Hydroxytyrosol and Oleuropein Inhibit Migration and Invasion via Induction of Autophagy in ER-Positive Breast Cancer Cell Lines (MCF7 and T47D)

References

• Ruocco N, Costantini S, Guariniello S, Costantini M. Polysaccharides from the marine environment with pharmacological, cosmeceutical and nutraceutical potential. Molecules. 2016; 21(5):551. doi:10.3390/molecules21050551
   PubMed Web of Science ®Google Scholar
• Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ, He J. Cancer statistics in China, 2015. CA Cancer J Clin. 2016; 66(2):115–32. doi:10.3322/caac.21338
   PubMed Web of Science ®Google Scholar
• Abu-Dahab R, et al. Mechanistic studies of antiproliferative effects of Salvia triloba and Salvia dominica (Lamiaceae) on breast cancer cell lines (MCF7 and T47D). Z Naturforsch C. 2014; 69(11-12):443–51.
   PubMed Web of Science ®Google Scholar
• Lu R, Hu X, Zhou J, Sun J, Zhu AZ, Xu X, Zheng H, Gao X, Wang X, Jin H, et al. COPS5 amplification and overexpression confers tamoxifen-resistance in ERalpha-positive breast cancer by degradation of NCoR. Nat Commun. 2016;7(1):12044., doi:10.1038/ncomms12044
   PubMed Web of Science ®Google Scholar
• Love RR, Young GS, Laudico AV, Van Dinh N, Uy GB, Quang LH, De La Peña AS, Dofitas RB, Bisquera OC, Siguan SSS, et al. Bone mineral density following surgical oophorectomy and tamoxifen adjuvant therapy for breast cancer. Cancer. 2013; 119(21):3746–52. doi:10.1002/cncr.28302
   PubMed Web of Science ®Google Scholar
• Shanmugam MK, Arfuso F, Kumar AP, Wang L, Goh BC, Ahn KS, Bishayee A, Sethi G. Modulation of diverse oncogenic transcription factors by thymoquinone, an essential oil compound isolated from the seeds of Nigella sativa Linn. Pharmacol Res. 2018; 133:213–4. doi:10.1016/j.phrs.2018.05.004
   PubMed Web of Science ®Google Scholar
• Bishayee A, Sethi G. Bioactive natural products in cancer prevention and therapy: progress and promise. Semin Cancer Biol. 2016; 40-41:1–3. doi:10.1016/j.semcancer.2016.08.006
   PubMed Web of Science ®Google Scholar
• Psaltopoulou T, Kosti RI, Haidopoulos D, Dimopoulos M, Panagiotakos DB. Olive oil intake is inversely related to cancer prevalence: a systematic review and a meta-analysis of 13,800 patients and 23,340 controls in 19 observational studies. Lipids Health Dis. 2011;10(1):127.
   PubMed Web of Science ®Google Scholar
• Casaburi I, Puoci F, Chimento A, Sirianni R, Ruggiero C, Avena P, Pezzi V. Potential of olive oil phenols as chemopreventive and therapeutic agents against cancer: a review of in vitro studies. Mol Nutr Food Res. 2013; 57(1):71–83. doi:10.1002/mnfr.201200503
   PubMed Web of Science ®Google Scholar
• Shamshoum H, Vlavcheski F, Tsiani E. Anticancer effects of oleuropein. Biofactors. 2017; 43(4):517–28. doi:10.1002/biof.1366
   PubMed Web of Science ®Google Scholar
• Han J, Talorete TPN, Yamada P, Isoda H. Anti-proliferative and apoptotic effects of oleuropein and hydroxytyrosol on human breast cancer MCF-7 cells. Cytotechnology. 2009; 59(1):45–53. doi:10.1007/s10616-009-9191-2
   PubMed Web of Science ®Google Scholar
• Elamin MH, Daghestani MH, Omer SA, Elobeid MA, Virk P, Al-Olayan EM, Hassan ZK, Mohammed OB, Aboussekhra A. Olive oil oleuropein has anti-breast cancer properties with higher efficiency on ER-negative cells. Food Chem Toxicol. 2013; 53:310–6. doi:10.1016/j.fct.2012.12.009
   PubMed Web of Science ®Google Scholar
• Cruz-Lozano M, González-González A, Marchal JA, Muñoz-Muela E, Molina MP, Cara FE, Brown AM, García-Rivas G, Hernández-Brenes C, Lorente JA, et al. Hydroxytyrosol inhibits cancer stem cells and the metastatic capacity of triple-negative breast cancer cell lines by the simultaneous targeting of epithelial-to-mesenchymal transition, Wnt/beta-catenin and TGFbeta signaling pathways. Eur J Nutr. 2019;58(8):3207–19. doi:10.1007/s00394-018-1864-1
   PubMed Web of Science ®Google Scholar
• Lu HY, et al. Hydroxytyrosol and Oleuropein Inhibit Migration and Invasion of MDA-MB-231 Triple-Negative Breast Cancer Cell via Induction of Autophagy. Anticancer Agents Med Chem, 2019;19(16):1983–90. doi: 10.2174/1871520619666190722101207
   Google Scholar
• Ozpolat B, Benbrook DM. Targeting autophagy in cancer management - strategies and developments. Cancer Manag Res. 2015;7:291–9. doi:10.2147/CMAR.S34859
   PubMed Web of Science ®Google Scholar
• Goldsmith J, Levine B, Debnath J. Autophagy and cancer metabolism. Meth Enzymol. 2014; 542:25–57. doi:10.1016/B978-0-12-416618-9.00002-9
   PubMed Web of Science ®Google Scholar
• Dalby K, Tekedereli I, Lopez-Berestein G, Ozpolat B. Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer. Autophagy. 2010;6(3):322–9. doi:10.4161/auto.6.3.11625
   PubMed Web of Science ®Google Scholar
• Mizushima N. The exponential growth of autophagy-related research: from the humble yeast to the Nobel Prize. FEBS Lett. 2017;591(5):681–9. doi:10.1002/1873-3468.12594
   PubMed Web of Science ®Google Scholar
• Pantano D, Luccarini I, Nardiello P, Servili M, Stefani M, Casamenti F. Oleuropein aglycone and polyphenols from olive mill waste water ameliorate cognitive deficits and neuropathology. Br J Clin Pharmacol. 2017; 83(1):54–62. doi:10.1111/bcp.12993
   PubMed Web of Science ®Google Scholar
• Cordero JG, García-Escudero R, Avila J, Gargini R, García-Escudero V. Benefit of oleuropein aglycone for alzheimer’s disease by promoting autophagy. Oxid Med Cell Longev. 2018; 2018:1–12. doi:10.1155/2018/5010741
   Web of Science ®Google Scholar
• Zhi L-Q, Yao S-X, Liu H-L, Li M, Duan N, Ma J-B. Hydroxytyrosol inhibits the inflammatory response of osteoarthritis chondrocytes via SIRT6-mediated autophagy. Mol Med Rep. 2018; 17(3):4035–42. doi:10.3892/mmr.2017.8353
   PubMed Web of Science ®Google Scholar
• Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA A Cancer Journal for Clinicians. 2014; 64(1):9–29. doi:10.3322/caac.21208
   PubMed Web of Science ®Google Scholar
• Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin. 2013; 63(1):11–30. doi:10.3322/caac.21166
   PubMed Web of Science ®Google Scholar
• Li Y, Jiang B, Zhu H, Qu X, Zhao L, Tan Y, Jiang Y, Liao M, Wu X. Inhibition of long non-coding RNA ROR reverses resistance to Tamoxifen by inducing autophagy in breast cancer. Tumour Biol. 2017; 39(6):101042831770579. p. 1010428317705790. doi:10.1177/1010428317705790
   Google Scholar
• Matysiak M, Kapka-Skrzypczak L, Jodłowska-Jędrych B, Kruszewski M. EMT promoting transcription factors as prognostic markers in human breast cancer. Arch Gynecol Obstet. 2017; 295(4):817–25. doi:10.1007/s00404-017-4304-1
   PubMed Web of Science ®Google Scholar
• Salem Y, Yacov N, Propheta-Meiran O, Breitbart E, Mendel I. Newly characterized motile sperm domain-containing protein 2 promotes human breast cancer metastasis. Int J Cancer. 2019; 144(1):125–35. doi:10.1002/ijc.31665
   PubMed Web of Science ®Google Scholar
• Li L-L, Xue A-M, Li B-X, Shen Y-W, Li Y-H, Luo C-L, Zhang M-C, Jiang J-Q, Xu Z-D, Xie J-H, et al. Erratum to: JMJD2A contributes to breast cancer progression through transcriptional repression of the tumor suppressor ARHI. Breast Cancer Res. 2016; 18(1):114. doi:10.1186/s13058-016-0776-3
   PubMed Web of Science ®Google Scholar
• Pavan S, Meyer-Schaller N, Diepenbruck M, Kalathur RKR, Saxena M, Christofori G. A kinome-wide high-content siRNA screen identifies MEK5-ERK5 signaling as critical for breast cancer cell EMT and metastasis. Oncogene. 2018; 37(31):4197–213. doi:10.1038/s41388-018-0270-8
   PubMed Web of Science ®Google Scholar
• Insua-Rodriguez J, et al. Stress signaling in breast cancer cells induces matrix components that promote chemoresistant metastasis. EMBO Mol Med. 2018; 10(10): e9003. doi:10.15252/emmm.201809003
   PubMed Web of Science ®Google Scholar
• Mowers EE, Sharifi MN, Macleod KF. Autophagy in cancer metastasis. Oncogene. 2017; 36(12):1619–30. doi:10.1038/onc.2016.333
   PubMed Web of Science ®Google Scholar
• Han Y, Fan S, Qin T, Yang J, Sun Y, Lu Y, Mao J, Li L. Role of autophagy in breast cancer and breast cancer stem cells (review). Int J Oncol. 2018; 52(4):1057–70. doi:10.3892/ijo.2018.4270
   PubMed Web of Science ®Google Scholar
• Guo Y, Pei X. Tetrandrine-induced autophagy in MDA-MB-231 triple-negative breast cancer cell through the inhibition of PI3K/AKT/mTOR signaling. Evid Based Complement Alternat Med. 2019; 2019:1–11. doi:10.1155/2019/7517431
   Web of Science ®Google Scholar
• Jia L, Huang S, Yin X, Zan Y, Guo Y, Han L. Quercetin suppresses the mobility of breast cancer by suppressing glycolysis through Akt-mTOR pathway mediated autophagy induction. Life Sci. 2018; 208:123–30. doi:10.1016/j.lfs.2018.07.027
   PubMed Web of Science ®Google Scholar
• Huang X, Gan G, Wang X, Xu T, Xie W. The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance. Autophagy. 2019; 15(7):1258–79. doi:10.1080/15548627.2019.1580105
   PubMed Web of Science ®Google Scholar
• Maroni P, Bendinelli P, Matteucci E, Locatelli A, Nakamura T, Scita G, Desiderio MA. Osteolytic bone metastasis is hampered by impinging on the interplay among autophagy, anoikis and ossification. Cell Death Dis. 2014;5(1):e1005–e1005. doi:10.1038/cddis.2013.465
   PubMed Web of Science ®Google Scholar
• Wang LH, Chan JL, Li W. Rapamycin together with herceptin significantly increased anti-tumor efficacy compared to either alone in ErbB2 over expressing breast cancer cells. Int J Cancer. 2007; 121(1):157–64. doi:10.1002/ijc.22606
   PubMed Web of Science ®Google Scholar
• Chen W-C, Hsu K-Y, Hung C-M, Lin Y-C, Yang N-S, Ho C-T, Kuo S-C, Way T-D. The anti-tumor efficiency of pterostilbene is promoted with a combined treatment of Fas signaling or autophagy inhibitors in triple negative breast cancer cells. Food Funct. 2014; 5(8):1856–65. doi:10.1039/C4FO00145A
   PubMed Web of Science ®Google Scholar
• Hong WK. General keynote: the impact of cancer chemoprevention. Gynecol Oncol. 2003; 88(1):S56–S8. doi:10.1006/gyno.2002.6685
   PubMed Web of Science ®Google Scholar
• Menendez JA, et al. Analyzing effects of extra-virgin olive oil polyphenols on breast cancer-associated fatty acid synthase protein expression using reverse-phase protein microarrays. Int J Mol Med. 2008; 22(4):433–9. doi:10.3892/ijmm_00000039
   PubMed Web of Science ®Google Scholar
• Bulotta S, Corradino R, Celano M, D’Agostino M, Maiuolo J, Oliverio M, Procopio A, Iannone M, Rotiroti D, Russo D. Antiproliferative & anticancer effects on breast cancer cells of oleuropein and its semisynthetic preacetylated derivatives. Food Chem. 2011;127(4):1609–14.
   Web of Science ®Google Scholar
• Sepporta MV, Fuccelli R, Rosignoli P, Ricci G, Servili M, Morozzi G, Fabiani R. Oleuropein inhibits tumour growth and metastases dissemination in ovariectomised nude mice with MCF‐7 human breast tumour xenografts. J Funct Foods. 2014;8:269–73.
   Web of Science ®Google Scholar
• Meschini R, D’Eliseo D, Filippi S, Bertini L, Bizzarri BM, Botta L, Saladino R, Velotti F. Tyrosinase-treated hydroxytyrosol-enriched olive vegetation waste with increased antioxidant activity promotes autophagy and inhibits the inflammatory response in human THP-1 monocytes. J Agric Food Chem. 2018; 66(46):12274–84. doi:10.1021/acs.jafc.8b03630
   PubMed Web of Science ®Google Scholar
• Achour I. Oleuropein prevents neuronal death, mitigates mitochondrial superoxide production and modulates autophagy in a dopaminergic cellular model. Int J Mol Sci. 2016; 17(8). pii: E1293. doi: 10.3390/ijms17081293
   PubMed Web of Science ®Google Scholar
• Visioli F, Poli A, Gall C. Antioxidant and other biological activities of phenols from olives and olive oil. Med Res Rev. 2002; 22(1):65–75. doi:10.1002/med.1028
   PubMed Web of Science ®Google Scholar
• Goldsmith CD, et al. The olive biophenols oleuropein and hydroxytyrosol selectively reduce proliferation, influence the cell cycle, and induce apoptosis in pancreatic cancer cells. Int J Mol Sci. 2018; 19(7):E1937. doi: 10.3390/ijms19071937
   PubMed Web of Science ®Google Scholar