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Review

Dietary Total Antioxidant Capacity (TAC) Significantly Reduces the Risk of Site-Specific Cancers: An Updated Systematic Review and Meta-Analysis

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Pages 721-739 | Received 26 Apr 2019, Accepted 06 May 2020, Published online: 28 May 2020

References

  • Fitzmaurice C, Dicker D, Pain A, Hamavid H, Moradi-Lakeh M, MacIntyre MF, Allen C, Hansen G, Woodbrook R, Wolfe C, et al. The global burden of cancer 2013. JAMA Oncol. 2015;1(4):505–27. doi:10.1001/jamaoncol.2015.0735
  • Doll R, Peto R. The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J Natl Cancer Inst. 1981;66(6):1191–308. doi: 10.1093/jnci/66.6.1192
  • World Cancer Research Fund, American Institute for Cancer Research. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. Washington, D. C.: American Institute for Cancer Research; 2007.
  • Do MH, Lee SS, Jung PJ, Lee MH. Intake of fruits, vegetables, and soy foods in relation to breast cancer risk in Korean women: a case-control study. Nutr Cancer. 2007;57(1):20–7. doi:10.1080/01635580701268063
  • Lissowska J, Gaudet MM, Brinton LA, Peplonska B, Sherman M, Szeszenia-Dabrowska N, Zatonski W, Garcia-Closas M. Intake of fruits, and vegetables in relation to breast cancer risk by hormone receptor status. Breast Cancer Res Treat. 2008;107(1):113–7. doi:10.1007/s10549-007-9524-9
  • Erten Şener D, Gönenç A, Akıncı M, Torun M. Lipid peroxidation and total antioxidant status in patients with breast cancer. Cell Biochem Funct. 2007;25(4):377–82. doi:10.1002/cbf.1308
  • Borek C. Dietary antioxidants and human cancer. Integr Cancer Ther. 2004;3(4):333–41. doi:10.1177/1534735404270578
  • Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact. 2006;160(1):1–40. doi:10.1016/j.cbi.2005.12.009
  • Srivastava S, Natu SM, Gupta A, Pal KA, Singh U, Agarwal GG, Singh U, Goel MM, Srivastava AN. Lipid peroxidation and antioxidants in different stages of cervical cancer: Prognostic significance. Indian J Cancer. 2009;46(4):297–302. doi:10.4103/0019-509X.55549
  • Eroglu M, Yilmaz N, Yalcinkaya S, Ay N, Aydin O, Sezer C. Enhanced HDL-cholesterol-associated anti-oxidant PON-1 activity in prostate cancer patients. Kaohsiung J Med Sci. 2013;29(7):368–73. doi:10.1016/j.kjms.2012.11.004
  • Wang D, Feng J-F, Zeng P, Yang Y-H, Luo J, Yang Y-W. Total oxidant/antioxidant status in sera of patients with thyroid cancers. Endocr Relat Cancer. 2011;18(6):773–82. doi:10.1530/ERC-11-0230
  • Feng J-F, Lu L, Zeng P, Yang Y-H, Luo J, Yang Y-W, Wang D. Serum total oxidant/antioxidant status and trace element levels in breast cancer patients. Int J Clin Oncol. 2012;17(6):575–83. doi:10.1007/s10147-011-0327-y
  • Halliwell B. Antioxidants in human health and disease. Annu Rev Nutr. 1996;16:33–50. doi:10.1146/annurev.nu.16.070196.000341
  • Boffetta P, Couto E, Wichmann J, Ferrari P, Trichopoulos D, Bueno-de-Mesquita HB, van Duijnhoven FJB, Büchner FL, Key T, Boeing H, et al. Fruit and vegetable intake and overall cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). J Natl Cancer Inst. 2010;102(8):529–37. doi:10.1093/jnci/djq072
  • Davis CD, Tsuji PA, Milner JA. Selenoproteins and cancer prevention. Annu Rev Nutr. 2012;32:73–95. doi:10.1146/annurev-nutr-071811-150740
  • Griffiths K, Aggarwal B, Singh R, Buttar H, Wilson D, De Meester F. Food antioxidants and their anti-inflammatory properties: A potential role in cardiovascular diseases and cancer prevention. Diseases. 2016;4(4):28. doi:10.3390/diseases4030028
  • Willett WC. Fruits, vegetables, and cancer prevention: Turmoil in the produce section. J Natl Cancer Inst. 2010;102(8):510–1. doi:10.1093/jnci/djq098
  • Steinmetz KA, Potter JD. Vegetables, fruit, and cancer prevention: a review. J Am Diet Assoc. 1996;96(10):1027–39. doi:10.1016/S0002-8223(96)00273-8
  • Chatterjee M, Saluja R, Kanneganti S, Chinta S, Dikshit M. Biochemical and molecular evaluation of neutrophil NOS in spontaneously hypertensive rats. Cell Mol Biol (Noisy-le-Grand). 2007;53:84–93. doi:10.1170/T779
  • Hajiluian G, Farhangi MA, Jahangiry L. Mediterranean dietary pattern and VEGF+ 405 G/C gene polymorphisms in patients with metabolic syndrome: An aspect of gene-nutrient interaction. Plos One. 2017;12(2):e0171637. doi:10.1371/journal.pone.0171637
  • Kang D-H. Oxidative stress, DNA damage, and breast cancer. AACN Clin Issues. 2002;13(4):540–9. doi:10.1097/00044067-200211000-00007
  • Dolara P, Bigagli E, Collins A. Antioxidant vitamins and mineral supplementation, life span expansion and cancer incidence: a critical commentary. Eur J Nutr. 2012;51(7):769–81. doi:10.1007/s00394-012-0389-2
  • Frei B. Efficacy of dietary antioxidants to prevent oxidative damage and inhibit chronic disease. J Nutr. 2004;134(11):3196S–8S. doi:10.1093/jn/134.11.3196S
  • Somannavar M, Kodliwadmath M. Correlation between oxidative stress and antioxidant defence in South Indian urban vegetarians and non-vegetarians. Eur Rev Med Pharmacol Sci. 2012;16:351–4.
  • Pelucchi C, Tramacere I, Bertuccio P, Tavani A, Negri E, La Vecchia C. Dietary intake of selected micronutrients and gastric cancer risk: an Italian case-control study. Ann Oncol. 2009;20(1):160–5. doi:10.1093/annonc/mdn536
  • Rossi M, Bosetti C, Negri E, Lagiou P, Vecchia CL. Flavonoids, proanthocyanidins, and cancer risk: a network of case-control studies from Italy. Nutr Cancer. 2010;62(7):871–7. doi:10.1080/01635581.2010.509534
  • Amiano P, Molina-Montes E, Molinuevo A, Huerta J-M, Romaguera D, Gracia E, Martín V, Castaño-Vinyals G, Pérez-Gómez B, Moreno V, et al. Association study of dietary non-enzymatic antioxidant capacity (NEAC) and colorectal cancer risk in the Spanish Multicase-Control Cancer (MCC-Spain) study. Eur J Nutr. 2019;58(6):2229–42. doi:10.1007/s00394-018-1773-3
  • Puchau B, Zulet MA, de Echavarri AG, Hermsdorff HH, Martinez JA. Dietary total antioxidant capacity: a novel indicator of diet quality in healthy young adults. J Am Coll Nutr. 2009;28(6):648–56. doi:10.1080/07315724.2009.10719797
  • Serafini M, Villano D, Spera G, Pellegrini N. Redox molecules and cancer prevention: the importance of understanding the role of the antioxidant network. Nutr Cancer. 2006;56(2):232–40. doi:10.1207/s15327914nc5602_15
  • Pellegrini N, Serafini M, Colombi B, Del Rio D, Salvatore S, Bianchi M, Brighenti F. Total antioxidant capacity of plant foods, beverages and oils consumed in Italy assessed by three different in vitro assays. J Nutr. 2003;133(9):2812–9. doi:10.1093/jn/133.9.2812
  • Serafini M, Bellocco R, Wolk A, Ekstrom AM. Total antioxidant potential of fruit and vegetables and risk of gastric cancer. Gastroenterology. 2002;123(4):985–91. doi:10.1053/gast.2002.35957
  • Cui X, Rosner B, Willett WC, Hankinson SE. Antioxidant intake and risk of endometrial cancer: results from the Nurses' Health Study. Int J Cancer. 2011;128(5):1169–78. doi:10.1002/ijc.25425
  • Serafini M, Jakszyn P, Luján-Barroso L, Agudo A, Bas Bueno-de-Mesquita H, van Duijnhoven FJB, Jenab M, Navarro C, Palli D, Boeing H, et al. Dietary total antioxidant capacity and gastric cancer risk in the European prospective investigation into cancer and nutrition study. Int J Cancer. 2012;131(4):E544–E554. doi:10.1002/ijc.27347
  • Gifkins D, Olson SH, Demissie K, Lu S-E, Kong A-NT, Bandera EV. Total and individual antioxidant intake and endometrial cancer risk: results from a population-based case-control study in New Jersey. Cancer Causes Control. 2012;23(6):887–95. doi:10.1007/s10552-012-9958-1
  • Nouraie M, Pietinen P, Kamangar F, Dawsey SM, Abnet CC, Albanes D, Virtamo J, Taylor PR. Fruits, vegetables, and antioxidants and risk of gastric cancer among male smokers. Cancer Epidemiol Biomarkers Prev. 2005;14(9):2087–92. doi:10.1158/1055-9965.EPI-05-0038
  • Lucas AL, Bosetti C, Boffetta P, Negri E, Tavani A, Serafini M, Polesel J, Serraino D, La Vecchia C, Rossi M, et al. Dietary total antioxidant capacity and pancreatic cancer risk: an Italian case-control study. Br J Cancer. 2016;115(1):102–7. doi:10.1038/bjc.2016.114
  • Russnes KM, Wilson KM, Epstein MM, Kasperzyk JL, Stampfer MJ, Kenfield SA, Smeland S, Blomhoff R, Giovannucci EL, Willett WC, et al. Total antioxidant intake in relation to prostate cancer incidence in the Health Professionals Follow-Up Study. Int J Cancer. 2014;134(5):1156–65. doi:10.1002/ijc.28438
  • Pantavos A, Ruiter R, Feskens EF, de Keyser CE, Hofman A, Stricker BH, Franco OH, Kiefte-de Jong JC. Total dietary antioxidant capacity, individual antioxidant intake and breast cancer risk: the Rotterdam Study. Int J Cancer. 2015;136(9):2178–86. doi:10.1002/ijc.29249
  • La Vecchia C, Decarli A, Serafini M, Parpinel M, Bellocco R, Galeone C, Bosetti C, Zucchetto A, Polesel J, Lagiou P, et al. Dietary total antioxidant capacity and colorectal cancer: a large case-control study in Italy. Int J Cancer. 2013;133(6):1447–51. doi:10.1002/ijc.28133
  • Zamora-Ros R, Fedirko V, Trichopoulou A, González CA, Bamia C, Trepo E, Nöthlings U, Duarte-Salles T, Serafini M, Bredsdorff L, et al. Dietary flavonoid, lignan and antioxidant capacity and risk of hepatocellular carcinoma in the European prospective investigation into cancer and nutrition study. Int J Cancer. 2013;133(10):2429–43. doi:10.1002/ijc.28257
  • Chang ET, Lee VS, Canchola AJ, Clarke CA, Purdie DM, Reynolds P, Anton-Culver H, Bernstein L, Deapen D, Peel D, et al. Diet and risk of ovarian cancer in the California Teachers Study cohort. Am J Epidemiol. 2007;165(7):802–13. doi:10.1093/aje/kwk065
  • Vece MM, Agnoli C, Grioni S, Sieri S, Pala V, Pellegrini N, Frasca G, Tumino R, Mattiello A, Panico S, et al. Dietary total antioxidant capacity and colorectal cancer in the Italian EPIC cohort. Plos One. 2015;10(11):e0142995. doi:10.1371/journal.pone.0142995
  • Parohan M, Sadeghi A, Khatibi SR, Nasiri M, Milajerdi A, Khodadost M, Sadeghi O. Dietary total antioxidant capacity and risk of cancer: a systematic review and meta-analysis on observational studies. Crit Rev Oncol Hematol. 2019;138:70–86. doi:10.1016/j.critrevonc.2019.04.003
  • Benetou V, Orfanos P, Lagiou P, Trichopoulos D, Boffetta P, Trichopoulou A. Vegetables and fruits in relation to cancer risk: evidence from the Greek EPIC cohort study. Cancer Epidemiol Biomarkers Prev. 2008;17(2):387–92. doi:10.1158/1055-9965.EPI-07-2665
  • Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010;25(9):603–5. doi:10.1007/s10654-010-9491-z
  • Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21(11):1539–58. doi:10.1002/sim.1186
  • de Oliveira DG, de Faria Ghetti F, Moreira APB, Hermsdorff HHM, de Oliveira JM, de Castro Ferreira LEVV. Association between dietary total antioxidant capacity and hepatocellular ballooning in nonalcoholic steatohepatitis: a cross-sectional study. Eur J Nutr. 2019;58(6):2263–70. doi:10.1007/s00394-018-1776-0
  • Kim K, Vance TM, Chen M-H, Chun OK. Dietary total antioxidant capacity is inversely associated with all-cause and cardiovascular disease death of US adults. Eur J Nutr. 2018;57(7):2469–76. doi:10.1007/s00394-017-1519-7
  • Kim K, Vance TM, Chun OK. Greater total antioxidant capacity from diet and supplements is associated with a less atherogenic blood profile in US adults. Nutrients. 2016;8(1):15. doi:10.3390/nu8010015
  • Vance TM, Wang Y, Su LJ, Fontham ETH, Steck SE, Arab L, Bensen JT, Mohler JL, Chen M-H, Chun OK, et al. Dietary total antioxidant capacity is inversely associated with prostate cancer aggressiveness in a population-based study. Nutr Cancer. 2016;68(2):214–24. doi:10.1080/01635581.2016.1134596
  • Wright ME, Mayne ST, Stolzenberg-Solomon RZ, Li Z, Pietinen P, Taylor PR, Virtamo J, Albanes D. Development of a comprehensive dietary antioxidant index and application to lung cancer risk in a cohort of male smokers. Am J Epidemiol. 2004;160(1):68–76. doi:10.1093/aje/kwh173
  • Karimi Z, Bahadoran Z, Abedini S, Rad AH, Rashidkhani B. Dietary total antioxidant capacity and the risk of breast cancer: A case-control study. East Mediterr Health J. 2015;21(8):564–71. doi:10.26719/2015.21.8.564
  • Praud D, Parpinel M, Serafini M, Bellocco R, Tavani A, Lagiou P, La Vecchia C, Rossi M. Non-enzymatic antioxidant capacity and risk of gastric cancer. Cancer Epidemiol. 2015;39(3):340–5. doi:10.1016/j.canep.2015.04.003
  • Rossi M, Tavani A, Ciociola V, Ferraroni M, Parpinel M, Serafini M, Bellocco R, Zucchetto A, Montella M, Serraino D, et al. Dietary total antioxidant capacity in relation to endometrial cancer risk: a case-control study in Italy. Cancer Causes Control. 2016;27(3):425–31. doi:10.1007/s10552-016-0719-4
  • Russnes KM, Möller E, Wilson KM, Carlsen M, Blomhoff R, Smeland S, Adami H-O, Grönberg H, Mucci LA, Bälter K, et al. Total antioxidant intake and prostate cancer in the Cancer of the Prostate in Sweden (CAPS) study. A case control study. BMC Cancer. 2016;16:438. doi:10.1186/s12885-016-2486-8
  • Kim J, Lee J, Oh JH, Chang HJ, Sohn DK, Shin A, Kim J. Circulating Interleukin-6 level, dietary antioxidant capacity, and risk of colorectal cancer. Antioxidants. 2019;8(12):595. doi:10.3390/antiox8120595
  • Gifkins D, Olson SH, Paddock L, King M, Demissie K, Lu S-E, Kong A-NT, Rodriguez-Rodriguez L, Bandera EV. Total and individual antioxidant intake and risk of epithelial ovarian cancer. BMC Cancer. 2012;12:211. doi:10.1186/1471-2407-12-211
  • Holtan SG, O'Connor HM, Fredericksen ZS, Liebow M, Thompson CA, Macon WR, Micallef IN, Wang AH, Slager SL, Habermann TM, et al. Food‐frequency questionnaire‐based estimates of total antioxidant capacity and risk of non‐Hodgkin lymphoma. Int J Cancer. 2012;131(5):1158–68. doi:10.1002/ijc.26491
  • Mekary RA, Wu K, Giovannucci E, Sampson L, Fuchs C, Spiegelman D, Willett WC, Smith-Warner SA. Total antioxidant capacity intake and colorectal cancer risk in the Health Professionals Follow-up Study. Cancer Causes Control. 2010;21(8):1315–21. doi:10.1007/s10552-010-9559-9
  • Zhong G-C, Pu J-Y, Wu Y-L, Yi Z-J, Wan L, Wang K, Hao F-B, Zhao Y, Gong J-P. Total antioxidant capacity and pancreatic cancer incidence and mortality in the prostate, lung, colorectal and ovarian cancer screening trial. Cancer Epidemiol Biomarkers Prev. 2020;29(5):1019–28. doi:10.1158/1055-9965.EPI-19-1511
  • Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, Rosso S, Coebergh JWW, Comber H, Forman D, Bray F. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer. 2013;49(6):1374–403. doi:10.1016/j.ejca.2012.12.027
  • Carreras-Torres R, Johansson M, Gaborieau V, Haycock PC, Wade KH, et al. The role of obesity, type 2 diabetes, and metabolic factors in pancreatic cancer: a Mendelian randomization study. J Natl Cancer Inst. 2017;109:1–9. doi:10.1093/jnci/djx012
  • Hung RJ, Ulrich CM, Goode EL, Brhane Y, Muir K, et al. Cross cancer genomic investigation of inflammation pathway for five common cancers: lung, ovary, prostate, breast, and colorectal cancer. J Natl Cancer Inst. 2015;107:246. doi:10.1093/jnci/djv246
  • Liu RH. Potential synergy of phytochemicals in cancer prevention: mechanism of action. J Nutr. 2004;134(12 Suppl):3479S–85S. doi:10.1093/jn/134.12.3479S
  • Davies AA, Davey Smith G, Harbord R, Bekkering GE, Sterne JAC, Beynon R, Thomas S. Nutritional interventions and outcome in patients with cancer or preinvasive lesions: systematic review. J Natl Cancer Inst. 2006;98(14):961–73. doi:10.1093/jnci/djj263
  • Lin J, Cook NR, Albert C, Zaharris E, Gaziano JM, Van Denburgh M, Buring JE, Manson JE. Vitamins C and E and beta carotene supplementation and cancer risk: a randomized controlled trial. J Natl Cancer Inst. 2009;101(1):14–23. doi:10.1093/jnci/djn438
  • Razquin C, Martinez JA, Martinez-Gonzalez MA, Mitjavila MT, Estruch R, Marti A. A 3 years follow-up of a Mediterranean diet rich in virgin olive oil is associated with high plasma antioxidant capacity and reduced body weight gain. Eur J Clin Nutr. 2009;63(12):1387–93. doi:10.1038/ejcn.2009.106
  • Vieira AR, Abar L, Vingeliene S, Chan DSM, Aune D, Navarro-Rosenblatt D, Stevens C, Greenwood D, Norat T. Fruits, vegetables and lung cancer risk: a systematic review and meta-analysis. Ann Oncol. 2016;27(1):81–96. doi:10.1093/annonc/mdv381
  • McBain AJ, Macfarlane GT. Ecological and physiological studies on large intestinal bacteria in relation to production of hydrolytic and reductive enzymes involved in formation of genotoxic metabolites. J Med Microbiol. 1998;47(5):407–16. doi:10.1099/00222615-47-5-407
  • London S, Willett W, Longcope C, McKinlay S. Alcohol and other dietary factors in relation to serum hormone concentrations in women at climacteric. Am J Clin Nutr. 1991;53(1):166–71. doi:10.1093/ajcn/53.1.166
  • Moutsatsou P. The spectrum of phytoestrogens in nature: our knowledge is expanding. Hormones (Athens). 2007;6(3):173–93.
  • Jones A, Pravadali-Cekic S, Dennis GR, Bashir R, Mahon PJ, Shalliker RA. Ferric reducing antioxidant potential (FRAP) of antioxidants using reaction flow chromatography. Anal Chim Acta. 2017;967:93–101. doi: 10.1007/s12161-019-01675-5
  • Kobayashi S, Murakami K, Sasaki S, Uenishi K, Yamasaki M, Hayabuchi H, Goda T, Oka J, Baba K, Ohki K, et al. Dietary total antioxidant capacity from different assays in relation to serum C-reactive protein among young Japanese women. Nutr J. 2012;11:91. doi:10.1186/1475-2891-11-91
  • Li X, Fang P, Mai J, Choi ET, Wang H, Yang X-f. Yang XF. Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers. J Hematol Oncol. 2013;6:19. doi:10.1186/1756-8722-6-19
  • Farhangi MA, Najafi M, Jafarabadi MA, Jahangiry L. Mediterranean dietary quality index and dietary phytochemical index among patients candidate for coronary artery bypass grafting (CABG) surgery. BMC Cardiovasc Disord. 2017;17(1):114. doi:10.1186/s12872-017-0544-z
  • Foksinski M, Gackowski D, Rozalski R, Siomek A, Guz J, Szpila A, Dziaman T, Olinski R. Effects of basal level of antioxidants on oxidative DNA damage in humans. Eur J Nutr. 2007;46(3):174–80. doi: 0.1007/s00394-006-0642-7 doi:10.1007/s00394-006-0642-7
  • Gorelik S, Ligumsky M, Kohen R, Kanner J. A novel function of red wine polyphenols in humans: prevention of absorption of cytotoxic lipid peroxidation products. FASEB J. 2008;22(1):41–6. doi:10.1096/fj.07-9041com
  • Farhangi MA, Najafi M. Dietary total antioxidant capacity (TAC) among candidates for coronary artery bypass grafting (CABG) surgery: Emphasis to possible beneficial role of TAC on serum vitamin D. Plos One. 2018;13(12):e0208806. doi:10.1371/journal.pone.0208806
  • Adami H-O, Hunter DJ, and, Trichopoulos D. Textbook of cancer epidemiology. Oxford University Press, USA, 2008.
  • Brozmanová J, Mániková D, Vlčková V, Chovanec M. Selenium: a double-edged sword for defense and offence in cancer. Arch Toxicol. 2010;84(12):919–38. doi:10.1007/s00204-010-0595-8
  • Dorgan JF, Sowell A, Swanson CA, Potischman N, Miller R, Schussler N, Stephenson HE. Relationships of serum carotenoids, retinol, alpha-tocopherol, and selenium with breast cancer risk: results from a prospective study in Columbia, Missouri (United States). Cancer Causes Control. 1998;9(1):89–97. doi:10.1023/a:1008857521992
  • Sato R, Helzlsouer KJ, Alberg AJ, Hoffman SC, Norkus EP, Comstock GW. Prospective study of carotenoids, tocopherols, and retinoid concentrations and the risk of breast cancer. Cancer Epidemiol Biomarkers Prev. 2002;11(5):451–7.

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