Metabolic Alterations Induced by Kudingcha Lead to Cancer Cell Apoptosis and Metastasis Inhibition

References

• Collignon J, Lousberg L, Schroeder H, and Jerusalem G: Triple-negative breast cancer: treatment challenges and solutions. Breast Cancer (Dove Med Press) 8, 93–107, 2016.
   PubMed Web of Science ®Google Scholar
• Guise TA, Kozlow WM, Heras-Herzig A, Padalecki SS, Yin JJ, et al. Molecular mechanisms of breast cancer metastases to bone. Clin Breast Cancer 5, S46–S53, 2005.
   PubMedGoogle Scholar
• Cleator S, Heller W, and Coombes RC: Triple-negative breast cancer: therapeutic options. The Lancet Oncol 8, 235–244, 2007.
   PubMed Web of Science ®Google Scholar
• De Marchi T, Foekens JA, Umar A, and Martens JW: Endocrine therapy resistance in estrogen receptor (ER)-positive breast cancer. Drug Discovery Today 21, 1181–1188, 2016.
   PubMed Web of Science ®Google Scholar
• DeBerardinis RJ, Lum JJ, Hatzivassiliou G, and Thompson CB: The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 7, 11–20, 2008.
   PubMed Web of Science ®Google Scholar
• Timmerman LA, Holton T, Yuneva M, Louie RJ, Padró M, et al. Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target. Cancer Cell 24, 450–465, 2013.
   PubMed Web of Science ®Google Scholar
• Kim S, Kim DH, Jung WH, and Koo JS: Metabolic phenotypes in triple-negative breast cancer. Tumor Biol 34, 1699–1712, 2013.
   PubMedGoogle Scholar
• Shen L, O’Shea JM, Kaadige MR, Cunha S, Wilde BR, et al. Metabolic reprogramming in triple-negative breast cancer through Myc suppression of TXNIP. Proc Natl Acad Sci USA 112, 5425–5430, 2015.
   PubMed Web of Science ®Google Scholar
• Alonso ÁM, Guillén DA, Barroso CG, Puertas B, García A, et al. Determination of antioxidant activity of wine byproducts and its correlation with polyphenolic content. J Agric Food Chem 50, 5832–5836, 2002.
   PubMed Web of Science ®Google Scholar
• Fan S, Zhang Y, Hu N, Sun Q, Ding X, et al. Extract of Kuding tea prevents high-fat diet-induced metabolic disorders in C57BL/6 mice via liver X receptor (LXR) β antagonism. PLoS One 7, e51007, 2012.
   PubMed Web of Science ®Google Scholar
• Song C, Xie C, Zhou Z, Yu S, and Fang N. Antidiabetic effect of an active components group from Ilex kudingcha and its chemical composition. Evid Based Complementary Altern Med: eCAM 2012, 12, 2012.
   Web of Science ®Google Scholar
• Zhu S, Jiang X, Jiang S, Lin G, Gong J, et al. GPR120 is not required for ω-3 PUFAs-induced cell growth inhibition and apoptosis in breast cancer cells . Cell Biol Int 42, 180–186, 2018.
   PubMed Web of Science ®Google Scholar
• Lin G, Zhu S, Wu Y, Song C, Wang W, et al. omega-3 free fatty acids and all-trans retinoic acid synergistically induce growth inhibition of three subtypes of breast cancer cell lines. Sci Rep 7, 2929, 2017.
   PubMed Web of Science ®Google Scholar
• Wang T, Zhang ZH, Wang K, et al. Inhibitory effects of BMP9 on breast cancer cells by regulating their interaction with pre-adipocytes/adipocytes. Oncotarget 8, 35890–35901, 2017.
   PubMedGoogle Scholar
• Zhu S, Ma L, Wu Y, Ye X, Zhang T, et al. FGF21 treatment ameliorates alcoholic fatty liver through activation of AMPK-SIRT1 pathway. Acta Biochim Biophys Sin 46, 1041–1048, 2014.
   Google Scholar
• Zhu S, Lin G, Song C, Wu Y, Feng N, et al. RA and omega-3 PUFA co-treatment activates autophagy in cancer cells. Oncotarget 8, 109135–109150, 2017.
   PubMedGoogle Scholar
• Zhu S, Feng N, Lin G, Tong Y, Jiang X, et al. Metabolic shift induced by omega-3 PUFAs and rapamycin lead to cancer cell death. Cell Physiol Biochem 48, 2318–2336, 2018.
   PubMedGoogle Scholar
• Evan GI, and Vousden KH: Proliferation, cell cycle and apoptosis in cancer. Nature 411, 342–348, 2001.
   PubMed Web of Science ®Google Scholar
• Acloque H, Adams MS, Fishwick K, Bronner-Fraser M, Nieto MA, et al. Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. J Clin Invest 119, 1438–1449, 2009.
   PubMed Web of Science ®Google Scholar
• Rhim AD, Mirek ET, Aiello NM, Maitra A, Bailey JM, et al. EMT and dissemination precede pancreatic tumor formation. Cell 148, 349–361, 2012.
   PubMed Web of Science ®Google Scholar
• Kalluri R: EMT: when epithelial cells decide to become mesenchymal-like cells. J Clin Invest 119, 1417–1419, 2009.
   PubMed Web of Science ®Google Scholar
• Yang L, Lee MM, Leung MM, and Wong YH: Regulator of G protein signaling 20 enhances cancer cell aggregation, migration, invasion and adhesion. Cell. Signalling 28, 1663–1672, 2016.
   PubMed Web of Science ®Google Scholar
• Zou P, Chen M, Ji J, Chen W, Chen X, et al. Auranofin induces apoptosis by ROS-mediated ER stress and mitochondrial dysfunction and displayed synergistic lethality with piperlongumine in gastric cancer. Oncotarget 6, 36505–36521, 2015.
   PubMedGoogle Scholar
• Li L, Xu LJ, Ma GZ, Dong YM, Peng Y, et al. The large-leaved Kudingcha (Ilex latifolia Thunb and Ilex kudingcha C.J. Tseng): a traditional Chinese tea with plentiful secondary metabolites and potential biological activities. J Nat Med 67, 425–437, 2013.
   PubMed Web of Science ®Google Scholar
• Hanahan D, and Weinberg RA: Hallmarks of cancer: the next generation. Cell 144, 646–674, 2011.
   PubMed Web of Science ®Google Scholar
• Vander Heiden MG, Cantley LC, and Thompson CB: Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324, 1029–1033, 2009.
   PubMed Web of Science ®Google Scholar
• Wu H, Chen Y-L, Yu Y, Zang J, Wu Y, et al. Ilex latifolia Thunb protects mice from HFD-induced body weight gain. Sci Rep 7, 14660, 2017.
   PubMed Web of Science ®Google Scholar
• Wang W, Weng Y, Ren W, et al. Biological roles of human bone morphogenetic protein 9 in the bone microenvironment of human breast cancer MDA-MB-231 cells. Am J Transl Res 7, 1660–1674, 2015.
   PubMed Web of Science ®Google Scholar
• Swede H, Gregorio DI, Tannenbaum SH, Brockmeyer JA, Ambrosone C, et al. Prevalence and prognostic role of triple-negative breast cancer by race: a surveillance study. Clin Breast Cancer 11, 332–341, 2011.
   PubMed Web of Science ®Google Scholar
• Fuentes-Mattei E, Velazquez-Torres G, Phan L, et al. Effects of obesity on transcriptomic changes and cancer hallmarks in estrogen receptor-positive breast cancer. J Natl Cancer Inst 106, 2014.
   PubMedGoogle Scholar
• Wahdan-Alaswad RS, Edgerton SM, Salem HS, and Thor AD: Metformin targets glucose metabolism in triple negative breast cancer. J Oncol Transl Res 4, 2018.
   PubMedGoogle Scholar
• Lian X, Wang G, Zhou H, Zheng Z, Fu Y, et al. Anticancer properties of fenofibrate: a repurposing use. J Cancer 9, 1527–1537, 2018.
   PubMed Web of Science ®Google Scholar
• Beckwitt CH, Brufsky A, Oltvai ZN, and Wells A: Statin drugs to reduce breast cancer recurrence and mortality. Breast Cancer Res 20, 2018.
   PubMed Web of Science ®Google Scholar
• Wu HL, Chen YL, Yu YY, et al. Ilex latifolia Thunb protects mice from HFD-induced body weight gain. Sci Rep 7, 2017.
   Google Scholar
• Warburg O: On the origin of cancer cells. Science 123, 309–314, 1956.
   PubMed Web of Science ®Google Scholar
• Hainaut P, and Plymoth A: Targeting the hallmarks of cancer: towards a rational approach to next-generation cancer therapy. Curr Opin Oncol 25, 50–51, 2013.
   PubMed Web of Science ®Google Scholar
• Yoshida S, Tsutsumi S, Muhlebach G, Sourbier C, Lee M-J, et al. Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis. Proc Natl Acad Sci USA 110, E1604–12, 2013.
   PubMed Web of Science ®Google Scholar
• Li L, Peng Y, Ma G, He C, Feng Y, et al. Quantitative analysis of five kudinosides in the large-leaved Kudingcha and related species from the genus Ilex by UPLC-ELSD. Phytochem Anal 23, 677–683, 2012.
   PubMed Web of Science ®Google Scholar