Moringa oleifera Aqueous Leaf Extract Induces Cell-Cycle Arrest and Apoptosis in Human Liver Hepatocellular Carcinoma Cells

References

• Jaeschke H, Gores GJ, Cederbaum AI, Hinson JA, Pessayre D, et al.: Mechanisms of hepatotoxicity. Toxicol Sci 65, 166–176, 2002.
   PubMed Web of Science ®Google Scholar
• El-Bakry K, Toson E, Serag M, and Aboser M: Hepatoprotective effect of Moringa oleifera leaves extract against carbon tetrachloride – induced liver damage in rats. World J Pharm Sci 5, 76–89, 2016.
   Google Scholar
• Hamid AS, Tesfamariam IG, Zhang Y, and Zhang Z: G. Aflatoxin B1-induced hepatocellular carcinoma in developing countries: geographical distribution, mechanism of action and prevention (Review). Oncol Lett 5, 1087–1092, 2013.
   PubMed Web of Science ®Google Scholar
• Stepien M, Fedirko V, Duarte-Salles T, Ferrari P, Freisling H, et al. Prospective association of liver function biomarkers with development of hepatobiliary cancers. Cancer Epidemiol 40, 179–187, 2016.
   PubMed Web of Science ®Google Scholar
• Qun W, Tao Y, Yi DC, Weijun L, Fu WY, et al.: Effective personalized treatment of advanced hepatic carcinoma based on Sorafenib. J Integr Oncol 5, 1–3, 2016.
   Google Scholar
• Rathi BS, Bodhankar SL, and Baheti AM: Evaluation of aqueous leaves extract of Moringa oleifera Linn for wound healing in albino rats. Indian J Exp Biol 44, 898–901, 2006.
   PubMedGoogle Scholar
• Berkovich L, Earon G, Ron I, Rimmon A, Vexler A, et al.: Moringa oleifera aqueous leaf extract down-regulates nuclear factor-kappaB and increases cytotoxic effect of chemotherapy in pancreatic cancer cells. BMC Complement Altern Med 13, 1–7, 2013.
   PubMed Web of Science ®Google Scholar
• Tiloke C, Phulukdaree A, and Chuturgoon AA: The antiproliferative effect of Moringa oleifera crude aqueous leaf extract on cancerous human alveolar epithelial cells. BMC Complem Altern Med 13, 1–8, 2013.
   PubMed Web of Science ®Google Scholar
• Phulukdaree A, Moodley D, and Chuturgoon AA: The effects of Sutherlandia frutescens extracts in cultured renal proximal and distal tubule epithelial cells. S Afri J Sci 106, 1–5, 2010.
   Web of Science ®Google Scholar
• Prasad TNVKV, and Elumalai EK: Biofabrication of Ag nanoparticles using Moringa oleifera leaf extract and their antimicrobial activity. Asian Pac J Trop Biomed 1, 439–442, 2011.
   PubMedGoogle Scholar
• Wilson K, and Walker J: Principles and Techniques of Biochemistry and Molecular Biology, Cambridge University Press, New York, 2005.
   Google Scholar
• Mossman T: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assay. J Immunol Methods 65, 55–63, 1983.
   PubMed Web of Science ®Google Scholar
• Halliwell B, and Chirico S: Lipid peroxidation: its mechanism, measurement, and significance. Am J Clin Nutr 57, 715S–725S, 1993.
   PubMed Web of Science ®Google Scholar
• Singh NP, McCoy MT, Tice RR, and Schneider EL: A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 1751, 184–191, 1988.
   Web of Science ®Google Scholar
• Bainor A, Chang L, McQuade TJ, Webb B, and Gestwicki JE: Bicinchoninic acid (BCA) assay in low volume. Anal Biochem 410, 310–312, 2011.
   PubMed Web of Science ®Google Scholar
• Yang Y, and Ma H: Western Blotting and ELISA techniques. Researcher 1, 67–86, 2009.
   Google Scholar
• Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, et al.: Global Cancer Statistics, 2012. CA Cancer J Clin 65, 87–108, 2015.
   PubMed Web of Science ®Google Scholar
• Monera TG, Wolfe AR, Maponga CC, Benet LZ, and Guglielmo J: Moringa oleifera leaf extracts inhibit 6beta-hydroxylation of testosterone by CYP3A4 . J Infect Dev Ctries 2, 379–383, 2008.
   PubMed Web of Science ®Google Scholar
• Ayala A, Muñoz MF, and Argüelles S: Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxid Med Cell Longev 2014, 1–31, 2014.
   Web of Science ®Google Scholar
• Tiloke C, Phulukdaree A, and Chuturgoon AA: The antiproliferative effect of Moringa oleifera crude aqueous leaf extract on human esophageal cancer cells. J Med Food 19, 398–403, 2016.
   PubMed Web of Science ®Google Scholar
• Ivashkevich A, Redon CE, Nakamura AJ, Martin RF, and Martin OA: Use of the γ-H2AX assay to monitor DNA damage and repair in translational cancer research. Cancer Lett 327, 123–133, 2012.
   PubMed Web of Science ®Google Scholar
• Meyer RG, Meyer-Ficca ML, and Kupper J-H: Adenoviral vectors for modulation of poly (ADP-ribose) polymerase-1 (PARP1) – dependent DNA repair as a predictive tool for chemotherapy. J Cell Biotechnol 2, 57–68, 2016.
   Google Scholar
• Sherr CJ, and Bartek J: Cell cycle-targeted cancer therapies. Ann Rev Cancer Biol 1, 2.1–2.7, 2016.
   Google Scholar
• Xi Z, Yao M, Li Y, Xie C, Holst J, et al. Guttiferone K impedes cell cycle re-entry of quiescent prostate cancer cells via stabilization of FBXW7 and subsequent c-MYC degradation. Cell Death Dis 7, 1–13, 2016.
   Web of Science ®Google Scholar
• Hengartner MO: The biochemistry of apoptosis. Nature 407, 770–776, 2000.
   PubMed Web of Science ®Google Scholar
• Li P, Zhou L, Zhao T, Liu X, Zhang P, et al. Caspase-9: structure, mechanisms and clinical application. Oncotarget 8, 23996–24008, 2017.
   PubMedGoogle Scholar
• Kedzierska H and Piekiełko-Witkowska A: Splicing factors of SR and hnRNP families as regulators of apoptosis in cancer. Cancer Lett 396, 53–65, 2017.
   PubMed Web of Science ®Google Scholar
• Murphy ME: The HSP70 family and cancer. Carcinogenesis 34, 1181–1188, 2013.
   PubMed Web of Science ®Google Scholar
• Garido C, Brunet M, Didelot C, Zermati Y, Schmitt E, et al.: Heat shock proteins 27 and 70 anti-apoptotic proteins with tumorigenic properties. Cell Cycle 5, 2592–2601, 2006.
   PubMed Web of Science ®Google Scholar
• Tiloke C, Phulukdaree A, Anand K, Gengan RM, and Chuturgoon AA: Moringa oleifera gold nanoparticles modulate oncogenes, tumor suppressor genes, and caspase-9 splice variants in A549 cells. J Cell Biochem 9999, 1–13, 2016.
   Google Scholar
• Goyal BR, Agrawal BB, Goyal RK, and Mahta AA: Phyto-pharmacology of Moringa oleifera Lam an overview. Nat Prod Rad 6, 347–353, 2007.
   Google Scholar
• Waterman C, Cheng DM, Rojas-Silva P, Poulev A, Dreifus J, et al. Stable, water extractable isothiocyanates from Moringa oleifera leaves attenuate inflammation in vitro. Phytochemistry 103, 114–122, 2014.
   PubMed Web of Science ®Google Scholar
• Boonsirichai K and Jetawattana S: Radiation-induced DNA double strand breaks and their modulations by treatments with Moringa oleifera Lam. leaf extracts: a cancer cell culture model. Atom Indo 40, 7–12, 2014.
   Google Scholar
• Jung IL: Soluble extract from Moringa oleifera leaves with a new anticancer activity. PLoS One 9, 1–10, 2014.
   Web of Science ®Google Scholar
• Sreelatha S, Jeyachitra A, and Padma PR: Antiproliferation and induction of apoptosis by Moringa oleifera leaf extract on human cancer cells. Food Chem Toxicol 49, 1270–1275, 2011.
   PubMed Web of Science ®Google Scholar