Citronellol, an Acyclic Monoterpene Induces Mitochondrial-Mediated Apoptosis through Activation of Proapoptotic Factors in MCF-7 and MDA-MB-231 Human Mammary Tumor Cells

References

• Siegel RL, Miller KD, Jemal A. Cancer statistics, 2017. CA Cancer J Clin. 2017;67(1):7–30. doi:10.3322/caac.21387
   PubMed Web of Science ®Google Scholar
• Balekouzou A, Yin P, Pamatika CM, Bekolo CE, Nambei SW, Djeintote M, Kota K, Mossoro-Kpinde CD, Shu C, Yin M, et al. Reproductive risk factors associated with breast cancer in women in Bangui: a case-control study. BMC Womens Health. 2017;17(1):14. doi:10.1186/s12905-017-0368-0
   PubMed Web of Science ®Google Scholar
• Weir R, Day P, Ali W. Risk factors for breast cancer in women. Nzht Report. 2007;10(2):11–64.
   Google Scholar
• Lakshma NV, Nagaseshadri B, Vishnuvardhan MV, Kamal A. Investigation of the apoptotic pathway induced by benzimidazole-oxindole conjugates against human breast cancer cells MCF-7. Bioorg Med Chem Lett. 2016;26(14):3313–7. doi:10.1016/j.bmcl.2016.05.045
   PubMed Web of Science ®Google Scholar
• Razak NA, Abu N, Ho WY, Zamberi NR, Tan SW, Alitheen NB, Long K, Yeap SK. Cytotoxicity of eupatorin in MCF-7 and MDA-MB-231 human breast cancer cells via cell cycle arrest, anti-angiogenesis and induction of apoptosis. Sci Rep. 2019;9(1):1514. doi:10.1038/s41598-018-37796-w
   PubMed Web of Science ®Google Scholar
• Favaloro B, Allocati N, Graziano V, Di Ilio C, De Laurenzi V. Role of apoptosis in disease. Aging (Albany NY). 2012;4(5):330–49. doi:10.18632/aging.100459
   PubMedGoogle Scholar
• Bruckheimer EM, Kyprianou N. Apoptosis in prostate carcinogenesis. A growth regulator and a therapeutic target. Cell Tissue Res. 2000;301(1):153–62. doi:10.1007/s004410000196
   PubMed Web of Science ®Google Scholar
• Sun SY, Hail N, Jr, Lotan R. Apoptosis as a novel target for cancer chemoprevention. J Natl Cancer Inst. 2004;96(9):662–72. doi:10.1093/jnci/djh123
   PubMedGoogle Scholar
• Ma W-D, Zou Y-P, Wang P, Yao X-H, Sun Y, Duan M-H, Fu Y-J, Yu B. Chimaphilin induces apoptosis in human breast cancer MCF-7 cells through a ROS-mediated mitochondrial pathway. Food Chem Toxicol. 2014;70:1–8. doi:10.1016/j.fct.2014.04.014
   PubMed Web of Science ®Google Scholar
• Gyawali R, Kim KS. Anticancer phytochemicals of citrus fruits – a review. J Anim Res. 2014;4 (1):85–95. doi:10.5958/2277-940X.2014.00079.5
   Google Scholar
• Oliveira MMM, Brugnera DF, Cardoso MG, Alves E, Piccoli RH. Disinfectant action of Cymbopogon sp. essential oils in different phases of biofilm formation by Listeria monocytogenes on stainless steel surface. Foo Contr. 2010;21(4):549–53. doi:10.1016/j.foodcont.2009.08.003
   Web of Science ®Google Scholar
• Gomes PB, Mata VG, Rodrigues AE. Production of rose geranium oil using supercritical fluid extraction. J Supercrit Fluids. 2007;41(1):50–60. doi:10.1016/j.supflu.2006.08.018
   Web of Science ®Google Scholar
• Santos MRV, Moreira FV, Fraga BP, Souza D. P d, Bonjardim LR, Quintans-Junior LJ. Cardiovascular effects of monoterpenes: a review. Rev Bras Farmacogn. 2011;21(4):764–71. doi:10.1590/S0102-695X2011005000119
   Google Scholar
• Boukhris M, Bouaziz M, Feki I, Jemai H, El Feki A, Sayadi S. Hypoglycemic and antioxidant effects of leafessential oil of Pelargonium graveolens L’ Her: in alloxan induced diabetic rats. Lipids Health Dis. 2012;11(1):81. doi:10.1186/1476-511X-11-81
   PubMed Web of Science ®Google Scholar
• Jayaganesh R, Pugalendhi P, Suganthi S. Dose-dependent chemopreventive effects of citronellol in DMBA-induced breast cancer among rats. Drug Dev Res. 2019;80(6):867–76.
   PubMed Web of Science ®Google Scholar
• Moshmann T. Rapid colorimetric assay for cellular growth andsurvival: application to proliferation and cytotoxicity assay. J Immunol Methods. 1983;65:55–63.
   PubMed Web of Science ®Google Scholar
• Halliwell B, Whiteman M. Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean? Br J Pharmacol. 2004;142(2):231–55. doi:10.1038/sj.bjp.0705776
   PubMed Web of Science ®Google Scholar
• Bhosle SM, Huilgol NG, Mishra KP. Enhancement of radiation induced oxidative stress and cytotoxicity in tumor cells byellagic acid. Clin Chim Acta. 2005;359(1-2):89–100. doi:10.1016/j.cccn.2005.03.037
   PubMed Web of Science ®Google Scholar
• Baskic D, Popovic S, Ristic P, Arsenijevic N. Analysis of cyclohexamide induced apoptosis inhuman leukocytes: fluorescence microscopy using annexin V/propidium iodide versus acridin orange/ethidium bromide. Cell Biol Int. 2006;30(11):924–32. doi:10.1016/j.cellbi.2006.06.016
   PubMed Web of Science ®Google Scholar
• Adefolaju GA, Theron KE, Hosie MJ. Effects of HIV protease, nucleoside/nonnucleoside reverse transcriptase inhibitors on Bax Bcl-2 and apoptosis in twocervical cell lines. Biomed. Pharmacother. 2014;68(2):241–51. doi:10.1016/j.biopha.2013.08.007
   PubMed Web of Science ®Google Scholar
• Singh NP, McCoy MT, Tice RR, Schneider EL. A simple technique for quantification of low levels of DNA damage in individual cells. Exp Cell Res. 1988;175(1):184–91. doi:10.1016/0014-4827(88)90265-0
   PubMed Web of Science ®Google Scholar
• Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenolreagent. J Biol Chem. 1951;193(1):265–75.
   PubMed Web of Science ®Google Scholar
• Gnanapragassam VS, Jain M, Batra SK. Analysis of tumorassociated mucin glycotopes by Western transfer methods. Methods Mol Biol. 2013;980:331–40.
   PubMedGoogle Scholar
• Tice RR, Agurell E, Anderson D, Burlinson B, Hartmann A, Kobayashi H, Miyamae Y, Rojas E, Ryu J-C, Sasaki YF. Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen. 2000;35(3):206–21. doi:10.1002/(SICI)1098-2280(2000)35:3<206::AID-EM8>3.0.CO;2-J
   PubMed Web of Science ®Google Scholar
• Sariego J. Breast cancer in the young patient. AM Surb. 2010;76(12):1397–400. doi:10.1177/000313481007601226
   PubMed Web of Science ®Google Scholar
• Baskar R, Lee KA, Yeo R, Yeoh KW. Cancer and radiation therapy: current advances and future directions. Int J Med Sci. 2012;9(3):193–9. doi:10.7150/ijms.3635
   PubMed Web of Science ®Google Scholar
• Shao Z-M, Shen Z-Z, Liu C-H, Sartippour MR, Go VL, Heber D, Nguyen M. Curcumin exerts multiple suppressive effects on human breast carcinoma cells. Int J Cancer. 2002;98(2):234–40. doi:10.1002/ijc.10183
   PubMed Web of Science ®Google Scholar
• Sutton KM, Doucette CD, Hoskin DW. NADPH quinone oxidoreductase 1 mediates breast cancer cell resistance to thymoquinone-induced apoptosis. Biochem Biophys Res Commun. 2012;426(3):421–6. doi:10.1016/j.bbrc.2012.08.111
   PubMed Web of Science ®Google Scholar
• Storz P. Reactive oxygen species in tumor progression. Front Biosci. 2005;10:1881–96. doi:10.2741/1667
   PubMed Web of Science ®Google Scholar
• Redza-Dutordoir M, Averill-Bates DA. Activation of apoptosis signalling pathways by reactive oxygen species. Biochim Biophys Acta. 2016;1863(12):2977–92. doi:10.1016/j.bbamcr.2016.09.012
   PubMed Web of Science ®Google Scholar
• Patel PB, Thakkar VR. L-carvone induces p53, caspase 3 mediated apoptosis and inhibits the migration of breast cancer cell lines. Nutr Cancer. 2014;66(3):453–62. doi:10.1080/01635581.2014.884230
   PubMed Web of Science ®Google Scholar
• Sarosiek KA, Letai A. Directly targeting the mitochondrial pathway of apoptosis for cancer therapy using BH3 mimetics - recent successes, current challenges and future promise. Febs J. 2016;283(19):3523–33. doi:10.1111/febs.13714
   PubMed Web of Science ®Google Scholar
• Martinou JC, Youle RJ. Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. Dev Cell. 2011;21(1):92–101. doi:10.1016/j.devcel.2011.06.017
   PubMed Web of Science ®Google Scholar
• Zorov DB, Juhaszova M, Sollott SJ. Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. Physiol Rev. 2014;94(3):909–50. doi:10.1152/physrev.00026.2013
   PubMed Web of Science ®Google Scholar
• Webster KA. Mitochondrial membrane permeabilization and cell death during myocardial infarction: roles of calcium and reactive oxygen species. Future Cardiol. 2012;8(6):863–84. doi:10.2217/fca.12.58
   PubMedGoogle Scholar
• Indran IR, Tufo G, Pervaiz S, Brenner C. Recent advances in apoptosis, mitochondria and drug resistance in cancer cells. Biochim Biophys Acta. 2011;1807(6):735–45. doi:10.1016/j.bbabio.2011.03.010
   PubMed Web of Science ®Google Scholar
• Janicke RU, Sprengart ML, Wati MR, Porter AG. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J Biol Chem. 1998;273(16):9357–60. doi:10.1074/jbc.273.16.9357
   PubMed Web of Science ®Google Scholar
• Hu CC, Tang CH, Wang JJ. Caspase activation in response to cytotoxic Rana catesbeiana ribonuclease in MCF-7 cells. FEBS Lett. 2001;503(1):65–8. doi:10.1016/S0014-5793(01)02691-6
   PubMed Web of Science ®Google Scholar
• Saleh AM, Al-Qudah MA, Nasr A, Rizvi SA, Borai A, Daghistani M. Comprehensive analysis of the chemical composition and in vitro cytotoxic mechanisms of Pallines spinosa flower and leaf essential oils against breast cancer cells. Cell Physiol Biochem. 2017;42(5):2043–65. doi:10.1159/000479900
   PubMed Web of Science ®Google Scholar
• Zhong Z, Chen X, Tan W, Xu Z, Zhou K, Wu T, Cui L, Wang Y. Germacrone inhibits the proliferation of breast cancer cell lines by inducing cell cycle arrest and promoting apoptosis. Eur J Pharmacol. 2011;667(1-3):50–5. doi:10.1016/j.ejphar.2011.03.041
   PubMed Web of Science ®Google Scholar