References
- Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. doi:https://doi.org/10.3322/caac.21492
- Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646–674. doi:https://doi.org/10.1016/j.cell.2011.02.013
- Alemi A, Zavar Reza J, Haghiralsadat F, Zarei Jaliani H, Haghi Karamallah M, Hosseini SA, Haghi Karamallah S. Paclitaxel and curcumin coadministration in novel cationic PEGylated niosomal formulations exhibit enhanced synergistic antitumor efficacy. J Nanobiotechnol. 2018;16(1):28. doi:https://doi.org/10.1186/s12951-018-0351-4
- Stage TB, Bergmann TK, Kroetz DL. Clinical pharmacokinetics of paclitaxel monotherapy: an updated literature review. Clin Pharmacokinet. 2018;57(1):7–19. doi:https://doi.org/10.1007/s40262-017-0563-z
- Aarland RC, Bañuelos-Hernández AE, Fragoso-Serrano M, Sierra-Palacios EDC, Díaz de León-Sánchez F, Pérez-Flores LJ, Rivera-Cabrera F, Mendoza-Espinoza JA. Studies on phytochemical, antioxidant, anti-inflammatory, hypoglycaemic and antiproliferative activities of Echinacea purpurea and Echinacea angustifolia extracts. Pharm Biol. 2017;55(1):649–656. doi:https://doi.org/10.1080/13880209.2016.1265989
- Zong L, Cheng G, Liu S, Pi Z, Liu Z, Song F. Reversal of multidrug resistance in breast cancer cells by a combination of ursolic acid with doxorubicin. J Pharm Biomed Anal. 2019;165:268–275. doi:https://doi.org/10.1016/j.jpba.2018.11.057
- Shareef M, Ashraf MA, Sarfraz M. Natural cures for breast cancer treatment. Saudi Pharm J. 2016;24(3):233–240. doi:https://doi.org/10.1016/j.jsps.2016.04.018
- Chicca A, Pellati F, Adinolfi B, Matthias A, Massarelli I, Benvenuti S, Martinotti E, Bianucci AM, Bone K, Lehmann R, et al. Cytotoxic activity of polyacetylenes and polyenes isolated from roots of Echinacea pallida. Br J Pharmacol. 2008;153(5):879–885. doi:https://doi.org/10.1038/sj.bjp.0707639
- Nyalambisa M, Oyemitan IA, Matewu R, Oyedeji OO, Oluwafemi OS, Songca SP, Nkeh-Chungag BN, Oyedeji AO. Volatile constituents and biological activities of the leaf and root of Echinacea species from South Africa. Saudi Pharm J. 2017;25(3):381–386. doi:https://doi.org/10.1016/j.jsps.2016.09.010
- Tsai YL, Chiu CC, Yi-Fu Chen J, Chan KC, Lin SD. Cytotoxic effects of Echinacea purpurea flower extracts and cichoric acid on human colon cancer cells through induction of apoptosis. J Ethnopharmacol. 2012;143(3):914–919. doi:https://doi.org/10.1016/j.jep.2012.08.032
- Barnes J, Anderson LA, Gibbons S, Phillipson JD. Echinacea species (Echinacea angustifolia (DC.) Hell., Echinacea pallida (Nutt.) Nutt., Echinacea purpurea (L.) Moench): a review of their chemistry, pharmacology and clinical properties. J Pharm Pharmacol. 2005;57(8):929–954. doi:https://doi.org/10.1211/0022357056127
- Rover MR, Brown RC. Quantification of total phenols in bio-oil using the Folin-Ciocalteu method. J Anal Appl Pyrolysis. 2013;104:366–371. doi:https://doi.org/10.1016/j.jaap.2013.06.011
- Chen HW, Chou FP, Lue SI, Hsu HK, Yang RC. Evidence of multi-step regulation of HSP72 expression in experimental sepsis. Shock. 1999;12(1):63–68. doi:https://doi.org/10.1097/00024382-199907000-00009
- Alvarez-Parrilla E, de la Rosa LA, Amarowicz R, Shahidi F. Antioxidant activity of fresh and processed Jalapeño and Serrano peppers. J Agric Food Chem. 2011;59(1):163–173. doi:https://doi.org/10.1021/jf103434u
- Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med. 1999;26(9–10):1231–1237. doi:https://doi.org/10.1016/S0891-5849(98)00315-3
- Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983;65(1–2):55–63. doi:https://doi.org/10.1016/0022-1759(83)90303-4
- Anguiano-Sevilla LA, Lugo-Cervantes E, Ordaz-Pichardo C, Rosas-Trigueros JL, Me J-F. Apoptosis induction of agave lechuguilla torrey extract on human lung adenocarcinoma cells (SK-LU-1). Int J Mol Sci. 2018;19(12):3765. doi:https://doi.org/10.3390/ijms19123765
- Chou TC. Drug combination studies and their synergy quantification using the Chou-Talalay method. Cancer Res. 2010;70(2):440–446. doi:https://doi.org/10.1158/0008-5472.CAN-09-1947
- Chou TC, Talalay P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul. 1984;22(C):27–55. doi:https://doi.org/10.1016/0065-2571(84)90007-4
- Maron DM, Ames BN. Revised methods for the Salmonella mutagenicity test. Mutat Res. 1983;113(3–4):173–215. doi:https://doi.org/10.1016/0165-1161(83)90010-9
- LeBaron MJ, Schisler MR, Stephen DKT, Dertinger DS, Gollapudi BB. Influence of counting methodology on erythrocyte ratios in the mouse micronucleus. Test Environ Mol. 2012;48:201–209. doi:https://doi.org/10.1002/em21754
- Myles EL. The inhibitory effect of Echinacea purpurea and Echinacea pallida on BT-549 and natural killer cells. MOJ Cell Sci Rep. 2017;4(3):88–96. doi:https://doi.org/10.15406/mojcsr.2017.04.00091
- Naczk M, Shahidi F. Extraction and analysis of phenolics in food. J Chromatogr A. 2004;1054(1–2):95–111. doi:https://doi.org/10.1016/S0021-9673(04)01409-8
- Fuchs-Tarlovsky V. Role of antioxidants in cancer therapy. Nutrition. 2013;29(1):15–21. doi:https://doi.org/10.1016/j.nut.2012.02.014
- Azzi A. Molecular mechanism of alpha-tocopherol action. Free Radic Biol Med. 2007;43(1):16–21. doi:https://doi.org/10.1016/j.freeradbiomed.2007.03.013
- Henning S, Zhang Y, Seeram N, Lee R-P, Wang P, Bowerman S, Heber D. Antioxidant capacity and phytochemical content of herbs and spices in dry, fresh and blended herb paste form. Int J Food Sci Nutr. 2011;62(3):219–225. doi:https://doi.org/10.3109/09637486.2010.530595
- Pandey KB, Rizvi SI. Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev. 2009;2(5):270–278. doi:https://doi.org/10.4161/oxim.2.5.9498
- Sudha S, Masilamani SM. Characterization of cytotoxic compound from marine sediment derived actinomycete Streptomyces avidinii strain SU4. Asian Pac J Trop Biomed. 2012;2(10):770–773. doi:https://doi.org/10.1016/S2221-1691(12)60227-5
- Dorai T, Aggarwal BB. Role of chemopreventive agents in cancer therapy. Cancer Lett. 2004;215(2):129–140. doi:https://doi.org/10.1016/j.canlet.2004.07.013
- Chicca A, Adinolfi B, Pellati F, Orlandini G, Benvenuti S, Nieri P. Cytotoxic activity and G1 Cell cycle arrest of a dienynone from Echinacea pallida. Planta Med. 2010;76(5):444–446. doi:https://doi.org/10.1055/s-0029-1186224
- Morandi S, Pellati F, Ori C, Adinolfi B, Nieri P, Benvenuti S, Prati F. Isolation, structure elucidation and total synthesis of a cytotoxic dienone from Echinacea pallida. Org Biomol Chem. 2008;6(23):4333–4339. doi:https://doi.org/10.1039/b812700j
- Pellati F, Calò S, Benvenuti S, Adinolfi B, Nieri P, Melegari M. Isolation and structure elucidation of cytotoxic polyacetylenes and polyenes from Echinacea pallida. Phytochemistry. 2006;67(13):1359–1364. doi:https://doi.org/10.1016/j.phytochem.2006.05.006
- Tacchini M, Spagnoletti A, Brighenti V, Prencipe FP, Benvenuti S, Sacchetti G, Pellati F. A new method based on supercritical fluid extraction for polyacetylenes and polyenes from Echinacea pallida (Nutt.) Nutt. roots. J Pharm Biomed Anal. 2017;146:1–6. doi:https://doi.org/10.1016/j.jpba.2017.07.053
- Gu Y, Chen T, Li G, Xu C, Zhenzhen X, Zhang J, He K, Zheng L, Guan Z, Su X, et al. Lower Beclin 1 downregulates HER2 expression to enhance tamoxifen sensitivity and predicts a favorable outcome for ER positive breast cancer. Oncotarget. 2017;8(32):52156–52177. doi:https://doi.org/10.18632/oncotarget.11044
- Castellaro AM, Rodriguez-Baili MC, Di Tada CE, Gil GA. Tumor-associated macrophages induce endocrine therapy resistance in ER + breast cancer cells. Cancers (Basel). 2019;11(2):189. doi:https://doi.org/10.3390/cancers11020189
- Schwartz GK, Shah MA. Targeting the cell cycle: a new approach to cancer therapy. J Clin Oncol. 2005;23(36):9408–9421. doi:https://doi.org/10.1200/JCO.2005.01.5594
- Birt DF, Hendrich S, Wang W. Dietary agents in cancer prevention: flavonoids and isoflavonoids. Pharmacol Ther. 2001;90(2–3):157–177. doi:https://doi.org/10.1016/S0163-7258(01)00137-1
- Dong L, Wang H, Niu J, Zou M, Wu N, Yu D, Wang Y, Zou Z. Echinacoside induces apoptotic cancer cell death by inhibiting the nucleotide pool sanitizing enzyme MTH1. Onco Targets Ther. 2015;8:3649–3664. doi:https://doi.org/10.2147/OTT.S94513
- O’Connell KJB, MJ. Cell cycle regulation by checkpoints. Methods Mol Biol. 2014;1170:477–499. doi:https://doi.org/10.1007/978-1-4939-0888-2
- Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 2018;25(3):486–541. doi:https://doi.org/10.1038/s41418-017-0012-4
- Ye J-C, Hsiao M-W, Hsieh C-H, Wu W-C, Hung Y-C, Chang W-C. Analysis of caffeic acid extraction from Ocimum gratissimum Linn. by high performance liquid chromatography and its effects on a cervical cancer cell line. Taiwan J Obstet Gynecol. 2010;49(3):266–271. doi:https://doi.org/10.1016/S1028-4559(10)60059-9
- Rezaei-Seresht H, Cheshomi H, Falanji F, Movahedi-Motlagh F, Hashemian M, Mireskandari E. Cytotoxic activity of caffeic acid and gallic acid against MCF-7 human breast cancer cells: an in silico and in vitro study. Avicenna J Phytomed. 2019;9(6):574–586. doi:https://doi.org/10.22038/AJP.2019.13475
- Martínez-Rodríguez OP, Thompson-Bonilla M del R, Me J-F. Association between obesity and breast cancer: molecular bases and the effect of flavonoids in signaling pathways. Crit Rev Food Sci Nutr. 2020;3:1–23. doi:https://doi.org/10.1080/10408398.2019.1708262
- Tang SM, Deng XT, Zhou J, Li QP, Ge XX, Miao L. Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects. Biomed Pharmacother. 2020;121:109604. doi:https://doi.org/10.1016/j.biopha.2019.109604
- Ahmed S, Khan H, Fratantonio D, Hasan MM, Sharifi S, Fathi N, Ullah H, Rastrelli L. Apoptosis induced by luteolin in breast cancer: mechanistic and therapeutic perspectives. Phytomedicine. 2019;59:152883. doi:https://doi.org/10.1016/j.phymed.2019.152883
- Wang X, Yang Y, An Y, Fang G. The mechanism of anticancer action and potential clinical use of kaempferol in the treatment of breast cancer. Biomed Pharmacother. 2019;117:109086. doi:https://doi.org/10.1016/j.biopha.2019.109086
- Ning X, Ren X, Xie X, Yan P, Wang D, Huang X. A caffeic acid phenethyl ester analog inhibits the proliferation of nasopharyngeal carcinoma cells via targeting epidermal growth factor receptor. J Biochem Mol Toxicol. 2020;34(7):e22491. doi:https://doi.org/10.1002/jbt.22491
- Ozturk G, Ginis Z, Akyol S, Erden G, Gurel A, Akyol O. The anticancer mechanism of caffeic acid phenethyl ester (CAPE): review of melanomas, lung and prostate cancers. Eur Rev Med Pharmacol Sci. 2012;16(15):2064–2068.
- Huang Q, Li S, Zhang L, Qiao X, Zhang Y, Zhao X, Xiao G, Li Z. CAPE-pNO(2) inhibited the growth and metastasis of triple-negative breast cancer via the EGFR/STAT3/Akt/E-cadherin signaling pathway. Front Oncol. 2019;9:461. doi:https://doi.org/10.3389/fonc.2019.00461
- Giró-Perafita A, Palomeras S, Lum DH, Blancafort A, Viñas G, Oliveras G, Pérez-Bueno F, Sarrats A, Welm AL, Puig T. Preclinical evaluation of fatty acid synthase and egfrinhibition in triple-negative breast cancer. Clin Cancer Res. 2016;22(18):4687–4697. doi:https://doi.org/10.1158/1078-0432.CCR-15-3133
- Muley H, Fadó R, Rodríguez-Rodríguez R, Casals N. Drug uptake-based chemoresistance in breast cancer treatment. Biochem Pharmacol. 2020;177:113959. doi:https://doi.org/10.1016/j.bcp.2020.113959
- Sudhagar S, Sathya S, Anuradha R, Gokulapriya G, Geetharani Y, Lakshmi BS. Inhibition of epidermal growth factor receptor by ferulic acid and 4-vinylguaiacol in human breast cancer cells. Biotechnol Lett. 2018;40(2):257–262. doi:https://doi.org/10.1007/s10529-017-2475-2
- Hashemi S, Sharifi A, Zareei S, Mohamedi G, Biglar M, Amanlou M. Discovery of direct inhibitor of KRAS oncogenic protein by natural products: a combination of pharmacophore search, molecular docking, and molecular dynamic studies. Res Pharma Sci. 2020;15(3):226. doi:https://doi.org/10.4103/1735-5362.288425
- Lefort S, Tan S, Balani S, Rafn B, Pellacani D, Hirst M, Sorensen PH, Eaves CJ. Initiation of human mammary cell tumorigenesis by mutant KRAS requires YAP inactivation. Oncogene. 2020;39(9):1957–1968. doi:https://doi.org/10.1038/s41388-019-1111-0
- Kharbanda A, Runkle K, Wang W, Witze ES. Induced sensitivity to EGFR inhibitors is mediated by palmitoylated cysteine 1025 of EGFR and requires oncogenic Kras. Biochem Biophys Res Commun. 2017;493(1):213–219. doi:https://doi.org/10.1016/j.bbrc.2017.09.044
- Tokumaru Y, Oshi M, Katsuta E, Yan L, Satyananda V, Matsuhashi N, Futamura M, Akao Y, Yoshida K, Takabe K. KRAS signaling enriched triple negative breast cancer is associated with favorable tumor immune microenvironment and better survival. Am J Cancer Res. 2020;10(3):897–907.
- Mokhlis HA, Bayraktar R, Kabil NN, Caner A, Kahraman N, Rodriguez-Aguayo C, Zambalde EP, Sheng J, Karagoz K, Kanlikilicer P, et al. The modulatory role of MicroRNA-873 in the progression of KRAS-driven cancers. Mol Ther Nucleic Acids. 2019;14:301–317. doi:https://doi.org/10.1016/j.omtn.2018.11.019
- Okamoto H, Matsukawa T, Doi S, Tsunoda T, Sawata Y, Naemura M, Ohnuki K, Shirasawa S, Kotake Y. Y. A novel resveratrol derivative selectively inhibits the proliferation of colorectal cancer cells with KRAS mutation. Mol Cell Biochem. 2018;442(1–2):39–45. doi:https://doi.org/10.1007/s11010-017-3191-x
- Balaji S, Udupa N, Chamallamudi M, Gupta V, Rangarajan A. Role of the drug transporter ABCC3 in breast cancer chemoresistance. PLoS One. 2016;11(5):e0155013. doi:https://doi.org/10.1371/journal.pone.0155013
- Costea T, Vlad OC, Miclea L-C, Ganea C, Szöllősi J, Mocanu M-M. Alleviation of multidrug resistance by flavonoid and non-flavonoid compounds in breast, lung, colorectal and prostate cancer. Int J Mol Sci. 2020;21(2):401. doi:https://doi.org/10.3390/ijms21020401
- Lu Y, Shan S, Li H, Shi J, Zhang X, Li Z. Reversal effects of bound polyphenol from foxtail millet bran on multidrug resistance in human HCT-8/Fu colorectal cancer cell. J Agric Food Chem. 2018;66(20):5190–5199. doi:https://doi.org/10.1021/acs.jafc.8b01659
- Rigalli JP, Niklas P, Guillermo S, Tocchetti N, Laura M, Johanna R. The phytoestrogens daidzein and equol inhibit the drug transporter BCRP/ABCG2 in breast cancer cells: potential chemosensitizing effect. Eur J Nutr. 2019;58(1):139–150. doi:https://doi.org/10.1007/s00394-017-1578-9
- Sonoki H, Tanimae A, Furuta T, Endo S, Matsunaga T, Ichihara K, Ikari A. Caffeic acid phenethyl ester down-regulates claudin-2 expression at the transcriptional and post-translational levels and enhances chemosensitivity to doxorubicin in lung adenocarcinoma A549 cells. J Nutr Biochem. 2018;56:205–214. doi:https://doi.org/10.1016/j.jnutbio.2018.02.016
- Umbuzeiro-Valent G, Roubicek DA, Haebisch EM. Mutagenic and antimutagenic evaluation of the juice of the leaves of Bryophyllum calycinum (Kalanchoe pinnata), a plant with antihistamine activity. Environ Mol Mutagen. 1999;33(4):325–327. doi:https://doi.org/10.1002/(sici)1098-2280(1999)33:4 < 325::aid-em10 > 3.0.co;2-e
- Yang Y, Zhang Z, Li S, Ye X, Li X, He K. Synergy effects of herb extracts: pharmacokinetics and pharmacodynamic basis. Fitoterapia. 2014;92:133–147. doi:https://doi.org/10.1016/j.fitote.2013.10.010
- HemaIswarya S, Doble M. Potential synergism of natural products in the treatment of cancer. Phytother Res. 2006;20(4):239–249. doi:https://doi.org/10.1002/ptr.1841