Phyla nodiflora L. Extracts Induce Apoptosis and Cell Cycle Arrest in Human Breast Cancer Cell Line, MCF-7

References

• Siegel RL, Miller KD, and Jemal A: Cancer statistics, 2018. CA Cancer J Clin 68, 7–30, 2018.
   PubMed Web of Science ®Google Scholar
• DeSantis CE, Ma J, Sauer AG, Newman LA, and Jemal A: Breast cancer statistics, 2017, racial disparity in mortality by state. CA Cancer J Clin 67, 439–448, 2017.
   PubMed Web of Science ®Google Scholar
• Koff JL, Ramachandiran S, and Bernal-Mizrachi L: A time to kill: Targeting apoptosis in cancer. Int J Mol Sci 16, 2942–2955, 2015.
   PubMed Web of Science ®Google Scholar
• Gordeziani M, Adamia G, Khatisashvili G, and Gigolashvili G: Programmed cell self-liquidation (apoptosis). Ann Agrar Sci 15, 148–154, 2017.
   Google Scholar
• Baig S, Seevasant I, Mohamad J, Mukheem A, Huri HZ, et al.: Potential of apoptotic pathway-targeted cancer therapeutic research: Where do we stand?. Cell Death Dis 7, e2058, 2016.
   PubMed Web of Science ®Google Scholar
• Nosrati N, Bakovic M, and Paliyath G: Molecular mechanisms and pathways as targets for cancer prevention and progression with dietary compounds. IJMS 18, 2050, 2017.
   Google Scholar
• Vanna S, Siddiqui IA, Sechi M, and Mukhtar H: Nanoformulation of natural products for prevention and therapy of prostate cancer. Cancer Lett 334, 142–151, 2013.
   PubMed Web of Science ®Google Scholar
• Aung TN, Qu Z, Kortschak RD, and Adelson DL: Understanding the effectiveness of natural compound mixtures in cancer through their molecular mode of action. IJMS 18, 656, 2017.
   Web of Science ®Google Scholar
• Lin FJ, Yen FL, Chen PC, Wang MC, Lin CN, et al.: HPLC-fingerprints and antioxidant constituents of Phyla nodiflora. Sci World J 2014, 528653, 2014.
   Google Scholar
• Ravikanth V, Ramesh P, Diwan PV, and Venkateswarlu Y: Halleridone and Hallerone from Phyla nodiflora as taxonomic markers. Biochem Syst Ecol 28, 905–906, 2000.
   PubMed Web of Science ®Google Scholar
• Siddiqui BS, Ahmed F, Ali SK, Perwaiz S, and Begum S: Steroidal constituents from the aerial parts of Lippia nodiflora Linn. Nat Prod Res 23, 436–441, 2009.
   PubMed Web of Science ®Google Scholar
• Balakrishnan G, Janakarajan L, Balakrishnan A, and Lakshmi BS: Molecular basis of the anti-inflammatory property exhibited by cyclo-pentano phenanthrenol isolated from Lippia nodiflora. Immunol Invest 39, 713–739, 2010.
   PubMed Web of Science ®Google Scholar
• Balamurugan R, Duraipandiyan V, and Ignacimuthu S: Antidiabetic activity of γ-sitosterol isolated from Lippia nodiflora L. in streptozotocin induced diabetic rats. Eur J Pharmacol 667, 410–418, 2011.
   PubMed Web of Science ®Google Scholar
• Sharma RA and Singh R: A review on Phyla nodiflora Linn: A wild wetland medicinal herb. Int J Phramaceu Sci Rev Res 20, 57–63, 2013.
   Google Scholar
• Yen F-L, Wang M-C, Liang C-J, Ko H-H, and Lee C-W: Melanogenesis inhibitor(s) from Phyla nodiflora extract. Evid Based Complement Alternat Med 2012, 867494, 2012.
   PubMedGoogle Scholar
• Durairaj AK, Mazumdar UK, Gupta M, and Selvan VT: Effect on inhibition of proliferation and antioxidant enzyme level of Lippia nodiflora in EAC cell line treated mice. J Comp Integ Med 1, 713–714, 2009.
   Google Scholar
• Vanajothi R, Sudha A, Manikandan R, Rameshthangam P, and Srinivasan P: Luffa acutangula and Lippia nodiflora leaf extract induces growth inhibitory effect through induction of apoptosis on human lung cancer cell line. Biomed Prev Nutri 2, 287–293, 2012.
   Google Scholar
• Liau M, Cheong BE, and Teoh PL: Antioxidant and anticancer properties of solvent partitioned extracts of Phyla nodiflora L. J Microbiol Biotech Food Sci 7, 42–46, 2017.
   Web of Science ®Google Scholar
• Teoh PL: Rabi’atul’awiyah MA, Cheong BE: Potential anticancer effect of Phyla nodiflora extracts in breast cancer cell line, MCF-7. World J Pharm Pharmaceu Sci 6, 6053–6061, 2013.
   Google Scholar
• Bano D and Prehn JHM: Apoptosis-inducing factor (AIF) in physiology and disease: The tale of a repented natural born killer. EBio Med 30, 29–37, 2018.
   PubMed Web of Science ®Google Scholar
• Candé C, Vahsen N, Garrido C, and Kroemer G: Apoptosis-inducing factor (AIF): caspase-independent after all. Cell Death Differ 11, 591–595, 2004.
   PubMed Web of Science ®Google Scholar
• He M-X and He Y-W: CFLAR/c-FLIPL: A star in the autophagy, apoptosis and necroptosis alliance. Autophagy 9, 791–793, 2013.
   PubMed Web of Science ®Google Scholar
• Chandra D and Tang DG : Mitochondrially localized active caspase-9 and caspase-3 result mostly from translocation from the cytosol and partly from caspase-mediated activation in the organelle. Lack of evidence for Apaf-1-mediated procaspase-9 activation in the mitochondriaJ Biol Chem 278, 17408–17420, 2003.
   PubMed Web of Science ®Google Scholar
• Nakanishi K, Maruyama M, Shibata T, and Morishima N: Identification of a caspase-9 substrate and detection of its cleavage in programmed cell death during mouse development. J Biol Chem 276, 41237–41244, 2001.
   PubMed Web of Science ®Google Scholar
• Wu W, Ma J, Shao N, Shi Y, Liu R, et al.: Co-targeting IGF-1R and autophagy enhances the effects of cell growth suppression and apoptosis induced by the IGF-1R inhibitor NVP-AEW541 in triple-negative breast cancer cells. PLoS One 12, e0169229, 2017.
   PubMed Web of Science ®Google Scholar
• Yuan J, Yin Z, Tao K, Wang G, and Gao J: Function of insulin-like growth factor 1 receptor in cancer resistance to chemotherapy (Review). Oncol Lett 15, 41–47, 2018.
   PubMed Web of Science ®Google Scholar
• Hata AN, Engelman JA, and Faber AC: The BCL-2 family: key mediators of the apoptotic response to targeted anti-cancer therapeutics. Cancer Discov 5, 475–487, 2015.
   PubMed Web of Science ®Google Scholar
• Bačević K, Lossaint G, Achour TN, Georget V, Fisher D, et al.: Cdk2 strengthens the intra-S checkpoint and counteracts cell cycle exit induced by DNA damage. Sci Rep 7, 13429, 2017.
   PubMed Web of Science ®Google Scholar
• Bendris N, Loukil A, Cheung C, Arsic N, Rebouissou C, et al.: Cyclin A2: a genuine cell cycle regulator?. Biomol Concepts 3, 535–543, 2012.
   PubMedGoogle Scholar
• Gong D and Ferrell JE: The roles of cyclin A2, B1, and B2 in early and late mitotic events. Mol Biol Cell 21, 3149–3161, 2010.
   PubMed Web of Science ®Google Scholar
• Teoh PL, Angelina YFC, Monica L, Lem FF, Kaling GP, et al.: Chemical composition and cytotoxic properties of Clinacanthus nutans root extracts. Pharmaceu Biol 55, 394–401, 2017.
   PubMed Web of Science ®Google Scholar