Evaluation of Cytotoxic Activity of Betanin Against U87MG Human Glioma Cells and Normal Human Lymphocytes and Its Anticancer Potential Through Mitochondrial Pathway

References

• Hanif F, Muzaffar K, Perveen K, Malhi SM, Simjee SU. Glioblastoma multiforme: a review of its epidemiology and pathogenesis through clinical presentation and treatment. Asian Pac J Cancer Prev. 2017;18(1):3–9. doi:10.22034/APJCP.2017.18.1.3
   PubMedGoogle Scholar
• Rock K, Mcardle O, Forde P, Dunne M, Fitzpatrick D, O'Neill B, Faul C. A clinical review of treatment outcomes in glioblastoma multiforme—the validation in a non-trial population of the results of a randomised Phase III clinical trial: has a more radical approach improved survival? BJR. 2012;85(1017):e729–e733. doi:10.1259/bjr/83796755
   Google Scholar
• Adamson C, Kanu OO, Mehta AI, Di C, Lin N, Mattox AK, Bigner DD. Glioblastoma multiforme: a review of where we have been and where we are going. Expert Opin Invest Drugs. 2009;18(8):1061–1083. doi:10.1517/13543780903052764
   PubMed Web of Science ®Google Scholar
• Thakkar JP, Dolecek TA, Horbinski C, Ostrom QT, Lightner DD, Barnholtz-Sloan JS, Villano JL. Epidemiologic and molecular prognostic review of glioblastoma. Cancer Epidemiol Prev Biomarkers. 2014;23(10):1985–1996. doi:10.1158/1055-9965.EPI-14-0275
   PubMed Web of Science ®Google Scholar
• Seyfried T, Sanderson T, El-Abbadi M, McGowan R, Mukherjee P. Role of glucose and ketone bodies in the metabolic control of experimental brain cancer. Br J Cancer. 2003;89(7):1375–1382. doi:10.1038/sj.bjc.6601269
   PubMed Web of Science ®Google Scholar
• Guntuku L, Naidu V, Yerra VG. Mitochondrial dysfunction in gliomas: pharmacotherapeutic potential of natural compounds. CN. 2016;14(6):567–583. doi:10.2174/1570159X14666160121115641
   Web of Science ®Google Scholar
• Jelluma N, Yang X, Stokoe D, Evan GI, Dansen TB, Haas-Kogan DA. Glucose withdrawal induces oxidative stress followed by apoptosis in glioblastoma cells but not in normal human astrocytes. Mol Cancer Res. 2006;4(5):319–330. doi:10.1158/1541-7786.MCR-05-0061
   PubMed Web of Science ®Google Scholar
• Leonardi R, Subramanian C, Jackowski S, Rock CO. Cancer-associated isocitrate dehydrogenase mutations inactivate NADPH-dependent reductive carboxylation. J Biol Chem. 2012;287(18):14615–14620. doi:10.1074/jbc.C112.353946
   PubMed Web of Science ®Google Scholar
• Ward PS, Patel J, Wise DR, Abdel-Wahab O, Bennett BD, Coller HA, Cross JR, Fantin VR, Hedvat CV, Perl AE, et al. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting α-ketoglutarate to 2-hydroxyglutarate. Cancer Cell. 2010;17(3):225–234. doi:10.1016/j.ccr.2010.01.020
   PubMed Web of Science ®Google Scholar
• Atanasov AG, Waltenberger B, Pferschy-Wenzig E-M, Linder T, Wawrosch C, Uhrin P, Temml V, Wang L, Schwaiger S, Heiss EH, et al. Discovery and resupply of pharmacologically active plant-derived natural products: a review. Biotechnol Adv. 2015;33(8):1582–1614. doi:10.1016/j.biotechadv.2015.08.001
   PubMed Web of Science ®Google Scholar
• Vieira Teixeira da Silva D, dos Santos Baião D, de Oliveira Silva F, Alves G, Perrone D, Mere Del Aguila E, M. Flosi Paschoalin V. Betanin, a natural food additive: stability, bioavailability, antioxidant and preservative ability assessments. Molecules. 2019;24(3):458. doi:10.3390/molecules24030458
   PubMed Web of Science ®Google Scholar
• Cvrljevic AN, Akhavan D, Wu M, Martinello P, Furnari FB, Johnston AJ, Guo D, Pike L, Cavenee WK, Scott AM, et al. Activation of Src induces mitochondrial localisation of de2-7EGFR (EGFRvIII) in glioma cells: implications for glucose metabolism. J Cell Sci. 2011;124(17):2938–2950. doi:10.1242/jcs.083295
   PubMed Web of Science ®Google Scholar
• Pourahmad J, Salimi A. Isolated human peripheral blood mononuclear cell (PBMC), a cost effective tool for predicting immunosuppressive effects of drugs and xenobiotics. Iran J Pharm Res. 2015;14(4):979.
   PubMed Web of Science ®Google Scholar
• Borhani S, Mozdarani H, Babalui S, Bakhshandeh M, Nosrati H. In vitro radiosensitizing effects of temozolomide on U87MG cell lines of human glioblastoma multiforme. Iran J Med Sci. 2017;42:258.
   PubMed Web of Science ®Google Scholar
• Lee C-W, Hsu L-F, Lee M-H, Lee I-T, Liu J-F, Chiang Y-C, Tsai M-H. Extracts of Artocarpus communis induce mitochondria-associated apoptosis via pro-oxidative activity in human glioblastoma cells. Front Pharmacol. 2018;9:411. doi:10.3389/fphar.2018.00411
   PubMed Web of Science ®Google Scholar
• Salimi A, Motallebi A, Ayatollahi M, Seydi E, Mohseni AR, Nazemi M, Pourahmad J. Selective toxicity of persian gulf sea cucumber holothuria parva on human chronic lymphocytic leukemia b lymphocytes by direct mitochondrial targeting. Environ Toxicol. 2017;32(4):1158–1169. doi:10.1002/tox.22312
   PubMed Web of Science ®Google Scholar
• Salimi A, Roudkenar MH, Sadeghi L, Mohseni A, Seydi E, Pirahmadi N, Pourahmad J. Ellagic acid, a polyphenolic compound, selectively induces ROS-mediated apoptosis in cancerous B-lymphocytes of CLL patients by directly targeting mitochondria. Redox Biol. 2015;6:461–471. doi:10.1016/j.redox.2015.08.021
   PubMed Web of Science ®Google Scholar
• Cai X, Sughrue ME. Glioblastoma: new therapeutic strategies to address cellular and genomic complexity. Oncotarget. 2018;9(10):9540. doi:10.18632/oncotarget.23476
   PubMedGoogle Scholar
• Zugazagoitia J, Guedes C, Ponce S, Ferrer I, Molina-Pinelo S, Paz-Ares L. Current challenges in cancer treatment. Clin Ther. 2016;38(7):1551–1566. doi:10.1016/j.clinthera.2016.03.026
   PubMed Web of Science ®Google Scholar
• Agbarya A, Ruimi N, Epelbaum R, Ben-Arye E, Mahajna J. Natural products as potential cancer therapy enhancers: a preclinical update. SAGE Open Med. 2014;2:205031211454692. doi:10.1177/2050312114546924
   PubMedGoogle Scholar
• Vengoji R, Macha MA, Batra SK, Shonka NA. Natural products: a hope for glioblastoma patients. Oncotarget. 2018;9(31):22194. doi:10.18632/oncotarget.25175
   PubMedGoogle Scholar
• Kim H, Moon JY, Ahn KS, Cho SK. Quercetin induces mitochondrial mediated apoptosis and protective autophagy in human glioblastoma U373MG cells. Oxid Med Cell Longevity. 2013;2013:1–10. doi:10.1155/2013/596496
   Web of Science ®Google Scholar
• Huang H, Lin H, Zhang X, Li J. Resveratrol reverses temozolomide resistance by downregulation of MGMT in T98G glioblastoma cells by the NF-κB-dependent pathway. Oncol Rep. 2012;27:2050–2056. doi:10.3892/or.2012.1715
   PubMed Web of Science ®Google Scholar
• Yang L, Wang Y, Guo H, Guo M. Synergistic anti-cancer effects of icariin and temozolomide in glioblastoma. Cell Biochem Biophys. 2015;71(3):1379–1385. doi:10.1007/s12013-014-0360-3
   PubMed Web of Science ®Google Scholar
• Markiewicz-Żukowska R, Borawska MH, Fiedorowicz A, Naliwajko SK, Sawicka D, Car H. Propolis changes the anticancer activity of temozolomide in U87MG human glioblastoma cell line. BMC Complement Altern Med. 2013;13(1):50. doi:10.1186/1472-6882-13-50
   PubMed Web of Science ®Google Scholar
• Khan MI. Plant betalains: safety, antioxidant activity, clinical efficacy, and bioavailability. Compr Rev Food Sci Food Saf. 2016;15(2):316–330. doi:10.1111/1541-4337.12185
   PubMed Web of Science ®Google Scholar
• Nowacki L, Vigneron P, Rotellini L, Cazzola H, Merlier F, Prost E, Ralanairina R, Gadonna J-P, Rossi C, Vayssade M, et al. Betanin‐enriched red beetroot (Beta vulgaris L.) extract induces apoptosis and autophagic cell death in MCF‐7 cells. Phytother Res. 2015;29(12):1964–1973. doi:10.1002/ptr.5491
   PubMed Web of Science ®Google Scholar
• Barbosa IA, Machado NG, Skildum AJ, Scott PM, Oliveira PJ. Mitochondrial remodeling in cancer metabolism and survival: potential for new therapies. Biochim Biophys Acta Rev Cancer. 2012;1826(1):238–254. doi:10.1016/j.bbcan.2012.04.005
   PubMed Web of Science ®Google Scholar
• Guntuku L, Naidu VG, Yerra VG. Mitochondrial dysfunction in gliomas: pharmacotherapeutic potential of natural compounds. Current Neuropharmacol. 2016;14(6):567–583.
   Google Scholar
• Arismendi-Morillo G. Electron microscopy morphology of the mitochondrial network in gliomas and their vascular microenvironment. Biochim Biophys Acta Bioenergy. 2011;1807(6):602–608. doi:10.1016/j.bbabio.2010.11.001
   Web of Science ®Google Scholar
• Wallace DC. Mitochondria and cancer. Nat Rev Cancer. 2012;12(10):685–698. doi:10.1038/nrc3365
   PubMed Web of Science ®Google Scholar
• Sreekanth D, Arunasree MK, Roy KR, Chandramohan Reddy T, Reddy GV, Reddanna P. Betanin a betacyanin pigment purified from fruits of Opuntia ficus-indica induces apoptosis in human chronic myeloid leukemia Cell line-K562. Phytomedicine. 2007;14(11):739–746. doi:10.1016/j.phymed.2007.03.017
   PubMed Web of Science ®Google Scholar
• Frank T, Stintzing FC, Carle R, Bitsch I, Quaas D, Straß G, Bitsch R, Netzel M. Urinary pharmacokinetics of betalains following consumption of red beet juice in healthy humans. Pharmacol Res. 2005;52(4):290–297. doi:10.1016/j.phrs.2005.04.005
   PubMed Web of Science ®Google Scholar
• Clifford T, Constantinou CM, Keane KM, West DJ, Howatson G, Stevenson EJ. The plasma bioavailability of nitrate and betanin from Beta vulgaris rubra in humans. Eur J Nutr. 2017;56(3):1245–1254. doi:10.1007/s00394-016-1173-5
   PubMed Web of Science ®Google Scholar