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Article

Synergistic Induction of Apoptosis by Quercetin and Curcumin in Chronic Myeloid Leukemia (K562) Cells: II. Signal Transduction Pathways Involved

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Pages 703-712 | Received 19 Dec 2019, Accepted 02 May 2020, Published online: 18 May 2020

References

  • Huang C-Y, Ju D-T, Chang C-F, Reddy PM, Velmurugan BK. A review on the effects of current chemotherapy drugs and natural agents in treating non–small cell lung cancer. Biomedicine (Taipei). 2017;7(4):23. doi:10.1051/bmdcn/2017070423
  • Flis S, Chojnacki T. Chronic myelogenous leukemia, a still unsolved problem: pitfalls and new therapeutic possibilities. Drug Des Devel Ther. 2019;13:825–43. doi:10.2147/DDDT.S191303
  • Li J, Halfter K, Zhang M, Saad C, Xu K, Bauer B, Huang Y, Shi L, Mansmann UR. Computational analysis of receptor tyrosine kinase inhibitors and cancer metabolism: implications for treatment and discovery of potential therapeutic signatures. BMC Cancer. 2019;19(1):600. doi:10.1186/s12885-019-5804-0
  • Güran M, Şanlıtürk G, Kerküklü NR, Altundağ EM, Yalçın AS. Combined effects of quercetin and curcumin on anti-inflammatory and antimicrobial parameters in vitro. Eur J Pharmacol. 2019;859:172486. doi:10.1016/j.ejphar.2019.172486
  • Kumar S, Pandey AK. Chemistry and biological activities of flavonoids: an overview. Sci World J. 2013;2013:162750. doi:10.1155/2013/162750
  • Sharma A, Kaur M, Katnoria JK, Nagpal AK. Polyphenols in food: Cancer prevention and apoptosis induction. Curr Med Chem. 2018;25(36):4740–57. doi:10.2174/0929867324666171006144208
  • Menezes JC, Orlikova B, Morceau F, Diederich M. Natural and synthetic flavonoids: structure–activity relationship and chemotherapeutic potential for the treatment of leukemia. Crit Rev Food Sci Nutr . 2016;56(sup1):S4–S28. doi:10.1080/10408398.2015.1074532
  • Kunnumakkara AB, Bordoloi D, Harsha C, Banik K, Gupta SC, Aggarwal BB. Curcumin mediates anticancer effects by modulating multiple cell signaling pathways. Clin Sci. 2017;131(15):1781–99. doi:10.1042/CS20160935
  • Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of curcumin: problems and promises. Mol Pharm. 2007;4(6):807–18. doi:10.1021/mp700113r
  • Mu C, Jia P, Yan Z, Liu X, Li X, Liu H. Quercetin induces cell cycle G1 arrest through elevating Cdk inhibitors p21 and p27 in human hepatoma cell line (HepG2)). Methods Find Exp Clin Pharmacol. 2007;29(3):179–84. doi:10.1358/mf.2007.29.3.1092095
  • Mutlu Altundağ E, Yılmaz AM, Koçtürk S, Taga Y, Yalçın AS. Synergistic induction of apoptosis by quercetin and curcumin in chronic myeloid leukemia (K562) cells. Nutr Cancer. 2018;70(1):97–108. doi:10.1080/01635581.2018.1380208
  • van Ginkel PR, Yan MB, Bhattacharya S, Polans AS, Kenealey JD. Natural products induce a G protein-mediated calcium pathway activating p53 in cancer cells. Toxicol Appl Pharmacol. 2015;288(3):453–62. doi:10.1016/j.taap.2015.08.016
  • Shehzad A, Lee YS. Molecular mechanisms of curcumin action: signal transduction. Biofactors. 2013;39(1):27–36. doi:10.1002/biof.1065
  • Panda AK, Chakraborty D, Sarkar I, Khan T, Sa G. New insights into therapeutic activity and anticancer properties of curcumin. J Exp Pharmacol. 2017;9:31–45. doi:10.2147/JEP.S70568
  • Shehzad A, Wahid F, Lee YS. Curcumin in cancer chemoprevention: molecular targets, pharmacokinetics, bioavailability, and clinical trials. Arch Pharm (Weinheim). 2010;343(9):489–99. doi:10.1002/ardp.200900319
  • Rafiq S, Raza MH, Younas M, Naeem F, Adeeb R, Iqbal J, Anwar P, Sajid U, Manzoor HM. Molecular targets of curcumin and future therapeutic role in leukemia. JBM. 2018;06(04):33–50. doi:10.4236/jbm.2018.64003
  • Russo M, Palumbo R, Tedesco I, Mazzarella G, Russo P, Iacomino G, Russo GL. Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line. FEBS Lett. 1999;462(3):322–8. doi:10.1016/s0014-5793(99)01544-6
  • Chen F-Y, Cao L-F, Wan H-X, Zhang M-Y, Cai J-Y, Shen L-J, Zhong J-H, Zhong H. Quercetin enhances adriamycin cytotoxicity through induction of apoptosis and regulation of mitogen-activated protein kinase/extracellular signal-regulated kinase/c-Jun N-terminal kinase signaling in multidrug-resistant leukemia K562 cells. Mol Med Rep. 2015;11(1):341–8. doi:10.3892/mmr.2014.2734
  • Mao B, Zhang Z, Wang G. BTG2: a rising star of tumor suppressors (review). Int J Oncol. 2015;46(2):459–64. doi:10.3892/ijo.2014.2765
  • Kawakubo H, Carey JL, Brachtel E, Gupta V, Green JE, Walden PD, Maheswaran S. Expression of the NF-kappaB-responsive gene BTG2 is aberrantly regulated in breast cancer. Oncogene. 2004;23(50):8310–9. doi:10.1038/sj.onc.1208008
  • Otto T, Sicinski P. Cell cycle proteins as promising targets in cancer therapy. Nat Rev Cancer. 2017;17(2):93–115. doi:10.1038/nrc.2016.138
  • Park M-J, Kim E-H, Park I-C, Lee H-C, Woo S-H, Lee J-Y, Hong Y-J, Rhee CH, Choi S-H, Shim B-S, et al. Curcumin inhibits cell cycle progression of immortalized human umbilical vein endothelial (ECV304) cells by up-regulating cyclin-dependent kinase inhibitor, p21WAF1/CIP1, p27KIP1 and p53. Int J Oncol. 2002;21(2):379–83.:
  • Martínez-Castillo M, Villegas-Sepúlveda N, Meraz-Rios MA, Hernández-Zavala A, Berumen J, Coleman MA, Orozco L, Cordova EJ. Curcumin differentially affects cell cycle and cell death in acute and chronic myeloid leukemia cells. Oncol Lett. 2018;15(5):6777–83. doi:10.3892/ol.2018.8112
  • Pulido-Moran M, Moreno-Fernandez J, Ramirez-Tortosa C, Ramirez-Tortosa M. Curcumin and health. Molecules. 2016;21(3):264doi:10.3390/molecules21030264
  • Lee H-P, Li T-M, Tsao J-Y, Fong Y-C, Tang C-H. Curcumin induces cell apoptosis in human chondrosarcoma through extrinsic death receptor pathway. Int Immunopharmacol. 2012;13(2):163–9. doi:10.1016/j.intimp.2012.04.002
  • Zhu G-H, Dai H-P, Shen Q, Ji O, Zhang Q, Zhai Y-L. Curcumin induces apoptosis and suppresses invasion through MAPK and MMP signaling in human monocytic leukemia SHI-1 cells. Pharm Biol. 2016;54(8):1303–11. doi:10.3109/13880209.2015.1060508
  • Fresno Vara JA, Casado E, de Castro J, Cejas P, Belda-Iniesta C, González-Barón M. PI3K/Akt signalling pathway and cancer. Cancer Treat Rev. 2004;30(2):193–204. doi:10.1016/j.ctrv.2003.07.007
  • Blume-Jensen P, Hunter T. Oncogenic kinase signalling. Nature. 2001;411(6835):355–65. doi:10.1038/35077225
  • Chu S, Li L, Singh H, Bhatia R. BCR-tyrosine 177 plays an essential role in Ras and Akt activation and in human hematopoietic progenitor transformation in chronic myelogenous leukemia. Cancer Res. 2007;67(14):7045–53. doi:10.1158/0008-5472.CAN-06-4312
  • Zhang J-Y, Lin M-T, Zhou M-J, Yi T, Tang Y-N, Tang S-L, Yang Z-J, Zhao Z-Z, Chen H-B. Combinational treatment of curcumin and quercetin against gastric cancer MGC-803 cells in vitro. Molecules. 2015;20(6):11524–34. doi:10.3390/molecules200611524
  • Yahfoufi N, Alsadi N, Jambi M, Matar C. The immunomodulatory and anti-inflammatory role of polyphenols. Nutrients. 2018;10(11):1618. doi:10.3390/nu10111618
  • Olivera A, Moore TW, Hu F, Brown AP, Sun A, Liotta DC, Snyder JP, Yoon Y, Shim H, Marcus AI, et al. Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties. Int Immunopharmacol. 2012;12(2):368–77. doi:10.1016/j.intimp.2011.12.009
  • Pfeffer LM. The role of nuclear factor κB in the interferon response. J Interferon Cytokine Res. 2011;31(7):553–9. doi:10.1089/jir.2011.0028
  • Held SAE, Heine A, Kesper AR, Schönberg K, Beckers A, Wolf D, Brossart P. Interferon gamma modulates sensitivity of CML cells to tyrosine kinase inhibitors. Oncoimmunology. 2016;5(1):e1065368. doi:10.1080/2162402X.2015.1065368
  • Bill MA, Bakan C, Benson DM, Fuchs J, Young G, Lesinski GB. Curcumin induces proapoptotic effects against human melanoma cells and modulates the cellular response to immunotherapeutic cytokines. Mol Cancer Ther. 2009;8(9):2726–35. doi:10.1158/1535-7163.MCT-09-0377
  • Kim JH, Gupta SC, Park B, Yadav VR, Aggarwal BB. Turmeric (Curcuma longa) inhibits inflammatory nuclear factor (NF)-κB and NF-κB-regulated gene products and induces death receptors leading to suppressed proliferation, induced chemosensitization, and suppressed osteoclastogenesis. Mol Nutr Food Res. 2012;56(3):454–65. doi:10.1002/mnfr.201100270

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