Hesperidin Induces ROS-Mediated Apoptosis along with Cell Cycle Arrest at G2/M Phase in Human Gall Bladder Carcinoma

References

• Sharma A, Sharma KL, Gupta A, Yadav A, and Kumar A: Gallbladder cancer epidemiology, pathogenesis and molecular genetics: recent update. World J Gastroenterol 23, 3978–3998, 2017.
   PubMed Web of Science ®Google Scholar
• Maurya SK, Tewari M, Mishra RR, and Shukla HS: Genetic aberrations in gallbladder cancer. Surg Oncol 21, 37–43, 2012.
   PubMed Web of Science ®Google Scholar
• Mazzanti P, Massacesi C, Rocchi MB, Mattioli R, and Lippe P: Randomized, multicenter, phase II study of gemcitabine plus cisplatin versus gemcitabine plus carboplatin in patients with advanced non-small cell lung cancer. Lung Cancer 41, 81–89, 2003.
   PubMed Web of Science ®Google Scholar
• Martin-Cordero C, Leon-Gonzalez AJ, Calderon-Montano JM, Burgos-Moron E, and Lopez-Lazaro M, Pro-oxidant natural products as anticancer agents. Curr Drug Targets 13, 1006–1028, 2012.
   PubMed Web of Science ®Google Scholar
• Garg A, Garg S, Zaneveld LJD, and Singla AK: Chemistry and pharmacology of the citrus bioflavonoid hesperidin. Phytother Res 15, 655–669, 2001.
   PubMed Web of Science ®Google Scholar
• Ahmadi A and Shadboorestan A: Oxidative stress and cancer; the role of hesperidin, a citrus natural bioflavonoid, as a cancer chemoprotective agent. Nutr Cancer 68, 29–39, 2016.
   PubMed Web of Science ®Google Scholar
• Zhang H. and Tsao R: Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects. Curr Opin Food Sci 8, 33–34, 2016.
   Web of Science ®Google Scholar
• Zhao J, Li Y, Gao J, and De Y: Hesperidin inhibits ovarian cancer cell viability through endoplasmic reticulum stress signaling pathways. Oncol Lett 14, 5569–5574, 2017.
   PubMed Web of Science ®Google Scholar
• Xia R, Sheng X, Xu X, Yu C, and Lu H: Hesperidin induces apoptosis and G0/G1 arrest in human non-small cell lung cancer A549 cells. Int J Mol Med 41, 464–472, 2018.
   PubMed Web of Science ®Google Scholar
• Julius A, Vedasendiyar R, Devakannan A, Rajaraman S, Rangasamy B, et al.: Effect of hesperidin for its anti-proliferative activity on liver cancer and cardio vascular diseases. Res J Pharm Technol10, 307–308, 2017.
   Google Scholar
• Homayouni F, Haidari F, Hedayati M, Zakerkish M, and Ahmadi K: Hesperidin supplementation alleviates oxidative DNA damage and lipid peroxidation in type 2 diabetes: a randomized double-blind placebo-controlled clinical trial. Phytother Res 31, 1539–1545, 2017.
   PubMed Web of Science ®Google Scholar
• Griffiths K, Aggarwal BB, Singh RB, Buttar HS, and Wilson D: Food antioxidants and their anti-inflammatory properties: a potential role in cardiovascular diseases and cancer prevention. Diseases 4, 28, 2016.
   PubMedGoogle Scholar
• Lee CJ, Wilson L, Jordan MA, Nguyen V, and Tang J, et al.: Hesperidin suppressed proliferations of both Human breast cancer and androgen‐dependent prostate cancer cells. Phytother Res 24 Suppl 1, S15-9, 2010.
   Web of Science ®Google Scholar
• Patil JR, Chidambara Murthy KN, Jayaprakasha GK, Chetti MB, and Patil BS: Bioactive compounds from Mexican lime (Citrus aurantifolia) juice induce apoptosis in human pancreatic cells. J Agric Food Chem 57, 10933–10942, 2009.
   PubMed Web of Science ®Google Scholar
• Aranganathan S and Nalini N: Efficacy of the potential chemopreventive agent, hesperetin (citrus flavanone), on 1,2-dimethylhydrazine induced colon carcinogenesis. Food Chem Toxicol 47, 2594–2600, 2009.
   PubMed Web of Science ®Google Scholar
• Prasad R and Katiyar SK: Bioactive phytochemical proanthocyanidins inhibit growth of head and neck squamous cell carcinoma cells by targeting multiple signaling molecules. PLoS One 7, e46404, 2012.
   PubMed Web of Science ®Google Scholar
• Khan F, Khan I, Farooqui A, and Ansari IA: Carvacrol induces reactive oxygen species (ROS)-mediated apoptosis along with cell cycle arrest at G0/G1 in human prostate cancer cells. Nutr Cancer 69, 1075–1087, 2017.
   PubMed Web of Science ®Google Scholar
• Wang Y, Yu H, Zhang J, Gao J, Ge X, et al.: Hesperidin inhibits HeLa cell proliferation through apoptosis mediated by endoplasmic reticulum stress pathways and cell cycle arrest. BMC Cancer 15, 682, 2015.
   PubMed Web of Science ®Google Scholar
• Farooqui A, Khan F, Khan I, and Ansari IA: Glycyrrhizin induces reactive oxygen species-dependent apoptosis and cell cycle arrest at G 0/G 1 in HPV18+ human cervical cancer HeLa cell line. Biomed Pharmacother 97, 752–764, 2018.
   PubMed Web of Science ®Google Scholar
• Sarkar S, Mazumdar A, Dash R, Sarkar D, Fisher PB, et al.: ZD6474, a dual tyrosine kinase inhibitor of EGFR and VEGFR-2, inhibits MAPK/ERK and AKT/PI3-K and induces apoptosis in breast cancer cells. Cancer Biol Ther 9, 592–603, 2010.
   PubMed Web of Science ®Google Scholar
• Xiong Y, Ye T, Wang M, Xia Y, Wang N, et al.: A novel cinnamide YLT26 induces breast cancer cells apoptosis via ROS-mitochondrial apoptotic pathway in vitro and inhibits lung metastasis in vivo. Cell Physiol Biochem 34, 1863–1876, 2014.
   PubMed Web of Science ®Google Scholar
• Cilla A, Rodrigo MJ, Zacarías L, De Ancos B, Sánchez-Moreno C, et al.: Protective effect of bioaccessible fractions of citrus fruit pulps against H2O2-induced oxidative stress in Caco-2 cells. Food Res Int 103, 335–344, 2018.
   PubMed Web of Science ®Google Scholar
• Roohbakhsh A, Parhiz H, Soltani F, Rezaee R, and Iranshahi M: Molecular mechanisms behind the biological effects of hesperidin and hesperetin for the prevention of cancer and cardiovascular diseases. Life Sci 124, 64–74, 2015.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Sun L, Cui L, and Feng Y: Prophylactic effects of triptolide on colon cancer development in azoxymethane/dextran sulfate sodiuminduced mouse model. Trop J Pharm Res 16, 2659–2665, 2017.
   Web of Science ®Google Scholar
• Hall AG: Review: the role of glutathione in the regulation of apoptosis. Eur J Clin Investig 29, 238–245, 1999.
   PubMed Web of Science ®Google Scholar
• Wong RS: Apoptosis in cancer: from pathogenesis to treatment. J Exp Clin Cancer Res 30, 87, 2011.
   PubMed Web of Science ®Google Scholar
• Cincin ZB, Unlu M, Kiran B, Bireller ES, Baran Y, et al.: Anti-proliferative, apoptotic and signal transduction effects of hesperidin in non-small cell lung cancer cells. Cell Oncol 38, 195–204, 2015.
   Web of Science ®Google Scholar
• Cohen GM: Caspases: the executioners of apoptosis. Biochem J 326, 1–16, 1997.
   PubMed Web of Science ®Google Scholar
• Trachootham D, Alexandre J, and Huang P: Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov 8, 579, 2009.
   PubMed Web of Science ®Google Scholar
• Fleury C, Mignotte B, and Vayssière JL: Mitochondrial reactive oxygen species in cell death signaling. Biochimie 84, 131–141, 2002.
   PubMed Web of Science ®Google Scholar
• Balaban RS: Modeling mitochondrial function. Am J Physiol Cell Physiol 291, C1107–C1113, 2006.
   PubMed Web of Science ®Google Scholar
• Emaus RK, Grunwald R, and Lemasters JJ: Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: spectral and metabolic properties. Biochim Biophys Acta Bioenerg 850, 436–448, 1986.
   PubMed Web of Science ®Google Scholar