Antiproliferative Effects of Thymoquinone in MCF-7 Breast and HepG2 Liver Cancer Cells: Possible Role of Ceramide and ER Stress

References

• Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65(2):87–108. doi:10.3322/caac.21262
   PubMed Web of Science ®Google Scholar
• Maass SW, Roorda C, Berendsen AJ, Verhaak PF, de Bock GH. The prevalence of long-term symptoms of depression and anxiety after breast cancer treatment: a systematic review. Maturitas. 2015;82(1):100–8. doi:10.1016/j.maturitas.2015.04.010
   PubMed Web of Science ®Google Scholar
• Sun B, Karin M. Obesity, inflammation, and liver cancer. J Hepatol. 2012;56(3):704–13. doi:10.1016/j.jhep.2011.09.020
   PubMed Web of Science ®Google Scholar
• Ahmad A, Husain A, Mujeeb M, Khan SA, Najmi AK, Siddique NA, Damanhouri ZA, Anwar F. A review on therapeutic potential of Nigella sativa: a miracle herb. Asian Pac J Trop Biomed. 2013;3(5):337–52. doi:10.1016/S2221-1691(13)60075-1
   PubMedGoogle Scholar
• Kooti W, Hasanzadeh-Noohi Z, Sharafi-Ahvazi N, Asadi-Samani M, Ashtary-Larky D. Phytochemistry, pharmacology, and therapeutic uses of black seed (Nigella sativa). Chin J Nat Med. 2016;14(10):732–45. doi:10.1016/S1875-5364(16)30088-7
   PubMed Web of Science ®Google Scholar
• Dajani EZ, Shahwan TG, Dajani NE. Overview of the preclinical pharmacological properties of Nigella sativa (black seeds): a complementary drug with historical and clinical significance. J. Physiol. Pharmacol. 2016;67(6):801–17.
   PubMed Web of Science ®Google Scholar
• Aycan İÖ, Elpek Ö, Akkaya B, Kıraç E, Tuzcu H, Kaya S, Coşkunfırat N, Aslan M. Diclofenac induced gastrointestinal and renal toxicity is alleviated by thymoquinone treatment. Food Chem Toxicol. 2018;118:795–804. doi:10.1016/j.fct.2018.06.038
   PubMed Web of Science ®Google Scholar
• Majdalawieh AF, Fayyad MW, Nasrallah GK. Anti-cancer properties and mechanisms of action of thymoquinone, the major active ingredient of Nigella sativa. Crit Rev Food Sci Nutr. 2017;57(18):3911–28. doi:10.1080/10408398.2016.1277971
   PubMed Web of Science ®Google Scholar
• Zhang L, Bai Y, Yang Y. Thymoquinone chemosensitizes colon cancer cells through inhibition of NF-κB. Oncol Lett. 2016;12(4):2840–5. doi:10.3892/ol.2016.4971
   PubMed Web of Science ®Google Scholar
• Liu X, Dong J, Cai W, Pan Y, Li R, Li B. The effect of thymoquinone on apoptosis of SK-OV-3 ovarian cancer cell by regulation of Bcl-2 and Bax. Int J Gynecol Cancer. 2017;27(8):1596–601. doi:10.1097/IGC.0000000000001064
   PubMed Web of Science ®Google Scholar
• Yang J, Kuang XR, Lv PT, Yan XX. Thymoquinone inhibits proliferation and invasion of human nonsmall-cell lung cancer cells via ERK pathway. Tumor Biol. 2015;36(1):259–69. doi:10.1007/s13277-014-2628-z
   PubMedGoogle Scholar
• Badary OA, Abd-Ellah MF, El-Mahdy MA, Salama SA, Hamada FM. Anticlastogenic activity of thymoquinone against benzo(a)pyrene in mice. Food Chem Toxicol. 2007;45(1):88–92. doi:10.1016/j.fct.2006.08.004
   PubMed Web of Science ®Google Scholar
• Towhid ST, Schmidt E-M, Schmid E, Münzer P, Qadri SM, Borst O, Lang F. Thymoquinone-induced platelet apoptosis. J Cell Biochem. 2011;112(11):3112–21. doi:10.1002/jcb.23237
   PubMed Web of Science ®Google Scholar
• Salmani JM, Asghar S, Lv H, Zhou J. Aqueous solubility and degradation kinetics of the phytochemical anticancer thymoquinone; probing the effects of solvents, pH and light. Molecules. 2014;19(5):5925–39. doi:10.3390/molecules19055925
   PubMed Web of Science ®Google Scholar
• Özer H, Aslan İ, Oruç MT, Çöpelci Y, Afşar E, Kaya S, Aslan M. Early postoperative changes of sphingomyelins and ceramides after laparoscopic sleeve gastrectomy. Lipids Health Dis. 2018;17(1):269. doi:10.1186/s12944-018-0917-z
   PubMed Web of Science ®Google Scholar
• Aslan M, Kıraç E, Kaya S, Özcan F, Salim O, Küpesiz OA. Decreased serum levels of sphingomyelins and ceramides in sickle cell disease patients. Lipids. 2018;53(3):313–22. doi:10.1002/lipd.12027
   PubMed Web of Science ®Google Scholar
• Yapar M, Aydogan H, Pahsa A, Besirbellioglu BA, Bodur H, Basustaoglu AC, Guney C, Avci IY, Sener K, Setteh MHA, et al. Rapid and quantitative detection of Crimean-Congo hemorrhagic fever virus by one-step real-time reverse transcriptase-PCR. Jpn J Infect Dis. 2005;58(6):358–62.:
   PubMed Web of Science ®Google Scholar
• Tuzcu H, Unal B, Kırac E, Konuk E, Ozcan F, Elpek GO, Demir N, Aslan M. Neutral sphingomyelinase inhibition alleviates apoptosis, but not ER stress, in liver ischemia-reperfusion injury. Free Radic Res. 2017;51(3):253–68. doi:10.1080/10715762.2017.1298103
   PubMed Web of Science ®Google Scholar
• Dastjerdi MN, Mehdiabady EM, Iranpour FG, Bahramian H. Effect of Thymoquinone on P53 Gene Expression and Consequence Apoptosis in Breast Cancer Cell Line. Int J Prev Med. 2016;7(1):66. doi:10.4103/2008-7802.180412
   PubMedGoogle Scholar
• Parbin S, Shilpi A, Kar S, Pradhan N, Sengupta D, Deb M, Rath SK, Patra SK. Insights into the molecular interactions of thymoquinone with histone deacetylase: evaluation of the therapeutic intervention potential against breast cancer. Mol Biosyst. 2016;12(1):48–58. doi:10.1039/C5MB00412H
   PubMedGoogle Scholar
• ElKhoely A, Hafez HF, Ashmawy AM, Badary O, Abdelaziz A, Mostafa A, Shouman SA. Chemopreventive and therapeutic potentials of thymoquinone in HepG2 cells: mechanistic perspectives. J Nat Med. 2015;69(3):313–23. doi:10.1007/s11418-015-0895-7
   PubMed Web of Science ®Google Scholar
• Ogretmen B, Hannun YA. Biologically active sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer. 2004;4(8):604–16. doi:10.1038/nrc1411
   PubMed Web of Science ®Google Scholar
• Ogretmen B. Sphingolipid metabolism in cancer signalling and therapy. Nat Rev Cancer. 2018;18(1):33–50. doi:10.1038/nrc.2017.96
   PubMed Web of Science ®Google Scholar
• Wu BX, Rajagopalan V, Roddy PL, Clarke CJ, Hannun YA. Identification and characterization of murine mitochondria-associated neutral sphingomyelinase (MA-nSMase), the mammalian sphingomyelin phosphodiesterase 5. J Biol Chem. 2010;285(23):17993–8002. doi:10.1074/jbc.M110.102988
   PubMed Web of Science ®Google Scholar
• Zidan A-AA, El-Ashmawy NE, Khedr EG, Ebeid E-ZM, Salem ML, Mosalam EM. Loading of doxorubicin and thymoquinone with F2 gel nanofibers improves the antitumor activity and ameliorates doxorubicin-associated nephrotoxicity. Life Sci. 2018;207:461–70. doi:10.1016/j.lfs.2018.06.008
   PubMed Web of Science ®Google Scholar
• Ashour AE, Abd-Allah AR, Korashy HM, Attia SM, Alzahrani AZ, Saquib Q, Bakheet SA, Abdel-Hamied HE, Jamal S, Rishi AK, et al. Thymoquinone suppression of the human hepatocellular carcinoma cell growth involves inhibition of IL-8 expression, elevated levels of TRAIL receptors, oxidative stress and apoptosis. Mol Cell Biochem. 2014;389(1-2):85–98. doi:10.1007/s11010-013-1930-1
   PubMed Web of Science ®Google Scholar
• Wu CC, Bratton SB. Regulation of the intrinsic apoptosis pathway by reactive oxygen species. Antioxid Redox Signal. 2013;19(6):546–58. doi:10.1089/ars.2012.4905
   PubMed Web of Science ®Google Scholar
• Shalini S, Dorstyn L, Dawar S, Kumar S. Old, new and emerging functions of caspases. Cell Death Differ. 2015;22(4):526–39. doi:10.1038/cdd.2014.216
   PubMed Web of Science ®Google Scholar
• Ruvolo PP. Ceramide regulates cellular homeostasis via diverse stress signaling pathways. Leukemia. 2001;15(8):1153–60. doi:10.1038/sj.leu.2402197
   PubMed Web of Science ®Google Scholar
• Hannun YA, Obeid LM. Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol. 2008;9(2):139–50. doi:10.1038/nrm2329
   PubMed Web of Science ®Google Scholar
• Maceyka M, Spiegel S. Sphingolipid metabolites in inflammatory disease. Nature. 2014;510(7503):58–67. doi:10.1038/nature13475
   PubMed Web of Science ®Google Scholar
• Ibrahim IM, Abdelmalek DH, Elfiky AA. GRP78: A cell’s response to stress. Life Sci. 2019;226:156–63. doi:10.1016/j.lfs.2019.04.022
   PubMed Web of Science ®Google Scholar
• Bailly C, Waring MJ. Pharmacological effectors of GRP78 chaperone in cancers. Biochem Pharmacol. 2019;163:269–78. doi:10.1016/j.bcp.2019.02.038
   PubMed Web of Science ®Google Scholar
• Zhang M, Du H, Huang Z, Zhang P, Yue Y, Wang W, Liu W, Zeng J, Ma J, Chen G, et al. Thymoquinone induces apoptosis in bladder cancer cell via endoplasmic reticulum stress-dependent mitochondrial pathway. Chem Biol Interact. 2018;292:65–75. doi:10.1016/j.cbi.2018.06.013
   PubMed Web of Science ®Google Scholar
• Liu Z, Xia Y, Li B, Xu H, Wang C, Liu Y, Li Y, Li C, Gao N, Li L, et al. Induction of ER stress-mediated apoptosis by ceramide via disruption of ER Ca(2+) homeostasis in human adenoid cystic carcinoma cells. Cell Biosci. 2014;4(1):71. doi:10.1186/2045-3701-4-71
   PubMed Web of Science ®Google Scholar
• Doan NTQ, Paulsen ES, Sehgal P, Møller JV, Nissen P, Denmeade SR, Isaacs JT, Dionne CA, Christensen SB. Targeting thapsigargin towards tumors. Steroids. 2015;97:2–7. doi:10.1016/j.steroids.2014.07.009
   PubMed Web of Science ®Google Scholar