136
Views
4
CrossRef citations to date
0
Altmetric
Research Article

Phytol Down-Regulates Expression of Some Cancer Stem Cell Markers and Decreases Side Population Proportion in Human Embryonic Carcinoma NCCIT Cells

, &
Pages 1520-1533 | Received 26 Sep 2019, Accepted 27 Jun 2020, Published online: 23 Jul 2020

References

  • Dalerba P, Cho RW, Clarke MF. Cancer stem cells: models and concepts. Annu Rev Med. 2007;58:267–84. doi:10.1146/annurev.med.58.062105.204854
  • Liu A, Yu X, Liu S. Pluripotency transcription factors and cancer stem cells: small genes make a big difference. Chin J Cancer. 2013;32(9):483–7. doi:10.5732/cjc.012.10282
  • Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med. 1997;3(7):730–7. doi:10.1038/nm0797-730
  • Schatton T, Frank MH. Cancer stem cells and human malignant melanoma. Pigment Cell Melanoma Res. 2008;21(1):39–55. doi:10.1111/j.1755-148X.2007.00427.x
  • Thomas M, Coyle K, Sultan M, Vaghar-Kashani A, Marcato P. Chemoresistance in cancer stem cells and strategies to overcome resistance. Chemotherapy. 2014;3(125):2.
  • Abdullah LN, Chow E-H. Mechanisms of chemoresistance in cancer stem cells. Clin Transl Med. 2013;2(1):3doi:10.1186/2001-1326-2-3
  • Shimoda M, Ota M, Okada Y. Isolation of cancer stem cells by side population method. In: Papaccio G, Desiderio V, editors. Cancer stem cells. Berlin (Germany): Springer; 2018. p. 49–59.
  • Greve B, Kelsch R, Spaniol K, Eich HT, Götte M. Flow cytometry in cancer stem cell analysis and separation. Cytometry A. 2012;81(4):284–93. doi:10.1002/cyto.a.22022
  • Najafi M, Farhood B, Mortezaee K. Cancer stem cells (CSCs) in cancer progression and therapy. J Cell Physiol. 2019;234(6):8381–95. doi:10.1002/jcp.27740
  • Chen K, Huang Y-h, Chen J-l. Understanding and targeting cancer stem cells: therapeutic implications and challenges. Acta Pharmacol Sin. 2013;34(6):732–40. doi:10.1038/aps.2013.27
  • Newman DJ, Cragg GM. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J Nat Prod. 2012;75(3):311–35. doi:10.1021/np200906s
  • Nobili S, Lippi D, Witort E, Donnini M, Bausi L, Mini E, Capaccioli S. Natural compounds for cancer treatment and prevention. Pharmacol Res. 2009;59(6):365–78. doi:10.1016/j.phrs.2009.01.017
  • Amin A, Gali-Muhtasib H, Ocker M, Schneider-Stock R. Overview of major classes of plant-derived anticancer drugs. Int J Biomed Sci. 2009;5(1):1–11.
  • Soltanian S, Mohamadi N, Rajaei P, Khodami M, Mohammadi M. Phytochemical composition, and cytotoxic, antioxidant, and antibacterial activity of the essential oil and methanol extract of Semenovia suffruticosa. Avicenna J Phytomed. 2019;9(2):143–52.
  • Soltanian S, Sheikhbahaei M, Mohamadi N. Cytotoxicity Evaluation of Methanol Extracts of Some Medicinal Plants on P19 Embryonal Carcinoma Cells. J App Pharm Sci. 2017;7(07):142–9. doi:10.7324/JAPS.2017.70722
  • Soltanian S, Riahirad H, Pabarja A, Jafari E, Khandani BK. Effect of Cinnamic acid and FOLFOX in diminishing side population and downregulating cancer stem cell markers in colon cancer cell line HT-29. DARU J Pharm Sci. 2018;26(1):19–29. doi:10.1007/s40199-018-0210-8
  • Soltanian S, Riahirad H, Pabarja A, Karimzadeh MR, Saeidi K. Kaempferol and docetaxel diminish side population and down-regulate some cancer stem cell markers in breast cancer cell line MCF-7. Biocell. 2018;41(2):33–40. doi:10.32604/biocell.2017.00033
  • Taylor WF, Jabbarzadeh E. The use of natural products to target cancer stem cells. Am J Cancer Res. 2017;7(7):1588–605.
  • Breitmaier B. Terpenes: flavors, fragrances, pharmaca, pheromones. Hoboken (NJ): John Wiley & Sons; 2006.
  • Davis EM, Croteau R. Cyclization enzymes in the biosynthesis of monoterpenes, sesquiterpenes, and diterpenes. In: Leeper FJ, Vederas JC, editors. Biosynthesis. Berlin (Germany): Springer; 2000. p. 53–95.
  • Castaigne S, Chomienne C, Daniel MT, Ballerini P, Berger R, Fenaux P, Degos L. All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results [see comments. Blood. 1990;76(9):1704–9. ].
  • Campos B, Wan F, Farhadi M, Ernst A, Zeppernick F, Tagscherer KE, Ahmadi R, Lohr J, Dictus C, Gdynia G, et al. Differentiation therapy exerts antitumor effects on stem-like glioma cells. Clin Cancer Res. 2010;16(10):2715–28.: doi:10.1158/1078-0432.CCR-09-1800
  • Yan Y, Li Z, Xu X, Chen C, Wei W, Fan M, Chen X, Li JJ, Wang Y, Huang J, et al. All-trans retinoic acids induce differentiation and sensitize a radioresistant breast cancer cells to chemotherapy. BMC Complement Altern Med. 2016;16(1):113: doi:10.1186/s12906-016-1088-y
  • Ohno R, Asou N, Ohnishi K. Treatment of acute promyelocytic leukemia: strategy toward further increase of cure rate. Leukemia. 2003;17(8):1454–63. doi:10.1038/sj.leu.2403031
  • Ginestier C, Wicinski J, Cervera N, Monville F, Finetti P, Bertucci F, Wicha MS, Birnbaum D, Charafe-Jauffret E. Retinoid signaling regulates breast cancer stem cell differentiation. Cell Cycle. 2009;8(20):3297–302. doi:10.4161/cc.8.20.9761
  • Ponthan F, BorgströM P, Hassan M, Wassberg E, Redfern CPF, Kogner P. The vitamin A analogues: 13-cis retinoic acid, 9-cis retinoic acid, and Ro 13-6307 inhibit neuroblastoma tumour growth in vivo. Med Pediatr Oncol. 2001;36(1):127–31. doi:10.1002/1096-911X(20010101)36:1<127::AID-MPO1030>3.0.CO;2-B
  • Verhoeven NM, Wanders RJA, Poll-The BT, Saudubray J-M, Jakobs C. The metabolism of phytanic acid and pristanic acid in man: a review. J Inherited Metab Disease. 1998;21(7):697–728. doi:10.1023/A:1005476631419
  • Komiya T, Kyohkon M, Ohwaki S, Eto J, Katsuzaki H, Imai K, Kataoka T, Yoshioka K, Ishii Y, Hibasami H. Phytol induces programmed cell death in human lymphoid leukemia Molt 4B cells. Int J Mol Med. 1999;4(4):377–457. doi:10.3892/ijmm.4.4.377
  • Kim C-W, Lee HJ, Jung JH, Kim YH, Jung D-B, Sohn EJ, Lee JH, Woo HJ, Baek N-I, Kim YC, et al. Activation of Caspase-9/3 and Inhibition of Epithelial Mesenchymal Transition are Critically Involved in Antitumor Effect of Phytol in Hepatocellular Carcinoma Cells. Phytother Res. 2015;29(7):1026–31. doi:10.1002/ptr.5342
  • Thakor P, Subramanian RB, Thakkar SS, Ray A, Thakkar VR. Phytol induces ROS mediated apoptosis by induction of caspase 9 and 3 through activation of TRAIL, FAS and TNF receptors and inhibits tumor progression factor Glucose 6 phosphate dehydrogenase in lung carcinoma cell line (A549). Biomed Pharmacother. 2017;92:491–500. doi:10.1016/j.biopha.2017.05.066
  • Sheeja L, Lakshmi D, Bharadwaj S, Parveen KS. Anticancer activity of phytol purified from Gracilaria edulis against human breast cancer cell line (MCF-7). Int J Curr Sci. 2016;19(4):36–46.
  • Radonić A, Blažević I, Mastelić J, Zekić M, Skočibušić M, Maravić A. Phytochemical analysis and antimicrobial activity of Cardaria draba (L.) Desv. volatiles. Chem Biodivers. 2011;8(6):1170–81. doi:10.1002/cbdv.201000370
  • Silva RO, Sousa FBM, Damasceno SRB, Carvalho NS, Silva VG, Oliveira FRMA, Sousa DP, Aragão KS, Barbosa ALR, Freitas RM, et al. Phytol, a diterpene alcohol, inhibits the inflammatory response by reducing cytokine production and oxidative stress. Fundam Clin Pharmacol. 2014;28(4):455–64.: doi:10.1111/fcp.12049
  • Teshima S, Shimosato Y, Hirohashi S, Tome Y, Hayashi I, Kanazawa H, Kakizoe T. Four new human germ cell tumor cell lines. Lab Invest. 1988;59(3):328–36.
  • Andrews PW. From teratocarcinomas to embryonic stem cells. Philos Trans R Soc Lond, B, Biol Sci. 2002;357(1420):405–17. doi:10.1098/rstb.2002.1058
  • Martin GR. Teratocarcinomas and mammalian embryogenesis. Science. 1980;209(4458):768–76. doi:10.1126/science.6250214
  • Andrews P, Matin M, Bahrami A, Damjanov I, Gokhale P, et al. Embryonic stem (ES) cells and embryonal carcinoma (EC) cells: opposite sides of the same coin. London (UK): Portland Press Limited; 2005.
  • Yang H-M, Do H-J, Kim D-K, Park J-K, Chang W-K, Chung H-M, Choi S-Y, Kim J-H. Transcriptional regulation of human Oct4 by steroidogenic factor-1. J Cell Biochem. 2007;101(5):1198–209. doi:10.1002/jcb.21244
  • Jin B, Ernst J, Tiedemann RL, Xu H, Sureshchandra S, Kellis M, Dalton S, Liu C, Choi J-H, Robertson KD, et al. Linking DNA methyltransferases to epigenetic marks and nucleosome structure genome-wide in human tumor cells. Cell Rep. 2012;2(5):1411–24.: doi:10.1016/j.celrep.2012.10.017
  • Tykwinska K, Lauster R, Knaus P, Rosowski M. Growth and differentiation factor 3 induces expression of genes related to differentiation in a model of cancer stem cells and protects them from retinoic acid-induced apoptosis. PloS One. 2013;8(8):e70612. doi:10.1371/journal.pone.0070612
  • Freberg CT, Dahl JA, Timoskainen S, Collas P. Epigenetic reprogramming of OCT4 and NANOG regulatory regions by embryonal carcinoma cell extract. Mol Biol Cell. 2007;18(5):1543–53. doi:10.1091/mbc.e07-01-0029
  • Hong SP, Wen J, Bang S, Park S, Song SY. CD44-positive cells are responsible for gemcitabine resistance in pancreatic cancer cells . Int J Cancer. 2009;125(10):2323–31. doi:10.1002/ijc.24573
  • Airley R. Cancer chemotherapy: basic science to the clinic. Hoboken (NJ): John Wiley & Sons; 2009.
  • Phi LTH, Sari IN, Yang Y-G, Lee S-H, Jun N, Kim KS, Lee YK, Kwon HY. Cancer stem cells (CSCs) in drug resistance and their therapeutic implications in cancer treatment. Stem Cells Int. 2018;2018:5416923. doi:10.1155/2018/5416923
  • Oh J, Hlatky L, Jeong Y-S, Kim D. Therapeutic effectiveness of anticancer phytochemicals on cancer stem cells. Toxins. 2016;8(7):199. doi:10.3390/toxins8070199
  • Iqbal J, Abbasi BA, Mahmood T, Kanwal S, Ali B, Shah SA, Khalil AT. Plant-derived anticancer agents: A green anticancer approach. Asian Pacific Journal of Tropical Biomedicine. 2017;7(12):1129–50. doi:10.1016/j.apjtb.2017.10.016
  • Scarpa E-S, Ninfali P. Phytochemicals as innovative therapeutic tools against cancer stem cells. Int J Mol Sci. 2015;16(7):15727–42. doi:10.3390/ijms160715727
  • Pejin B, Kojic V, Bogdanovic G. An insight into the cytotoxic activity of phytol at in vitro conditions. Nat Prod Res. 2014;28(22):2053–6. doi:10.1080/14786419.2014.921686
  • Islam MT, Streck L, de Alencar MVOB, Cardoso Silva SW, da Conceição Machado K, da Conceição Machado K, Gomes Júnior AL, Paz MFCJ, da Mata AMOF, de Castro E Sousa JM, et al. Evaluation of toxic, cytotoxic and genotoxic effects of phytol and its nanoemulsion. Chemosphere. 2017;177:93–101.: doi:10.1016/j.chemosphere.2017.02.145
  • Sakthivel R, Malar DS, Devi KP. Phytol shows anti-angiogenic activity and induces apoptosis in A549 cells by depolarizing the mitochondrial membrane potential. Biomed Pharmacother. 2018;105:742–52. doi:10.1016/j.biopha.2018.06.035
  • Wei LS, Wendy W, Siong JYF, Syamsumir DF. Characterization of antimicrobial, antioxidant, anticancer properties and chemical composition of Sauropus androgynus stem extract. Acta Medica Lituanica. 2011;18(1):12–16. doi:10.6001/actamedica.v18i1.1808
  • Roche J. The epithelial-to-mesenchymal transition in cancer. Basel (Switzerland): Multidisciplinary Digital Publishing Institute; 2018.
  • Pearson GW. Control of invasion by epithelial-to-mesenchymal transition programs during metastasis. JCM. 2019;8(5):646. doi:10.3390/jcm8050646
  • Moustakas A, de Herreros AG. Epithelial-mesenchymal transition in cancer. Mol Oncol. 2017;11(7):715–7. doi:10.1002/1878-0261.12094
  • Rizzino A. Sox2 and Oct-3/4: a versatile pair of master regulators that orchestrate the self-renewal and pluripotency of embryonic stem cells . Wiley Interdiscip Rev Syst Biol Med. 2009;1(2):228–36. doi:10.1002/wsbm.12
  • Boyer LA, Lee TI, Cole MF, Johnstone SE, Levine SS, Zucker JP, Guenther MG, Kumar RM, Murray HL, Jenner RG, et al. Core transcriptional regulatory circuitry in human embryonic stem cells. cell. 2005;122(6):947–56.: doi:10.1016/j.cell.2005.08.020
  • Wang C, Xie J, Guo J, Manning HC, Gore JC, Guo N. Evaluation of CD44 and CD133 as cancer stem cell markers for colorectal cancer. Oncol Rep. 2012;28(4):1301–8. doi:10.3892/or.2012.1951
  • Dean M. ABC transporters, drug resistance, and cancer stem cells. J Mammary Gland Biol Neoplasia. 2009;14(1):3–9. doi:10.1007/s10911-009-9109-9
  • Chen L-S, Wang A-X, Dong B, Pu K-F, Yuan L-H, Zhu Y-M. A new prospect in cancer therapy: targeting cancer stem cells to eradicate cancer. Chin J Cancer. 2012;31(12):564–72. doi:10.5732/cjc.011.10444
  • Wu C-P, Calcagno AM, Ambudkar SV. Reversal of ABC drug transporter-mediated multidrug resistance in cancer cells: evaluation of current strategies. Curr Mol Pharmacol. 2008;1(2):93–105. doi:10.2174/1874467210801020093
  • Wu C, Alman BA. Side population cells in human cancers. Cancer Lett. 2008;268(1):1–9. doi:10.1016/j.canlet.2008.03.048
  • Vasiliou V, Pappa A, Petersen DR. Role of aldehyde dehydrogenases in endogenous and xenobiotic metabolism. Chem Biol Interact. 2000;129(1-2):1–19. doi:10.1016/s0009-2797(00)00211-8
  • Moreb JS. Aldehyde dehydrogenase as a marker for stem cells. Curr Stem Cell Res Ther. 2008;3(4):237–46. doi:10.2174/157488808786734006
  • Damjanov I, Horvat B, Gibas Z. Retinoic acid-induced differentiation of the developmentally pluripotent human germ cell tumor-derived cell line, NCCIT. Lab Invest. 1993;68(2):220–32.
  • Andrews PW. Retinoic acid induces neuronal differentiation of a cloned human embryonal carcinoma cell line in vitro. Dev Biol. 1984;103(2):285–93. doi:10.1016/0012-1606(84)90316-6
  • Massard C, Deutsch E, Soria J. Tumour stem cell-targeted treatment: elimination or differentiation. Ann Oncol. 2006;17(11):1620–4. doi:10.1093/annonc/mdl074
  • Soltanian S, Matin MM. Cancer stem cells and cancer therapy. Tumour Biol. 2011;32(3):425–40. doi:10.1007/s13277-011-0155-8
  • Soltanian S, Dehghani H, Matin MM, Bahrami AR. Expression analysis of BORIS during pluripotent, differentiated, cancerous, and non-cancerous cell states. Acta Biochim Biophys Sin (Shanghai)). 2014;46(8):647–58. doi:10.1093/abbs/gmu045
  • Soltanian S, Dehghani H. BORIS: a key regulator of cancer stemness. Cancer Cell Int. 2018;18(1):154doi:10.1186/s12935-018-0650-8
  • Stevanovic M. Modulation of SOX2 and SOX3 gene expression during differentiation of human neuronal precursor cell line NTERA2. Mol Biol Rep. 2003;30(2):127–32. doi:10.1023/a:1023961009869
  • Rassouli FB, Matin MM, Bahrami AR, Ghaffarzadegan K, Cheshomi H, Lari S, Memar B, Kan MS. Evaluating stem and cancerous biomarkers in CD15 + CD44+ KYSE30 cells. Tumour Biol. 2013;34(5):2909–20. doi:10.1007/s13277-013-0853-5
  • Popovic J, Stanisavljevic D, Schwirtlich M, Klajn A, Marjanovic J, Stevanovic M. Expression analysis of SOX14 during retinoic acid induced neural differentiation of embryonal carcinoma cells and assessment of the effect of its ectopic expression on SOXB members in HeLa cells. PloS One. 2014;9(3):e91852doi:10.1371/journal.pone.0091852
  • Boer B, Kopp J, Mallanna S, Desler M, Chakravarthy H, Wilder PJ, Bernadt C, Rizzino A. Elevating the levels of Sox2 in embryonal carcinoma cells and embryonic stem cells inhibits the expression of Sox2:Oct-3/4 target genes. Nucleic Acids Res. 2007;35(6):1773–86. doi:10.1093/nar/gkm059
  • Adachi K, Suemori H, Yasuda S, Nakatsuji N, Kawase E. Role of SOX2 in maintaining pluripotency of human embryonic stem cells. Genes Cells. 2010;15(5):455–70. doi:10.1111/j.1365-2443.2010.01400.x
  • Drakulic D, Krstic A, Stevanovic M. Establishment and initial characterization of SOX2-overexpressing NT2/D1 cell clones. Genet Mol Res. 2012;11(2):1385–400. doi:10.4238/2012.May.15.9
  • Kopp JL, Ormsbee BD, Desler M, Rizzino A. Small increases in the level of Sox2 trigger the differentiation of mouse embryonic stem cells. Stem Cells. 2008;26(4):903–11. doi:10.1634/stemcells.2007-0951
  • Episkopou V. SOX2 functions in adult neural stem cells. Trends Neurosci. 2005;28(5):219–21. doi:10.1016/j.tins.2005.03.003
  • Gasimli L, Stansfield HE, Nairn AV, Liu H, Paluh JL, Yang B, Dordick JS, Moremen KW, Linhardt RJ. Structural remodeling of proteoglycans upon retinoic acid-induced differentiation of NCCIT cells. Glycoconj J. 2013;30(5):497–510. doi:10.1007/s10719-012-9450-x
  • Herreros-Villanueva M, Er T-K, Bujanda L. Retinoic acid reduces stem cell-like features in pancreatic cancer cells. Pancreas. 2015;44(6):918–24. doi:10.1097/MPA.0000000000000373
  • Nguyen PH, Giraud J, Staedel C, Chambonnier L, Dubus P, Chevret E, Boeuf H, Gauthereau X, Rousseau B, Fevre M, et al. All-trans retinoic acid targets gastric cancer stem cells and inhibits patient-derived gastric carcinoma tumor growth. Oncogene. 2016;35(43):5619–28.: doi:10.1038/onc.2016.87
  • Bouriez D, Giraud J, Gronnier C, Varon C. Efficiency of all-trans retinoic acid on gastric cancer: a narrative literature review. IJMS. 2018;19(11):3388. doi:10.3390/ijms19113388
  • Tallman MS, Andersen JW, Schiffer CA, Appelbaum FR, Feusner JH, Ogden A, Shepherd L, Willman C, Bloomfield CD, Rowe JM, et al. All-trans-retinoic acid in acute promyelocytic leukemia. N Engl J Med. 1997;337(15):1021–8.: doi:10.1056/NEJM199710093371501
  • Florea A-M, Büsselberg D. Cisplatin as an anti-tumor drug: cellular mechanisms of activity, drug resistance and induced side effects. Cancers (Basel). 2011;3(1):1351–71. doi:10.3390/cancers3011351
  • Park S, Sung J, Chung N. Berberine diminishes side population and down-regulates stem cell-associated genes in the pancreatic cancer cell lines PANC-1 and MIA PaCa-2. Mol Cell Biochem. 2014;394(1-2):209–15. doi:10.1007/s11010-014-2096-1
  • Kim JB, Ko E, Han W, Shin I, Park SY, Noh D-Y. Berberine diminishes the side population and ABCG2 transporter expression in MCF-7 breast cancer cells. Planta Med. 2008;74(14):1693–700. doi:10.1055/s-0028-1088313

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.