Improvement of Rat Sperm Chromatin Integrity and Spermatogenesis with Omega 3 following Bleomycin, Etoposide and Cisplatin Treatment

References

• Holstein A-F, Davidoff M, Schulze W. Understanding spermatogenesis is a prerequisite for treatment. Reprod Biol Endocrinol. 2003;1(1):107. doi:10.1186/1477-7827-1-107
   PubMedGoogle Scholar
• Arav V, Sych V, Zheleznyak E. Effect of pinealectomy on circadian rhythm of spermatogenesis. Bull Exp Biol Med. 2003;136(6):604–6. doi:10.1023/B:BEBM.0000020216.01084.da
   PubMed Web of Science ®Google Scholar
• Martianov I, Brancorsini S, Catena R, Gansmuller A, Kotaja N, Parvinen M, Sassone-Corsi P, Davidson I. Polar nuclear localization of H1T2, a histone H1 variant, required for spermatid elongation and DNA condensation during spermiogenesis. PNAS. 2005;102(8):2808–13. doi:10.1073/pnas.0406060102
   PubMed Web of Science ®Google Scholar
• Steger K. Transcriptional and translational regulation of gene expression in haploid spermatids. Anatomy and Embryology. 1999;199(6):471–87. doi:10.1007/s004290050245
   PubMedGoogle Scholar
• Stein GS, Stein JL. Histones and other basic nuclear proteins.Florida, CRC press; 1989.
   Google Scholar
• Mohammad HN-E, Mohammad S, Shahnaz R, Maryam A, Shahla R, Fariba M, Mohammad M. Effect of sperm DNA damage and sperm protamine deficiency on fertilization and embryo development post-ICSI. Reprod Biomed Online. 2005;11(2):198–205. doi:10.1016/S1472-6483(10)60959-5
   PubMed Web of Science ®Google Scholar
• Khara K, Vlad M, Griffiths M, Kennedy C. Human protamines and male infertility. J Assist Reprod Genet. 1997;14(5):282–90. doi:10.1007/BF02765830
   PubMed Web of Science ®Google Scholar
• de Yebra L, Ballescá J-L, Vanrell JA, Corzett M, Balhorn R, Oliva R. Detection of P2 precursors in the sperm cells of infertile patients who have reduced protamine P2 levels. Fertility and Sterility. 1998;69(4):755–9. doi:10.1016/S0015-0282(98)00012-0
   PubMed Web of Science ®Google Scholar
• Nasr-Esfahani MH, Salehi M, Razavi S, Mardani M, Bahramian H, Steger K, Oreizi F. Effect of protamine-2 deficiency on ICSI outcome. Reprod Biomed Online. 2004;9(6):652–8. doi:10.1016/S1472-6483(10)61776-2
   PubMed Web of Science ®Google Scholar
• Dt C, Liu L. Altered protamine 2 expression is uncommon in donors of known fertility, but common among men with poor fertilizing capacity, and may reflect other abnormalities of spermiogenesis. Journal of Andrology. 2001;22(4):604–10.
   PubMedGoogle Scholar
• Mengual L, Ballescá JL, Ascaso C, Oliva R. Marked differences in protamine content and P1/P2 ratios in sperm cells from percoll fractions between patients and controls. J Androl. 2003;24(3):438–47. doi:10.1002/j.1939-4640.2003.tb02692.x
   PubMedGoogle Scholar
• Ahmadi A, Ng S-C. Destruction of protamine in human sperm inhibits sperm binding and penetration in the zona-free hamster penetration test but increases sperm head decondensation and male pronuclear formation in the hamster–ICSI assay. J Assisted Reprod Genet. 1999;16(3):128–32. doi: 10.1023/A:1022527714175
   PubMed Web of Science ®Google Scholar
• Delbes G, Hales BF, Robaire B. Effects of the chemotherapy cocktail used to treat testicular cancer on sperm chromatin integrity. J Androl. 2007;28(2):241–9. doi:10.2164/jandrol.106.001487
   PubMedGoogle Scholar
• O'flaherty CM, Chan PT, Hales BF, Robaire B. Sperm chromatin structure components are differentially repaired in cancer survivors. J Androl. 2012;33(4):629–36. doi:10.2164/jandrol.111.015388
   PubMedGoogle Scholar
• Yagmurca M, Erdogan H, Iraz M, Songur A, Ucar M, Fadillioglu E. Caffeic acid phenethyl ester as a protective agent against doxorubicin nephrotoxicity in rats. Clin Chim Acta. 2004;348(1-2):27–34. doi:10.1016/j.cccn.2004.03.035
   PubMed Web of Science ®Google Scholar
• Maselli J, Hales BF, Chan P, Robaire B. Exposure to bleomycin, etoposide, and cis-platinum alters rat sperm chromatin integrity and sperm head protein profile. Biol Reprod. 2012;86(5):1–10. doi:10.1095/biolreprod.111.098616
   Web of Science ®Google Scholar
• Sheng K, Liang X, Huang S, Xu W. The role of histone ubiquitination during spermatogenesis. BioMed Res Int. 2014;2014:1–8. doi:10.1155/2014/870695
   Web of Science ®Google Scholar
• Bagheri-Sereshki N, Hales BF, Robaire B. The effects of chemotherapeutic agents, bleomycin, etoposide, and cisplatin, on chromatin remodeling in male rat germ cells. Biol Reprod. 2016;94(4):1–9. doi:10.1095/biolreprod.115.137802
   Web of Science ®Google Scholar
• Kopp H-G, Kuczyk M, Classen J, Stenzl A, Kanz L, Mayer F, Bamberg M, Hartmann JT. Advances in the treatment of testicular cancer. Drugs. 2006;66(5):641–59. doi:10.2165/00003495-200666050-00005
   PubMed Web of Science ®Google Scholar
• Ahmed EA, Omar HM, Elghaffar SKA, Ragb SMM, Nasser AY. The antioxidant activity of vitamin C, DPPD and L-cysteine against cisplatin-induced testicular oxidative damage in rats. Food Chem Toxicol. 2011;49(5):1115–21. doi:10.1016/j.fct.2011.02.002
   PubMed Web of Science ®Google Scholar
• Shin H-J, Kwon H-K, Lee J-H, Anwar MA, Choi S. Etoposide induced cytotoxicity mediated by ROS and ERK in human kidney proximal tubule cells. Sci Rep. 2016;6(1):34064. doi:10.1038/srep34064
   PubMed Web of Science ®Google Scholar
• Wood OL, Spark A, Spark A. Medical nutrition therapy guidelines for treating the breast cancer patient. J American Diet Assoc. 1996;96(9):A35. doi:10.1016/S0002-8223(96)00434-8
   PubMedGoogle Scholar
• Yeh Y-C, Lai H-C, Ting C-T, Lee W-L, Wang L-C, Wang K-Y, Lai H-C, Liu T-J. Protection by doxycycline against doxorubicin-induced oxidative stress and apoptosis in mouse testes. Biochem Pharmacol. 2007;74(7):969–80. doi:10.1016/j.bcp.2007.06.031
   PubMed Web of Science ®Google Scholar
• Uygur R, Aktas C, Tulubas F, Uygur E, Kanter M, Erboga M, Caglar V, Topcu B, Ozen OA. Protective effects of fish omega‐3 fatty acids on doxorubicin‐induced testicular apoptosis and oxidative damage in rats. Andrologia. 2014;46(8):917–26. doi:10.1111/and.12173
   PubMed Web of Science ®Google Scholar
• Rooke J, Shao C, Speake B. Effects of feeding tuna oil on the lipid composition of pig spermatozoa and in vitro characteristics of semen. Reproduction. 2001;121(2):315–22. doi:10.1530/rep.0.1210315
   PubMed Web of Science ®Google Scholar
• Fair S, Doyle D, Diskin M, Hennessy A, Kenny D. The effect of dietary n-3 polyunsaturated fatty acids supplementation of rams on semen quality and subsequent quality of liquid stored semen. Theriogenology. 2014;81(2):210–9. doi:10.1016/j.theriogenology.2013.09.002
   PubMed Web of Science ®Google Scholar
• Estienne M, Harper A, Crawford R. Dietary supplementation with a source of omega-3 fatty acids increases sperm number and the duration of ejaculation in boars. Theriogenology. 2008;70(1):70–6. doi:10.1016/j.theriogenology.2008.02.007
   PubMed Web of Science ®Google Scholar
• Yeste M, Barrera X, Coll D, Bonet S. The effects on boar sperm quality of dietary supplementation with omega-3 polyunsaturated fatty acids differ among porcine breeds. Theriogenology. 2011;76(1):184–96. doi:10.1016/j.theriogenology.2011.01.032
   PubMed Web of Science ®Google Scholar
• Mitre R, Cheminade C, Allaume P, Legrand P, Legrand AB. Oral intake of shark liver oil modifies lipid composition and improves motility and velocity of boar sperm. Theriogenology. 2004;62(8):1557–66. doi:10.1016/j.theriogenology.2004.02.004
   PubMed Web of Science ®Google Scholar
• Kelso K, Redpath A, Noble R, Speake B. Lipid and antioxidant changes in spermatozoa and seminal plasma throughout the reproductive period of bulls. J Reprod Fertil. 1997;109(1):1–6. doi:10.1530/jrf.0.1090001
   PubMedGoogle Scholar
• Kilarkaje N, Mousa AM, Al-Bader MM, Khan KM. Antioxidants enhance the recovery of three cycles of bleomycin, etoposide, and cisplatin–induced testicular dysfunction, pituitary-testicular axis, and fertility in rats. Fertil Steril. 2013;100(4):1151–9. e5. doi:10.1016/j.fertnstert.2013.06.019
   PubMed Web of Science ®Google Scholar
• Hashemi F, Razavi S, Khadivi FJ. The protective effects of Omega3 on ubiquitination and protamination of rat sperm after bleomycin, etoposide, and cisplatin treatment. Nutr Cancer. 2018;70(8):1308–1314.
   PubMed Web of Science ®Google Scholar
• Razavi SR, Khadivi F, Hashemi F, Bakhtiari A. Effect of zinc on spermatogenesis and sperm chromatin condensation in bleomycin. Etoposide, Cisplatin Treated Rats. 2018;20(4):521.
   Google Scholar
• Nasr-Esfahani MH, Razavi S, Mardani M. Andrology: Relation between different human sperm nuclear maturity tests and in vitro fertilization. J Assisted Reprod Genet. 2001;18(4):221–7. doi:10.1023/A:1009412130417
   Web of Science ®Google Scholar
• Vaez A, Mardani M, Razavi S. Impact of saffron on rat sperm membrane integrity and spermatogenesis status. Adv Biomed Res. 2014;3(1):145. doi:10.4103/2277-9175.135163
   PubMedGoogle Scholar
• Aguilar-Mahecha A, Hales BF, Robaire B. Chronic cyclophosphamide treatment alters the expression of stress response genes in rat male germ cells. Biol Reprod. 2002;66(4):1024–32. doi:10.1095/biolreprod66.4.1024
   PubMed Web of Science ®Google Scholar
• Kim S-H, Lee I-C, Baek H-S, Moon C, Kim S-H, Kim J-C. Protective effect of diallyl disulfide on cyclophosphamide-induced testicular toxicity in rats. Lab Anim Res. 2013;29(4):204–11. doi:10.5625/lar.2013.29.4.204
   PubMedGoogle Scholar
• Saradha B, Mathur P. Effect of environmental contaminants on male reproduction. Environ Toxicol Pharmacol. 2006;21(1):34–41. doi:10.1016/j.etap.2005.06.004
   PubMed Web of Science ®Google Scholar
• Akbari A, Jelodar G, Nazifi S, Afsar T, Nasiri K. The effect of oxidative stress and antioxidants on men fertility. Zahedan J Res Med Sci. 2019;21(4):1–7. doi:10.5812/zjrms.85655
   Google Scholar
• Vanderwall DE, Lui SM, Wu W, Turner CJ, Kozarich JW, Stubbe J. A model of the structure of HOO-Co· bleomycin bound to d (CCAGTACTGG): recognition at the d (GpT) site and implications for double-stranded DNA cleavage. Chem Biol. 1997;4(5):373–87. doi:10.1016/S1074-5521(97)90128-9
   PubMedGoogle Scholar
• Russell LB, Hunsicker PR, Hack AM, Ashley T. Effect of the topoisomerase-II inhibitor etoposide on meiotic recombination in male mice. Mutat Res/Genet Toxicol Environ Mutagen. 2000;464(2):201–12. doi:10.1016/S1383-5718(99)00185-0
   PubMed Web of Science ®Google Scholar
• Wang D, Lippard SJ. Cellular processing of platinum anticancer drugs. Nat Rev Drug Discov. 2005;4(4):307–20. doi:10.1038/nrd1691
   PubMed Web of Science ®Google Scholar
• Maselli J, Hales BF, Robaire B. The effects of chemotherapy with bleomycin, etoposide, and cis-platinum (BEP) on rat sperm chromatin remodeling, fecundity and testicular gene expression in the progeny. Biol Reprod. 2013;89(4):1–9. doi:10.1095/biolreprod.113.110759
   Web of Science ®Google Scholar
• Liu M, Hales BF, Robaire B. Effects of four chemotherapeutic agents, bleomycin, etoposide, cisplatin, and cyclophosphamide, on DNA damage and telomeres in a mouse spermatogonial cell line. Biol Reprod. 2014;90(4):1–10. doi:10.1095/biolreprod.114.117754
   Web of Science ®Google Scholar
• Balhorn R, Brewer L, Corzett M. DNA condensation by protamine and arginine‐rich peptides: Analysis of toroid stability using single DNA molecules. Mol Reprod Dev. 2000;56(S2):230–4. doi:10.1002/(SICI)1098-2795(200006)56:2+<230::AID-MRD3>3.0.CO;2-V
   PubMed Web of Science ®Google Scholar
• Bagheri-Sereshki N, Hales BF, Robaire B. The effects of chemotherapeutic agents, bleomycin, etoposide, and cisplatin, on chromatin remodeling in male rat germ cells. Biol Reprod. 2016;94(4): 81. doi: 10.1095/biolreprod.115.137802
   PubMed Web of Science ®Google Scholar
• Türk G, Ateşşahin A, Sönmez M, Çeribaşi AO, Yüce A. Improvement of cisplatin-induced injuries to sperm quality, the oxidant-antioxidant system, and the histologic structure of the rat testis by ellagic acid. Fertil Steril. 2008;89(5):1474–81. doi:10.1016/j.fertnstert.2007.04.059
   PubMed Web of Science ®Google Scholar
• Ghezzi M, Berretta M, Bottacin A, Palego P, Sartini B, Cosci I, Finos L, Selice R, Foresta C, Garolla A. Impact of BEP or carboplatin chemotherapy on testicular function and sperm nucleus of subjects with testicular germ cell tumor. Front Pharmacol. 2016;7:122. doi:10.3389/fphar.2016.00122
   PubMed Web of Science ®Google Scholar
• Maldjian A, Pizzi F, Gliozzi T, Cerolini S, Penny P, Noble R. Changes in sperm quality and lipid composition during cryopreservation of boar semen. Theriogenology. 2005;63(2):411–21. doi:10.1016/j.theriogenology.2004.09.021
   PubMed Web of Science ®Google Scholar
• Am-In N, Kirkwood R, Techakumphu M, Tantasuparuk W. Lipid profiles of sperm and seminal plasma from boars having normal or low sperm motility. Theriogenology. 2011;75(5):897–903. doi:10.1016/j.theriogenology.2010.10.032
   PubMed Web of Science ®Google Scholar
• Vernet P, Aitken R, Drevet J. Antioxidant strategies in the epididymis. Mol Cell Endocrinol. 2004;216(1-2):31–9. doi:10.1016/j.mce.2003.10.069
   PubMed Web of Science ®Google Scholar
• Gomez E, Irvine D, Aitken R. Evaluation of a spectrophotometric assay for the measurement of malondialdehyde and 4-hydroxyalkenals in human spermatozoa: relationships with semen quality and sperm function. International Journal of Andrology. 1998;21(2):81–94. doi:10.1046/j.1365-2605.1998.00106.x
   PubMedGoogle Scholar
• Lewis S, Aitken R. DNA damage to spermatozoa has impacts on fertilization and pregnancy. Cell Tissue Res. 2005;322(1):33–41. doi:10.1007/s00441-005-1097-5
   PubMed Web of Science ®Google Scholar
• Gürler H, Calisici O, Calisici D, Bollwein H. Effects of feeding omega-3-fatty acids on fatty acid composition and quality of bovine sperm and on antioxidative capacity of bovine seminal plasma. Anim Reprod Sci. 2015;160:97–104. doi:10.1016/j.anireprosci.2015.07.010
   PubMed Web of Science ®Google Scholar