Glycyrrhizin Mediates Downregulation of Notch Pathway Resulting in Initiation of Apoptosis and Disruption in the Cell Cycle Progression in Cervical Cancer Cells

References

• Global cancer observatory 2018 report (https://gco.iarc.fr/today/data/factsheets/cancers/23-Cervix-uteri-fact-sheet.pdf.).
   Google Scholar
• Beddoe AM. Elimination of cervical cancer: challenges for developing countries. Ecancermedicalscience. 2019;13:975. doi:https://doi.org/10.3332/ecancer.2019.975
   PubMed Web of Science ®Google Scholar
• Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA A Cancer J Clin. 2019;69(1):7–34. doi:https://doi.org/10.3322/caac.21551
   PubMed Web of Science ®Google Scholar
• Bobdey S, Sathwara J, Jain A, Balasubramaniam G. Burden of cervical cancer and role of screening in India. Indian J Med Paediatr Oncol. 2016;37(4):278–85. doi:https://doi.org/10.4103/0971-5851.195751
   PubMed Web of Science ®Google Scholar
• Ahmad A, Ansari IA. A comprehensive review on crosstalk of human papilloma virus oncoproteins and developmental/self-renewal pathways during the pathogenesis of uterine cervical cancer. Curr Mol Med. 2020; doi:https://doi.org/10.2174/1566524020666200925160015
   Web of Science ®Google Scholar
• Wang Z, Li Y, Ahmad A, Azmi AS, Banerjee S, Kong D, Sarkar FH. Targeting Notch signaling pathway to overcome drug resistance for cancer therapy. Biochim Biophys Acta. 2010;1806(2):258–67. doi:https://doi.org/10.1016/j.bbcan.2010.06.001
   PubMed Web of Science ®Google Scholar
• Bray SJ. Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol. 2006;7(9):678–89. doi:https://doi.org/10.1038/nrm2009
   PubMed Web of Science ®Google Scholar
• Borggrefe T, Liefke R. Fine-tuning of the intracellular canonical Notch signaling pathway. Cell Cycle. 2012;11(2):264–76. doi:https://doi.org/10.4161/cc.11.2.18995
   PubMed Web of Science ®Google Scholar
• Borggrefe T, Oswald F. The Notch signaling pathway: transcriptional regulation at Notch target genes. Cell Mol Life Sci. 2009;66(10):1631–46. doi:https://doi.org/10.1007/s00018-009-8668-7
   PubMed Web of Science ®Google Scholar
• Pang RT, Leung CO, Ye TM, Liu W, Chiu PC, Lam KK, Lee KF, Yeung WS. MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells. Carcinogenesis. 2010;31(6):1037–44. doi:https://doi.org/10.1093/carcin/bgq066
   PubMed Web of Science ®Google Scholar
• Ouyang L, Luo Y, Tian M, Zhang SY, Lu R, Wang JH, Kasimu R, Li X. Plant natural products: from traditional compounds to new emerging drugs in cancer therapy. Cell Prolif. 2014;47(6):506–15. doi:https://doi.org/10.1111/cpr.12143
   PubMed Web of Science ®Google Scholar
• Lee KJ, Choi JH, Jeong HG. Hepatoprotective and antioxidant effects of the coffee diterpenes kahweol and cafestol on carbon tetrachloride-induced liver damage in mice. Food Chem Toxicol. 2007;45(11):2118–25. doi:https://doi.org/10.1016/j.fct.2007.05.010
   PubMed Web of Science ®Google Scholar
• Adianti M, Aoki C, Komoto M, Deng L, Shoji I, Wahyuni TS, Lusida MI, Soetjipto Fuchino H, Kawahara N, Hotta H. Anti-hepatitis C virus compounds obtained from Glycyrrhiza uralensis and other Glycyrrhiza species. Microbiol Immunol. 2014;58(3):180–7. doi:https://doi.org/10.1111/1348-0421.12127
   PubMed Web of Science ®Google Scholar
• Akamatsu H, Komura J, Asada Y, Niwa Y. Mechanism of anti-inflammatory action of glycyrrhizin: effect on neutrophil functions including reactive oxygen species generation. Planta Med. 1991;57(2):119–21. doi:https://doi.org/10.1055/s-2006-960045
   PubMed Web of Science ®Google Scholar
• Tiwari RK, Chandrakar P, Gupta CL, Sayyed U, Shekh R, Bajpai P. Leishmanial CpG DNA nanovesicles: a propitious prophylactic approach against visceral leishmaniasis. Int Immunopharmacol. 2021;90:107181. ISSN 1567-5769 . doi:https://doi.org/10.1016/j.intimp.2020.107181
   PubMed Web of Science ®Google Scholar
• Wang Y, Yu H, Zhang J, Gao J, Ge X, Lou G. Hesperidin inhibits HeLa cell proliferation through apoptosis mediated by endoplasmic reticulum stress pathways and cell cycle arrest. BMC Cancer. 2015;15:682. doi:https://doi.org/10.1186/s12885-015-1706-y
   PubMed Web of Science ®Google Scholar
• Mohapatra P, Satapathy SR, Das D, Siddharth S, Choudhuri T, Kundu CN. Resveratrol mediated cell death in cigarette smoke transformed breast epithelial cells is through induction of p21Waf1/Cip1 and inhibition of long patch base excision repair pathway. Toxicol Appl Pharmacol. 2014;275(3):221–31. doi:https://doi.org/10.1016/j.taap.2014.01.011
   PubMed Web of Science ®Google Scholar
• Ansari IA, Ahmad A, Imran MA, Saeed M, Ahmad I. Organosulphur compounds induce apoptosis and cell cycle arrest in cervical cancer cells via downregulation of HPV E6 and E7 oncogenes. [published online ahead of print, 2020 Aug 18]. Anticancer Agents Med Chem. 2020; https://doi.org/10.2174/1871520620999200818154456. doi:https://doi.org/10.2174/1871520620999200818154456
   PubMed Web of Science ®Google Scholar
• Johnson LV, Walsh ML, Chen LB. Localization of mitochondria in living cells with rhodamine 123. Proc Natl Acad Sci USA. 1980;77(2):990–4. doi:https://doi.org/10.1073/pnas.77.2.990
   PubMed Web of Science ®Google Scholar
• Tiwari RK, Singh S, Gupta CL, et al. Repolarization of glioblastoma macrophage cells using non-agonistic Dectin-1 ligand encapsulating TLR-9 agonist: plausible role in regenerative medicine against brain tumor. Int J Neurosci. 2020;1–8. [published online ahead of print, 2020 Apr 19]. doi:https://doi.org/10.1080/00207454.2020.1750393
   Web of Science ®Google Scholar
• Zhang L, Huo X, Liao Y, Yang F, Gao L, Cao L. Zeylenone, a naturally occurring cyclohexene oxide, inhibits proliferation and induces apoptosis in cervical carcinoma cells via PI3K/AKT/mTOR and MAPK/ERK pathways. Sci Rep. 2017;7(1):1669. doi:https://doi.org/10.1038/s41598-017-01804-2
   PubMed Web of Science ®Google Scholar
• Park YJ, Kim EK, Moon S, Hong DP, Bae JY, Kim J. Human telomerase reverse transcriptase is a promising target for cancer inhibition in squamous cell carcinomas. Anticancer Res. 2014;34(11):6389–95.
   PubMed Web of Science ®Google Scholar
• Zhang Z-L, Liu G-C, Peng L, Zhang C, Jia Y-M, Yang W-H, Mao L. Effect of PAK1 gene silencing on proliferation and apoptosis in hepatocellular carcinoma cell lines MHCC97-H and HepG2 and cells in xenograft tumor. Gene Ther. 2018;25(4):284–96. doi:https://doi.org/10.1038/s41434-018-0016-9
   PubMed Web of Science ®Google Scholar
• Tsikitis M, Zhang Z, Edelman W, Zagzag D, Kalpana GV. Genetic ablation of Cyclin D1 abrogates genesis of rhabdoid tumors resulting from Ini1 loss. Proc Natl Acad Sci USA. 2005;102(34):12129–34. doi:https://doi.org/10.1073/pnas.0505300102
   PubMed Web of Science ®Google Scholar
• Sun DW, Zhang HD, Mao L, Mao CF, Chen W, Cui M, Ma R, Cao HX, Jing CW, Wang Z, et al. Luteolin inhibits breast cancer development and progression in vitro and in vivo by suppressing notch signaling and regulating MiRNAs. Cell Physiol Biochem. 2015;37(5):1693–711. doi:https://doi.org/10.1159/000438535
   PubMedGoogle Scholar
• Choi K, Ahn Y-H, Gibbons DL, Tran HT, Creighton CJ, Girard L, Minna JD, Qin FX-F, Kurie JM. Distinct biological roles for the notch ligands Jagged-1 and Jagged-2. J Biol Chem. 2009;284(26):17766–74. doi:https://doi.org/10.1074/jbc.M109.003111
   PubMed Web of Science ®Google Scholar
• Elumalai P, Gunadharini DN, Senthilkumar K, Banudevi S, Arunkumar R, Benson CS, Sharmila G, Arunakaran J. Induction of apoptosis in human breast cancer cells by nimbolide through extrinsic and intrinsic pathway. Toxicol Lett. 2012;215(2):131–42. doi:https://doi.org/10.1016/j.toxlet.2012.10.008
   PubMed Web of Science ®Google Scholar
• NavaneethaKrishnan S, Rosales JL, Lee KY. ROS-mediated cancer cell killing through dietary phytochemicals. Oxid Med Cell Longev. 2019;2019:9051542. doi:https://doi.org/10.1155/2019/9051542
   PubMed Web of Science ®Google Scholar
• He G, Mu T, Yuan Y, Yang W, Zhang Y, Chen Q, Bian M, Pan Y, Xiang Q, Chen Z, et al. Effects of notch signaling pathway in cervical cancer by curcumin mediated photodynamic therapy and its possible mechanisms in vitro and in vivo. J Cancer. 2019;10(17):4114–22. doi:https://doi.org/10.7150/jca.30690
   PubMed Web of Science ®Google Scholar
• Ferlay J, Colombet M, Soerjomataram I, Mathers C, Parkin DM, Piñeros M, Znaor A, Bray F. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 2019;144(8):1941–53. doi:https://doi.org/10.1002/ijc.31937
   PubMed Web of Science ®Google Scholar
• Farooqui A, Khan F, Khan I, Ansari IA. Glycyrrhizin induces reactive oxygen species-dependent apoptosis and cell cycle arrest at G0/G1 in HPV18+ human cervical cancer HeLa cell line. Biomed Pharmacother. 2018;97:752–64. doi:https://doi.org/10.1016/j.biopha.2017.10.147
   PubMed Web of Science ®Google Scholar
• Barry MA, Behnke CA, Eastman A. Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia. Biochem Pharmacol. 1990;40(10):2353–62. . PMID: 2244936. doi:https://doi.org/10.1016/0006-2952(90)90733-2
   PubMed Web of Science ®Google Scholar
• Favaloro B, Allocati N, Graziano V, Di Ilio C, De Laurenzi V. Role of apoptosis in disease. Aging (Albany NY)). 2012;4(5):330–49. doi:https://doi.org/10.18632/aging.100459
   PubMedGoogle Scholar
• Wong RS. Apoptosis in cancer: from pathogenesis to treatment. J Exp Clin Cancer Res. 2011;30:87. doi:https://doi.org/10.1186/1756-9966-30-87
   PubMed Web of Science ®Google Scholar
• Tang DG, Li L, Chopra DP, Porter AT. Extended survivability of prostate cancer cells in the absence of trophic factors: increased proliferation, evasion of apoptosis, and the role of apoptosis proteins. Cancer Res. 1998;58(15):3466–79.
   PubMed Web of Science ®Google Scholar
• Taylor RC, Cullen SP, Martin SJ. Apoptosis: controlled demolition at the cellular level. Nat Rev Mol Cell Biol. 2008;9(3):231–41. doi:https://doi.org/10.1038/nrm2312
   PubMed Web of Science ®Google Scholar
• Kapinova A, Kubatka P, Golubnitschaja O, Kello M, Zubor P, Solar P, Pec M. Dietary phytochemicals in breast cancer research: anticancer effects and potential utility for effective chemoprevention. Environ Health Prev Med. 2018;23(1):36. doi:https://doi.org/10.1186/s12199-018-0724-1
   PubMed Web of Science ®Google Scholar
• Ying TH, Yang SF, Tsai SJ, Hsieh SC, Huang YC, Bau DT, Hsieh YH. Fisetin induces apoptosis in human cervical cancer HeLa cells through ERK1/2-mediated activation of caspase-8-/caspase-3-dependent pathway. Arch Toxicol. 2012;86(2):263–73. doi:https://doi.org/10.1007/s00204-011-0754-6
   PubMed Web of Science ®Google Scholar
• Slee EA, Adrain C, Martin SJ. Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis. J Biol Chem. 2001;276(10):7320–6. doi:https://doi.org/10.1074/jbc.M008363200
   PubMed Web of Science ®Google Scholar
• Ross MF, Kelso GF, Blaikie FH, James AM, Cochemé HM, Filipovska A, Da Ros T, Hurd TR, Smith RA, Murphy MP. Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology. Biochemistry (Mosc). 2005;70(2):222–30. doi:https://doi.org/10.1007/s10541-005-0104-5
   PubMed Web of Science ®Google Scholar
• Petrosillo G, Ruggiero FM, Paradies G. Role of reactive oxygen species and cardiolipin in the release of cytochrome c from mitochondria. FASEB J. 2003;17(15):2202–8. doi:https://doi.org/10.1096/fj.03-0012com
   PubMed Web of Science ®Google Scholar
• Otto T, Sicinski P. Cell cycle proteins as promising targets in cancer therapy. Nat Rev Cancer. 2017;17(2):93–115. doi:https://doi.org/10.1038/nrc.2016.138
   PubMed Web of Science ®Google Scholar
• Qie S, Diehl JA. Cyclin D1, cancer progression, and opportunities in cancer treatment. J Mol Med (Berl). 2016;94(12):1313–26. doi:https://doi.org/10.1007/s00109-016-1475-3
   PubMed Web of Science ®Google Scholar
• Wei M, Liu B, Gu Q, Su L, Yu Y, Zhu Z. Stat6 cooperates with Sp1 in controlling breast cancer cell proliferation by modulating the expression of p21(Cip1/WAF1) and p27 (Kip1). Cell Oncol (Dordr)). 2013;36(1):79–93. doi:https://doi.org/10.1007/s13402-012-0115-3
   PubMed Web of Science ®Google Scholar
• Kale J, Osterlund EJ, Andrews DW. BCL-2 family proteins: changing partners in the dance towards death. Cell Death Differ. 2018;25(1):65–80. doi:https://doi.org/10.1038/cdd.2017.186
   PubMed Web of Science ®Google Scholar
• Groth C, Fortini ME. Therapeutic approaches to modulating Notch signaling: current challenges and future prospects. Semin Cell Dev Biol. 2012;23(4):465–72. doi:https://doi.org/10.1016/j.semcdb.2012.01.016
   PubMed Web of Science ®Google Scholar
• Weijzen S, Zlobin A, Braid M, Miele L, Kast WM. HPV16 E6 and E7 oncoproteins regulate Notch-1 expression and cooperate to induce transformation. J Cell Physiol. 2003;194(3):356–62. doi:https://doi.org/10.1002/jcp.10217
   PubMed Web of Science ®Google Scholar
• Sun Y, Zhang R, Zhou S, Ji Y. Overexpression of Notch1 is associated with the progression of cervical cancer. Oncol Lett. 2015;9(6):2750–6. doi:https://doi.org/10.3892/ol.2015.3143
   PubMed Web of Science ®Google Scholar
• Yao J, Duan L, Fan M, Yuan J, Wu X. Notch1 induces cell cycle arrest and apoptosis in human cervical cancer cells: involvement of nuclear factor kappa B inhibition. Int J Gynecol Cancer. 2007;17(2):502–10. doi:https://doi.org/10.1111/j.1525-1438.2007.00872.x
   PubMed Web of Science ®Google Scholar
• Tripathi R, Rath G, Jawanjal P, Bharadwaj M, Mehrotra R. ≤Cyclin D1 protein affecting global women’s health by regulating HPV mediated adenocarcinoma of the uterine cervix. Sci Rep. 2019;9(1):1–6. doi:https://doi.org/10.1038/s41598-019-41394-9
   PubMed Web of Science ®Google Scholar