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Original Articles

Feasibility, Safety, and Beneficial Effects of MCT-Based Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Trial Study

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Pages 627-634 | Received 12 Feb 2019, Accepted 26 Jul 2019, Published online: 09 Sep 2019

References

  • Warburg O: On the origin of cancer cells. Science 123, 309–314, 1956.
  • Moreno-Sánchez R, Rodríguez-Enríquez S, Marín-Hernández A, and Saavedra E: Energy metabolism in tumor cells. FEBS J 274, 1393–1418, 2007.
  • DeBerardinis RJ, Sayed N, Ditsworth D, and Thompson CB: Brick by brick: metabolism and tumor cell growth. Curr Opin Genet Dev 18, 54–61, 2008.
  • Gatenby RA, Gawlinski ET, Gmitro AF, Kaylor B, and Gillies RJ: Acid-mediated tumor invasion: a multidisciplinary study. Cancer Res 66, 5216–5223, 2006.
  • King A and Gottlieb E: Glucose metabolism and programmed cell death: an evolutionary and mechanistic perspective. Curr Opin Cell Biol 21, 885–893, 2009.
  • Wright C and Simone NL: Obesity and tumor growth: inflammation, immunity, and the role of a ketogenic diet. Curr Opin Clin Nutr Metab Care 19, 294–299, 2016.
  • Schmidt M, Pfetzer N, Schwab M, Strauss I, and Kämmerer U: Effects of a ketogenic diet on the quality of life in 16 patients with advanced cancer: a pilot trial. Nutr Metab (Lond) 8, 54, 2011.
  • Klement RJ and Sweeney RA: Impact of a ketogenic diet intervention during radiotherapy on body composition: II. Protocol of a randomised phase I study (KETOCOMP). Clin Nutr Espen 12, e1–e6, 2016.
  • Tan-Shalaby JL, Carrick J, Edinger K, Genovese D, Liman AD, et al.: Modified Atkins diet in advanced malignancies-final results of a safety and feasibility trial within the Veterans Affairs Pittsburgh Healthcare System. Nutr Metab (Lond) 13, 52, 2016.
  • Zahra A, Fath MA, Opat E, Mapuskar KA, Bhatia SK, et al.: Consuming a ketogenic diet while receiving radiation and chemotherapy for locally advanced lung cancer and pancreatic cancer: the University of Iowa experience of two phase 1 clinical trials. Radiat Res 187, 743–754, 2017.
  • Rieger J, Bähr O, Maurer GD, Hattingen E, Franz K, et al.: ERGO: a pilot study of ketogenic diet in recurrent glioblastoma. Erratum in/ijo/45/6/2605. Int J Oncol 44, 1843–1852, 2014.
  • Zuccoli G, Marcello N, Pisanello A, Servadei F, Vaccaro S, et al.: Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: case report. Nutr Metab (Lond) 7, 33, 2010.
  • İyikesici MS, Slocum AK, Slocum A, Berkarda FB, Kalamian M, et al.: Efficacy of metabolically supported chemotherapy combined with ketogenic diet, hyperthermia, and hyperbaric oxygen therapy for stage IV triple-negative breast cancer. Cureus 9, e1445, 2017.
  • Tóth C and Clemens Z: Halted progression of soft palate cancer in a patient treated with the paleolithic ketogenic diet alone: a 20-months follow-up. Am J Med Case Rep 4, 288–292, 2016.
  • Elsakka A, Bary MA, Abdelzaher E, Elnaggar M, Kalamian M, et al.: Management of glioblastoma multiforme in a patient treated with ketogenic metabolic therapy and modified standard of care: a 24-month follow-up. Front Nutr 5, 20, 2018.
  • Klement RJ and Sweeney RA: Impact of a ketogenic diet intervention during radiotherapy on body composition: I. Initial clinical experience with six prospectively studied patients. BMC Res Notes 9, 143, 2016.
  • Vance V, Mourtzakis M, McCargar L, and Hanning R: Weight gain in breast cancer survivors: prevalence, pattern and health consequences. Obes Rev 12, 282–294, 2011.
  • Makari-Judson G, Braun B, Jerry DJ, and Mertens WC: Weight gain following breast cancer diagnosis: implication and proposed mechanisms. World J Clin Oncol 5, 272–282, 2014.
  • Thivat E, Thérondel S, Lapirot O, Abrial C, Gimbergues P, et al.: Weight change during chemotherapy changes the prognosis in non-metastatic breast cancer for the worse. BMC Cancer 10, 648, 2010.
  • Chlebowski RT, Aiello E, and McTiernan A: Weight loss in breast cancer patient management. J Clin Oncol 20, 1128–1143, 2002.
  • Playdon MC, Bracken MB, Sanft TB, Ligibel JA, Harrigan M, et al.: Weight gain after breast cancer diagnosis and all-cause mortality: systematic review and meta-analysis. J Natl Cancer Inst 107, djv275, 2015.
  • Poole EM, Tworoger SS, Hankinson SE, Schernhammer ES, Pollak MN, et al.: Body size in early life and adult levels of insulin-like growth factor 1 and insulin-like growth factor binding protein 3. Am J Epidemiol 174, 642–651, 2011.
  • Yu H and Rohan T: Role of the insulin-like growth factor family in cancer development and progression. J Natl Cancer Inst 92, 1472–1489, 2000.
  • Harvey AE, Lashinger LM, and Hursting SD: The growing challenge of obesity and cancer: an inflammatory issue. Ann N Y Acad Sci 1229, 45–52, 2011.
  • Georgiadis MS, Steinberg SM, Hankins LA, Ihde DC, and Johnson BE: Obesity and therapy-related toxicity in patients treated for small-cell lung cancer. J Natl Cancer Inst 87, 361–366, 1995.
  • Champ CE, Volek JS, Siglin J, Jin L, and Simone NL: Weight gain, metabolic syndrome, and breast cancer recurrence: are dietary recommendations supported by the data?. Int J Breast Cancer 2012, 506868, 2012.
  • Sherwin R, Hendler R, and Felig P: Effect of ketone infusions on amino acid and nitrogen metabolism in man. J Clin Invest 55, 1382–1390, 1975.
  • Khodadadi S, Sobhani N, Mirshekar S, Ghiasvand R, Pourmasoumi M, et al.: Tumor cells growth and survival time with the ketogenic diet in animal models: a systematic review. Int J Prev Med 25, 35, 2017.

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