289
Views
24
CrossRef citations to date
0
Altmetric
Articles

Dietary Ziziphus jujuba Fruit Attenuates Colitis-Associated Tumorigenesis: A Pivotal Role of the NF-κB/IL-6/JAK1/STAT3 Pathway

, , , &
Pages 120-132 | Received 18 Oct 2017, Accepted 02 May 2019, Published online: 28 May 2019

References

  • Chen J, Liu X, Li Z, Qi A, and Yao P: A review of dietary Ziziphus jujuba fruit (Jujube): developing health food supplements for brain protection. Evid Based Complement Alternat Med 2017, 3019568, 2017.
  • Chen J, Yan AL, Lam KYC, Lam CTW, Li N, et al. A chemically standardized extract of Ziziphus jujuba fruit (Jujube) stimulates expressions of neurotrophic factors and anti-oxidant enzymes in cultured astrocytes. Phytother Res 28, 1727–1730, 2014.
  • Seo EJ, Lee SY, Kang SS, and Jung Y-S: Zizyphus jujuba and its active component jujuboside B inhibit platelet aggregation. Phytother Res 27, 829–834, 2013.
  • Lam CTW, Chan PH, Lee PSC, Lau KM, Kong AYY, et al. Chemical and biological assessment of Jujube (Ziziphus jujuba)-containing herbal decoctions: Induction of erythropoietin expression in cultures. J Chromatogr B 1026, 254–262, 2016.
  • Lam CTW, Gong AGW, Lam KYC, Zhang LM, Chen J-P, et al. Jujube-containing herbal decoctions induce neuronal differentiation and the expression of anti-oxidant enzymes in cultured PC12 cells. J Ethnopharmacol 188, 275–283, 2016.
  • Wojdyło A, Carbonell-Barrachina ÁA, Legua P, and Hernández F: Phenolic composition, ascorbic acid content, and antioxidant capacity of Spanish jujube (Ziziphus jujube Mill.) fruits. Food Chem 201, 307–314, 2016.
  • Shi N, Clinton SK, Liu Z, Wang Y, Riedl KM, et al. Strawberry phytochemicals inhibit azoxymethane/dextran sodium sulfate-induced colorectal carcinogenesis in Crj: CD-1 mice. Nutrients 7, 1696–1715, 2015.
  • Health Promotion Administration (HPA). Cancer Registry Annual Report, 2014.
  • Saadatdoust Z, Pandurangan AK, Ananda Sadagopan SK, Mohd Esa N, Ismail A, and Mustafa MR: Dietary cocoa inhibits colitis associated cancer: a crucial involvement of the IL-6/STAT3 pathway. J Nutr Biochem 26, 1547–1558, 2015.
  • Grivennikov SI, and Karin M: Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage. Ann Rheum Dis 70, 4–8, 2011.
  • Wang SW, and Sun YM : The IL-6/JAK/STAT3 pathway: potential therapeutic strategies in treating colorectal cancer (Review). Int J Oncol 44, 1032–1340, 2014.
  • Pryczynicz A, Gryko M, Niewiarowska K, Cepowicz D, Ustymowicz M, et al. Bax protein may influence the invasion of colorectal cancer. World J Gastroenterol 20, 1305–1310, 2014.
  • Ju J, Kim YJ, Park ES, and Park KY: Korean solar salt ameliorates colon carcinogenesis in an AOM/DSS-induced C57BL/6 mouse model. Prev Nutr Food Sci 22, 149–155, 2017.
  • WCRF. World Cancer Research Fund/American Institute for Cancer Research. Food, Nutrition, Physical Activity, and the Prevention of Cancer: A Global Perspective, 1–537. AICR, Washington, DC, 2007.
  • Yu C, Wen X-D, Zhang Z, Zhang C-F, Wu X-H, et al. American ginseng attenuates azoxymethane/dextran sodium sulfate-induced colon carcinogenesis in mice. J Ginseng Res 39, 14–21, 2015.
  • Cooper HS, Murthy SN, Shah RS, and Sedergran DJ: Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest 69, 238–249, 1993.
  • Okayasu I, Ohkusa T, Kajiura K, Kanno J, and Sakamoto S: Promotion of colorectal neoplasia in experimental murine ulcerative colitis. Gut 39, 87–92, 1996.
  • Degagné E, Pandurangan A, Bandhuvula P, Kumar A, Eltanawy A, et al. Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs. J Clin Invest 124, 5368–5384, 2014.
  • Tanaka T, Kohno H, Suzuki R, Yamada Y, Sugie S, and Mori H: A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate. Cancer Sci 94, 965–973, 2003.
  • Melgar S, Karlsson A, and MichaëLsson E: Acute colitis induced by dextran sulfate sodium progresses to chronicity in C57BL/6 but not in BALB/c mice: correlation between symptoms and inflammation. Am J Physiol Gastrointest Liver Physiol 288, G1328–1338, 2005.
  • Tian Y, Wang K, Wang Z, Li N, and Ji G: Chemopreventive effect of dietary glutamine on colitis-associated colon tumorigenesis in mice. Carcinogenesis 34, 1593–1600, 2013.
  • Chen LH, Song JL, Qian Y, Zhao X, Suo HY, and Li J: Increased preventive effect on colon carcinogenesis by use of resistant starch (RS3) as the carrier for polysaccharide of Larimichthys crocea swimming bladder. Int J Mol Sci 15, 817–829, 2014.
  • Takahashi M, and Wakabayashi K: Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents. Cancer Sci 95, 475–480, 2004.
  • Khanbhai M, Shah M, Cantanhede G, Ilyas S, and Richards T: The problem of anaemia in patients with colorectal cancer. ISRN Hematol 2014, 547914, 2014.
  • Bai L, Zhang H, Liu Q, Zhao Y, Cui X, et al. Chemical characterization of the main bioactive constituents from fruits of Ziziphus jujuba. Food Funct 7, 2870–2877, 2016.
  • Xie JH, Tang W, Jin ML, Li JE, and Xie MY: Recent advances in bioactive polysaccharides from Lycium barbarum L., Zizyphus jujuba Mill, Plantago spp., and Morus spp.: structures and functionalities. Food Hydrocoll 60, 148–160, 2016.
  • Yu ZP, Xu DD, Lu LF, Zheng XD, and Chen W: Immunomodulatory effect of a formula developed from American ginseng and Chinese jujube extracts in mice. J Zhejiang Univ Sci B 17, 147–157, 2016.
  • Yu H, Pardoll D, and Jove R: STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 9, 798–809, 2009.
  • Chung YC, and Chang YF: Serum interleukin-6 levels reflect the disease status of colorectal cancer. J Surg Oncol 83, 222–226, 2003.
  • Klampfer L: Cytokines, inflammation and colon cancer. Curr Cancer Drug Targets 11, 451–464, 2011.
  • Cornick S, Tawiah A, and Chadee K: Roles and regulation of the mucus barrier in the gut. Tissue Barriers 3, e982426, 2015.
  • Zeineldin M, A, Miller M, Sullivan R, L, and Neufeld K: Nuclear adenomatous polyposis coli suppresses colitis-associated tumorigenesis in mice. Carcinogenesis 35, 1881–1890, 2014.
  • Sheng YH, Hasnain SZ, Florin THJ, and McGuckin MA: Mucins in inflammatory bowel diseases and colorectal cancer. J Gastroenterol Hepatol 27, 28–38, 2012.
  • Cascio S, and Finn OJ: Complex of MUC1, CIN85 and Cbl in colon cancer progression and metastasis. Cancers (Basel) 7, 342–352, 2015.
  • Goyal R, Sharma PL, and Singh M: Possible attenuation of nitric oxide expression in anti-inflammatory effect of Ziziphus jujuba in rat. J Nat Med 65, 514–518, 2011.
  • Hammi KM, Hammami M, Rihouey C, Cerf DL, Ksouri R, and Majdoub H: Optimization extraction of polysaccharide from Tunisian Zizyphus lotus fruit by response surface methodology: composition and antioxidant activity. Food Chem 212, 476–484, 2016.
  • Li JW, Fan LP, and Ding SD: Isolation, purification and structure of a new water-soluble polysaccharide from Zizyphus jujuba cv. Jinsixiaozao. Carbohydr Polym 83, 477–482, 2011.
  • Wang Y, Liu X, Zhang J, Liu G, Liu Y, et al. Structural characterization and in vitro antitumor activity of polysaccharides from Zizyphus jujuba cv. Muzao. RSC Adv 5, 7860–7867, 2015.
  • Yue Y, Wu S, Zhang H, Zhang X, Niu Y, et al. Characterization and hepatoprotective effect of polysaccharides from Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou sarcocarp. Food Chem Toxicol 74, 76–84, 2014.
  • Dulai PS, Sandborn WJ, and Gupta S: Colorectal cancer and dysplasia in inflammatory bowel disease: a review of disease epidemiology, pathophysiology, and management. Cancer Prev Res (Phila) 9, 887–894, 2016.
  • O’Connor A, Qasim A, and O’MoráIn CA: The long-term risk of continuous immunosuppression using thioguanides in inflammatory bowel disease. Ther Adv Chronic Dis 1, 7–16, 2010.
  • Boland PM, and Ma WW: Immunotherapy for Colorectal Cancer. Cancers (Basel) 9, 50, 2017.
  • Sido A, Radhakrishnan S, Kim SW, Eriksson E, Shen F, et al. A food-based approach that targets interleukin-6, a key regulator of chronic intestinal inflammation and colon carcinogenesis. J Nutr Biochem 43, 11–17, 2017.
  • Luo WP, Fang YJ, Lu MS, Zhong X, Chen YM, and Zhang CX: High consumption of vegetable and fruit colour groups is inversely associated with the risk of colorectal cancer: a case-control study. Br J Nutr 113, 1129–1138, 2015.
  • Gao QH, Wu CS, and Wang M: The jujube (Ziziphus jujuba Mill.) fruit: a review of current knowledge of fruit composition and health benefits. J Agric Food Chem 61, 3351–3363, 2013.
  • Plastina P, Bonofiglio D, Vizza D, Fazio A, Rovito D, et al. Identification of bioactive constituents of Ziziphus jujube fruit extracts exerting antiproliferative and apoptotic effects in human breast cancer cells. J Ethnopharmacol 140, 325–332, 2012.
  • Choi S-H, Ahn J-B, Kim H-J, Im N-K, Kozukue N, et al. Changes in free amino acid, protein, and flavonoid content in jujube (Ziziphus jujube) fruit during eight stages of growth and antioxidative and cancer cell inhibitory effects by extracts. J Agric Food Chem 60, 10245–10255, 2012.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.