PPAR Receptors Expressed from Vectors Containing CMV Promoter Can Enhance Self-Transcription in the Presence of Fatty Acids from CLA-Enriched Egg Yolks—A Novel Method for Studies of PPAR Ligands

References

• Kersten S, Desvergne B, and Wahli W: Roles of PPARs in health and disease. Nature 405, 421–424, 2000.
   PubMed Web of Science ®Google Scholar
• Schoonjans K, Staels B, and Auwerx J: Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J Lipid Res 37, 907–925, 1996.
   PubMed Web of Science ®Google Scholar
• Rauwel B, Mariamé B, Martin H, Nielsen R, Allart S, et al. Activation of peroxisome proliferator-activated receptor gamma by human cytomegalovirus for de novo replication impairs migration and invasiveness of cytotrophoblasts from early placentas. J Virol 84, 2946–2954, 2010.
   PubMed Web of Science ®Google Scholar
• Koronowicz AA, Banks P, Domagała D, Master A, Leszczyńska T, et al. Fatty acid extract from CLA-enriched egg yolks can mediate transcriptome reprogramming of MCF-7 cancer cells to prevent their growth and proliferation. Genes Nutr 11, 22, 2016.
   PubMed Web of Science ®Google Scholar
• Desvergne B and Wahli W: Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev 20, 649–688, 1999.
   PubMed Web of Science ®Google Scholar
• Berger J and Moller DE: The mechanisms of action of PPARs. Annu Rev Med 53, 409–435, 2002.
   PubMed Web of Science ®Google Scholar
• Dong J-T: Anticancer activities of PPARγ in breast cancer are context-dependent. Am J Pathol 182, 1972–1975, 2013.
   PubMed Web of Science ®Google Scholar
• Youssef J and Badr M: Peroxisome proliferator-activated receptors and cancer: challenges and opportunities. Br J Pharmacol 164, 68–82, 2011.
   PubMed Web of Science ®Google Scholar
• Koga H, Sakisaka S, Harada M, Takagi T, Hanada S, et al. Involvement of p21(WAF1/Cip1), p27(Kip1), and p18(INK4c) in troglitazone-induced cell-cycle arrest in human hepatoma cell lines. Hepatology 33, 1087–1097, 2001.
   PubMed Web of Science ®Google Scholar
• Motomura W, Okumura T, Takahashi N, Obara T, and Kohgo Y: Activation of peroxisome proliferator-activated receptor gamma by troglitazone inhibits cell growth through the increase of p27KiP1 in human pancreatic carcinoma cells. Cancer Res 60, 5558–5564, 2000.
   PubMed Web of Science ®Google Scholar
• Zaytseva YY, Wallis NK, Southard RC, and Kilgore MW: The PPARγ antagonist T0070907 suppresses breast cancer cell proliferation and motility via both PPARγ-dependent and -independent mechanisms. Anticancer Res 31, 813–823, 2011.
   PubMed Web of Science ®Google Scholar
• Lu W, Che P, Zhang Y, Li H, Zou S, et al. HL005 – a new selective PPARγ antagonist specifically inhibits the proliferation of MCF-7. J Steroid Biochem Mol Biol 124, 112–120, 2011.
   PubMed Web of Science ®Google Scholar
• Koronowicz AA, Banks P, Master A, Domagała D, Piasna-Słupecka E, et al. Fatty acids of CLA-enriched egg yolks can induce transcriptional activation of peroxisome proliferator-activated receptors in MCF-7 breast cancer cells. PPAR Res 2017, 2865283, 2017.
   PubMed Web of Science ®Google Scholar
• Gijsbers L, van Eekelen HD, de Haan LH, Swier JM, Heijink NL, et al. Induction of peroxisome proliferator-activated receptor γ (PPARγ)-mediated gene expression by tomato (Solanum lycopersicum L.) extracts. J Agric Food Chem 61, 3419–3427, 2013.
   PubMed Web of Science ®Google Scholar
• El Roz A, Bard JM, Huvelin JM, and Nazih H: The anti-proliferative and pro-apoptotic effects of the trans9, trans11 conjugated linoleic acid isomer on MCF-7 breast cancer cells are associated with LXR activation. Prostaglandins Leukot Essent Fatty Acids 88, 265–272, 2013.
   PubMed Web of Science ®Google Scholar
• Pierre AS, Minville-Walz M, Fèvre C, Hichami A, Gresti J, et al. Trans-10, cis-12 conjugated linoleic acid induced cell death in human colon cancer cells through reactive oxygen species-mediated ER stress. Biochim Biophys Acta 1831, 759–768, 2013.
   PubMed Web of Science ®Google Scholar
• Koronowicz AA, Dulińska-Litewka J, Pisulewski P, and Laidler P: Wpływ lipidów żółtka jaja kurzego wzbogaconego w izomery sprzężonego kwasu linolowego na proliferację komórek MCF-7. Żywnosc. Nauka. Technologia. Jakosc/Food Sci Technol Qual 16, 55–61, 2009. Polish.
   Google Scholar
• Lee KW, Lee HJ, Cho HY, and Kim YJ: Role of the conjugated linoleic acid in the prevention of cancer. Crit Rev Food Sci Nutr 45, 135–144, 2005.
   PubMed Web of Science ®Google Scholar
• Bhattacharya A, Banu J, Rahman M, Causey J, and Fernandes G: Biological effects of conjugated linoleic acids in health and disease. J Nutr Biochem 17, 789–810, 2006.
   PubMed Web of Science ®Google Scholar
• Ip C, Dong Y, Ip MM, Banni S, Carta G, et al. Conjugated linoleic acid isomers and mammary cancer prevention. Nutr Cancer 43, 52–58, 2002.
   PubMed Web of Science ®Google Scholar
• Bocca C, Bozzo F, Gabriel L, and Miglietta A: Conjugated linoleic acid inhibits Caco-2 cell growth via ERK-MAPK signaling pathway. J Nutr Biochem 18, 332–340, 2007.
   PubMed Web of Science ®Google Scholar
• Wan X, Yuan X, Yang X, Li Y, and Zhong L: Studies on mechanism of cis9,trans11-CLA and trans10,cis12-CLA inducing apoptosis of human breast cancer cell line MCF-7. Chin-Ger J Clin Oncol 9, 583–589, 2010.
   Google Scholar
• Lu G, Zhang G, Zheng X, Zeng Y, Xu Z, et al. c9,t11-conjugated linoleic acid induces HCC cell apoptosis and correlation with PPAR-γ signaling pathway. Am J Transl Res 7, 2752–2763, 2015.
   PubMed Web of Science ®Google Scholar
• Bozzo F, Bocca C, Colombatto S, and Miglietta A: Antiproliferative effect of conjugated linoleic acid in caco-2 cells: involvement of PPARγ and APC/β-catenin pathways. Chem Biol Interact 169, 110–121, 2007.
   PubMed Web of Science ®Google Scholar
• De La Torre A, Debiton E, Juanéda P, Durand D, Chardigny JM, et al. Beef conjugated linoleic acid isomers reduce human cancer cell growth even when associated with other beef fatty acids. Br J Nutr 95, 346–352, 2006.
   PubMed Web of Science ®Google Scholar
• Miller A, Stanton C, Murphy J, and Devery R: Conjugated linoleic acid (CLA)-enriched milk fat inhibits growth and modulates CLA-responsive biomarkers in MCF-7 and SW480 human cancer cell lines. Br J Nutr 90, 877, 2003.
   PubMed Web of Science ®Google Scholar
• Koronowicz AA, Banks P, Szymczyk B, Leszczyńska T, Master A, et al. Dietary conjugated linoleic acid affects blood parameters, liver morphology and expression of selected hepatic genes in laying hens. Br Poul Sci 57, 663–673, 2016.
   PubMed Web of Science ®Google Scholar
• Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method. Methods 25, 402–408, 2001.
   PubMed Web of Science ®Google Scholar
• Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schütz G, et al. The nuclear receptor superfamily: the second decade. Cell 83, 835–839, 1995.
   PubMed Web of Science ®Google Scholar
• Peters JM, Cheung C, and Gonzalez FJ: Peroxisome proliferator-activated receptor-α and liver cancer: where do we stand? J Mol Med 83, 774–785, 2005.
   PubMed Web of Science ®Google Scholar
• Suchanek KM, May FJ, Robinson JA, Lee WJ, Holman NA, et al. Peroxisome proliferator-activated receptor α in the human breast cancer cell lines MCF-7 and MDA-MB-231. Mol Carcinog 34, 165–171, 2002.
   PubMed Web of Science ®Google Scholar
• Chandran K, Goswami S, and Sharma-Walia N: Implications of a peroxisome proliferator-activated receptor alpha (PPARα) ligand clofibrate in breast cancer. Oncotarget 7, 15577–15599, 2016.
   PubMedGoogle Scholar
• Zhang N, Chu ES, Zhang J, Li X, Liang Q, et al. Peroxisome proliferator activated receptor alpha inhibits hepatocarcinogenesis through mediating NF-κB signaling pathway. Oncotarget 5, 8330–8340, 2014.
   PubMedGoogle Scholar
• Maggiora M, Oraldi M, Muzio G, and Canuto RA: Involvement of PPARα and PPARγ in apoptosis and proliferation of human hepatocarcinoma HepG2 cells. Cell Biochem Funct 28, 571–577, 2010.
   PubMed Web of Science ®Google Scholar
• Peters JM, Foreman JE, and Gonzalez FJ: Dissecting the role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) in colon, breast, and lung carcinogenesis. Cancer Metastasis Rev 30, 619–640, 2011.
   PubMed Web of Science ®Google Scholar
• Girroir EE, Hollingshead HE, Billin AN, Willson TM, Robertson GP, et al. Peroxisome proliferator-activated receptor-beta/delta (PPARβ/δ) ligands inhibit growth of UACC903 and MCF7 human cancer cell lines. Toxicology 243, 236–243, 2008.
   PubMed Web of Science ®Google Scholar
• Wang X, Wang G, Shi Y, Sun L, Gorczynski R, et al. PPAR-delta promotes survival of breast cancer cells in harsh metabolic conditions. Oncogenesis 5, e232, 2016.
   PubMed Web of Science ®Google Scholar
• Ham SA, Yoo T, Hwang JS, Kang ES, Lee WJ, et al. Ligand-activated PPARδ modulates the migration and invasion of melanoma cells by regulating Snail expression. Am J Cancer Res 4, 674–682, 2014.
   PubMed Web of Science ®Google Scholar
• Wang D, Ning W, Xie D, Guo L, and DuBois RN: Peroxisome proliferator-activated receptor δ confers resistance to peroxisome proliferator-activated receptor γ-induced apoptosis in colorectal cancer cells. Oncogene 31, 1013–1023, 2012.
   PubMed Web of Science ®Google Scholar
• Zheng ZH, Yang Y, Lu XH, Zhang H, Shui XX, et al. Mycophenolic acid induces adipocyte-like differentiation and reversal of malignancy of breast cancer cells partly through PPARγ. Eu J Pharmacol 658, 1–8, 2011.
   PubMed Web of Science ®Google Scholar
• Freudlsperger C, Moll I, Schumacher U, and Thies A: Anti-proliferative effect of peroxisome proliferator-activated receptor gamma agonists on human malignant melanoma cells in vitro. Anticancer Drugs 17, 325–332, 2006.
   PubMed Web of Science ®Google Scholar
• Sertznig P, Seifert M, Tilgen W, and Reichrath J: Present concepts and future outlook: function of peroxisome proliferator-activated receptors (PPARs) for pathogenesis, progression, and therapy of cancer. J Cell Physiol 212, 1–12, 2007.
   PubMed Web of Science ®Google Scholar
• Hojka A and Rapak A: Receptory aktywowane proliferatorami peroksysomów (PPAR). Właściwości antyproliferacyjne. Postepy Hig Med Dośw 65, 404–413, 2011. Polish.
   Google Scholar
• Cimini A, Cristiano L, Colafarina S, Benedetti E, Di Loreto S, et al. PPARγ-dependent effects of conjugated linoleic acid on the human glioblastoma cell line (ADF). Int J Cancer 117, 923–933, 2005.
   PubMed Web of Science ®Google Scholar
• Wang L and Wang ZY: The Wilms’ tumor suppressor WT1 induces estrogen-independent growth and anti-estrogen insensitivity in ER-positive breast cancer MCF7 cells. Oncol Rep 23, 1109–1117, 2010.
   PubMed Web of Science ®Google Scholar
• Voutila J, Saetrom P, Mintz P, Sun G, Alluin J, et al. Gene expression profile changes after short-activating RNA-mediated induction of endogenous pluripotency factors in human mesenchymal stem cells. Mol Ther Nucleic Acids 1, e35, 2012.
   PubMedGoogle Scholar
• Master A, Wójcicka A, Giżewska K, Popławski P, Williams GR, and Nauman A: A novel method for gene-specific enhancement of protein translation by targeting 5′-UTRs of selected tumor suppressors. PLoS One 11, e0155359, 2016.
   PubMed Web of Science ®Google Scholar
• Master A and Nauman A: THRB (thyroid hormone receptor, beta). Atlas Genet Cytogenet Oncol Haematol 18, 400–433, 2014.
   Google Scholar
• Master A, Wójcicka A, Piekiełko-Witkowska A, Bogusławska J, Popławski P, et al. Untranslated regions of thyroid hormone receptor beta 1 mRNA are impaired in human clear cell renal cell carcinoma. Biochim Biophys Acta 1802, 995–1005, 2010.
   PubMed Web of Science ®Google Scholar
• Miyamoto T, Kaneko A, Kakizawa T, Yajima H, Kamijo K, et al. Inhibition of peroxisome proliferator signaling pathways by thyroid hormone receptor. Competitive binding to the response element. J Biol Chem 272, 7752–7758, 1997.
   PubMed Web of Science ®Google Scholar