Staple Food Fortification with Folic Acid and Iron and Gastrointestinal Cancers: Critical Appraisal of Long-Term National Fortification

References

• Abdollahi Z, Elmadfa I, Djazayeri A, Sadeghian S, Freisling H, Salehi Mazandarani F, Mohamed K. Folate, vitamin B12 and homocysteine status in women of childbearing age: baseline data of folic acid wheat flour fortification in Iran. Ann Nutr Metab. 2008;53(2):143–150. doi:10.1159/000170890
   PubMed Web of Science ®Google Scholar
• Horton S, Ross J. The economics of iron deficiency. Food Policy. 2003;28(1):51–75. doi:10.1016/S0306-9192(02)00070-2
   Web of Science ®Google Scholar
• www.ffinetwork.org/country_profiles [accessed 2018 May 25].
   Google Scholar
• Crider KS, Bailey LB, Berry RJ. Folic acid food fortification – its history, effect, concerns, and future directions. Nutrients. 2011;3(3):370–384. doi:10.3390/nu3030370
   PubMed Web of Science ®Google Scholar
• Fonseca-Nunes A, Jakszyn P, Agudo A. Iron and cancer risk—a systematic review and meta-analysis of the epidemiological evidence. Cancer Epidemiol Biomark Prev. 2014;23(1):12-31. doi:10.1158/1055-9965.EPI-13-0733
   Web of Science ®Google Scholar
• Datta M, Vitolins MZ. Food fortification and supplement use – are there health implications? Crit Rev Food Sci Nutr. 2016;56(13):2149–2159. doi:10.1080/10408398.2013.818527
   PubMed Web of Science ®Google Scholar
• Wald NJ, Morris JK, Blakemore C. Public health failure in the prevention of neural tube defects: time to abandon the tolerable upper intake level of folate. Public Health Rev. 2018;39:2. doi:10.1186/s40985-018-0079-6
   PubMed Web of Science ®Google Scholar
• Somi MH, Golzari M, Farhang S, Naghashi S, Abdollahi L. Gastrointestinal cancer incidence in East Azerbaijan, Iran: update on 5 year incidence and trends. Asian Pac J Cancer Prev. 2014;15(9):3945–3949. doi:10.7314/apjcp.2014.15.9.3945
   PubMedGoogle Scholar
• Somi MH, Farhang S, Mirinezhad SK, Naghashi S, Seif-Farshad M, Golzari M. Cancer in East Azerbaijan, Iran: results of a population-based cancer registry. Asian Pac J Cancer Prev. 2008;9(2):327–330.
   PubMedGoogle Scholar
• www.amar.org [accessed 2018 Sep 25].
   Google Scholar
• Mahdavi-Roshan M, Ramezani A. Overview of flour fortification program with iron and folic acid in Iran. J Health Res Commun 2017;3(1):57–68.
   Google Scholar
• Ahmad OB, Boschi-Pinto C, Lopez AD, Murray CJ, Lozano R, Inoue M. Age standardization of rates: a new WHO standard. Geneva: World Health Organization; 2001. p. 9.
   Google Scholar
• Boyle P, Parkin D. Chapter 11. Statistical methods for registries. In: Jensen OM, Parkin DM, MacLennan R, Muir CS, Skeet RG, editors. Cancer registration: principles and methods. IARC Scientific Publication No. 95. Lyon: International Agency for Research on Cancer; 1991. p. 126–158.
   Google Scholar
• Kim HJ, Fay MP, Feuer EJ, Midthune DN. Permutation tests for joinpoint regression with applications to cancer rates. Statist Med. 2000;19(3):335–351. doi:10.1002/(SICI)1097-0258(20000215)19:3<335::AID-SIM336>3.0.CO;2-Z
   PubMed Web of Science ®Google Scholar
• Abdollahi Z, Elmadfa I, Djazayery A, Golalipour MJ, Sadighi J, Salehi F, Sadeghian Sharif S. Efficacy of flour fortification with folic acid in women of childbearing age in Iran. Ann Nutr Metab. 2011;58(3):188–196. doi:10.1159/000329726
   PubMed Web of Science ®Google Scholar
• Hirsch S, Sanchez H, Albala C, de la Maza MP, Barrera G, Leiva L, Bunout D. Colon cancer in Chile before and after the start of the flour fortification program with folic acid. Eur J Gastroenterol Hepatol. 2009;21:346–349.
   Web of Science ®Google Scholar
• Mason JB, Dickstein A, Jacques PF, Haggarty P, Selhub J, Dallal G, Rosenberg IH. A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: a hypothesis. Cancer Epidemiol Biomark Prev. 2007;16(7):1325–1329. doi:10.1158/1055-9965.EPI-07-0329
   PubMed Web of Science ®Google Scholar
• Moazzen S, Dolatkhah R, Tabrizi JS, Shaarbafi J, Alizadeh BZ, de Bock GH, Dastgiri S. Folic acid intake and folate status and colorectal cancer risk: a systematic review and meta-analysis. Clin Nutr. 2018;37(6 Pt A):1926-1934. doi:10.1016/j.clnu.2017.10.010
   PubMedGoogle Scholar
• Kim YI. Folate and colorectal cancer: an evidence-based critical review. Mol Nutr Food Res. 2007;51(3):267–292. doi:10.1002/mnfr.200600191
   PubMed Web of Science ®Google Scholar
• Wurzelmann JI, Silver A, Schreinemachers DM, Sandler RS, Everson RB. Iron intake and the risk of colorectal cancer. Cancer Epidemiol Biomark Prev. 1996;5:503–507.
   PubMed Web of Science ®Google Scholar
• Pellis L, Dommels Y, Venema D, van Polanen A, Lips E, Baykus H, Kok F, Kampman E, Keijer J. High folic acid increases cell turnover and lowers differentiation and iron content in human HT29 colon cancer cells. Br J Nutr. 2008;99(4):703–708. doi:10.1017/S0007114507824147
   PubMed Web of Science ®Google Scholar
• Zhao Y, Guo C, Hu H, Zheng L, Ma J, Jiang L, Zhao E, Li H. Folate intake, serum folate levels and esophageal cancer risk: an overall and dose-response meta-analysis. Oncotarget. 2017;8(6):10458–10469. doi:10.18632/oncotarget.14432
   PubMedGoogle Scholar
• Larsson SC, Giovannucci E, Wolk A. Folate intake, MTHFR polymorphisms, and risk of esophageal, gastric, and pancreatic cancer: a meta-analysis. Gastroenterology. 2006;131(4):1271–1283. doi:10.1053/j.gastro.2006.08.010
   PubMed Web of Science ®Google Scholar
• Tio M, Andrici J, Cox MR, Eslick GD. Folate intake and the risk of upper gastrointestinal cancers: a systematic review and meta-analysis. J Gastroenterol Hepatol. 2014;29(2):250–258. doi:10.1111/jgh.12446
   PubMed Web of Science ®Google Scholar
• Corley DA, Kubo A, Levin TR, Habel L, Zhao W, Leighton P, Rumore G, Quesenberry C, Buffler P, Block G. Iron intake and body iron stores as risk factors for Barrett’s esophagus: a community-based study. Am J Gastroenterol. 2008;103(12):2997–3004. doi:10.1111/j.1572-0241.2008.02156.x
   PubMed Web of Science ®Google Scholar