Quercetin Triggers Induction of Apoptotic and Lysosomal Death of Sensitive and Multidrug Resistant Leukaemia HL60 Cells

References

• Borst P, Jonkers J, Rottenberg S. What makes tumors multidrug resistant? Cell Cycle. 2007;6(22):2782–7. doi:10.4161/cc.6.22.4936
   PubMed Web of Science ®Google Scholar
• Lage H. An overview of cancer multidrug resistance: a still unsolved problem. Cell Mol Life Sci. 2008;65(20):3145–67. doi:10.1007/s00018-008-8111-5
   PubMed Web of Science ®Google Scholar
• Luqmani YA. Mechanisms of drug resistance in cancer chemotherapy. Med Princ Pract. 2005;14(1):35–48. doi:10.1159/000086183
   PubMed Web of Science ®Google Scholar
• Baguley BC. Multiple drug resistance mechanisms in cancer. Mol Biotechnol. 2010;46(3):308–16. doi:10.1007/s12033-010-9321-2
   PubMed Web of Science ®Google Scholar
• Kampa M, Nifli AP, Notas G, Castanas E. Polyphenols and cancer cell growth. Rev Physiol Biochem Pharmacol. 2007;159:79–113. doi:10.1007/112_2006_0702
   PubMed Web of Science ®Google Scholar
• Afzal M, Safer AM, Menon M. Green tea polyphenols and their potential role in health and disease. Inflammopharmacology. 2015;23(4):151–61. doi:10.1007/s10787-015-0236-1
   PubMed Web of Science ®Google Scholar
• Tsao R. Chemistry and biochemistry of dietary polyphenols. Nutrients. 2010;2(12):1231–46. doi:10.3390/nu2121231
   PubMed Web of Science ®Google Scholar
• Ciolino HP, Daschner PJ, Yeh GC. Dietary flavonols quercetin and kaempferol are ligands of the aryl hydrocarbon receptor that affect CYP1A1 transcription differentially. Biochem J. 1999;340(3):715–22. doi:10.1042/0264-6021:3400715
   PubMed Web of Science ®Google Scholar
• Bode AM, Dong Z. Signal transduction pathways: targets for green and black tea polyphenols. J Biochem Mol Biol. 2003;36(1):66–77. doi:10.5483/BMBRep.2003.36.1.066
   PubMedGoogle Scholar
• Ramos S. Cancer chemoprevention and chemotherapy: dietary polyphenols and signalling pathways. Mol Nutr Food Res. 2008;52(5):507–26. doi:10.1002/mnfr.200700326
   PubMed Web of Science ®Google Scholar
• Sen T, Dutta A, Chatterjee A. Epigallocatechin-3-gallate (EGCG) downregulates gelatinase-B (MMP-9) by involvement of FAK/ERK/NFκB and AP-1 in the human breast cancer cell line MDA-MB-231. Anticancer Drugs. 2010;21(6):632–44. doi:10.1097/cad.0b013e32833a4385
   PubMed Web of Science ®Google Scholar
• Tewari D, Nabavi SF, Nabavi SM, Sureda A, Farooqi AA, Atanasov AG, Vacca RA, Sethi G, Bishayee A. Targeting activator protein 1 signaling pathway by bioactive natural agents: possible therapeutic strategy for cancer prevention and intervention. Pharmacol Res. 2018;128:366–75. doi:10.1016/j.phrs.2017.09.014
   PubMed Web of Science ®Google Scholar
• Jeong C-H, Joo SH. Downregulation of reactive oxygen species in apoptosis. J Cancer Prev. 2016;21(1):13–20. doi:10.15430/JCP.2016.21.1.13
   PubMedGoogle Scholar
• Neuwirthová J, Gál B, Smilek P, Urbánková P. Potential of the flavonoid quercetin to prevent and treat cancer—current status of research. Klin Onkol. 2018;31(3):184–90. doi:10.14735/amko2018184
   PubMedGoogle Scholar
• Chen C, Zhou J, Ji C. Quercetin: a potential drug to reverse multidrug resistance. Life Sci. 2010;87(11-12):333–8. doi:10.1016/j.lfs.2010.07.004
   PubMed Web of Science ®Google Scholar
• Maso V, Calgarotto AK, Franchi GC, Nowill AE, Filho PL, Vassallo J, Saad STO. Multitarget effects of quercetin in leukemia. Cancer Prev Res. 2014;7(12):1240–50. doi:10.1158/1940-6207.CAPR-13-0383
   PubMed Web of Science ®Google Scholar
• Khan F, Niaz K, Maqbool F, Ismail Hassan F, Abdollahi M, Nagulapalli Venkata K, Nabavi S, Bishayee A. Molecular targets underlying the anticancer effects of quercetin: an update. Nutrients. 2016;8(9):529. doi:10.3390/nu8090529
   PubMed Web of Science ®Google Scholar
• Rauf A, Imran M, Khan IA, Ur-Rehman M, Gilani SA, Mehmood Z, Mubarak MS. Anticancer potential of quercetin: a comprehensive review. Phytother Res. 2018;32(11):2109–30. doi:10.1002/ptr.6155
   PubMed Web of Science ®Google Scholar
• Murtaza I, Marra G, Schlapbach R, Patrignani A, Künzli M, Wagner U, Sabates J, Dutt A. A preliminary investigation demonstrating the effect of quercetin on the expression of genes related to cell-cycle arrest, apoptosis and xenobiotic metabolism in human CO115 colon-adenocarcinoma cells using DNA microarray. Biotechnol Appl Biochem. 2006;45(1):29–36. doi:10.1042/BA20060044
   PubMed Web of Science ®Google Scholar
• Chou C-C, Yang J-S, Lu H-F, Ip S-W, Lo C, Wu C-C, Lin J-P, Tang N-Y, Chung J-G, Chou M-J, et al. Quercetin-mediated cell cycle arrest and apoptosis involving activation of a caspase cascade through the mitochondrial pathway in human breast cancer MCF-7 cells. Arch Pharm Res. 2010;33(8):1181–91. doi:10.1007/s12272-010-0808-y
   PubMed Web of Science ®Google Scholar
• Vidya Priyadarsini R, Senthil Murugan R, Maitreyi S, Ramalingam K, Karunagaran D, Nagini S. The flavonoid quercetin induces cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells through p53 induction and NF-κB inhibition. Eur J Pharmacol. 2010;649(1-3):84–91. doi:10.1016/j.ejphar.2010.09.020
   PubMed Web of Science ®Google Scholar
• Yuan Z, Long C, Junming T, Qihuan L, Youshun Z, Chan Z. Quercetin-induced apoptosis of HL-60 cells by reducing PI3K/Akt. Mol Biol Rep. 2012;39(7):7785–93. doi:10.1007/s11033-012-1621-0
   PubMed Web of Science ®Google Scholar
• Youn H, Jeong J-C, Jeong YS, Kim E-J, Um S-J. Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36:944–51.
   PubMed Web of Science ®Google Scholar
• Chang Y-F, Chi C-W, Wang J-J. Reactive oxygen species production is involved in quercetin-induced apoptosis in human hepatoma cells. Nutr Cancer. 2006;55(2):201–9. doi:10.1207/s15327914nc5502_12
   PubMed Web of Science ®Google Scholar
• Wang IK, Lin-Shiau SY, Lin JK. Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells. Eur J Cancer. 1999;35(10):1517–25. doi:10.1016/S0959-8049(99)00168-9
   PubMed Web of Science ®Google Scholar
• Granado-Serrano AB, Martín MA, Bravo L, Goya L, Ramos S. Quercetin induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI-3-kinase/Akt and ERK pathways in a human hepatoma cell line (HepG2). J Nutr. 2006;136(11):2715–21. doi:10.1093/jn/136.11.2715
   PubMed Web of Science ®Google Scholar
• Mateus PG, Wolf VG, Borges MS, Ximenes Valdeci F. Quercetin: prooxidant effect and apoptosis in cancer. In: Atta-ur-Rahman, editor. Studies in natural products chemistry. Vol. 58. Amsterdam (Netherlands): Elsevier; 2018. p. 265–88.
   Google Scholar
• Sakao K, Fujii M, Hou DX. Clarification of the role of quercetin hydroxyl groups in superoxide generation and cell apoptosis by chemical modification. Biosci Biotechnol Biochem. 2009;73(9):2048–53. doi:10.1271/bbb.90253
   PubMed Web of Science ®Google Scholar
• Lee W-J, Hsiao M, Chang J-L, Yang S-F, Tseng T-H, Cheng C-W, Chow J-M, Lin K-H, Lin Y-W, Liu C-C, et al. Quercetin induces mitochondrial-derived apoptosis via reactive oxygen species-mediated ERK activation in HL-60 leukemia cells and xenograft. Arch Toxicol. 2015;89(7):1103–17. doi:10.1007/s00204-014-1300-0
   PubMed Web of Science ®Google Scholar
• Bishayee K, Ghosh S, Mukherjee A, Sadhukhan R, Mondal J, Khuda-Bukhsh AR. Quercetin induces cytochrome-c release and ROS accumulation to promote apoptosis and arrest the cell cycle in G2/M, in cervical carcinoma: signal cascade and drug-DNA interaction. Cell Prolif. 2013;46(2):153–63. doi:10.1111/cpr.12017
   PubMed Web of Science ®Google Scholar
• Trincheri NF, Nicotra G, Follo C, Castino R, Isidoro C. Resveratrol induces cell death in colorectal cancer cells by a novel pathway involving lysosomal cathepsin D. Carcinogenesis. 2007;28(5):922–31. doi:10.1093/carcin/bgl223
   PubMed Web of Science ®Google Scholar
• Zhang Y, Yang N-D, Zhou F, Shen T, Duan T, Zhou J, Shi Y, Zhu X-Q, Shen H-M. (-)-Epigallocatechin-3-gallate induces non-apoptotic cell death in human cancer cells via ROS-mediated lysosomal membrane permeabilization. PLoS One. 2012;7(10):e46749. doi:10.1371/journal.pone.0046749
   PubMed Web of Science ®Google Scholar
• Chen Q-Y, Shi J-G, Yao Q-H, Jiao D-M, Wang Y-Y, Hu H-Z, Wu Y-Q, Song J, Yan J, Wu L-J, et al. Lysosomal membrane permeabilization is involved in curcumin-induced apoptosis of A549 lung carcinoma cells. Mol Cell Biochem. 2012;359(1-2):389–98. doi:10.1007/s11010-011-1033-9
   PubMed Web of Science ®Google Scholar
• Mena S, Rodríguez ML, Ponsoda X, Estrela JM, Jäättela M, Ortega AL. Pterostilbene-induced tumor cytotoxicity: a lysosomal membrane permeabilization-dependent mechanism. PLoS One. 2012;7(9):e44524. doi:10.1371/journal.pone.0044524
   PubMed Web of Science ®Google Scholar
• Lahiri DK, Schnabel B. DNA isolation by a rapid method from human blood samples: effects of MgCl2, EDTA, storage time, and temperature on DNA yield and quality. Biochem Genet. 1993;31(7-8):321–8. doi:10.1007/BF00553174
   PubMed Web of Science ®Google Scholar
• Nowak R, Tarasiuk J. Anthraquinone antitumour agents, doxorubicin, pirarubicin and benzoperimidine BP1, trigger caspase-3/caspase-8-dependent apoptosis of leukaemia sensitive HL60 and resistant HL60/VINC and HL60/DOX cells. Anticancer Drugs. 2012;23(4):380–92. doi:10.1097/CAD.0b013e32834f8ab4
   PubMed Web of Science ®Google Scholar
• Jäättelä M. Multiple cell death pathways as regulators of tumour initiation and progression. Oncogene. 2004;23(16):2746–56. doi:10.1038/sj.onc.1207513
   PubMed Web of Science ®Google Scholar
• Mellor HR, Callaghan R. Resistance to chemotherapy in cancer: a complex and integrated cellular response. Pharmacology. 2008;81(4):275–300. doi:10.1159/000115967
   PubMed Web of Science ®Google Scholar
• Takeuchi R, Hoshijima H, Nagasaka H, Chowdhury SA, Kikuchi H, Kanda Y, Kunii S, Kawase M, Sakagami H. Induction of non-apoptotic cell death by morphinone in human promyelocytic leukemia HL-60 cells. Anticancer Res. 2006;26(5A):3343–8.
   PubMed Web of Science ®Google Scholar
• Bursch W, Karwan A, Mayer M, Dornetshuber J, Fröhwein U, Schulte-Hermann R, Fazi B, Di Sano F, Piredda L, Piacentini M, et al. Cell death and autophagy: cytokines, drugs, and nutritional factors. Toxicology. 2008;254(3):147–57.: doi:10.1016/j.tox.2008.07.048
   PubMed Web of Science ®Google Scholar
• Wu JC, Lai CS, Badmaev V, Nagabhushanam K, Ho CT, et al. Tetrahydrocurcumin, a major metabolite of curcumin, induced autophagic cell death through coordinative modulation of PI3K/Akt-mTOR and MAPK signaling pathways in human leukemia HL-60 cells. Mol Nutr Food Res. 2011;55:1–9.:
   Web of Science ®Google Scholar
• Groth-Pedersen L, Jäättelä M. Combating apoptosis and multidrug resistant cancers by targeting lysosomes. Cancer Lett. 2013;332(2):265–74. doi:10.1016/j.canlet.2010.05.021
   PubMed Web of Science ®Google Scholar
• Fehrenbacher N, Jäättelä M. Lysosomes as targets for cancer therapy. Cancer Res. 2005;65(8):2993–5. doi:10.1158/0008-5472.CAN-05-0476
   PubMed Web of Science ®Google Scholar
• Boya P, Kroemer G. Lysosomal membrane permeabilization in cell death. Oncogene. 2008;27(50):6434–51. doi:10.1038/onc.2008.310
   PubMed Web of Science ®Google Scholar
• Kirkegaard T, Jäättelä M. Lysosomal involvement in cell death and cancer. Biochim Biophys Acta. 2009;1793(4):746–54. doi:10.1016/j.bbamcr.2008.09.008
   PubMed Web of Science ®Google Scholar
• Turk B, Turk V. Lysosomes as “suicide bags” in cell death: myth or reality? J Biol Chem. 2009;284(33):21783–7. doi:10.1074/jbc.R109.023820
   PubMed Web of Science ®Google Scholar
• Mileo AM, Miccadei S. Polyphenols as modulator of oxidative stress in cancer disease: new therapeutic strategies. Oxid Med Cell Longev. 2016;2016:1–17. doi:10.1155/2016/6475624
   Web of Science ®Google Scholar
• Costa C, Tsatsakis A, Mamoulakis C, Teodoro M, Briguglio G, Caruso E, Tsoukalas D, Margina D, Dardiotis E, Kouretas D, et al. Current evidence on the effect of dietary polyphenols intake on chronic diseases. Food Chem Toxicol. 2017;110:286–99. doi:10.1016/j.fct.2017.10.023
   PubMed Web of Science ®Google Scholar
• Maruszewska A, Kostrzewa-Nowak D, Adamus J, Czupryńska K, Maryniak D, Gebicki J, Tarasiuk J. The ability of selected pyridinium salts to increase the cytotoxic activity of vincristine but not doxorubicin towards sensitive and multidrug resistant promyelocytic leukaemia HL60 cells. J Pharm Pharmacol. 2008;60(5):647–53. doi:10.1211/jpp.60.5.0011
   PubMed Web of Science ®Google Scholar
• Kostrzewa-Nowak D, Tarasiuk J. Bioreductive activation of mitoxantrone by NADPH cytochrome P450 reductase does not change its apoptotic stimuli properties in regard to sensitive and multidrug resistant leukaemia HL60 cells. Eur J Pharmacol. 2013;721(1-3):141–50. doi:10.1016/j.ejphar.2013.09.041
   PubMed Web of Science ®Google Scholar
• Mertens-Talcott SU, Bomser JA, Romero C, Talcott ST, Percival SS. Ellagic acid potentiates the effect of quercetin on p21waf1/cip1, p53, and MAP-kinases without affecting intracellular generation of reactive oxygen species in vitro. J Nutr. 2005;135(3):609–14. doi:10.1093/jn/135.3.609
   PubMed Web of Science ®Google Scholar
• Kalinina EV, Ivanova-Radkevich VI, Chernov NN. Role of microRNAs in the regulation of redox-dependent processes. Biochemistry Moscow. 2019;84(11):1233–46. doi:10.1134/S0006297919110026
   Google Scholar
• Engedal N, Žerovnik E, Rudov A, Galli F, Olivieri F, Procopio AD, Rippo MR, Monsurrò V, Betti M, Albertini MC, et al. From oxidative stress damage to pathways, networks, and autophagy via microRNAs. Oxid Med Cell Longev. 2018;2018:1–16. doi:10.1155/2018/4968321
   Web of Science ®Google Scholar
• He J, Jiang BH. Interplay between reactive oxygen species and microRNAs in cancer. Curr Pharmacol Rep. 2016;2(2):82–90. doi:10.1007/s40495-016-0051-4
   PubMedGoogle Scholar
• Wang C, Ku P, Nie X, Bao S, Wang Z, Li K. Effects of simvastatin on the PXR signaling pathway and the liver histology in Mugilogobius abei. Sci Total Environ. 2019;651:399–409. doi:10.1016/j.scitotenv.2018.09.133
   PubMed Web of Science ®Google Scholar
• Tsang TY, Tang WY, Chan JYW, Co NN, Au Yeung CL, Yau PL, Kong SK, Fung KP, Kwok TT. P-glycoprotein enhances radiation-induced apoptotic cell death through the regulation of miR-16 and Bcl-2 expressions in hepatocellular carcinoma cells. Apoptosis. 2011;16(5):524–35. doi:10.1007/s10495-011-0581-5
   PubMed Web of Science ®Google Scholar
• Ramos AM, Aller P. Quercetin decreases intracellular GSH content and potentiates the apoptotic action of the antileukemic drug arsenic trioxide in human leukemia cell lines. Biochem Pharmacol. 2008;75(10):1912–23. doi:10.1016/j.bcp.2008.02.007
   PubMed Web of Science ®Google Scholar
• Li C, Zhang WJ, Choi J, Frei B. Quercetin affects glutathione levels and redox ratio in human aortic endothelial cells not through oxidation but formation and cellular export of quercetin-glutathione conjugates and upregulation of glutamate-cysteine ligase. Redox Biol. 2016;9:220–8. doi:10.1016/j.redox.2016.08.012
   PubMed Web of Science ®Google Scholar
• Jones DJL, Lamb JH, Verschoyle RD, Howells LM, Butterworth M, Lim CK, Ferry D, Farmer PB, Gescher AJ. Characterisation of metabolites of the putative cancer chemopreventive agent quercetin and their effect on cyclo-oxygenase activity. Br J Cancer. 2004;91(6):1213–9. doi:10.1038/sj.bjc.6602091
   PubMed Web of Science ®Google Scholar
• Spencer JP, Kuhnle GG, Williams RJ, Rice-Evans C. Intracellular metabolism and bioactivity of quercetin and its in vivo metabolites. Biochem J. 2003;372(1):173–81. doi:10.1042/bj20021972
   PubMed Web of Science ®Google Scholar
• Huang Z, Pinto JT, Deng H, Richie JP, Jr. Inhibition of caspase-3 activity and activation by protein glutathionylation. Biochem Pharmacol. 2008;75(11):2234–44. doi:10.1016/j.bcp.2008.02.026
   PubMed Web of Science ®Google Scholar
• Anathy V, Roberson EC, Guala AS, Godburn KE, Budd RC, Janssen-Heininger YMW. Redox-based regulation of apoptosis: S-glutathionylation as a regulatory mechanism to control cell death. Antioxid Redox Signal. 2012;16(6):496–505. doi:10.1089/ars.2011.4281
   PubMed Web of Science ®Google Scholar
• Dalle-Donne I, Colombo G, Gagliano N, Colombo R, Giustarini D, Rossi R, Milzani A. S-glutathiolation in life and death decisions of the cell. Free Radic Res. 2011;45(1):3–15. doi:10.3109/10715762.2010.515217
   PubMed Web of Science ®Google Scholar
• Lin KT, Xue JY, Sun FF, Wong PYK. Reactive oxygen species participate in peroxynitrite-induced apoptosis in HL-60 cells. Biochem Biophys Res Commun. 1997;230(1):115–9. doi:10.1006/bbrc.1996.5897
   PubMed Web of Science ®Google Scholar
• Baek YM, Hwang HJ, Kim SW, Hwang HS, Lee SH, Kim JA, Yun JW. A comparative proteomic analysis for capsaicin-induced apoptosis between human hepatocarcinoma (HepG2) and human neuroblastoma (SK-N-SH) cells. Proteomics. 2008;8(22):4748–67. doi:10.1002/pmic.200800094
   PubMed Web of Science ®Google Scholar
• Collins JA, Schandl CA, Young KK, Vesely J, Willingham MC. Major DNA fragmentation is a late event in apoptosis. J Histochem Cytochem. 1997;45(7):923–34. doi:10.1177/002215549704500702
   PubMed Web of Science ®Google Scholar
• Wolf D, Rotter V. Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells. Proc Natl Acad Sci USA. 1985;82(3):790–4. doi:10.1073/pnas.82.3.790
   PubMed Web of Science ®Google Scholar
• Sigal A, Rotter V. Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome. Cancer Res. 2000;60(24):6788–93.
   PubMed Web of Science ®Google Scholar
• Olivier M, Eeles R, Hollstein M, Khan MA, Harris CC, Hainaut P. The IARC TP53 database: New online mutation analysis and recommendations to users. Hum Mutat. 2002;19(6):607–14. doi:10.1002/humu.10081
   PubMed Web of Science ®Google Scholar
• Giovannini C, Masella R. Role of polyphenols in cell death control. Nutr Neurosci. 2012;15(3):134–49. doi:10.1179/1476830512Y.0000000006
   PubMed Web of Science ®Google Scholar
• Pozo-Guisado E, Merino JM, Mulero-Navarro S, Lorenzo-Benayas MJ, Centeno F, Alvarez-Barrientos A, Salguero PMF. Resveratrol-induced apoptosis in MCF-7 human breast cancer cells involves a caspase-independent mechanism with downregulation of Bcl-2 and NF-κB. Int J Cancer. 2005;115(1):74–84. doi:10.1002/ijc.20856
   PubMed Web of Science ®Google Scholar
• Kumar S, Eroglu E, Stokes JA, Scissum-Gunn K, Saldanha SN, Singh UP, Manne U, Ponnazhagan S, Mishra MK. Resveratrol induces mitochondria-mediated, caspase-independent apoptosis in murine prostate cancer cells. Oncotarget. 2017;8(13):20895–908. doi:10.18632/oncotarget.14947
   PubMedGoogle Scholar
• Kapoor S. Luteolin and its inhibitory effect on tumor growth in systemic malignancies. Exp Cell Res. 2013;319(6):777–8. doi:10.1016/j.yexcr.2013.01.006
   PubMed Web of Science ®Google Scholar
• Reddivari L, Vanamala J, Chintharlapalli S, Safe SH, Miller JC. Anthocyanin fraction from potato extracts is cytotoxic to prostate cancer cells through activation of caspase-dependent and caspase-independent pathways. Carcinogenesis. 2007;28(10):2227–35. doi:10.1093/carcin/bgm117
   PubMed Web of Science ®Google Scholar
• Khorsandi L, Saki G, Bavarsad N, Mombeini M. Silymarin induces a multi-targeted cell death process in the human colon cancer cell line HT-29. Biomed Pharmacother. 2017;94:890–7. doi:10.1016/j.biopha.2017.08.015
   PubMed Web of Science ®Google Scholar
• Yang ZJ, Chee CE, Huang S, Sinicrope FA. The role of autophagy in cancer: therapeutic implications. Mol Cancer Ther. 2011;10(9):1533–41. doi:10.1158/1535-7163.MCT-11-0047
   PubMed Web of Science ®Google Scholar
• Serrano-Puebla A, Boya P. Lysosomal membrane permeabilization as a cell death mechanism in cancer cells. Biochem Soc Trans. 2018;46(2):207–15. doi:10.1042/BST20170130
   PubMed Web of Science ®Google Scholar
• Maruszewska A, Tarasiuk J. Antitumour effects of selected plant polyphenols, gallic acid and ellagic acid, on sensitive and multidrug-resistant leukaemia HL60 cells. Phytother Res. 2019;33(4):1208–21. doi:10.1002/ptr.6317
   PubMed Web of Science ®Google Scholar
• Bielak-Zmijewska A, Piwocka K, Magalska A, Sikora E. P-glycoprotein expression does not change the apoptotic pathway induced by curcumin in HL-60 cells. Cancer Chemother Pharmacol. 2004;53(2):179–85. doi:10.1007/s00280-003-0705-x
   PubMed Web of Science ®Google Scholar
• Choi MR, Najafi F, Safa AR, Drexler HCA. Analysis of changes in the proteome of HL-60 promyeloid leukemia cells induced by the proteasome inhibitor PSI. Biochem Pharmacol. 2008;75(12):2276–1288. doi:10.1016/j.bcp.2008.03.017
   PubMed Web of Science ®Google Scholar
• Nowak R, Tarasiuk J. Retaining cytotoxic activity of anthrapyridone CO1 against multidrug resistant cells is related to the ability to induce concomitantly apoptosis and lysosomal death of leukaemia HL60/VINC and HL60/DOX cells. J Pharm Pharmacol. 2013;65(6):855–67. doi:10.1111/jphp.12042
   PubMed Web of Science ®Google Scholar
• Mediavilla-Varela M, Pacheco FJ, Almaguel F, Perez J, Sahakian E, Daniels TR, Leoh L, Padilla A, Wall NR, Lilly MB, et al. Docetaxel-induced prostate cancer cell death involves concomitant activation of caspase and lysosomal pathways and is attenuated by LEDGF/p75. Mol Cancer. 2009;8(1):68.,.: doi:10.1186/1476-4598-8-68
   PubMed Web of Science ®Google Scholar
• Foghsgaard L, Wissing D, Mauch D, Lademann U, Bastholm L, Boes M, Elling F, Leist M, Jäättelä M. Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor. J Cell Biol. 2001;153(5):999–1010. doi:10.1083/jcb.153.5.999
   PubMed Web of Science ®Google Scholar
• Kågedal K, Johansson U, Öllinger K. The lysosomal protease cathepsin D mediates apoptosis induced by oxidative stress. FASEB J. 2001;15(9):1592–4. doi:10.1096/fj.00-0708fje
   PubMed Web of Science ®Google Scholar
• Paquet C, Sané AT, Beauchemin M, Bertrand R. Caspase- and mitochondrial dysfunction-dependent mechanisms of lysosomal leakage and cathepsin B activation in DNA damage-induced apoptosis. Leukemia. 2005;19(5):784–91. doi:10.1038/sj.leu.2403717
   PubMed Web of Science ®Google Scholar
• Johansson A-C, Appelqvist H, Nilsson C, Kågedal K, Roberg K, Öllinger K. Regulation of apoptosis-associated lysosomal membrane permeabilization. Apoptosis. 2010;15(5):527–40. doi:10.1007/s10495-009-0452-5
   PubMed Web of Science ®Google Scholar
• Aits S, Jaattela M. Lysosomal cell death at a glance. J Cell Sci. 2013;126(9):1905–12. doi:10.1242/jcs.091181
   PubMed Web of Science ®Google Scholar