References
- Cory H, Passarelli S, Szeto J, Tamez M, Mattei J. The role of polyphenols in human health and food systems: a mini-review. Front Nutr. 2018;5:87. doi:https://doi.org/10.3389/fnut.2018.00087.
- Skibola CF, Smith MT. Potential health impacts of excessive flavonoid intake. Free Radic Biol Med. 2000;29(3–4):375–83. doi:https://doi.org/10.1016/s0891-5849(00)00304-x
- Selassie CD, Kapur S, Verma RP, Rosario M. Cellular apoptosis and cytotoxicity of phenolic compounds: a quantitative structure-activity relationship study. J Med Chem. 2005;48(23):7234–7242. doi:https://doi.org/10.1021/jm050567w
- Kim H-S, Quon MJ, Kim J-A. New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate. Redox Biol. 2014;2:187–195. doi:https://doi.org/10.1016/j.redox.2013.12.022
- Ramos S. Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention. J Nutr Biochem. 2007;18(7):427–442. doi:https://doi.org/10.1016/j.jnutbio.2006.11.004
- Lambert JD, Elias RJ. The antioxidant and pro-oxidant activities of green tea polyphenols: a role in cancer prevention. Arch Biochem Biophys. 2010;501(1):65–72. doi:https://doi.org/10.1016/j.abb.2010.06.013
- Zaveri NT. Green tea and its polyphenolic catechins: medicinal uses in cancer and noncancer applications. Life Sci. 2006;78(18):2073–2080. doi:https://doi.org/10.1016/j.lfs.2005.12.006
- Grzesik M, Naparło K, Bartosz G, Sadowska-Bartosz I. Antioxidant properties of catechins: comparison with other antioxidants. Food Chem. 2018;241:480–492. doi:https://doi.org/10.1016/j.foodchem.2017.08.117
- Singh BN, Shankar S, Srivastava RK. Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications. Biochem Pharmacol. 2011;82(12):1807–1821. doi:https://doi.org/10.1016/j.bcp.2011.07.093
- Von Gadow A, Joubert E, Hansmann CF. Comparison of the antioxidant activity of rooibos tea (Aspalathus linearis) with green, oolong and black tea. Food Chem. 1997;60(1):73–77. doi:https://doi.org/10.1016/S0308-8146(96)00312-3
- Snijman PW, Joubert E, Ferreira D, Li X-C, Ding Y, Green IR, Gelderblom WCA. Antioxidant activity of the dihydrochalcones aspalathin and nothofagin and their corresponding flavones in relation to other rooibos (Aspalathus linearis) Flavonoids, Epigallocatechin Gallate, and Trolox. J Agric Food Chem. 2009;57(15):6678–6684. doi:https://doi.org/10.1021/jf901417k
- Shimamura N, Miyase T, Umehara K, Warashina T, Fujii S. Phytoestrogens from Aspalathus linearis. Biol Pharm Bull. 2006;29(6):1271–1274. doi:https://doi.org/10.1248/bpb.29.1271
- Muller CJF, Joubert E, de Beer D, Sanderson M, Malherbe CJ, Fey SJ, Louw J. Acute assessment of an aspalathin-enriched green rooibos (Aspalathus linearis) extract with hypoglycemic potential. Phytomedicine. 2012;20(1):32–39. doi:https://doi.org/10.1016/j.phymed.2012.09.010
- Magcwebeba TU, Swart P, Swanevelder S, Joubert E, Gelderblom WCA. Anti-inflammatory effects of Aspalathus linearis and Cyclopia spp. extracts in a UVB/keratinocyte (HaCaT) model utilising interleukin-1α accumulation as biomarker. Molecules. 2016;21(10):1323. doi:https://doi.org/10.3390/molecules21101323
- Lee W, Kim K-M, Bae J-S. Ameliorative effect of aspalathin and nothofagin from rooibos (Aspalathus linearis) on HMGB1-Induced septic responses in vitro and in vivo. Am J Chin Med. 2015;43:1–22. doi.org/ doi:https://doi.org/10.1142/S0192415X15500573.
- Marnewick J, Joubert E, Joseph S, Swanevelder S, Swart P, Gelderblom W. Inhibition of tumour promotion in mouse skin by extracts of rooibos (Aspalathus linearis) and honeybush (Cyclopia intermedia), unique South African herbal teas. Cancer Lett. 2005;224(2):193–202. doi:https://doi.org/10.1016/j.canlet.2004.11.014
- Marnewick JL, van der Westhuizen FH, Joubert E, Swanevelder S, Swart P, Gelderblom WCA. Chemoprotective properties of rooibos (Aspalathus linearis), honeybush (Cyclopia intermedia) herbal and green and black (Camellia sinensis) teas against cancer promotion induced by fumonisin B1 in rat liver. Food Chem Toxicol. 2009;47(1):220–229. doi:https://doi.org/10.1016/j.fct.2008.11.004
- Sissing L, Marnewick J, de Kock M, Swanevelder S, Joubert E, Gelderblom W. Modulating effects of rooibos and honeybush herbal teas on the development of esophageal papillomas in rats. Nutr Cancer. 2011;63(4):600–610. doi:https://doi.org/10.1080/01635581.2011.539313
- Huang S-H, Tseng J-C, Lin C-Y, Kuo Y-Y, Wang B-J, Kao Y-H, Muller CJF, Joubert E, Chuu C-P. Rooibos suppresses proliferation of castration-resistant prostate cancer cells via inhibition of Akt signaling. Phytomedicine. 2019;64:153068. doi:https://doi.org/10.1016/j.phymed.2019.153068
- Walters NA, de Villiers A, Joubert E, de Beer D. Improved HPLC method for rooibos phenolics targeting changes due to fermentation. J Food Comp Anal. 2017;55:20–29. doi:https://doi.org/10.1016/j.jfca.2016.11.003
- Kawano A, Nakamura H, Hata S-i, Minakawa M, Miura Y, Yagasaki K. Hypoglycemic effect of aspalathin, a rooibos tea component from Aspalathus linearis, in type 2 diabetic model db/db mice. Phytomedicine. 2009;16(5):437–443. doi:https://doi.org/10.1016/j.phymed.2008.11.009
- Johnson R, Beer D. d, Dludla PV, Ferreira D, Muller CJF, Joubert E. Aspalathin from rooibos (Aspalathus linearis): a bioactive C-glucosyl dihydrochalcone with potential to target the metabolic syndrome. Planta Med. 2018;84(9–10):568–583. doi:https://doi.org/10.1055/s-0044-100622
- Theoharides TC, Asadi S, Panagiotidou S. A case series of a luteolin formulation (NeuroProtek®) in children with autism spectrum disorders. Int J Immunopathol Pharmacol. 2012;25(2):317–323. doi:https://doi.org/10.1177/039463201202500201
- Ueda H, Yamazaki C, Yamazaki M. Luteolin as an anti-inflammatory and anti-allergic constituent of Perilla frutescens. Biol Pharm Bull. 2002;25(9):1197–1202. doi:https://doi.org/10.1248/bpb.25.1197
- Dihal AA, de Boer VCJ, van der Woude H, Tilburgs C, Bruijntjes JP, Alink GM, Rietjens IMCM, Woutersen RA, Stierum RH. Quercetin, but not Its glycosidated conjugate rutin, inhibits azoxymethane-induced colorectal carcinogenesis in F344 rats. J Nutr. 2006;136(11):2862–2867. doi:https://doi.org/10.1093/jn/136.11.2862
- Zhang N, Ying M-D, Wu Y-P, Zhou Z-H, Ye Z-M, Li H, Lin D-S. Hyperoside, a flavonoid compound, inhibits proliferation and stimulates osteogenic differentiation of human osteosarcoma cells. Plos One. 2014;9(7):e98973. doi:https://doi.org/10.1371/journal.pone.0098973
- He M, Min J-W, Kong W-L, He X-H, Li J-X, Peng B-W. A review on the pharmacological effects of vitexin and isovitexin. Fitoterapia. 2016;115:74–85. doi:https://doi.org/10.1016/j.fitote.2016.09.011
- Lam KY, Ling APK, Koh RY, Wong YP, Say YH. A review on medicinal properties of orientin. Adv Pharmacol Sci. 2016;2016:4104595–4104599. doi:https://doi.org/10.1155/2016/4104595
- Orfali G. d C, Duarte AC, Bonadio V, Martinez NP, de Araújo MEMB, Priviero FBM, Carvalho PO, Priolli DG. Review of anticancer mechanisms of isoquercitin. World J Clin Oncol. 2016;7(2):189–199. doi:https://doi.org/10.5306/wjco.v7.i2.189
- Wang L, Yue Z, Guo M, Fang L, Bai L, Li X, Tao Y, Wang S, Liu Q, Zhi D, et al. Dietary flavonoid hyperoside induces apoptosis of activated human LX-2 hepatic stellate cell by suppressing canonical NF-κB Signaling. Biomed Res Int. 2016;2016:1068528. doi:https://doi.org/10.1155/2016/1068528
- Joubert E, de Beer D, CJ, Malherbe CJ. Herbal teas - exploring untapped potential and strengthening commercialisation. S Afr J Bot. 2017;110:1–3. doi:https://doi.org/10.1016/j.sajb.2017.01.204
- Magcwebeba TU, Riedel S, Swanevelder S, Swart P, De Beer D, Joubert E, Andreas Gelderblom WC. The potential role of polyphenols in the modulation of skin cell viability by Aspalathus linearis and Cyclopia spp. herbal tea extracts in vitro. J Pharm Pharmacol. 2016;68(11):1440–1453. doi:https://doi.org/10.1111/jphp.12629
- Singleton VL, Rossi JA. Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am J Enol Vitic. 1965;16:144–158.
- Arthur H, Joubert E, De Beer D, Malherbe CJ, Witthuhn RC. Phenylethanoid glycosides as major antioxidants in Lippia multiflora herbal infusion and their stability during steam pasteurisation of plant material. Food Chem. 2011;127(2):581–588. doi:https://doi.org/10.1016/j.foodchem.2011.01.044
- Benzie IFF, Strain JJ. The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay. Anal Biochem. 1996;239(1):70–76. doi:https://doi.org/10.1006/abio.1996.0292
- Hayes MA, Roberts E, Roomi MW, Safe SH, Farber E, Cameron RG. Comparative influences of different PB-type and 3-MC-type polychlorinated biphenyl-induced phenotypes on cytocidal hepatotoxicity of bromobenzene and acetaminophen. Toxicol Appl Pharmacol. 1984;76(1):118–127. doi:https://doi.org/10.1016/0041-008x(84)90035-8
- Ahmad N, Feyes DK, Agarwal R, Mukhtar H, Nieminen AL. Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells. J Natl Cancer Inst. 1997;89(24):1881–1886. doi:https://doi.org/10.1093/jnci/89.24.1881
- Leung HW-C, Kuo C-L, Yang W-H, Lin C-H, Lee H-Z. Antioxidant enzymes activity involvement in luteolin-induced human lung squamous carcinoma CH27 cell apoptosis. Eur J Pharmacol. 2006;534(1–3):12–18. doi:https://doi.org/10.1016/j.ejphar.2006.01.021
- D’Archivio M, Santangelo C, Scazzocchio B, Varì R, Filesi C, Masella R, Giovannini C. Modulatory effects of polyphenols on apoptosis induction: relevance for cancer prevention. IJMS. 2008;9(3):213–228. doi:https://doi.org/10.3390/ijms9030213
- Mileo AM, Miccadei S. Polyphenols as modulator of oxidative stress in cancer disease: new therapeutic strategies. Oxid Med Cell Longev. 2016;2016:6475624. http://dx.doi.org/ doi:https://doi.org/10.1155/2016/6475624
- Hegedűs C, Kovács K, Polgár Z, Regdon Z, Szabó É, Robaszkiewicz A, Forman HJ, Martner A, Virág L. Redox control of cancer cell destruction. Redox Biol. 2018;16:59–74. doi:https://doi.org/10.1016/j.redox.2018.01.015
- Acharya A, Das I, Chandhok D, Saha T. Redox regulation in cancer: a double-edged sword with therapeutic potential. Oxid Med Cell Longev. 2010;3(1):23–34. doi:https://doi.org/10.4161/oxim.3.1.10095
- Manda G, Isvoranu G, Comanescu MV, Manea A, Debelec Butuner B, Korkmaz KS. The redox biology network in cancer pathophysiology and therapeutics. Redox Biol. 2015;5:347–357. doi:https://doi.org/10.1016/j.redox.2015.06.014
- Liu Y, Li Q, Zhou L, Xie N, Nice EC, Zhang H, Huang C, Lei Y. Cancer drug resistance: redox resetting renders a way. Oncotarget. 2016;7(27):42740–42761. doi:https://doi.org/10.18632/oncotarget.8600
- Seeram NP, Adams LS, Hardy ML, Heber D. Total cranberry extract vs its phytochemical constituents: antiproliferative and synergistic effects against human tumor cell lines. J Agric Food Chem. 2005;52:12–25.
- Han DH, Jeong JH, Kim JH. Anti-proliferative and apoptosis induction activity of green tea polyphenols on human promyelocytic leukemia HL-60 cells. Anticancer Res. 2009;29(4):1417–1421.
- Xie C-M, Chan WY, Yu S, Zhao J, Cheng CHK. Bufalin induces autophagy-mediated cell death in human colon cancer cells through reactive oxygen species generation and JNK activation. Free Radic Biol Med. 2011;51(7):1365–1375. doi:https://doi.org/10.1016/j.freeradbiomed.2011.06.016
- Suzuki H, Tomida A, Tsuruo T. A novel mutant from apoptosis-resistant colon cancer HT-29 cells showing hyper-apoptotic response to hypoxia, low glucose and cisplatin. Jpn J Cancer Res. 1998;89(11):1169–1178. doi:https://doi.org/10.1111/j.1349-7006.1998.tb00512.x
- Lyamzaev KG, Tokarchuk AV, Panteleeva AA, Mulkidjanian AY, Skulachev VP, Chernyak BV. Induction of autophagy by depolarization of mitochondria. Autophagy. 2018;14(5):921–924. doi:https://doi.org/10.1080/15548627.2018.1436937
- Leist M, Single B, Castoldi AF, Kühnle S, Nicotera P. Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis. J Exp Med. 1997;185(8):1481–1486. doi:https://doi.org/10.1084/jem.185.8.1481
- Nikoletopoulou V, Markaki M, Palikaras K, Tavernarakis N. Crosstalk between apoptosis, necrosis and autophagy. Biochim Biophys Acta. 2013;1833(12):3448–3459. doi:https://doi.org/10.1016/j.bbamcr.2013.06.001
- Epstein T, Gatenby RA, Brown JS. The Warburg effect as an adaptation of cancer cells to rapid fluctuations in energy demand. Plos One. 2017;12(9):e0185085. https://doi.org/10.1371/journal.pone. 0185085. doi:https://doi.org/10.1371/journal.pone.0185085
- Zhang Y, Chen X, Gueydan C, Han J. Plasma membrane changes during programmed cell deaths. Cell Res. 2018;28(1):9–21. doi:https://doi.org/10.1038/cr.2017.133
- Eales KL, Hollinshead KER, Tennant DA. Hypoxia and metabolic adaptation of cancer cells. Oncogenesis. 2016; 5:e190. doi:https://doi.org/10.1038/oncsis.2015.50
- Limami Y, Pinon A, Leger DY, Mousseau Y, Cook-Moreau J, Beneytout J-L, Delage C, Liagre B, Simon A. HT-29 colorectal cancer cells undergoing apoptosis overexpress COX-2 to delay ursolic acid-induced cell death. Biochimie. 2011;93(4):749–757. doi:https://doi.org/10.1016/j.biochi.2011.01.003
- Aires V, Colin DJ, Doreau A, Di Pietro A, Heydel J-M, Artur Y, Latruffe N, Delmas D. P-Glycoprotein 1 affects chemoactivities of resveratrol against human colorectal cancer cells. Nutrients. 2019;11(9):2098. doi:https://doi.org/10.3390/nu11092098
- Przystupski D, Michel O, Rossowska J, Kwiatkowski S, Saczko J, Kulbacka J. The modulatory effect of green tea catechin on drug resistance in human ovarian cancer cells. Med Chem Res. 2019;28(5):657–667. doi:https://doi.org/10.1007/s00044-019-02324-6
- Jodoin J, Demeule M, BëLiveau R. Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols. Biochim et Biophys Acta. 2002;1542(1–3):149–159. doi:https://doi.org/10.1016/S0167-4889(01)00175-6
- Bai J, Zhao S, Fan X, Chen Y, Zou X, Hu M, Wang B, Jin J, Wang X, Hu J, et al. Inhibitory effects of flavonoids on P-glycoprotein in vitro and in vivo: food/herb-drug interactions and structure-activity relationships. Toxicol Appl Pharmacol. 2019;369:49–59. doi:https://doi.org/10.1016/j.taap.2019.02.010
- Chen G, Wang F, Trachootham D, Huang P. Preferential killing of cancer cells with mitochondrial dysfunction by natural compounds. Mitochondrion . 2010;10(6):614–625. doi:https://doi.org/10.1016/j.mito.2010.08.001
- Mahbub AA, Le Maitre CL, Haywood-Small SL, McDougall GJ, Cross NA, Jordan-Mahy N. Differential effects of polyphenols on proliferation and apoptosis in human myeloid and lymphoid leukemia cell lines. Anticancer Agents Med Chem. 2013;13(10):1601–1613. doi:https://doi.org/10.2174/18715206113139990303
- Khiewkamrop P, Phunsomboon P, Richert L, Pekthong D, Srisawang P. Epistructured catechins, EGCG and EC facilitate apoptosis induction through targeting de novo lipogenesis pathway in HepG2 cells. Cancer Cell Int. 2018;18:46. doi:https://doi.org/10.1186/s12935-018-0539-6
- Perron NR, Brumaghim JL. A review of the antioxidant mechanisms of polyphenol compounds related to iron binding. Cell Biochem Biophys. 2009;53(2):75–100. doi:https://doi.org/10.1007/s12013-009-9043-x
- Cherrak SA, Mokhtari-Soulimane N, Berroukeche F, Bensenane B, Cherbonnel A, Merzouk H, Elhabiri M. In vitro antioxidant versus metal ion chelating properties of flavonoids: a structure-activity investigation. Plos One. 2016;11(10):e0165575. 0165575. doi:https://doi.org/10.1371/journal.pone
- Jovanović IN, Miličević A. A new, simplified model for the estimation of polyphenol oxidation potentials based on the number of OH groups. Arh Hig Rada Toksikol. 2017;68(2):93–98. doi:https://doi.org/10.1515/aiht-2017-68-2988
- Eghbaliferiz S, Iranshahi M. Prooxidant activity of polyphenols, flavonoids, anthocyanins and carotenoids: updated review of mechanisms and catalyzing metals. Phytother Res. 2016:30(9):1–13. doi:https://doi.org/10.1002/ptr.5643
- Magcwebeba TU, Swart P, Swanevelder S, Joubert E, Gelderblom WCA. Chemopreventive properties of green tea, rooibos and honeybush extracts in skin cells in vitro. Molecules. 2016;21(12):1622. doi:https://doi.org/10.3390/molecules21121622.63
- Joubert E, Winterton P, Britz TJ, Gelderblom WCA. Antioxidant and pro-oxidant activities of aqueous extracts and crude polyphenolic fractions of rooibos (Aspalathus linearis). J Agric Food Chem. 2005;53(26):10260–10267. doi:https://doi.org/10.1021/jf051355a
- Van der Merwe JD, de Beer D, Joubert E, Gelderblom WCA. Short-term and sub-Chronic dietary exposure to aspalathin-enriched green rooibos (Aspalathus linearis) extract affects rat liver function and antioxidant status. Molecules. 2015;20(12):22674–22690. doi:https://doi.org/10.3390/molecules201219868
- Yuan L, Wei S, Wang J, Liu X. Isoorientin induces apoptosis and autophagy simultaneously by reactive oxygen species (ROS)-related p53, PI3K/Akt, JNK, and p38 signaling pathways in HepG2 cancer cells. J Agric Food Chem. 2014;62(23):5390–5400. doi:https://doi.org/10.1021/jf500903g
- Lee C-Y, Chien Y-S, Chiu T-H, Huang W-W, Lu C-C, Chiang J-H, Yang J-S. Apoptosis triggered by vitexin in U937 human leukemia cells via a mitochondrial signaling signaling pathway. Oncol Rep. 2012;28(5):1883–1888. doi:https://doi.org/10.3892/or.2012.2000
- Shen S-C, Chen Y-C, Hsu F-L, Lee W-R. Differential apoptosis-inducing effect of quercetin and its glycosides in human promyeloleukemic HL-60 cells by alternative activation of the caspase 3 cascade . J Cell Biochem. 2003;89(5):1044–1055. doi:https://doi.org/10.1002/jcb.10559
- Qanungo S, Das M, Haldar S, Basu A. Epigallocatechin-3-gallate induces mitochondrial membrane depolarization and caspase-dependent apoptosis in pancreatic cancer cells. Carcinogenesis . 2005;26(5):958–967. doi:https://doi.org/10.1093/carcin/bgi040
- Roy P, Nigam N, George J, Srivastava S, Shukla Y. Induction of apoptosis by tea polyphenols mediated through mitochondrial cell death pathway in mouse skin tumors. Cancer Biol Ther. 2009;8(13):1281–1287. doi:https://doi.org/10.4161/cbt.8.13.8728
- Tan X, Hu D, Li S, Han Y, Zhang Y, Zhou D. Differences of four catechins in cell cycle arrest and induction of apoptosis in LoVo cells. Cancer Lett. 2000;158(1):1–6. doi:https://doi.org/10.1016/S0304-3835(00)00445-6
- Saiki S, Sasazawa Y, Imamichi Y, Kawajiri S, Fujimaki T, Tanida I, Kobayashi H, Sato F, Sato S, Ishikawa K-I, et al. Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition. Autophagy. 2011;7(2):176–187. doi:https://doi.org/10.4161/auto.7.2.14074
- Marozienė A, Nemeikaitė-Čėnienė A, Vidžiūnaitė R, Čėnas N. Correlation between mammalian cell cytotoxicity of flavonoids and the redox potential of phenoxyl radical/phenol couple. Acta Biochim Pol. 2012;59(2):299–305.
- Moridani MY, Galati G, O'Brien PJ. Comparative quantitative structure toxicity relationships for flavonoids evaluated in isolated rat hepatocytes and HeLa tumor cells. Chem Biol Interact. 2002;139(3):251–264. doi:https://doi.org/10.1016/S0009-2797(02)00005-4
- Li Y, Revalde J, Paxton JW. The effects of dietary and herbal phytochemicals on drug transporters. Adv Drug Deliv Rev. 2017;116:45–62. doi:https://doi.org/10.1016/j.addr.2016.09.004
- Nemeikaitė-Čėnienė A, Imbrasaitė A, Sergedienė E, Čėnas N. Quantitative structure–activity relationships in prooxidant cytotoxicity of polyphenols: role of potential of phenoxyl radical/phenol redox couple. Arch Biochem Biophys. 2005;441(2):182–190. doi:https://doi.org/10.1016/j.abb.2005.07.002
- Abrahams S, Samodien S, Lilly M, Joubert E, Gelderblom WCA. Differential modulation of gene expression encoding hepatic and renal xenobiotic metabolizing enzymes by an aspalathin-enriched rooibos extract and aspalathin. Planta Med. 2019;85(01):6–13. doi:https://doi.org/10.1055/a-0656-7500
- Patel O, Muller CJF, Joubert E, Rosenkranz B, Taylor MJC, Louw J, Awortwe C. Pharmacokinetic interaction of green rooibos extract with atorvastatin and metformin in rats. Front Pharmacol. 2019;10:1243. doi:https://doi.org/10.3389/fphar.2019.01243
- Hu J, Webster D, Cao J, Shao A. The safety of green tea and green tea extract consumption in adults - results of a systematic review. Regul Toxicol Pharmacol. 2018;95:412–433. doi:https://doi.org/10.1016/j.yrtph.2018.03.019
- Mennen LI, Walker R, Bennetau-Pelissero C, Scalbert A. Risks and safety of polyphenol consumption. Am J Clin Nutr. 2005;81(1 Suppl):326S–3299S. doi:https://doi.org/10.1093/ajcn/81.1.326S