Higher Glucose Enhances Breast Cancer Cell Aggressiveness

References

• Siegel RL, Miller KD, and Jemal A: Cancer statistics, 2015. CA Cancer J Clin 65, 5–29, 2015.
   PubMed Web of Science ®Google Scholar
• Moreno-Sánchez R, Rodríguez-Enríquez S, Marín-Hernández A, and Saavedra E: Energy metabolism in tumor cells. FEBS J 274, 1393–1418, 2007.
   PubMed Web of Science ®Google Scholar
• Gillies RJ, Robey I, and Gatenby RA: Causes and consequences of increased glucose metabolism of cancers. J Nucl Med 49, 24–41, 2008.
   PubMed Web of Science ®Google Scholar
• Meienhofer M, Medicis E, Cognet M, and Kahn A: Regulation of genes for glycolytic enzymes in cultured rat hepatoma cell lines. Eur J Biochem 169, 237–243, 1987.
   PubMedGoogle Scholar
• Osthus RC, Shim H, Kim S, Li Q, Reddy R, et al.: Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc. J Biol Chem 275, 21797–21800, 2000.
   PubMed Web of Science ®Google Scholar
• Gatenby RA and Gillies RJ: Why do cancers have high aerobic glycolysis?. Nat Rev Cancer 4, 891–899, 2004.
   PubMed Web of Science ®Google Scholar
• Li Y, Song YH, Li F, Yang T, Lu YW, and Geng YJ: MicroRNA-221 regulates high glucose-induced endothelial dysfunction. Biochem Biophys Res Commun 381, 81–83, 2009.
   PubMed Web of Science ®Google Scholar
• Zhou X, Hurst RD, Templeton D, and Whiteside C: High glucose alters actin assembly in glomerular mesangial and epithelial cells. Lab Inv 3, 372–383, 1995.
   Google Scholar
• Kaverina I and Straube A: Regulation of cell migration by dynamic microtubules. Semin Cell Dev Biol 22, 968–974, 2011.
   PubMed Web of Science ®Google Scholar
• Masur K, Vetter C, Hinz A, Tomas N, Henrich H, et al.: Diabetogenic glucose and insulin concentrations modulate transcription and protein levels involved in tumour cell migration, adhesion and proliferation. Br J Cancer 104, 345–352, 2011.
   PubMed Web of Science ®Google Scholar
• Santos JM, Khan ZS, Munir MT, Tarafdar K, Rahman SM, and Hussain F: Vitamin D3 decreases glycolysis and invasiveness, and increases cellular stiffness in breast cancer cells. J Nutr Biochem 53, 11–20, 2018.
   Web of Science ®Google Scholar
• Suresh S: Biomechanics and biophysics of cancer cells. Act Mat 55, 3989–4014, 2007.
   Web of Science ®Google Scholar
• Lekka M, Pogoda K, Gostek J, Klymenko O, Prauzner-Bechcicki S, et al.: Cancer cell recognition-mechanical phenotype. Micron 43, 1259–1266, 2012.
   PubMed Web of Science ®Google Scholar
• Dolcet X, Llobet D, Pallares J, and Matias-Guiu X: NF-kB in development and progression of human cancer. Virchows Arch 446, 475–482, 2005.
   PubMed Web of Science ®Google Scholar
• Yu Y and Feng Y: The role of kinesin family proteins in tumorigenesis and progression: potential biomarkers and molecular targets for cancer therapy. Cancer 116, 5150–5160, 2010.
   PubMed Web of Science ®Google Scholar
• Beg AA and Baltimore D: An essential role for NF-kappa B in preventing TNF-alpha-induced cell death. Science 274, 782–784, 1996.
   PubMed Web of Science ®Google Scholar
• Woehlke G, Ruby AK, Hart CL, Ly B, Hom-Booher N, and Vale R: Microtubule interaction site of the kinesin motor. Cell 90, 207–216, 1997.
   PubMed Web of Science ®Google Scholar
• Kondaveeti Y, Reed IK, and White BA: Epithelial-mesenchymal transition induces similar metabolic alterations in two dependent breast cancer cell lines. Cancer Lett 364, 44–58, 2015.
   PubMed Web of Science ®Google Scholar
• Li L and Li W: Epithelial-mesenchymal transition in human cancer: comprehensive reprogramming of metabolism, epigenetics, and differentiation. Pharm Therap 150, 33–46, 2015.
   PubMed Web of Science ®Google Scholar
• Wick AN, Drury DR, Nakada HI, and Wolfe JB: With technical support of Britton B and Grabowski R. Localization of the primary metabolic block produced by 2-deoxyglucose. J Biol Chem 224, 963–969, 1957.
   PubMed Web of Science ®Google Scholar
• Han J, Zhang L, Guo H, Wysham WZ, Roque D, et al.: Glucose promotes cell proliferation, glucose uptake and invasion in endometrial cancer cells via AMPK/mTOR/S6 and MAPK signaling. Gyn Onc 138, 668–675, 2015.
   PubMed Web of Science ®Google Scholar
• Valster A, Tran NL, Nakada M, Berens ME, Chan AY, et al.: Cell migration and invasion assays. Methods 37, 208–215, 2005.
   PubMed Web of Science ®Google Scholar
• Santos JM, Martinez-Zaguilán R, Facanha AR, Hussain F, and Sennoune SR: Vacuolar H+-ATPase in the nuclear membranes regulates nucleo-cytosolic proton gradients. Am J Phys Cell Phys 311, C547–C558, 2016.
   PubMed Web of Science ®Google Scholar
• Santos JM and Hussain F: Magnesium chloride increases apoptosis and decreases prostate cancer cells migration. Funct Foods Health Dis 8, 62–78, 2018.
   Web of Science ®Google Scholar
• Khan ZS, Santos JM, and Hussain F: Aggressive prostate cancer cell nuclei have reduced stiffness. Biomicrofluidics 12, 014102, 2018.
   PubMed Web of Science ®Google Scholar
• Albini A, Iwamoto Y, Kleinman HK, Martin GR, Aaronson SA, et al.: A rapid in vitro assay for quantifying the invasive potential of tumor cells. Cancer Res 47, 3239–3245, 1987.
   PubMed Web of Science ®Google Scholar
• Jolly MK, Boareto M, Huang B, Jia D, Lu M, et al.: Implications of the hybrid epithelial/mesenchymal phenotype in metastasis. Front Oncol 5, 1–19, 2015.
   PubMed Web of Science ®Google Scholar
• Wahdan-Alaswad R, Fan Z, Edgerton SM, Liu B, Deng XS, et al.: Glucose promotes breast cancer aggression and reduces metformin efficacy. Cell Cycle 24, 3759–3769, 2013.
   Web of Science ®Google Scholar
• Macheda ML, Rogers S, and Best JD: Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer. J Cell Physiol 202, 654–662, 2005.
   PubMed Web of Science ®Google Scholar
• Bustamante E, Morris HP, and Pedersen PL: Energy metabolism of tumor cells. Requirement for a form of hexokinase with a propensity for mitochondrial binding. J Biol Chem 256, 8699–8704, 1981.
   PubMed Web of Science ®Google Scholar
• Rempel A, Mathupala SP, Griffin CA, Hawkins AL, and Pedersen PL: Glucose catabolism in cancer cells: amplification of the gene encoding type II hexokinase. Cancer Res 56, 2468–2471, 1996.
   PubMed Web of Science ®Google Scholar
• Katabi MM, Chan HLB, Karp SE, and Batist G: Hexokinase type II: a novel tumor-specific promoterfor gene-targeted therapy differentially expressed and regulated in human cancer cells. Human Gene Ther 10, 155–164, 1999.
   PubMed Web of Science ®Google Scholar
• Rho M, Kim J, Jee C, Lee YM, Lee HE, et al.: Expression of type 2 hexokinase and mitochondria-related genes in gastric carcinoma tissues and cell lines. Anticancer Res 27, 251–258, 2007.
   PubMed Web of Science ®Google Scholar
• Gatenby RA, Smallbone K, Maini PK, Rose F, Averill J, et al.: Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer. Br J Cancer 97, 646–653, 2007.
   PubMed Web of Science ®Google Scholar
• Yamaguchi H and Condeelis J: Regulation of the actin cytoskeleton in cancer cell migration and invasion. Biochim Biophys Acta 1773, 642–652, 2007.
   PubMed Web of Science ®Google Scholar
• Faria EC, Ma N, Gazi E, Gardner P, Brown M, et al.: Measurement of elastic properties of prostate cancer cells using AFM. Analyst 133, 1498–1500, 2008.
   PubMed Web of Science ®Google Scholar
• Swaminathan V, Mythreye K, O'Brien ET, Berchuck A, Blobe GC, et al.: Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines. Cancer Res 71, 5075–5080, 2011.
   PubMed Web of Science ®Google Scholar
• Huber MA, Zoitei N, Baumann B, Grünert S, Sommer A, et al.: NF-kB is essential for epithelial mesenchymal transition and metastasis in a model of breast cancer progression. J Clin Invest 114, 569–581, 2004.
   PubMed Web of Science ®Google Scholar
• Naugler WE and Karin M: NF-kB and cancer - identifying targets and mechanisms. Curr Opinion Genet Dev 18, 19–26, 2008.
   PubMed Web of Science ®Google Scholar
• Hirsch HA, Iliopoulos D, and Struhl K: Metformin inhibits the inflammatory response associated with cellular transformation and cancer stemcell growth. Proc Natl Acad Sci USA 110, 972–977, 2013.
   PubMed Web of Science ®Google Scholar
• Urruticoechea A, Smith I, and Dowsett M: Proliferation marker Ki-67 in early breast cancer. J Clin Oncol 23, 7212–7220, 2005.
   PubMed Web of Science ®Google Scholar
• Helbig G, Christopherson KW, Bhat-Nakshatri P, Kumar S, Kishimoto H, et al.: NF-kappaB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4. J Biol Chem 278, 21631–21638, 2003.
   PubMed Web of Science ®Google Scholar
• Vazquez-Martin A, Oliveras-Ferraros C, Cufí S, Del Barco S, Martin-Castillo B, et al.: Metformin regulates breast cancer stem cell ontogeny by transcriptional regulation of the epithelial mesenchymal transition (EMT) status. Cell Cycle 9, 3814–3831, 2010.
   Web of Science ®Google Scholar
• Hazan RB, Phillips GR, Qiao RF, Norton L, and Aaronson SA: Exogenous expression of N-cadherin in breast cancer cells induces cell migration. J Cell Biol 148, 779–790, 2000.
   PubMed Web of Science ®Google Scholar