484
Views
21
CrossRef citations to date
0
Altmetric
Original Article

Curcumin induces DNA damage by mediating homologous recombination mechanism in triple negative breast cancer

, , ORCID Icon, ORCID Icon &
Pages 1057-1066 | Received 10 May 2019, Accepted 15 Sep 2019, Published online: 01 Oct 2019

References

  • Dent R, Trudeau M, Pritchard KI, Hanna WM, Kahn HK, et al.: Triple-negative breast cancer: clinical features and patterns of recurrence. Clin Cancer Res 13, 4429–4434, 2007.
  • Foulkes WD, Smith IE, and Reis-Filho JS: Triple-negative breast cancer. N Engl J Med 363, 1938–1948, 2010.
  • Anders C and Carey LA: Understanding and treating triple-negative breast cancer. Oncology (Williston Park, NY) 22, 1233–1239, 2008.
  • Ma CX, Luo J, and Ellis MJ: Molecular profiling of triple negative breast cancer. Breast Dis 32, 73–84, 2010.
  • Sporikova Z, Koudelakova V, Trojanec R, and Hajduch M: Genetic markers in triple-negative breast cancer. Clin Breast Cancer 18, e841–e850, 2018.
  • Pareja F, Geyer FC, Marchiò C, Burke KA, Weigelt B, et al.: Triple-negative breast cancer: the importance of molecular and histologic subtyping, and recognition of low-grade variants. NPJ Breast Cancer 2, 16036, 2016.
  • Xie Y, Gou Q, Wang Q, Zhong X, and Zheng H: The role of BRCA status on prognosis in patients with triple-negative breast cancer. Oncotarget. 8, 87151–87162, 2017.
  • Maksimenko J, Irmejs A, Nakazawa-Miklasevica M, Melbarde-Gorkusa I, Trofimovics G, et al.: Prognostic role of BRCA1 mutation in patients with triple-negative breast cancer. Oncol Lett 7, 278–284, 2014.
  • Cousineau I, Abaji C, and Belmaaza A: BRCA1 regulates RAD51 function in response to DNA damage and suppresses spontaneous sister chromatid replication slippage: implications for sister chromatid cohesion, genome stability, and carcinogenesis. Cancer Res 65, 11384–11391, 2005.
  • Zhang J: The role of BRCA1 in homologous recombination repair in response to replication stress: significance in tumorigenesis and cancer therapy. Cell Biosci 3, 11, 2013.
  • Wu J, Lu LY, and Yu X: The role of BRCA1 in DNA damage response. Protein Cell 1, 117–123, 2010.
  • Sancar A, Lindsey-Boltz LA, Unsal-Kaçmaz K, and Linn S: Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem 73, 39–85, 2004.
  • Firsanov DV, Solovjeva LV, and Svetlova MP: H2AX phosphorylation at the sites of DNA double-strand breaks in cultivated mammalian cells and tissues. Clin Epigenetics 2, 283–297, 2011.
  • Podhorecka M, Skladanowski A, and Bozko P: H2AX phosphorylation: Its role in DNA damage response and cancer therapy. J Nucleic Acids 2010, 2010. doi:10.4061/2010/920161
  • Bouchard VJ, Rouleau M, and Poirier GG: PARP-1, a determinant of cell survival in response to DNA damage. Exp Hematol 31, 446–454, 2003.
  • Ko HL and Ren EC: Functional aspects of PARP1 in DNA repair and transcription. Biomolecules 2, 524–548, 2012.
  • Hewlings S and Kalman D: Curcumin: a review of its’ effects on human health. Foods 6, 2017. doi:10.3390/foods6100092
  • Perrone D, Ardito F, Giannatempo G, Dioguardi M, Troiano G, et al.: Biological and therapeutic activities, and anticancer properties of curcumin. Exp Ther Med 10, 1615–1623, 2015.
  • Panda AK, Chakraborty D, Sarkar I, Khan T, and Sa G: New insights into therapeutic activity and anticancer properties of curcumin. JEP 31, 31–45, 2017.
  • Liu D and Chen Z: The effect of curcumin on breast cancer cells. J Breast Cancer 16, 133–137, 2013.
  • Song X, Zhang M, Dai E, and Luo Y: Molecular targets of curcumin in breast cancer (Review). Mol Med Rep 19, 23–29, 2019.
  • Banik U, Parasuraman S, Adhikary AK, and Othman NH: Curcumin: the spicy modulator of breast carcinogenesis. J Exp Clin Cancer Res 36, 98, 2017.
  • Wang Y, Yu J, Cui R, Lin J, and Ding X: Curcumin in treating breast cancer: a review. J Lab Autom 21, 723–731, 2016.
  • Ogiwara H, Ui A, Shiotani B, Zou L, Yasui A, and Kohno T: Curcumin suppresses multiple DNA damage response pathways and has potency as a sensitizer to PARP inhibitor. Carcinogenesis 34, 2486–2497, 2013.
  • Rowe DL, Ozbay T, O'Regan RM, and Nahta R: Modulation of the BRCA1 protein and induction of apoptosis in triple negative breast cancer cell lines by the polyphenolic compound curcumin. Breast Cancer (Auckl) 2, 61–75, 2009.
  • Cridge BJ, Larsen L, and Rosengren RJ: Curcumin and its derivatives in breast cancer: current developments and potential for the treatment of drug-resistant cancers. Oncol Discov 1, 6, 2013.
  • Lai HW, Chien SY, Kuo SJ, Tseng LM, Lin HY, et al.: The potential utility of curcumin in the treatment of HER-2-overexpressed breast cancer: an in vitro and in vivo comparison study with herceptin. Evid Based Complement Alternat Med 2012, 486568, 2012.
  • Prakash R, Zhang Y, Feng W, and Jasin M: Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins. Cold Spring Harb Perspect Biol 7, a016600, 2015.
  • Gachechiladze M, Škarda J, Soltermann A, and Joerger M: RAD51 as a potential surrogate marker for DNA repair capacity in solid malignancies. Int J Cancer 141, 1286–1294, 2017.
  • Krum SA, Dalugdugan l. R, Ed, Miranda-Carboni GA, and Lane TF: BRCA1 forms a functional complex with γ-H2AX as a late response to genotoxic stress. J Nucleic Acids 2010, 2010.
  • Guney Eskiler G, Cecener G, Egeli U, and Tunca B: Triple negative breast cancer: new therapeutic approaches and BRCA status. APMIS 126, 371–379, 2018.
  • Young SR, Pilarski RT, Donenberg T, Shapiro C, Hammond LS, et al.: The prevalence of BRCA1 mutations among young women with triple-negative breast cancer. BMC Cancer 9, 86, 2009.
  • Brouckaert O, Wildiers H, Floris G, and Neven P: Update on triple‐negative breast cancer: prognosis and management strategies. Int J Womens Health 4, 511–520, 2012.
  • Zhao Q, Guan J, Qin Y, Ren P, Zhang Z, et al.: Curcumin sensitizes lymphoma cells to DNA damage agents through regulating Rad51-dependent homologous recombination. Biomed Pharmacother 97, 115–119, 2018.
  • Nikoletopoulou V, Markaki M, Palikaras K, and Tavernarakis N: Crosstalk between apoptosis, necrosis and autophagy. Biochim Biophys Acta 1833, 3448–3459, 2013.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.