186
Views
6
CrossRef citations to date
0
Altmetric
Original Article

Feasibility of Intravenous Iron Isomaltoside to Improve Anemia and Quality of Life During Palliative Chemotherapy for Esophagogastric Adenocarcinoma

, , , , &
Pages 1106-1117 | Received 11 Feb 2018, Accepted 05 Jul 2018, Published online: 10 Sep 2018

References

  • Ludwig H, Van Belle S, Barrett-Lee P, Birgegard G, Bokemeyer C, et al.: The European Cancer Anaemia Survey (ECAS): a large, multinational, prospective survey defining the prevalence, incidence, and treatment of anaemia in cancer patients. Eur J Cancer 40, 2293–2306, 2004.
  • Groopman JE and Itri LM: Chemotherapy-induced anemia in adults: incidence and treatment. J Natl Cancer Inst 91, 1616–1634, 1999.
  • Ludwig H, Muldur E, Endler G, and Hubl W.: Prevalence of iron deficiency across different tumors and its association with poor performance status, disease status and anemia. Ann Oncol 24, 1886–1892, 2013.
  • Cunningham D, Allum WH, Stenning SP, Thompson JN, Van de Velde CJ, et al.: Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med 355, 11–20, 2006.
  • Wagner AD, Unverzagt S, Grothe W, Kleber G, Grothey A, et al.: Chemotherapy for advanced gastric cancer. Cochrane Database Syst Rev 3, CD004064, 2010.
  • Caro JJ, Salas M, Ward A, and Goss G: Anemia as an independent prognostic factor for survival in patients with cancer: a systemic, quantitative review. Cancer 91, 2214–2221, 2001.
  • Harper P and Littlewood T: Anaemia of cancer: impact on patient fatigue and long-term outcome. Oncology 69, 2–7, 2005.
  • Ludwig H, Evstatiev R, Kornek G, Aapro M, Bauernhofer T, et al.: Iron metabolism and iron supplementation in cancer patients. Wien Klin Wochenschr 127, 907–919, 2015.
  • Teicher BA, Holden SA, al-Achi A, and Herman TS: Classification of antineoplastic treatments by their differential toxicity toward putative oxygenated and hypoxic tumor subpopulations in vivo in the FSaIIC murine fibrosarcoma. Cancer Res 50, 3339–3344, 1990.
  • Van Belle SJ and Cocquyt V: Impact of haemoglobin levels on the outcome of cancers treated with chemotherapy. Crit Rev Oncol Hematol 47, 1–11, 2003.
  • Stone P, Richardson A, Ream E, Smith AG, Kerr DJ, et al.: Cancer-related fatigue: inevitable, unimportant and untreatable? Results of a multi-centre patient survey. Cancer Fatigue Forum. Ann Oncol 11, 971–975, 2000.
  • Ludwig H and Strasser K: Symptomatology of anemia. Semin Oncol 28, 7–14, 2001.
  • Khorana AA, Francis CW, Blumberg N, Culakova E, Refaai MA, et al.: Blood transfusions, thrombosis, and mortality in hospitalized patients with cancer. Arch Intern Med 168, 2377–2381, 2008.
  • Gordon MS: Managing anemia in the cancer patient: old problems, future solutions. Oncologist 7, 331–341, 2002.
  • Grotto HZ: Anaemia of cancer: an overview of mechanisms involved in its pathogenesis. Med Oncol 25, 12–21, 2008.
  • Adamson JW: The anemia of inflammation/malignancy: mechanisms and management. Hematology Am Soc Hematol Educ Program, 159–165, 2008. doi:10.1182/asheducation-2008.1.159
  • Goodnough LT, Nemeth E, and Ganz T: Detection, evaluation, and management of iron-restricted erythropoiesis. Blood 116, 4754–4761, 2010.
  • Henry DH, Dahl NV, Auerbach M, Tchekmedyian S, and Laufman LR; Intravenous ferric gluconate significantly improves response to epoetin alfa versus oral iron or no iron in anemic patients with cancer receiving chemotherapy. Oncologist 12, 231–242, 2007.
  • Aapro M, Osterborg A, Gascon P, Ludwig H, and Beguin Y: Prevalence and management of cancer-related anaemia, iron deficiency and the specific role of i.v. iron. Ann Oncol 23, 1954–1962, 2012.
  • Steinmetz HT: The role of intravenous iron in the treatment of anemia in cancer patients. Ther Adv Hematol 3, 177–191, 2012.
  • Demetri GD, Kris M, Wade J, Degos L, and Cella D: Quality-of-life benefit in chemotherapy patients treated with epoetin alfa is independent of disease response or tumor type: results from a prospective community oncology study. Procrit Study Group. J Clin Oncol 16, 3412–3425, 1998.
  • Gabrilove JL, Cleeland CS, Livingston RB, Sarokhan B, Winer E, et al.: Clinical evaluation of once-weekly dosing of epoetin alfa in chemotherapy patients: improvements in hemoglobin and quality of life are similar to three-times-weekly dosing. J Clin Oncol 19, 2875–2882, 2001.
  • Littlewood TJ, Bajetta E, Nortier JW, Vercammen E, Rapoport B, et al.: Effects of epoetin alfa on hematologic parameters and quality of life in cancer patients receiving nonplatinum chemotherapy: results of a randomized, double-blind, placebo-controlled trial. J Clin Oncol 19, 2865–2874, 2001.
  • Glaspy J: The impact of epoetin alfa on quality of life during cancer chemotherapy: a fresh look at an old problem. Semin Hematol 34, 20–26, 1997.
  • Bohlius J, Schmidlin K, Brillant C, Schwarzer G, Trelle S, et al.: Recombinant human erythropoiesis-stimulating agents and mortality in patients with cancer: a meta-analysis of randomised trials. Lancet 373, 1532–1542, 2009.
  • Spivak JL: The anaemia of cancer: death by a thousand cuts. Nat Rev Cancer 5, 543–555, 2005.
  • Henry DH, Dahl NV, and Auerbach MA: Thrombocytosis and venous thromboembolism in cancer patients with chemotherapy induced anemia may be related to ESA induced iron restricted erythropoiesis and reversed by administration of IV iron. Am J Hematol 87, 308–310, 2012.
  • Rizzo JD, Brouwers M, Hurley P, Seidenfeld J, Somerfield MR, et al.: American Society of Clinical Oncology/American Society of Hematology Clinical Practice Guideline update on the use of epoetin and darbepoetin in adult patients with cancer. J Oncol Pract 6, 317–320, 2010.
  • Schrijvers D, De Samblanx H, Roila F, and E.G.W. Group: Erythropoiesis-stimulating agents in the treatment of anaemia in cancer patients: ESMO Clinical Practice Guidelines for use. Ann Oncol 21, v244–v247, 2010.
  • Hedenus M, Birgegard G, Nasman P, Ahlberg L, Karlsson T, et al.: Addition of intravenous iron to epoetin beta increases hemoglobin response and decreases epoetin dose requirement in anemic patients with lymphoproliferative malignancies: a randomized multicenter study. Leukemia 21, 627–632, 2007.
  • Rodgers 3rd GM, Becker PS, Blinder M, Cella D, Chanan-Khan A, et al.: Cancer- and chemotherapy-induced anemia. J Natl Compr Canc Netw 10, 628–653, 2012.
  • Bokemeyer C, Aapro MS, Courdi A, Foubert J, Link H, et al.: EORTC guidelines for the use of erythropoietic proteins in anaemic patients with cancer: 2006 update. Eur J Cancer 43, 258–270, 2007.
  • Steinmetz T, Tschechne B, Harlin O, Klement B, Franzem M, et al.: Clinical experience with ferric carboxymaltose in the treatment of cancer- and chemotherapy-associated anaemia. Ann Oncol 24, 475–482, 2013.
  • Kim YT, Kim SW, Yoon BS, Cho HJ, Nahm EJ, et al.: Effect of intravenously administered iron sucrose on the prevention of anemia in the cervical cancer patients treated with concurrent chemoradiotherapy. Gynecol Oncol 105, 199–204, 2007.
  • Dangsuwan P and Manchana T: Blood transfusion reduction with intravenous iron in gynecologic cancer patients receiving chemotherapy. Gynecol Oncol 116, 522–525, 2010.
  • Athibovonsuk P, Manchana T, and Sirisabya N: Prevention of blood transfusion with intravenous iron in gynecologic cancer patients receiving platinum-based chemotherapy. Gynecol Oncol 131, 679–682, 2013.
  • Hedenus M, Karlsson T, Ludwig H, Rzychon B, Felder M, et al.: Intravenous iron alone resolves anemia in patients with functional iron deficiency and lymphoid malignancies undergoing chemotherapy. Med Oncol 31, 302, 2014.
  • Ganzoni AM: Intravenous iron-dextran: therapeutic and experimental possibilities. Schweiz Med Wochenschr 100, 301–303, 1970.
  • Cella D: The Functional Assessment of Cancer Therapy-Anemia (FACT-An) Scale: a new tool for the assessment of outcomes in cancer anemia and fatigue. Semin Hematol 34, 13–19, 1997.
  • EuroQol G: EuroQol – a new facility for the measurement of health-related quality of life. Health Policy 16, 199–208, 1990.
  • Johnston BC, Ebrahim S, Carrasco-Labra A, Furukawa TA, Patrick DL, et al.: Minimally important difference estimates and methods: a protocol. BMJ Open 5, e007953, 2015.
  • Lancaster GA, Dodd S, and Williamson PR: Design and analysis of pilot studies: recommendations for good practice. J Eval Clin Pract 10, 307–312, 2004.
  • Chadwick C, Varagunam M, Brand C, and Cromwell D: 2016 Annual Report of the National Oesophago-Gastric Cancer Audit (NOGCA). HQIP, 2016. http://www.hqip.org.uk/wp-content/uploads/2018/02/national-oesphago-gastric-cancer-audit-2016.pdf
  • Evstatiev R, Marteau P, Iqbal T, Khalif IL, Stein J, et al.: FERGIcor, a randomized controlled trial on ferric carboxymaltose for iron deficiency anemia in inflammatory bowel disease. Gastroenterology 141, 846 e1-2–853 e1-2, 2011.
  • Cella D, Kallich J, McDermott A, and Xu X: The longitudinal relationship of hemoglobin, fatigue and quality of life in anemic cancer patients: results from five randomized clinical trials. Ann Oncol 15, 979–986, 2004.
  • Yakymenko D, Frandsen KB, Christensen IJ, Norgaard A, Johansson PI, et al.: Randomised feasibility study of a more liberal haemoglobin trigger for red blood cell transfusion compared to standard practice in anaemic cancer patients treated with chemotherapy. Transfus Med, 28, 208–215, 2018.
  • Crawford J, Cella D, Cleeland CS, Cremieux PY, Demetri GD, et al.: Relationship between changes in hemoglobin level and quality of life during chemotherapy in anemic cancer patients receiving epoetin alfa therapy. Cancer 95, 888–895, 2002.
  • Auerbach M and Macdougall IC: Safety of intravenous iron formulations: facts and folklore. Blood Transfus 12, 296–300, 2014.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.