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Article

Protective Effect of Chrysin, a Dietary Flavone against Genotoxic and Oxidative Damage Induced by Mitomycin C in Balb/C Mice

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Pages 329-338 | Received 02 May 2019, Accepted 24 Mar 2020, Published online: 09 Apr 2020

References

  • Loibl S, von Minckwitz G, Schwedler K, Schmidt KA, Hoper D, Kaufmann M, Costa SD. Mitomycin C, 5-fluorouracil and folinic acid (Mi-Fu-Fo) as salvage chemotherapy in breast cancer patients with liver metastases and impaired hepatic function: a phase II study. Anticancer Drugs. 2004;15:719–24.
  • Gnad-Vogt SU, Hofheinz RD, Saussele S, Kreil S, Willer A, Willeke F, Pilz L, Hehlmann R, Hochhaus A. Pegylated liposomal doxorubicin and mitomycin C in combination with infusional 5-fluorouracil and sodium folinic acid in the treatment of advanced gastric cancer: results of a phase II trial. Anticancer Drugs. 2005;16:435–40.
  • Tomasz M. Mitomycin C: small, fast and deadly (but very selective). Chem Biol. 1995;2(9):575–9. doi:10.1016/1074-5521(95)90120-5
  • Grisolia CK. A comparison between mouse and fish micronucleus test using cyclophosphamide, mitomycin C and various pesticides. Mutation Res/Genetic Toxicol Environ Mutagen. 2002;518(2):145–50. doi:10.1016/S1383-5718(02)00086-4
  • Pawar AA, Vikram A, Tripathi DN, Padmanabhan S, Ramarao P, et al. Modulation of mitomycin C-induced genotoxicity by acetyl- and thio- analogues of salicylic acid. In Vivo. 2009;23:303–7.
  • Offord E, van Poppel G, Tyrrell R. Markers of oxidative damage and antioxidant protection: current status and relevance to disease. Free Radic Res. 2000;33(Suppl):S5–S19.
  • Ortega-Gutiérrez S, López-Vicente M, Lostalé F, Fuentes-Broto L, Martínez-Ballarín E, García JJ. Protective effect of melatonin against mitomycin C-induced genotoxic damage in peripheral blood of rats. J Biomed Biotechnol. 2009;2009:1–6. doi:10.1155/2009/791432
  • Sontakke YA, Fulzele R. Cytogenetic study on genotoxicity of antitumor-antibiotic Mitomycin C. Biomedical Research. 2009;20(1):40–44.
  • Mokdad Bzeouich I, Mustapha N, Maatouk M, Ghedira K, Ghoul M, Chekir-Ghedira L. Genotoxic and anti-genotoxic effects of esculin and its oligomer fractions against mitomycin C-induced DNA damages in mice. Regul Toxicol Pharm. 2016;82:48–52. doi:10.1016/j.yrtph.2016.11.002
  • Rjiba-Touati K, Ayed-Boussema I, Guedri Y, Achour A, Bacha H, Abid S. Role of recombinant human erythropoietin in mitomycin C-induced genotoxicity: analysis of DNA fragmentation, chromosome aberrations and micronuclei in rat bone-marrow cells. Mutat Res. 2013;753(1):48–53. doi:10.1016/j.mrgentox.2012.12.011
  • Rjiba-Touati K, Ayed-Boussema I, Soualeh N, Achour A, Bacha H, Abid S. Antioxidant and antigenotoxic role of recombinant human erythropoeitin against alkylating agents: cisplatin and mitomycin C in cultured Vero cells. Exp Biol Med (Maywood). 2013;238(8):943–50. doi:10.1177/1535370213494643
  • Bodduluru LN, Kasala ER, Thota N, Barua CC, Sistla R. Chemopreventive and therapeutic effects of nimbolide in cancer: the underlying mechanisms. Toxicol in Vitro. 2014;28(5):1026–35. doi:10.1016/j.tiv.2014.04.011
  • Bokulić A, Garaj-Vrhovac V, Brajša K, Ðurić K, Glojnarić I, Šitum K. The effect of apigenin on cyclophosphamide and doxorubicin genotoxicity in vitro and in vivo. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2011;46(5):526–33. doi:10.1080/10934529.2011.551744
  • Aranganathan S, Nalini N. Efficacy of the potential chemopreventive agent, hesperetin (citrus flavanone), on 1, 2-dimethylhydrazine induced colon carcinogenesis. Food Chem Toxicol. 2009;47(10):2594–600. doi:10.1016/j.fct.2009.07.019
  • Kasala ER, Bodduluru LN, Barua CC, Madhana RM, Dahiya V, Budhani MK, Mallugari RR, Maramreddy SR, Gogoi R. Chemopreventive effect of chrysin, a dietary flavone against benzo (a) pyrene induced lung carcinogenesis in Swiss albino mice. Pharmacol Rep. 2016;68(2):310–8. doi:10.1016/j.pharep.2015.08.014
  • Barbaric M, Miskovic K, Bojic M, Loncar MB, Smolcic-Bubalo A. Chemical composition of the ethanolic propolis extracts and its effect on HeLa cells. J Ethnopharmacol. 2011;135:772–8. doi:10.1016/j.jep.2011.04.015
  • Pichichero E, Cicconi R, Mattei M, Muzi MG, Canini A. Acacia honey and chrysin reduce proliferation of melanoma cells through alterations in cell cycle progression. Int J Oncol. 2010;37:973–81. doi:10.3892/ijo_00000748
  • Khan R, Khan AQ, Qamar W, Lateef A, Tahir M, Rehman MU, Ali F, Sultana S. Chrysin protects against cisplatin-induced colon. toxicity via amelioration of oxidative stress and apoptosis: probable role of p38MAPK and p53. Toxicol Appl Pharmacol. 2012;258(3):315–29. doi:10.1016/j.taap.2011.11.013
  • Jiang Y, Gong FL, Zhao GB, Li J. Chrysin suppressed inflammatory responses and the inducible nitric oxide synthase pathway after spinal cord injury in rats. IJMS. 2014;15(7):12270–9. doi:10.3390/ijms150712270
  • Ryu S, Lim W, Bazer FW, Song G. Chrysin induces death of prostate cancer cells by inducing ROS and ER stress. J Cell Physiol. 2017;232(12):3786–97. doi:10.1002/jcp.25861
  • Samarghandian S, Nezhad MA, Mohammadi G. Role of caspases, Bax and Bcl-2 in chrysin-induced apoptosis in the A549 human lung adenocarcinoma epithelial cells. ACAMC. 2014;14(6):901–9. doi:10.2174/1871520614666140209144042
  • Zhang Q, Ma S, Liu BIN, Liu JIE, Zhu R, Li M. Chrysin induces cell apoptosis via activation of the p53/Bcl-2/caspase-9 pathway in hepatocellular carcinoma cells. Exp Ther Med. 2016;12(1):469–74. doi:10.3892/etm.2016.3282
  • Pushpavalli G, Kalaiarasi P, Veeramani C, Pugalendi KV. Effect of chrysin on hepatoprotective and antioxidant status in D-galactosamine-induced hepatitis in rats. Eur J Pharmacol. 2010;631(1-3):36–41. doi:10.1016/j.ejphar.2009.12.031
  • Kasala ER, Bodduluru LN, Madana RM, V AK, Gogoi R, Barua CC. Chemopreventive and therapeutic potential of chrysin in cancer: mechanistic perspectives. Toxicol Lett. 2015;233(2):214–25. doi:10.1016/j.toxlet.2015.01.008
  • Lee YJ, Chung HY, Kwak HK, Yoon S. The effects of A. senticosus supplementation on serum lipid profiles, biomarkers of oxidative stress, and lymphocyte DNA damage in postmenopausal women. Biochem Biophys Res Commun. 2008;375(1):44–8. doi:10.1016/j.bbrc.2008.07.097
  • Collins AR, Dobson VL, Dušinská M, Kennedy G, Štětina R. The comet assay: what can it really tell us?. Mutat Res. 1997;375(2):183–93. doi:10.1016/S0027-5107(97)00013-4
  • Waters MD, Brady AL, Stack HF, Brockman HE. Antimutagenicity profiles for some model compounds. Mutat Res. 1990;238(1):57–85. doi:10.1016/0165-1110(90)90039-E
  • Soumaya K-J, Dhekra M, Fadwa C, Zied G, Ilef L, Kamel G, Leila C-G. Pharmacological, antioxidant, genotoxic studies and modulation of rat splenocyte functions by Cyperus rotundus extracts. BMC Complement Altern Med. 2013;13(1):28. doi:10.1186/1472-6882-13-28
  • Madrigal-Bujaidar E, Barriga SD, Cassani M, Marquez P, Revuelta P. In vivo and in vitro antigenotoxic effect of nordihydroguaiaretic acid against SCEs induced by methyl methanesulfonate. Mutation Res/Genetic Toxicol Environ Mutagenesis. 1998;419(1–3):163–8. doi:10.1016/S1383-5718(98)00128-4
  • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72(1–2):248–54. doi:10.1016/0003-2697(76)90527-3
  • Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95(2):351–8. doi:10.1016/0003-2697(79)90738-3
  • Jollow DJ, Mitchell JR, Zampaglione N, Gillette JR. Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite. Pharmacology. 1974;11(3):151–69. doi:10.1159/000136485
  • Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG. Selenium: biochemical role as a component of glutathione peroxidase. Science. 1973;179(4073):588–90. doi:10.1126/science.179.4073.588
  • Habig WH, Pabst MJ, Jakoby WB. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem. 1974;249:7130–9.
  • Beauchamp C, Fridovich I. Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. Anal Biochem. 1971;44(1):276–87. doi:10.1016/0003-2697(71)90370-8
  • Claiborne A. Catalase activity. In CRC handbook of methods for oxygen radical research; 1985; vol. 1, p. 283–4.
  • Meadows AT, Baum E, Fossati-Bellani F, Green D, Jenkin RD, Marsden B, Nesbit M, Newton W, Oberlin O, Sallan SG. Second malignant neoplasms in children: an update from the Late Effects Study Group. JCO. 1985;3(4):532–8. doi:10.1200/JCO.1985.3.4.532
  • Aydemir N, Çelikler S, Bilaloğlu R. In vitro genotoxic effects of the anticancer drug gemcitabine in human lymphocytes. Mutation Res/Gen Toxicol Environ Mutagenesis. 2005;582(1-2):35–41. doi:10.1016/j.mrgentox.2004.12.013
  • Jia WZ, Zhao JC, Sun XL, Yao ZG, Wu HL. Additive anticancer effects of chrysin and low dose cisplatin in human malignant glioma cell (U87) proliferation and evaluation of the mechanistic pathway. J Buon. 2015;20:1327–36.
  • Siddique YH, Beg T, Afzal M. Antigenotoxic effect of apigenin against anti-cancerous drugs. Toxicol in Vitro. 2008;22(3):625–31. doi:10.1016/j.tiv.2007.12.002
  • Dulout FN, Pastori MC, Olivero OA. Malathion-induced chromosomal aberrations in bone-marrow cells of mice: dose-response relationships. Mutat Res. 1983;122(2):163–7. doi:10.1016/0165-7992(83)90055-6
  • Tucker JD, Preston RJ. Chromosome aberrations, micronuclei, aneuploidy, sister chromatid exchanges, and cancer risk assessment. Mutat Res. 1996;365(1-3):147–59. doi:10.1016/S0165-1110(96)90018-4
  • Trivedi P, Kushwaha S, Tripathi D, Jena G. Cardioprotective effects of hesperetin against doxorubicin-induced oxidative stress and DNA damage in rat. Cardiovasc Toxicol. 2011;11(3):215–25. doi:10.1007/s12012-011-9114-2
  • Siddique YH, Afzal M. Antigenotoxic effect of apigenin against mitomycin C induced genotoxic damage in mice bone marrow cells. Food Chem Toxicol. 2009;47(3):536–9. doi:10.1016/j.fct.2008.12.006
  • Teebor GW, Boorstein RJ, Cadet J. The repairability of oxidative free radical mediated damage to DNA: a review. Int J Radiat Biol. 1988;54(2):131–50. doi:10.1080/09553008814551591
  • Abbas T, Olivier M, Lopez J, Houser S, Xiao G, Kumar GS, Tomasz M, Bargonetti J. Differential activation of p53 by the various adducts of mitomycin C. J Biol Chem. 2002;277(43):40513–9. doi:10.1074/jbc.M205495200
  • Shi X, Liao S, Mi H, Guo C, Qi D, Li F, Zhang C, Yang Z. Hesperidin prevents retinal and plasma abnormalities in streptozotocin-induced diabetic rats. Molecules. 2012;17(11):12868–81. doi:10.3390/molecules171112868
  • Dincer Y, Akcay T, Alademir Z, Ilkova H. Effect of oxidative stress on glutathione pathway in red blood cells from patients with insulin-dependent diabetes mellitus. Metabolism. 2002;51(10):1360–2. doi:10.1053/meta.2002.35192
  • Premkumar K, Pachiappan A, Abraham SK, Santhiya ST, Gopinath PM, Ramesh A. Effect of Spirulina fusiformis on cyclophosphamide and mitomycin-C induced genotoxicity and oxidative stress in mice. Fitoterapia. 2001;72(8):906–11. doi:(01)00340-9 doi:10.1016/S0367-326X(01)00340-9
  • Kamaraj S, Ramakrishnan G, Anandakumar P, Jagan S, Devaki T. Antioxidant and anticancer efficacy of hesperidin in benzo(a)pyrene induced lung carcinogenesis in mice. Invest New Drugs. 2009;27(3):214–22. doi:10.1007/s10637-008-9159-7
  • Cao G, Sofic E, Prior RL. Antioxidant and prooxidant behavior of flavonoids: structure-activity relationships. Free Radic Biol Med. 1997;22(5):749–60. doi:10.1016/S0891-5849(96)00351-6

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