References
- Schlörmann W, Glei M. Potential health benefits of beta-glucan from barley und oat. Ernahrungs Umschau. 2017;64:M555–M559.
- Tosh SM. Review of human studies investigating the post-prandial blood-glucose lowering ability of oat and barley food products. Eur J Clin Nutr. 2013;67(4):310–317. doi:https://doi.org/10.1038/ejcn.2013.25
- Whitehead A, Beck EJ, Tosh S, Wolever TM. Cholesterol-lowering effects of oat beta-glucan: a meta-analysis of randomized controlled trials. Am J Clin Nutr. 2014;100(6):1413–1421. doi:https://doi.org/10.3945/ajcn.114.086108
- Baik BK, Ullrich SE. Barley for food: characteristics, improvement, and renewed interest. J Cereal Sci. 2008;48(2):233–242. doi:https://doi.org/10.1016/j.jcs.2008.02.002
- Charalampopoulos D, Wang R, Pandiella SS, Webb C. Application of cereals and cereal components in functional foods: a review. Int J Food Microbiol. 2002;79(1–2):131–41. doi:https://doi.org/10.1016/s0168-1605(02)00187-3
- EFSA. Scientific opinion on the substantiation of health claims related to beta-glucans from oats and barley and maintenance of normal blood LDL-cholesterol concentrations (ID 1236, 1299), increase in satiety leading to a reduction in energy intake (ID 851, 852), reduction of post-prandial glycaemic responses (ID 821, 824), and “digestive function” (ID 850) pursuant to Article 13(1) of regulation (EC) No 1924/2006. EFSA J. 2011;9: 2207–2221.
- Aune D, Chan DSM, Lau R, Vieira R, Greenwood DC, et al. Dietary fibre, whole grains, and risk of colorectal cancer: systematic review and dose-response meta-analysis of prospective studies. Br Med J. 2011;343:d6617.
- Malcomson FC. Mechanisms underlying the effects of nutrition, adiposity and physical activity on colorectal cancer risk. Nutr Bull. 2018;43(4):400–415. doi:https://doi.org/10.1111/nbu.12359
- Murphy N, Norat T, Ferrari P, Jenab M, Bueno-de-Mesquita B, Skeie G, Dahm CC, Overvad K, Olsen A, Tjønneland A, et al. Dietary fibre intake and risks of cancers of the colon and rectum in the European prospective investigation into cancer and nutrition (EPIC). PLoS One. 2012;7(6):e39361. doi:https://doi.org/10.1371/journal.pone.0039361
- Hussain PR, Rather SA, Suradkar PP. Structural characterization and evaluation of antioxidant, anticancer and hypoglycemic activity of radiation degraded oat (Avena sativa) beta-glucan. Radiat Phys Chem. 2018;144:218–230. doi:https://doi.org/10.1016/j.radphyschem.2017.08.018
- Shah A, Ahmad M, Ashwar BA, Gani A, Masoodi FA, Wani IA, Wani SM, Gani A. Effect of γ-irradiation on structure and nutraceutical potential of β-D-glucan from barley (Hordeum vulgare). Int J Biol Macromol. 2015;72:1168–1175. doi:https://doi.org/10.1016/j.ijbiomac.2014.08.056
- Schlörmann W, Atanasov J, Lorkowski S, Dawczynski C, Glei M. Study on chemopreventive effects of raw and roasted β-glucan-rich waxy winter barley using an in vitro human colon digestion model. Food Funct. 2020;11(3):2626–2638
- Glei M, Zetzmann S, Lorkowski S, Dawczynski C, Schlörmann W. Chemopreventive effects of raw and roasted oat flakes after in vitro fermentation with human faecal microbiota. Int J Food Sci Nutr. 2020;1–13.
- Lahouar L, Ghrairi F, Arem AE, Sghaeir W, Felah ME, Salem HB, Sriha B, Achour L. Attenuation of histopathological alterations of colon, liver and lung by dietary fibre of barley Rihane in azoxymethane-treated rats. Food Chem. 2014;149:271–276. doi:https://doi.org/10.1016/j.foodchem.2013.10.101
- Wang H-C, Hung C-H, Hsu J-D, Yang M-Y, Wang S-J, Wang C-J. Inhibitory effect of whole oat on aberrant crypt foci formation and colon tumor growth in ICR and BALB/c mice. J Cereal Sci. 2011;53(1):73–77. doi:https://doi.org/10.1016/j.jcs.2010.09.009
- Turunen KT, Pletsa V, Georgiadis P, Triantafillidis JK, Karamanolis D, Kyriacou A. Impact of β-glucan on the fecal water genotoxicity of polypectomized patients. Nutr Cancer. 2016;68(4):560–567. doi:https://doi.org/10.1080/01635581.2016.1156713
- Henrion M, Francey C, Le KA, Lamothe L. Cereal B-Glucans: the impact of processing and how it affects physiological responses. Nutrients. 2019;11(8):1729. doi:https://doi.org/10.3390/nu11081729
- Makela N, Brinck O, Sontag-Strohm T. Viscosity of beta-glucan from oat products at the intestinal phase of the gastrointestinal model. Food Hydrocolloid. 2020;100.
- Schlörmann W, Zetzmann S, Wiege B, Haase NU, Greiling A, Lorkowski S, Dawczynski C, Glei M. Impact of different roasting conditions on chemical composition, sensory quality and physicochemical properties of waxy-barley products. Food Funct. 2019;10(9):5436–5445. doi:https://doi.org/10.1039/c9fo01429b
- Schlörmann W, Zetzmann S, Wiege B, Haase NU, Greiling A. Impact of different roasting conditions on sensory properties and health-related compounds of oat products. Food Chem. 2020;307.
- Schlörmann W, Lamberty J, Ludwig D, Lorkowski S, Glei M. In vitro-fermented raw and roasted walnuts induce expression of CAT and GSTT2 genes, growth inhibition, and apoptosis in LT97 colon adenoma cells. Nutr Res. 2017;47:72–80. doi:https://doi.org/10.1016/j.nutres.2017.09.004
- Stein K, Borowicki A, Scharlau D, Scheu K, Brenner-Weiss G, Obst U, Hollmann J, Lindhauer M, Wachter N, Glei M, et al. Modification of an in vitro model simulating the whole digestive process to investigate cellular endpoints of chemoprevention. Br J Nutr. 2011;105(5):678–687. doi:https://doi.org/10.1017/S0007114510004320
- Klein A, Friedrich U, Vogelsang H, Jahreis G. Lactobacillus acidophilus 74-2 and Bifidobacterium animalis subsp lactis DGCC 420 modulate unspecific cellular immune response in healthy adults. Eur J Clin Nutr. 2008;62(5):584–593. doi:https://doi.org/10.1038/sj.ejcn.1602761
- Chaney AL, Marbach EP. Modified reagents for determination of urea and ammonia. Clin Chem. 1962;8:130–132.
- Richter M, Jurek D, Wrba F, Kaserer K, Wurzer G, Karner-Hanusch J, Marian B. Cells obtained from colorectal microadenomas mirror early premalignant growth patterns in vitro. Eur J Cancer. 2002;38(14):1937–1945. doi:https://doi.org/10.1016/s0959-8049(02)00158-2
- Veeriah S, Hofmann T, Glei M, Dietrich H, Will F, Schreier P, Knaup B, Pool-Zobel BL. Apple polyphenols and products formed in the gut differently inhibit survival of human cell lines derived from colon adenoma (LT97) and carcinoma (HT29). J Agric Food Chem. 2007;55(8):2892–2900. doi:https://doi.org/10.1021/jf063386r
- Schlörmann W, Hiller B, Jahns F, Zöger R, Hennemeier I, Wilhelm A, Lindhauer MG, Glei M. Chemopreventive effects of in vitro digested and fermented bread in human colon cells. Eur J Nutr. 2012;51(7):827–839. doi:https://doi.org/10.1007/s00394-011-0262-8
- Schlörmann W, Lamberty J, Lorkowski S, Ludwig D, Mothes H, Saupe C, Glei M. Chemopreventive potential of in vitro fermented nuts in LT97 colon adenoma and primary epithelial colon cells. Mol Carcinog. 2017;56(5):1461–1471. doi:https://doi.org/10.1002/mc.22606
- Glei M, Fischer S, Lamberty J, Ludwig D, Lorkowski S, Schlörmann W. Chemopreventive potential of in vitro fermented raw and roasted hazelnuts in LT97 colon adenoma cells. Anticancer Res. 2018;38(1):83–93. doi:https://doi.org/10.21873/anticanres.12195
- Pfaffl MW, Horgan GW, Dempfle L. Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res. 2002;30:36.
- Rieu I, Powers SJ. Real-time quantitative RT-PCR: design, calculations, and statistics. Plant Cell. 2009;21(4):1031–1033. doi:https://doi.org/10.1105/tpc.109.066001
- Hinnebusch BF, Meng S, Wu JT, Archer SY, Hodin RA. The effects of short-chain fatty acids on human colon cancer cell phenotype are associated with histone hyperacetylation. J Nutr. 2002;132(5):1012–1017. doi:https://doi.org/10.1093/jn/132.5.1012
- Topping DL, Clifton PM. Short-chain fatty acids and human colonic function: Roles of resistant starch and nonstarch polysaccharides. Physiol Rev. 2001;81(3):1031–1064. doi:https://doi.org/10.1152/physrev.2001.81.3.1031
- Hamer HM, Jonkers D, Venema K, Vanhoutvin S, Troost FJ, Brummer R-J. Review article: the role of butyrate on colonic function. Aliment Pharmacol Ther. 2008;27(2):104–119. doi:https://doi.org/10.1111/j.1365-2036.2007.03562.x
- Comino P, Williams BA, Gidley MJ. In vitro fermentation gas kinetics and end-products of soluble and insoluble cereal flour dietary fibres are similar. Food Funct. 2018;9(2):898–905. doi:https://doi.org/10.1039/c7fo01724c
- Hernot DC, Boileau TW, Bauer LL, Swanson KS, Fahey GC. In vitro digestion characteristics of unprocessed and processed whole grains and their components. J Agric Food Chem. 2008;56(22):10721–10726. doi:https://doi.org/10.1021/jf801944a
- Hughes R, Magee EA, Bingham S. Protein degradation in the large intestine: relevance to colorectal cancer. Curr Issues Intest Microbiol. 2000;1(2):51–58.
- Scharlau D, Borowicki A, Habermann N, Hofmann T, Klenow S, Miene C, Munjal U, Stein K, Glei M. Mechanisms of primary cancer prevention by butyrate and other products formed during gut flora-mediated fermentation of dietary fibre. Mutat Res. 2009;682(1):39–53. doi:https://doi.org/10.1016/j.mrrev.2009.04.001
- Borowicki A, Stein K, Scharlau D, Scheu K, Brenner-Weiss G, Obst U, Hollmann J, Lindhauer M, Wachter N, Glei M, et al. Fermented wheat aleurone inhibits growth and induces apoptosis in human HT29 colon adenocarcinoma cells. Br J Nutr. 2010;103(3):360–369. doi:https://doi.org/10.1017/S0007114509991899
- Kautenburger T, Beyer-Sehlmeyer G, Festag G, Haag N, Kühler S, Küchler A, Weise A, Marian B, Peters WHM, Liehr T, et al. The gut fermentation product butyrate, a chemopreventive agent, suppresses glutathione S-transferase theta (hGSTT1) and cell growth more in human colon adenoma (LT97) than tumor (HT29) cells. J Cancer Res Clin Oncol. 2005;131(10):692–700. doi:https://doi.org/10.1007/s00432-005-0013-4
- Beyer-Sehlmeyer G, Glei M, Hartmann E, Hughes R, Persin C, Böhm V, Rowland I, Schubert R, Jahreis G, Pool-Zobel BL, et al. Butyrate is only one of several growth inhibitors produced during gut flora-mediated fermentation of dietary fibre sources. Br J Nutr. 2003;90(6):1057–1070. doi:https://doi.org/10.1079/bjn20031003
- Mosele JI, Motilva MJ, Ludwig IA. Beta-glucan and phenolic compounds: their concentration and behavior during in vitro gastrointestinal digestion and colonic fermentation of different barley-based food products. J Agric Food Chem. 2018;66(34):8966–8975. doi:https://doi.org/10.1021/acs.jafc.8b02240
- Nordlund E, Aura A-M, Mattila I, Kössö T, Rouau X, Poutanen K. Formation of phenolic microbial metabolites and short-chain fatty acids from rye, wheat, and oat bran and their fractions in the metabolical in vitro colon model. J Agric Food Chem. 2012;60(33):8134–8145. doi:https://doi.org/10.1021/jf3008037
- Wang P, Chen H, Zhu Y, McBride J, Fu J, Sang S. Oat avenanthramide-C (2c) is biotransformed by mice and the human microbiota into bioactive metabolites. J Nutr. 2015;145(2):239–245. doi:https://doi.org/10.3945/jn.114.206508
- Lineback DR, Coughlin JR, Stadler RH. Acrylamide in foods: a review of the science and future considerations. Annu Rev Food Sci Technol. 2012;3:15–35. doi:https://doi.org/10.1146/annurev-food-022811-101114
- Jahns F, Wilhelm A, Jablonowski N, Mothes H, Greulich KO, Glei M. Butyrate modulates antioxidant enzyme expression in malignant and non-malignant human colon tissues. Mol Carcinog. 2015;54(4):249–260. doi:https://doi.org/10.1002/mc.22102
- Sauer J, Richter KK, Pool-Zobel BL. Physiological concentrations of butyrate favorably modulate genes of oxidative and metabolic stress in primary human colon cells. J Nutr Biochem. 2007;18(11):736–745. doi:https://doi.org/10.1016/j.jnutbio.2006.12.012
- Su Z-Y, Shu L, Khor TO, Lee JH, Fuentes F, Kong A-NT. A perspective on dietary phytochemicals and cancer chemoprevention: oxidative stress, nrf2, and epigenomics. Top Curr Chem. 2013;329:133–162. doi:https://doi.org/10.1007/128_2012_340
- Yaku K, Enami Y, Kurajyo C, Matsui-Yuasa I, Konishi Y, Kojima-Yuasa A. The enhancement of phase 2 enzyme activities by sodium butyrate in normal intestinal epithelial cells is associated with Nrf2 and p53. Mol Cell Biochem. 2012;370(1–2):7–14. doi:https://doi.org/10.1007/s11010-012-1392-x