Dietary Choices Modulate Colorectal Cancer Stem Cells: A Role of FXR Nuclear Receptor

References

• Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018. 68(6):394–424. doi:10.3322/caac.21492.
   PubMed Web of Science ®Google Scholar
• Ferlay J, Colombet M, Soerjomataram I, Mathers C, Parkin DM, Piñeros M, Znaor A, Bray F. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 2019;144(8):1941–1953. doi:10.1002/ijc.31937
   PubMed Web of Science ®Google Scholar
• Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M, Haegebarth A, Korving J, Begthel H, Peters PJ, et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature. 2007;449(7165):1003–1007. doi:10.1038/nature06196
   PubMed Web of Science ®Google Scholar
• Barker N, Ridgway RA, van Es JH, van de Wetering M, Begthel H, van den Born M, Danenberg E, Clarke AR, Sansom OJ, Clevers H, et al. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature. 2009;457(7229):608–611. doi:10.1038/nature07602
   PubMed Web of Science ®Google Scholar
• Dalerba P, Dylla SJ, Park IK, Liu R, Wang X, Cho RW, Hoey T, Gurney A, Huang EH, Simeone DM, et al. Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci USA. 2007;104(24):10158–10163. doi:10.1073/pnas.0703478104
   PubMed Web of Science ®Google Scholar
• Haraguchi N, Ohkuma M, Sakashita H, Matsuzaki S, Tanaka F, Mimori K, Kamohara Y, Inoue H, Mori M. CD133 + CD44+ population efficiently enriches colon cancer initiating cells. Ann Surg Oncol. 2008;15(10):2927–2933. doi:10.1245/s10434-008-0074-0
   PubMed Web of Science ®Google Scholar
• Munro MJ, Wickremesekera SK, Peng L, Tan ST, Itinteang T. Cancer stem cells in colorectal cancer: a review. J Clin Pathol. 2018;71(2):110–116. doi:10.1136/jclinpath-2017-204739
   PubMed Web of Science ®Google Scholar
• Meurette O, Mehlen P. Notch signaling in the tumor microenvironment. Cancer Cell. 2018;34(4):536–548. doi:10.1016/j.ccell.2018.07.009
   PubMed Web of Science ®Google Scholar
• Fodde R, Smits R, Clevers H. APC, signal transduction and genetic instability in colorectal cancer. Nat Rev Cancer. 2001;1(1):55–67. doi:10.1038/35094067
   PubMed Web of Science ®Google Scholar
• Dalerba P, Kalisky T, Sahoo D, Rajendran PS, Rothenberg ME, Leyrat AA, Sim S, Okamoto J, Johnston DM, Qian D, et al. Single-cell dissection of transcriptional heterogeneity in human colon tumors. Nat Biotechnol. 2011;29(12):1120–1127. doi:10.1038/nbt.2038
   PubMed Web of Science ®Google Scholar
• Prasetyanti PR, Medema JP. Intra-tumor heterogeneity from a cancer stem cell perspective. Mol Cancer. 2017;16(1):41. doi:10.1186/s12943-017-0600-4
   PubMed Web of Science ®Google Scholar
• Fu T, Coulter S, Yoshihara E, Oh TG, Fang S, Cayabyab F, Zhu Q, Zhang T, Leblanc M, Liu S, et al. FXR regulates intestinal cancer stem cell proliferation. Cell. 2019;176(5):1098–1112.e18. doi:10.1016/j.cell.2019.01.036
   PubMed Web of Science ®Google Scholar
• Catalano V, Dentice M, Ambrosio R, Luongo C, Carollo R, Benfante A, Todaro M, Stassi G, Salvatore D. Activated thyroid hormone promotes differentiation and chemotherapeutic sensitization of colorectal cancer stem cells by regulating Wnt and BMP4 signaling. Cancer Res. 2016;76(5):1237–1244. doi:10.1158/0008-5472.CAN-15-1542
   PubMed Web of Science ®Google Scholar
• Zhan T, Rindtorff N, Boutros M. Wnt signaling in cancer. Oncogene. 2017;36(11):1461–1473. doi:10.1038/onc.2016.304
   PubMed Web of Science ®Google Scholar
• Lau EYT, Ho NPY, Lee T. Cancer stem cells and their microenvironment: biology and therapeutic implications. Stem Cells Int. 2017; 2017:3714190. doi:10.1155/2017/3714190
   PubMed Web of Science ®Google Scholar
• Tomasetti C, Li L, Vogelstein B. Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention. Science. 2017;355(6331):1330–1334. doi:10.1126/science.aaf9011
   PubMed Web of Science ®Google Scholar
• Gregorieff A, Liu Y, Inanlou MR, Khomchuk Y, Wrana JL. Yap-dependent reprogramming of Lgr5(+) stem cells drives intestinal regeneration and cancer. Nature. 2015;526(7575):715–718. doi:10.1038/nature15382
   PubMed Web of Science ®Google Scholar
• Rodríguez-Colman MJ, Schewe M, Meerlo M, Stigter E, Gerrits J, Pras-Raves M, Sacchetti A, Hornsveld M, Oost KC, Snippert HJ, et al. Interplay between metabolic identities in the intestinal crypt supports stem cell function. Nature. 2017;543(7645):424–427. doi:10.1038/nature21673
   PubMed Web of Science ®Google Scholar
• Beyaz S, Mana MD, Roper J, Kedrin D, Saadatpour A, Hong S-J, Bauer-Rowe KE, Xifaras ME, Akkad A, Arias E, et al. High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature. 2016;531(7592):53–58. doi:10.1038/nature17173
   PubMed Web of Science ®Google Scholar
• Lambertz IU, Luo L, Berton TR, Schwartz SL, Hursting SD, Conti CJ, Fuchs-Young R. Early exposure to a high fat/high sugar diet increases the mammary stem cell compartment and mammary tumor risk in female mice. Cancer Prev Res (Phila). 2017;10(10):553–562. doi:10.1158/1940-6207.CAPR-17-0131
   PubMed Web of Science ®Google Scholar
• Mana MD, Kuo EY-S, Yilmaz ÖH. Dietary regulation of adult stem cells. Curr Stem Cell Rep. 2017;3(1):1–8. doi:10.1007/s40778-017-0072-x
   PubMed Web of Science ®Google Scholar
• Yilmaz ÖH. Dietary regulation of the origins of cancer. Sci Transl Med. 2018;10(453):eaat8285. doi:10.1126/scitranslmed.aat8285
   PubMed Web of Science ®Google Scholar
• Karunanithi S, Levi L, DeVecchio J, Karagkounis G, Reizes O, Lathia JD, Kalady MF, Noy N. RBP4-STRA6 pathway drives cancer stem cell maintenance and mediates high-fat diet-induced colon carcinogenesis. Stem Cell Rep. 2017;9(2):438–450. doi:10.1016/j.stemcr.2017.06.002
   PubMed Web of Science ®Google Scholar
• Wang C-Z, Huang W-H, Zhang C-F, Wan J-Y, Wang Y, Yu C, Williams S, He T-C, Du W, Musch MW, et al. Role of intestinal microbiome in American ginseng-mediated colon cancer prevention in high fat diet-fed AOM/DSS mice [corrected]. Clin Transl Oncol. 2018;20(3):302–312. doi:10.1007/s12094-017-1717-z
   PubMed Web of Science ®Google Scholar
• Francescangeli F, De Angelis ML, Zeuner A. Dietary factors in the control of gut homeostasis, intestinal stem cells, and colorectal cancer. Nutrients. 2019;11(12):2936. doi:10.3390/nu11122936
   PubMed Web of Science ®Google Scholar
• Hermetet F, Buffière A, Aznague A, Pais de Barros JP, Bastie JN, Delva L, Quéré R. High-fat diet disturbs lipid raft/TGF-β signaling-mediated maintenance of hematopoietic stem cells in mouse bone marrow. Nat Commun. 2019;10(1):523. doi:10.1038/s41467-018-08228-0
   PubMed Web of Science ®Google Scholar
• Piazzi G, Prossomariti A, Baldassarre M, Montagna C, Vitaglione P, Fogliano V, et al. A Mediterranean diet mix has chemopreventive effects in a murine model of colorectal cancer modulating apoptosis and the gut microbiota. Front Oncol. 2019;9:140.
   PubMed Web of Science ®Google Scholar
• Sivaprakasam S, Prasad PD, Singh N. Benefits of short-chain fatty acids and their receptors in inflammation and carcinogenesis. Pharmacol Ther. 2016;164:144–151. doi:10.1016/j.pharmthera.2016.04.007
   PubMed Web of Science ®Google Scholar
• Chen J, Vitetta L. Inflammation-modulating effect of butyrate in the prevention of colon cancer by dietary fiber. Clin Colorectal Cancer. 2018;17(3):e541–e544. doi:10.1016/j.clcc.2018.05.001
   PubMed Web of Science ®Google Scholar
• Feng W, Ao H, Peng C. Gut microbiota, short-chain fatty acids, and herbal medicines. Front Pharmacol. 2018;9:1354. doi:10.3389/fphar.2018.01354
   PubMed Web of Science ®Google Scholar
• Romagnolo DF, Donovan MG, Doetschman TC, Selmin OI. Linoleic acid induces epigenetics alterations associated with colonic inflammation and cancer. Nutrients. 2019;11(1):171. doi:10.3390/nu11010171
   PubMed Web of Science ®Google Scholar
• Downes M, Verdecia MA, Roecker AJ, Hughes R, Hogenesch JB, Kast-Woelbern HR, Bowman ME, Ferrer J-L, Anisfeld AM, Edwards PA, et al. A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Trends Mol Med. 2011;17:564–572.
   PubMed Web of Science ®Google Scholar
• Modica S, Murzilli S, Salvatore L, Schmidt DR, Moschetta A. Nuclear bile acid receptor FXR protects against intestinal tumorigenesis. Cancer Res. 2008;68:9589–9594.
   PubMed Web of Science ®Google Scholar
• Thomas C, Pellicciari R, Pruzanski M, Auwerx J, Schoonjans K. Targeting bile-acid signalling for metabolic diseases. Nat Rev Drug Discov. 2008;7(8):678–693. doi:10.1038/nrd2619
   PubMed Web of Science ®Google Scholar
• Degirolamo C, Modica S, Palasciano G, Moschetta A. Bile acids and colon cancer: solving the puzzle with nuclear receptors. Mol Cell. 2003;11:1079–1092.
   PubMed Web of Science ®Google Scholar
• Su H, Ma C, Liu J, Li N, Gao M, Huang A, Wang X, Huang W, Huang X. Downregulation of nuclear receptor FXR is associated with multiple malignant clinicopathological characteristics in human hepatocellular carcinoma. Am J Physiol Gastrointest Liver Physiol. 2012; 303(11):G1245–G1253. doi:10.1152/ajpgi.00439.2011
   PubMed Web of Science ®Google Scholar
• Fu T, Zhao X, Evans RM. Liver cancer checks in when bile acid clocks out. Cancer Cell. 2016;30(6):827–828. doi:10.1016/j.ccell.2016.11.012
   PubMed Web of Science ®Google Scholar
• Parks DJ, Blanchard SG, Bledsoe RK, Chandra G, Consler TG, Kliewer SA, Stimmel JB, Willson TM, Zavacki AM, Moore DD, et al. Bile acids: natural ligands for an orphan nuclear receptor. Science. 1999;284(5418):1365–1368. doi:10.1126/science.284.5418.1365
   PubMed Web of Science ®Google Scholar
• Kumar A, Swami S, Sharma NK. Distinct DNA metabolism and anti-proliferative effects of goat urine metabolites: an explanation for xeno-tumor heterogeneity. Curr Chem Biol. 2020;14(1):48–57. 2020. doi:10.2174/2212796814666200310102512
   Google Scholar
• Löhr CV. One hundred two tumors in 100 goats (1987-2011). Vet Pathol. 2013;50(4):668–675. doi:10.1177/0300985812471544
   PubMed Web of Science ®Google Scholar
• Guan F, Tabrizian T, Novaj A, Nakanishi M, Rosenberg DW, Huffman DM. Dietary walnuts protect against obesity-driven intestinal stem cell decline and tumorigenesis. Front Nutr. 2018;5:37. doi:10.3389/fnut.2018.00037
   PubMed Web of Science ®Google Scholar
• Beyaz S, Yilmaz ÖH. molecular pathways: dietary regulation of stemness and tumor initiation by the PPAR-δ pathway. Clin Cancer Res. 2016;22(23):5636–5641. doi:10.1158/1078-0432.CCR-16-0775
   PubMed Web of Science ®Google Scholar
• Selmin OI, Fang C, Lyon AM, Doetschman TC, Thompson PA, Martinez JD, Smith JW, Lance PM, Romagnolo DF. Inactivation of adenomatous polyposis coli reduces bile acid/farnesoid X receptor expression through Fxr gene CpG methylation in mouse colon tumors and human colon cancer cells. J Nutr. 2016;146(2):236–242. doi:10.3945/jn.115.216580
   PubMed Web of Science ®Google Scholar
• Sayin SI, Wahlström A, Felin J, Jäntti S, Marschall H-U, Bamberg K, Angelin B, Hyötyläinen T, Orešič M, Bäckhed F, et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab. 2013;17(2):225–235. doi:10.1016/j.cmet.2013.01.003
   PubMed Web of Science ®Google Scholar
• Hua F, Shang S, Yang Y-W, Zhang H-Z, Xu T-L, Yu J-J, Zhou D-D, Cui B, Li K, Lv X-X, et al. TRIB3 interacts with β-catenin and TCF4 to increase stem cell features of colorectal cancer stem cells and tumorigenesis. Gastroenterology. 2019;156(3):708–721. doi:10.1053/j.gastro.2018.10.031
   PubMed Web of Science ®Google Scholar
• Ji S, Liu Q, Zhang S, Chen Q, Wang C, Zhang W, Xiao C, Li Y, Nian C, Li J, et al. FGF15 Activates hippo signaling to suppress bile acid metabolism and liver tumorigenesis. Dev Cell. 2019;48(4):460–474.e9. doi:10.1016/j.devcel.2018.12.021
   PubMed Web of Science ®Google Scholar
• Zhang Y, Gong W, Dai S, Huang G, Shen X, Gao M, Xu Z, Zeng Y, He F. Downregulation of human farnesoid X receptor by miR-421 promotes proliferation and migration of hepatocellular carcinoma cells. Mol Cancer Res. 2012;10(4):516–522. doi:10.1158/1541-7786.MCR-11-0473
   PubMed Web of Science ®Google Scholar
• Jiang Y, Iakova P, Jin J, Sullivan E, Sharin V, Hong I-H, Anakk S, Mayor A, Darlington G, Finegold M, et al. Farnesoid X receptor inhibits gankyrin in mouse livers and prevents development of liver cancer. Hepatology. 2013;57(3):1098–1106. doi:10.1002/hep.26146
   PubMed Web of Science ®Google Scholar
• Valanejad L, Lewis K, Wright M, Jiang Y, D'Souza A, Karns R, Sheridan R, Gupta A, Bove K, Witte D, et al. FXR-Gankyrin axis is involved in development of pediatric liver cancer. Carcinogenesis. 2017;38(7):738–747. doi:10.1093/carcin/bgx050
   PubMed Web of Science ®Google Scholar
• Soisson SM, Parthasarathy G, Adams AD, Sahoo S, Sitlani A, Sparrow C, Cui J, Becker JW. Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation. Proc Natl Acad Sci USA. 2008;105(14):5337–5342. doi:10.1073/pnas.0710981105
   PubMed Web of Science ®Google Scholar
• Wang H, Zhao Z, Zhou J, Guo Y, Wang G, Hao H, Xu X. A novel intestinal-restricted FXR agonist. Bioorg Med Chem Lett. 2017;27(15):3386–3390. doi:10.1016/j.bmcl.2017.06.003
   PubMed Web of Science ®Google Scholar
• Barone I, Vircillo V, Giordano C, Gelsomino L, Győrffy B, Tarallo R, Rinaldi A, Bruno G, Caruso A, Romeo F, et al. Activation of Farnesoid X Receptor impairs the tumor-promoting function of breast cancer-associated fibroblasts. Cancer Lett. 2018;437:89–99. doi:10.1016/j.canlet.2018.08.026
   PubMed Web of Science ®Google Scholar
• Di Matteo S, Nevi L, Costantini D, Overi D, Carpino G, Safarikia S, Giulitti F, Napoletano C, Manzi E, De Rose AM, et al. The FXR agonist obeticholic acid inhibits the cancerogenic potential of human cholangiocarcinoma. PLoS One. 2019;14(1):e0210077. doi:10.1371/journal.pone.0210077
   PubMed Web of Science ®Google Scholar
• Merk D, Sreeramulu S, Kudlinzki D, Saxena K, Linhard V, Gande SL, Hiller F, Lamers C, Nilsson E, Aagaard A, et al. Molecular tuning of farnesoid X receptor partial agonism. Nat Commun. 2019; 10(1):2915. doi:10.1038/s41467-019-10853-2
   PubMed Web of Science ®Google Scholar