilian J Microbiol 43(4), 1255–60, 2012. doi:10.1590/S1517-83822012000400003.
   PubMed Web of Science ®Google Scholar
• Dwivedi V, Shrivastava R, Hussain S, Ganguly C, Bharadwaj M: Comparative anticancer potential of clove (Syzygium aromaticum)—an Indian spice—against cancer cell lines of various anatomical origin. Asian Pac J Cancer Prev 12(8), 1989–93, 2011.
   PubMedGoogle Scholar
• Kumar K, Yadav A, Srivastava S, Paswan S, Sankar Dutta A: Recent trends in Indian traditional herbs syzygium aromaticum and its health benefits. J Pharmacognosy Phytochemistry 1, 1(1), 2012.
   Google Scholar
• Zheng GQ, Kenney PM, Lam LK: Sesquiterpenes from clove (Eugenia caryophyllata) as potential anticarcinogenic agents. J Nat Prod 55(7), 999–1003, 1992. doi:10.1021/np50085a029.
   PubMed Web of Science ®Google Scholar
• Srivastava KC, Malhotra N: Acetyl eugenol, a component of oil of cloves (Syzygium aromaticum L.) inhibits aggregation and alters arachidonic acid metabolism in human blood platelets. Prostaglandins, leukot Essent Fatty acids 42(1), 73–81, 1991. doi:10.1016/0952-3278(91)90070-L.
   PubMed Web of Science ®Google Scholar
• Nagababu E, Lakshmaiah N: Inhibitory effect of eugenol on non-enzymatic lipid peroxidation in rat liver mitochondria. Biochem Pharmacol 43(11):2393–400, 1992. doi:10.1016/0006-2952(92)90318-D.
   PubMed Web of Science ®Google Scholar
• Murakami Y, Shoji M, Hanazawa S, Tanaka S, Fujisawa S: Preventive effect of bis-eugenol, a eugenol ortho dimer, on lipopolysaccharide-stimulated nuclear factor kappa B activation and inflammatory cytokine expression in macrophages. Biochem Pharmacol 66(6), 1061–6, 2003. doi:10.1016/S0006-2952(03)00419-2.
   PubMed Web of Science ®Google Scholar
• Oya T, Osawa T, Kawakishi S: Spice constituents scavenging free radicals and inhibiting pentosidine formation in a model system. Biosci, Biotechnol Biochem. 61(2):263–6, 1997. doi:10.1271/bbb.61.263.
   PubMed Web of Science ®Google Scholar
• Banerjee S, Panda CK, Das S: Clove (Syzygium aromaticum L.), a potential chemopreventive agent for lung cancer. Carcinogenesis 27(8), 1645–54, 2006. doi:10.1093/carcin/bgi372.
   PubMed Web of Science ®Google Scholar
• Banerjee S, Das S: Anticarcinogenic effects of an aqueous infusion of cloves on skin carcinogenesis. Asian Pacific J Cancer Prev 6(3), 304, 2005.
   PubMedGoogle Scholar
• Peng Y, Yuan J, Liu F, Ye J: Determination of active components in rosemary by capillary electrophoresis with electrochemical detection. J Pharm Biomed Anal 39(3), 431–7, 2005. doi:10.1016/j.jpba.2005.03.033.
   PubMed Web of Science ®Google Scholar
• Chang SS, Ostric‐Matijasevic BI, Hsieh OA, HUANG CL: Natural antioxidants from rosemary and sage. J Food Sci 42(4), 1102–6, 1977. doi:10.1111/j.1365-2621.1977.tb12676.x.
   Web of Science ®Google Scholar
• Frankel EN, Huang SW, Aeschbach R, Prior E: Antioxidant activity of a rosemary extract and its constituents, carnosic acid, carnosol, and rosmarinic acid, in bulk oil and oil-in-water emulsion. J Agric Food Chem 44(1), 131–5, 1996. doi:10.1021/jf950374p.
   Web of Science ®Google Scholar
• Brewer MS: Natural antioxidants: sources, compounds, mechanisms of action, and potential applications. Compr Rev Food Sci Food Saf 10(4), 221–47, 2011. doi:10.1111/j.1541-4337.2011.00156.x.
   Web of Science ®Google Scholar
• Wang H, Oo Khor T, Shu L, Su ZY, Fuentes F, et al.: Plants vs. cancer: a review on natural phytochemicals in preventing and treating cancers and their druggability. Anti-Cancer Agents Med Chem (Formerly Curr Med Chem-Anti-Cancer Agents) 12(10), 1281–305, 2012.
   PubMed Web of Science ®Google Scholar
• Nichols JA, Katiyar SK: Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms. Arch Dermatol Res 302(2), 71–83, 2010. doi:10.1007/s00403-009-1001-3.
   PubMed Web of Science ®Google Scholar
• Katta R, Brown DN: Diet and skin cancer: The potential role of dietary antioxidants in nonmelanoma skin cancer prevention. J Skin Cancer 2015. doi:10.1155/2015/893149.
   PubMed Web of Science ®Google Scholar
• Huang MT, Ho CT, Wang ZY, Ferraro T, Lou YR, et al.: Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid. Cancer Res 54(3), 701–8, 1994.
   PubMed Web of Science ®Google Scholar
• Rašković A, Milanović I, Pavlović N, Ćebović T, Vukmirović S, Mikov M: Antioxidant activity of rosemary (Rosmarinus officinalis L.) essential oil and its hepatoprotective potential. BMC Complement Altern Med 14(1), 225, 2014. doi:10.1186/1472-6882-14-225.
   PubMed Web of Science ®Google Scholar
• Laughton MJ, Evans PJ, Moroney MA, Hoult JR, Halliwell B: Inhibition of mammalian 5-lipoxygenase and cyclo-oxygenase by flavonoids and phenolic dietary additives: relationship to antioxidant activity and to iron ion-reducing ability. Biochem Pharmacol 42(9), 1673–81, 1991. doi:10.1016/0006-2952(91)90501-U.
   PubMed Web of Science ®Google Scholar
• Huang HC, Huang CY, Lin‐Shiau SY, Lin JK: Ursolic acid inhibits IL‐1β or TNF‐α‐induced C6 glioma invasion through suppressing the association ZIP/p62 with PKC‐ζ and downregulating the MMP‐9 expression. Mol Carcinog 48(6), 517–31, 2009. doi:10.1002/mc.20490.
   PubMed Web of Science ®Google Scholar
• Sancheti G, Goyal PK: Effect of rosmarinus officinalis in modulating 7, 12‐dimethylbenz anthracene induced skin tumorigenesis in mice. Phytother Res 20(11), 981–6, 2006. doi:10.1002/ptr.1989.
   PubMed Web of Science ®Google Scholar
• Cattaneo L, Cicconi R, Mignogna G, Giorgi A, Mattei M, et al.: Anti-proliferative effect of Rosmarinus officinalis L. extract on human melanoma A375 cells. PloS one 10(7), e0132439, 2015. doi:10.1371/journal.pone.0132439.
   PubMed Web of Science ®Google Scholar
• Yesil-Celiktas O, Sevimli C, Bedir E, Vardar-Sukan F: Inhibitory effects of rosemary extracts, carnosic acid and rosmarinic acid on the growth of various human cancer cell lines. Plant Foods Human Nutr (Formerly Qualitas Plantarum) 65(2), 158–63, 2010. doi:10.1007/s11130-010-0166-4.
   PubMed Web of Science ®Google Scholar
• Panahi Y, Taghizadeh M, Marzony ET, Sahebkar A: Rosemary oil vs minoxidil 2% for the treatment of androgenetic alopecia: a randomized comparative trial. Skinmed 13(1), 15–21, 2015.
   PubMedGoogle Scholar
• Hay IC, Jamieson M, Ormerod AD: Randomized trial of aromatherapy: successful treatment for alopecia areata. Arch Dermatol 134(11), 1349–52, 1998. doi:10.1001/archderm.134.11.1349.
   PubMed Web of Science ®Google Scholar
• Lukaczer D, Darland G, Tripp M, Liska DA, Lerman RH, et al.: A Pilot trial evaluating meta050, a proprietary combination of reduced iso‐alpha acids, rosemary extract and oleanolic acid in patients with arthritis and fibromyalgia. Phytother Res 19(10), 864–9, 2005. doi:10.1002/ptr.1709.
   PubMed Web of Science ®Google Scholar
• Rezaee R, Hosseinzadeh H: Safranal: from an aromatic natural product to a rewarding pharmacological agent. Iranian J Basic Med Sci 16(1), 12, 2013.
   PubMed Web of Science ®Google Scholar
• Gutheil W.G., Reed G., Ray A., Anant S., Dhar A: Crocetin: an agent derived from saffron for prevention and therapy for cancer. Curr Pharm Biotechnol 13, 173–179, 2012. doi:10.2174/138920112798868566.
   PubMed Web of Science ®Google Scholar
• Champalal K.D., Nilakshi N., Gadiya R.V., Abhyankar M.M: Detailed profile of Crocus sativus. Int J Pharm Biol Sci 2, 530–540, 2011.
   Google Scholar
• Winterhalter, P.; Straubinger, M: Saffron-renewed interest in an ancient spice. Food Rev. Int 16, 39–59, 2000. doi:10.1081/FRI-100100281.
   Web of Science ®Google Scholar
• Liakopoulou-Kyriakides, M., Kyriakidis, D: Crocus sativus-biological active constituents. Stud Nat Prod Chem 16, 293–312, 2002. doi:10.1016/S1572-5995(02)80009-6.
   Google Scholar
• Tanaka T, Shnimizu M, Moriwaki H: Cancer chemoprevention by carotenoids. Molecules 17(3), 3202–42, 2012. doi:10.3390/molecules17033202.
   PubMed Web of Science ®Google Scholar
• Milajerdi A, Djafarian K, Hosseini B: The toxicity of saffron (Crocus sativus L.) and its constituents against normal and cancer cells. J Nutr Intermediary Metab 3, 23–32, 2016. doi:10.1016/j.jnim.2015.12.332.
   Google Scholar
• Tarantilis P, Morjani H, Polissiou M: Manfait Inhibition of growth and induction of differentiation of promyelocytic leukemia (HL-60) by carotenoids from Crocus sativus L. Anticancer Res 14(5A), 1913–1918, 1994.
   PubMed Web of Science ®Google Scholar
• Chryssanthi DG, Lamari FN, Iatrou G, Pylara A., Karamanos NK, et al.: Inhibition of breast cancer cell proliferation by style constituents of different Crocus species. Anticancer Res. 27(1A), 357–362, 2007.
   PubMed Web of Science ®Google Scholar
• Das I, Chakrabarty RN, Das S: Saffron can prevent chemically induced skin carcinogenesis in Swiss albino mice. Asian Pac J Cancer Prev 5, 70–6, 2004.
   PubMedGoogle Scholar
• Aung H.H., Wang C.Z., Ni M: Crocin from Crocus sativus possesses significant antiproliferation effects on human colorectal cancer cells. Exp Oncol 29, 175–180, 2007.
   PubMedGoogle Scholar
• Das I, Das S, Saha T: Saffron suppresses oxidative stress in DMBA-induced skin carcinoma: a histopathological study. Acta Histochem. 112(4), 317–27, 2010. doi:10.1016/j.acthis.2009.02.003.
   PubMed Web of Science ®Google Scholar
• Hoshyar R., Bathaie S.Z., Sadeghizadeh M: Crocin triggers the apoptosis through increasing the Bax/Bcl-2 ratio and caspase activation in human gastric adenocarcinoma, AGS, cells. DNA Cell Biol 32, 50–57, 2013. doi:10.1089/dna.2012.1866.
   PubMed Web of Science ®Google Scholar
• Abdullaev F, Frenkel G: Effect of saffron on cell colony formation and cellular nucleic acid and protein synthesis. BioFactors Oxf. Engl 3(3), 201–204, 1992.
   PubMed Web of Science ®Google Scholar
• G Gutheil W, Reed G, Ray A, Anant S, Dhar A: Crocetin: an agent derived from saffron for prevention and therapy for cancer. Curr Pharm Biotechnol 13(1), 173–9, 2012. doi:10.2174/138920112798868566.
   PubMed Web of Science ®Google Scholar
• Talaei A, Moghadam MH, Tabassi SA, Mohajeri SA: Crocin, the main active saffron constituent, as an adjunctive treatment in major depressive disorder: A randomized, double-blind, placebo-controlled, pilot clinical trial. J Affect Disord 174, 51–6, 2015. doi:10.1016/j.jad.2014.11.035.
   PubMed Web of Science ®Google Scholar
• Akhondzadeh S, Sabet MS, Harirchian MH, Togha M, Cheraghmakani H, et al.: Saffron in the treatment of patients with mild to moderate Alzheimer's disease: a 16‐week, randomized and placebo‐controlled trial. J Clin Pharm Ther 35(5), 581–8, 2010. doi:10.1111/j.1365-2710.2009.01133.x.
   PubMed Web of Science ®Google Scholar
• Epstein JB, Marcoe JH: Topical application of capsaicin for treatment of oral neuropathic pain and trigeminal neuralgia. Oral Surg, Oral Med, Oral Pathol 77(2), 135–40, 1994. doi:10.1016/0030-4220(94)90275-5.
   PubMedGoogle Scholar
• Ellison N, Loprinzi CL, Kugler J, Hatfield AK, Miser A, et al.: Phase III placebo-controlled trial of capsaicin cream in the management of surgical neuropathic pain in cancer patients. J Clin Oncol 15(8), 2974–80, 1997. doi:10.1200/JCO.1997.15.8.2974.
   PubMed Web of Science ®Google Scholar
• Derry S, Lloyd R, Moore RA, McQuay HJ: Topical capsaicin for chronic neuropathic pain in adults. Cochrane Database Syst Rev 4, 2009.
   Web of Science ®Google Scholar
• Giri TK, Pramanik K, Barman TK, Maity S: Nano-encapsulation of dietary phytoconstituent capsaicin on emulsome: evaluation of anticancer activity through the measurement of liver oxidative stress in rats. Anti-Cancer Agents Med Chem 2017.
   PubMed Web of Science ®Google Scholar
• Elkholi IE, Hazem NM, ElKashef WF, Sobh MA, Shaalan D, et al.: Evaluation of anti-cancer potential of capsaicin-loaded trimethyl chitosan-based nanoparticles in HepG2 hepatocarcinoma cells. J Nanomed Nanotechnol 5(240), 2, 2014.
   Google Scholar
• Brown KC, Witte TR, Hardman WE, Luo H, Chen YC, et al.: Capsaicin displays anti-proliferative activity against human small cell lung cancer in cell culture and nude mice models via the E2F pathway. PLoS one 5(4), e10243, 2010. doi:10.1371/journal.pone.0010243.
   PubMed Web of Science ®Google Scholar
• Park SY, Kim JY, Lee SM, Jun CH, Cho SB, et al.: Capsaicin induces apoptosis and modulates MAPK signaling in human gastric cancer cells. Mol Med Rep 9(2), 499–502, 2014. doi:10.3892/mmr.2013.1849.
   PubMed Web of Science ®Google Scholar
• Lau JK, Brown KC, Dom AM, Witte TR, Thornhill BA, et al.: Capsaicin induces apoptosis in human small cell lung cancer via the TRPV6 receptor and the calpain pathway. Apoptosis: An Int J Programmed Cell Death 19(8), 1190, 2014. doi:10.1007/s10495-014-1007-y.
   PubMed Web of Science ®Google Scholar
• Lee GR, Jang SH, Kim CJ, Kim AR, Yoon DJ, et al.: Capsaicin suppresses the migration of cholangiocarcinoma cells by down-regulating matrix metalloproteinase-9 expression via the AMPK-NF-[kappa] B signaling pathway. Clin Exp Metastasis 31(8), 897, 2014. doi:10.1007/s10585-014-9678-x.
   PubMed Web of Science ®Google Scholar
• Ramos-Torres Á, Bort A, Morell C, Rodríguez-Henche N, Díaz-Laviada I: The pepper's natural ingredient capsaicin induces autophagy blockage in prostate cancer cells. Oncotarget 7(2), 1569, 2016. doi:10.18632/oncotarget.6415.
   PubMedGoogle Scholar
• Bode AM, Dong Z: The two faces of capsaicin. Cancer Res 71(8), 2809–14, 2011. doi:10.1158/0008-5472.CAN-10-3756.
   PubMed Web of Science ®Google Scholar
• Bernstein JE, Parish LC, Rapaport M, Rosenbaum MM, Roenigk HH: Effects of topically applied capsaicin on moderate and severe psoriasis vulgaris. J Am Acad Dermatol 15(3), 504–7, 1986. doi:10.1016/S0190-9622(86)70201-6.
   PubMed Web of Science ®Google Scholar
• Weisshaar E, Heyer G, Forster C, Handwerker HO: Effect of topical capsaicin on the cutaneous reactions and itching to histamine in atopic eczema compared to healthy skin. Arch Dermatol Res 290(6), 306–11, 1998. doi:10.1007/s004030050309.
   PubMed Web of Science ®Google Scholar