References
- dos Santos DS, dos Santos Goldenberg RC. Doxorubicin-Induced Cardiotoxicity: From Mechanisms to Development of Efficient Therapy. IntechOpen. 2018.
- Todaro MC, Oreto L, Qamar R, Paterick TE, Carerj S, Khandheria BK. Cardioncology: state of the heart. Int J Cardiol. 2013;168(2):680–687. doi:https://doi.org/10.1016/j.ijcard.2013.03.133
- Zhao L, Zhang B. Doxorubicin induces cardiotoxicity through upregulation of death receptors mediated apoptosis in cardiomyocytes. Sci Rep. 2017;7(1):1–11. doi:https://doi.org/10.1038/srep44735
- Renu K, Abilash VG, Tirupathi Pichai PB, Arunachalam S. Molecular mechanism of doxorubicin-induced cardiomyopathy–An update. Eur J Pharmacol. 2018;818:241–253. doi:https://doi.org/10.1016/j.ejphar.2017.10.043
- He H, Luo Y, Qiao Y, Zhang Z, Yin D, Yao J, You J, He M. Curcumin attenuates doxorubicin-induced cardiotoxicity via suppressing oxidative stress and preventing mitochondrial dysfunction mediated by 14-3-3γ. Food Funct. 2018;9(8):4404–4418. doi:https://doi.org/10.1039/C8FO00466H
- Fadillioğlu E, Erdoğan H, Söğüt S, Kuku I. Protective effects of erdosteine against doxorubicin‐induced cardiomyopathy in rats. J Appl Toxicol. 2003;23(1):71–74. doi:https://doi.org/10.1002/jat.889
- Kuzu M, Kandemir FM, Yildirim S, Kucukler S, Caglayan C, Turk E. Morin attenuates doxorubicin-induced heart and brain damage by reducing oxidative stress, inflammation and apoptosis. Biomed Pharmacother. 2018;106:443–453. doi:https://doi.org/10.1016/j.biopha.2018.06.161
- Colak MC, Parlakpinar H, Tasdemir S, Samdanci E, Kose E, Polat A, Sarihan E, Acet A. Therapeutic effects of ivabradine on hemodynamic parameters and cardiotoxicity induced by doxorubicin treatment in rat. Hum Exp Toxicol. 2012;31(9):945–954. doi:https://doi.org/10.1177/0960327112438288
- Zhao L, Tao X, Qi Y, Xu L, Yin L, Peng J. Protective effect of dioscin against doxorubicin-induced cardiotoxicity via adjusting microRNA-140-5p-mediated myocardial oxidative stress. Redox Biol. 2018;16:189–198. doi:https://doi.org/10.1016/j.redox.2018.02.026
- Lee V, Randhawa AK, Singal PK. Adriamycin-induced myocardial dysfunction in vitro is mediated by free radicals. Am J Physiol. 1991;261(4):H989–H995. doi:https://doi.org/10.1152/ajpheart.1991.261.4.H989
- Nowak D, Pierscinski G, Drzewoski J. Ambroxol inhibits doxorubicin-induced lipid peroxidation in heart of mice. Free Radic Biol Med. 1995;19(5):659–663. doi:https://doi.org/10.1016/0891-5849(95)00028-V
- Govender J, Loos B, Marais E, Engelbrecht A-M. Melatonin improves cardiac and mitochondrial function during doxorubicin-induced cardiotoxicity: a possible role for peroxisome proliferator-activated receptor gamma coactivator 1-alpha and sirtuin activity? Toxicol Appl Pharmacol. 2018;358:86–101. doi:https://doi.org/10.1016/j.taap.2018.06.031
- Liu D, Ma Z, Di S, Yang Y, Yang J, Xu L, Reiter RJ, Qiao S, Yuan J. AMPK/PGC1α activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis. Free Radic Biol Med. 2018;129:59–72. doi:https://doi.org/10.1016/j.freeradbiomed.2018.08.032
- Chen RC, Xu XD, Zhi Liu X, Sun GB, Zhu YD, Dong X, Wang J, Zhang HJ, Zhang Q, Sun XB. Total flavonoids from Clinopodium chinense (Benth.) O. Ktze protect against doxorubicin-induced cardiotoxicity in vitro and in vivo. Evid Based Complement Alternat Med. 2015;2015:1–17. doi:https://doi.org/10.1155/2015/472565
- Lipshultz SE, Alvarez JA, Scully RE. Anthracycline associated cardiotoxicity in survivors of childhood cancer. Heart. 2007;94(4):525–533. doi:https://doi.org/10.1136/hrt.2007.136093
- Chen T, Deng Z, Zhao R, Shen H, Li W. SYKT alleviates doxorubicin-induced cardiotoxicity via modulating ROS-mediated p53 and MAPK signal pathways. Evid Based Complement Alternat Med. 2018;2018:1–11. doi:https://doi.org/10.1155/2018/2581031
- Tang F, Zhou X, Wang L, Shan L, Li C, Zhou H, Lee SM-Y, Hoi MP-M. A novel compound DT-010 protects against doxorubicin-induced cardiotoxicity in zebrafish and H9c2 cells by inhibiting reactive oxygen species-mediated apoptotic and autophagic pathways. Eur J Pharmacol. 2018;820:86–96. doi:https://doi.org/10.1016/j.ejphar.2017.12.021
- Xu MF, Tang PL, Qian ZM, Ashraf M. Effects by doxorubicin on the myocardium are mediated by oxygen free radicals. Life Sci. 2001;68(8):889–901. doi:https://doi.org/10.1016/S0024-3205(00)00990-5
- Menna P, Gonzalez Paz O, Chello M, Covino E, Salvatorelli E, Minotti G. Anthracycline cardiotoxicity. Expert Opin Drug Saf. 2012;11(sup1):S21–S36. doi:https://doi.org/10.1517/14740338.2011.589834
- Chang D, Li H, Qian C, Wang Y. DiOHF protects against doxorubicin-induced cardiotoxicity through ERK1 signaling pathway. Front Pharmacol. 2019;10:1081.
- Singal P, Li T, Kumar D, Danelisen I, Iliskovic N. Adriamycin-induced heart failure: mechanisms and modulation. Mol Cell Biochem. 2000;207(1/2):77–86. doi:https://doi.org/10.1023/A:1007094214460
- Doroshow JH, Locker GY, Myers C. Enzymatic defenses of the mouse heart against reactive oxygen metabolites: alterations produced by doxorubicin. J Clin Invest. 1980;65(1):128–135. doi:https://doi.org/10.1172/JCI109642
- Zhou S, Palmeira CM, Wallace KB. Doxorubicin-induced persistent oxidative stress to cardiac myocytes. Toxicol Lett. 2001;121(3):151–157. doi:https://doi.org/10.1016/S0378-4274(01)00329-0
- Razmaraii N, Babaei H, Mohajjel Nayebi A, Asadnasab G, Ashrafi Helan J, Azarmi Y. Cardioprotective effect of phenytoin on doxorubicin-induced cardiac toxicity in a rat model. J Cardiovasc Pharmacol. 2016;67(3):237–245. doi:https://doi.org/10.1097/FJC.0000000000000339
- Razavi BM, Hosseinzadeh H. Saffron as an antidote or a protective agent against natural or chemical toxicities. DARU J Pharm Sci. 2015;23(1):31. doi:https://doi.org/10.1186/s40199-015-0112-y
- Ghasemzadeh Rahbardar M, Hosseinzadeh H. Therapeutic effects of rosemary (Rosmarinus officinalis L.) and its active constituents on nervous system disorders. Iran J Basic Med Sci. 2020;23:1100–1112.
- Virk P, Elobeid M, Hamad S, Korany Z, Al-Amin M. Ameliorative effects of Embilica officinalis and Rosmarinus officinalis on cadmium-induced oxidative stress in Wistar rats. J Med Plant Res. 2013;7:805–818.
- Mohamed WA, Abd-Elhakim YM, Farouk SM. Protective effects of ethanolic extract of rosemary against lead-induced hepato-renal damage in rabbits. Exp Toxicol Pathol. 2016;68(8):451–461. doi:https://doi.org/10.1016/j.etp.2016.07.003
- Salama WH, Abdel-Aty AM, Fahmy AS. Rosemary leaves extract: anti-snake action against Egyptian Cerastes venom. J Tradit Complement Med. 2018;8(4):465–475. doi:https://doi.org/10.1016/j.jtcme.2017.10.001
- Rahbardar MG, Amin B, Mehri S, Mirnajafi-Zadeh SJ, Hosseinzadeh H. Anti-inflammatory effects of ethanolic extract of Rosmarinus officinalis L. and rosmarinic acid in a rat model of neuropathic pain. Biomed Pharmacother. 2017;86:441–449. doi:https://doi.org/10.1016/j.biopha.2016.12.049
- Ghasemzadeh MR, Amin B, Mehri S, Mirnajafi-Zadeh SJ, Hosseinzadeh H. Effect of alcoholic extract of aerial parts of Rosmarinus officinalis L. on pain, inflammation and apoptosis induced by chronic constriction injury (CCI) model of neuropathic pain in rats. J Ethnopharmacol. 2016;194:117–130. doi:https://doi.org/10.1016/j.jep.2016.08.043
- Lee J, Jung E, Kim Y, Lee J, Park J, Hong S, Hyun C-G, Park D, Kim YS. Rosmarinic acid as a downstream inhibitor of IKK‐β in TNF‐α‐induced upregulation of CCL11 and CCR3. Br J Pharmacol. 2006;148(3):366–375. doi:https://doi.org/10.1038/sj.bjp.0706728
- Lu C, Zou Y, Liu Y, Niu Y. Rosmarinic acid counteracts activation of hepatic stellate cells via inhibiting the ROS-dependent MMP-2 activity: Involvement of Nrf2 antioxidant system. Toxicol Appl Pharmacol. 2017;318:69–78. doi:https://doi.org/10.1016/j.taap.2017.01.008
- Rahbardar MG, Amin B, Mehri S, Mirnajafi-Zadeh SJ, Hosseinzadeh H. Rosmarinic acid attenuates development and existing pain in a rat model of neuropathic pain: an evidence of anti-oxidative and anti-inflammatory effects. Phytomedicine. 2018;40:59–67. doi:https://doi.org/10.1016/j.phymed.2018.01.001
- Scheckel KA, Degner SC, Romagnolo DF. Rosmarinic acid antagonizes activator protein-1–dependent activation of cyclooxygenase-2 expression in human cancer and nonmalignant cell lines. J Nutr. 2008;138(11):2098–2105. doi:https://doi.org/10.3945/jn.108.090431
- Zhang M, Yan H, Li S, Yang J. Rosmarinic acid protects rat hippocampal neurons from cerebral ischemia/reperfusion injury via the Akt/JNK3/caspase-3 signaling pathway. Brain Res. 2017;1657:9–15. doi:https://doi.org/10.1016/j.brainres.2016.11.032
- Zhang X, Ma Z-G, Yuan Y-P, Xu S-C, Wei W-Y, Song P, Kong C-Y, Deng W, Tang Q-Z. Rosmarinic acid attenuates cardiac fibrosis following long-term pressure overload via AMPKα/Smad3 signaling. Cell Death Dis. 2018;9(2):1–14. doi:https://doi.org/10.1038/s41419-017-0123-3
- Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain. 1983;16:109–110.
- Petersen M, Simmonds MS. Rosmarinic acid. Phytochemistry. 2003;62(2):121–125. doi:https://doi.org/10.1016/S0031-9422(02)00513-7
- Razmaraii N, Babaei H, Mohajjel Nayebi A, Assadnassab G, Ashrafi Helan J, Azarmi Y. Cardioprotective effect of grape seed extract on chronic doxorubicin-induced cardiac toxicity in Wistar rats. Adv Pharm Bull. 2016;6(3):423–433. doi:https://doi.org/10.15171/apb.2016.055
- Razavi BM, Hosseinzadeh H, Movassaghi AR, Imenshahidi M, Abnous K. Protective effect of crocin on diazinon induced cardiotoxicity in rats in subchronic exposure. Chem Biol Interact. 2013;203(3):547–555. doi:https://doi.org/10.1016/j.cbi.2013.03.010
- Ghasemzadeh Rahbardar M, Hemadeh B, Razavi BM, Eisvand F, Hosseinzadeh H. Effect of carnosic acid on acrylamide induced neurotoxicity: in vivo and in vitro experiments. Drug Chem Toxicol. 2020;1–8.
- Pratt CM, Ruberg S, Morganroth J, McNutt B, Woodward J, Harris S, Ruskin J, Moyé L. Dose-response relation between terfenadine (Seldane) and the QTc interval on the scalar electrocardiogram: distinguishing a drug effect from spontaneous variability. Am Heart J. 1996;131(3):472–480. doi:https://doi.org/10.1016/S0002-8703(96)90525-6
- Mirsky I, Pfeffer JM, Pfeffer MA, Braunwald E. The contractile state as the major determinant in the evolution of left ventricular dysfunction in the spontaneously hypertensive rat. Circ Res. 1983;53(6):767–778. doi:https://doi.org/10.1161/01.RES.53.6.767
- Thomas L, Bellmont S, Christen MO, Roche BL, Monassier L. Cardiovascular and survival effects of sympatho‐inhibitors in adriamycin‐induced cardiomyopathy in rats. Fundam Clin Pharmacol. 2004;18(6):649–655. doi:https://doi.org/10.1111/j.1472-8206.2004.00282.x
- De Jong S, van Veen T, de Bakker J, Van Rijen H. Monitoring cardiac fibrosis: a technical challenge. Neth Heart J. 2012;20(1):44–48. doi:https://doi.org/10.1007/s12471-011-0226-x
- Razavi M, Hosseinzadeh H, Abnous K, Motamedshariaty VS, Imenshahidi M. Crocin restores hypotensive effect of subchronic administration of diazinon in rats. Iran J Basic Med Sci. 2013;16:64–72.
- Moron MS, Depierre JW, Mannervik B. Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochim Biophys Acta Gen Subj. 1979;582(1):67–78. doi:https://doi.org/10.1016/0304-4165(79)90289-7
- Mousavi SH, Tavakkol-Afshari J, Brook A, Jafari-Anarkooli I. Role of caspases and Bax protein in saffron-induced apoptosis in MCF-7 cells. Food Chem Toxicol. 2009;47(8):1909–1913. doi:https://doi.org/10.1016/j.fct.2009.05.017
- Esmaeelpanah E, Rahmatkhah A, Poormahmood N, Razavi BM, Vahdati Hasani F, Hosseinzadeh H. Protective effect of green tea aqueous extract on acrylamide induced neurotoxicity. Jundishapur J Nat Pharm Prod. 2015;10(2):e18406. doi:https://doi.org/10.17795/jjnpp-18406
- Mokni M, Hamlaoui-Guesmi S, Amri M, Marzouki L, Limam F, Aouani E. Grape seed and skin extract protects against acute chemotherapy toxicity induced by doxorubicin in rat heart. Cardiovasc Toxicol. 2012;12(2):158–165. doi:https://doi.org/10.1007/s12012-012-9155-1
- Boghdady NAE. Antioxidant and antiapoptotic effects of proanthocyanidin and Ginkgo biloba extract against doxorubicin‐induced cardiac injury in rats. Cell Biochem Funct. 2013;31(4):344–351. doi:https://doi.org/10.1002/cbf.2907
- Cigremis Y, Parlakpinar H, Polat A, Colak C, Ozturk F, Sahna E, Ermis N, Acet A. Beneficial role of aminoguanidine on acute cardiomyopathy related to doxorubicin-treatment. Mol Cell Biochem. 2006;285(1-2):149–154. doi:https://doi.org/10.1007/s11010-005-9072-8
- Hequet O, Le QH, Moullet I, Pauli E, Salles G, Espinouse D, Dumontet C, Thieblemont C, Arnaud P, Antal D, et al. Subclinical late cardiomyopathy after doxorubicin therapy for lymphoma in adults. JCO. 2004;22(10):1864–1871. doi:https://doi.org/10.1200/JCO.2004.06.033
- Danesi R, Bernardini N, Agen C, Costa M, Zaccaro L, Pieracci D, Malvaldi G, Del Tacca M. Reduced cardiotoxicity and increased cytotoxicity in a novel anthracycline analogue, 4′-amino-3′-hydroxy-doxorubicin. Cancer Chemother Pharmacol. 1992;29(4):261–265. doi:https://doi.org/10.1007/BF00685942
- van Acker SABE, Kramer K, Voest EE, Grimbergen JA, Zhang J, van der Vijgh WJF, Bast A, van Acker SABE. Doxorubicin-induced cardiotoxicity monitored by ECG in freely moving mice A new model to test potential protectors. Cancer Chemother Pharmacol. 1996;38(1):95–101. doi:https://doi.org/10.1007/s002800050453
- Hazari MS, Haykal-Coates N, Winsett DW, Costa DL, Farraj AK. Continuous electrocardiogram reveals differences in the short-term cardiotoxic response of Wistar-Kyoto and spontaneously hypertensive rats to doxorubicin. Toxicol Sci. 2009;110(1):224–234. doi:https://doi.org/10.1093/toxsci/kfp092
- Aygun H, Gul S. Cardioprotective effect of melatonin and agomelatine on doxorubicin-induced cardiotoxicity in a rat model: an electrocardiographic, scintigraphic and biochemical study. BLL. 2019;120(04):249–255. doi:https://doi.org/10.4149/BLL_2019_045
- Takemura G, Fujiwara H. Doxorubicin-induced cardiomyopathy: from the cardiotoxic mechanisms to management. Prog Cardiovasc Dis. 2007;49(5):330–352. doi:https://doi.org/10.1016/j.pcad.2006.10.002
- Farhad H, Staziaki PV, Addison D, Coelho-Filho OR, Shah RV, Mitchell RN, Szilveszter B, Abbasi SA, Kwong RY, Scherrer-Crosbie M, et al. Characterization of the changes in cardiac structure and function in mice treated with anthracyclines using serial cardiac magnetic resonance imaging. Circ Cardiovasc Imaging. 2016;9(12):e003584. doi:https://doi.org/10.1161/CIRCIMAGING.115.003584
- Ponikowski P, Anker SD, Chua TP, Szelemej R, Piepoli M, Adamopoulos S, Webb-Peploe K, Harrington D, Banasiak W, Wrabec K, et al. Depressed heart rate variability as an independent predictor of death in chronic congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Card. 1997;79(12):1645–1650. doi:https://doi.org/10.1016/S0002-9149(97)00215-4
- Mattila M, Söderström M, Ailanen L, Savontaus E, Savontaus M. The effects of neuropeptide Y overexpression on the mouse model of doxorubicin-induced cardiotoxicity. Cardiovasc Toxicol. 2020;20(3):328–311. doi:https://doi.org/10.1007/s12012-019-09557-2
- Tong J, Ganguly P, Singal P. Myocardial adrenergic changes at two stages of heart failure due to adriamycin treatment in rats. Am J Physiol. 1991;260(3):H909–H916. doi:https://doi.org/10.1152/ajpheart.1991.260.3.H909
- Kenk M, Thackeray JT, Thorn SL, Dhami K, Chow BJ, Ascah KJ, DaSilva JN, Beanlands RS. Alterations of pre-and postsynaptic noradrenergic signaling in a rat model of adriamycin-induced cardiotoxicity. J Nucl Cardiol. 2010;17(2):254–263. doi:https://doi.org/10.1007/s12350-009-9190-x
- Merlet N, Piriou N, Rozec B, Grabherr A, Lauzier B, Trochu J-N, Gauthier C. Increased beta2-adrenoceptors in doxorubicin-induced cardiomyopathy in rat. PLoS One. 2013;8(5):e64711. doi:https://doi.org/10.1371/journal.pone.0064711
- Villani F, Galimberti M, Monti E, Cova D, Lanza E, Rozza-Dionigi A, Favalli L, Poggi P. Effect of ICRF-187 pretreatment against doxorubicin-induced delayed cardiotoxicity in the rat. Toxicol Appl Pharmacol. 1990;102(2):292–299. doi:https://doi.org/10.1016/0041-008X(90)90028-S
- Fernandez‐Chas M, Curtis M, Niederer S. Mechanism of doxorubicin cardiotoxicity evaluated by integrating multiple molecular effects into a biophysical model. Br J Pharmacol. 2018;175(5):763–781. doi:https://doi.org/10.1111/bph.14104
- Warpe VS, Mali VR, Arulmozhi S, Bodhankar SL, Mahadik KR. Cardioprotective effect of ellagic acid on doxorubicin induced cardiotoxicity in wistar rats. J Acute Med. 2015;5(1):1–8. doi:https://doi.org/10.1016/j.jacme.2015.02.003
- Kim Y, Ma A-G, Kitta K, Fitch SN, Ikeda T, Ihara Y, Simon AR, Evans T, Suzuki YJ. Anthracycline-induced suppression of GATA-4 transcription factor: implication in the regulation of cardiac myocyte apoptosis. Mol Pharmacol. 2003;63(2):368–377. doi:https://doi.org/10.1124/mol.63.2.368
- Aries A, Paradis P, Lefebvre C, Schwartz RJ, Nemer M. Essential role of GATA-4 in cell survival and drug-induced cardiotoxicity. Proc Natl Acad Sci. 2004;101(18):6975–6980. doi:https://doi.org/10.1073/pnas.0401833101
- Viswanatha Swamy AHM, Koti BC, Ronad PM, Wangikar U, Thippeswamy AHM, Manjula DV. Cardioprotective effect of ascorbic acid on doxorubicin-induced myocardial toxicity in rats. Indian J Pharmacol. 2011;43(5):507–511. doi:https://doi.org/10.4103/0253-7613.84952
- Cheah HY, Šarenac O, Arroyo JJ, Vasić M, Lozić M, Glumac S, Hoe SZ, Hindmarch CCT, Murphy D, Kiew LV, et al. Hemodynamic effects of HPMA copolymer based doxorubicin conjugate: a randomized controlled and comparative spectral study in conscious rats. Nanotoxicology. 2017;11(2):210–222. doi:https://doi.org/10.1080/17435390.2017.1285071
- Zhang X, Hu C, Kong C-Y, Song P, Wu H-M, Xu S-C, Yuan Y-P, Deng W, Ma Z-G, Tang Q-Z, et al. FNDC5 alleviates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via activating AKT. Cell Death Differ. 2020;27(2):540–555. doi:https://doi.org/10.1038/s41418-019-0372-z
- Toutounchi NS, Afrooziyan A, Rameshrad M, Rezabakhsh A, Vaez H, Hamedeyazdan S, Fathiazad F, Garjani A. Cardioprotective effects of rosmarinic acid on isoproterenol-induced myocardial infarction in rats. Pharm Sci. 2017;23(2):103–111. doi:https://doi.org/10.15171/PS.2017.16
- Elberry AA, Abdel-Naim AB, Abdel-Sattar EA, Nagy AA, Mosli HA, Mohamadin AM, Ashour OM. Cranberry (Vaccinium macrocarpon) protects against doxorubicin-induced cardiotoxicity in rats. Food Chem Toxicol. 2010;48(5):1178–1184. doi:https://doi.org/10.1016/j.fct.2010.02.008
- Chatterjee K, Zhang J, Honbo N, Karliner JS. Doxorubicin cardiomyopathy. Cardiology. 2010;115(2):155–162. doi:https://doi.org/10.1159/000265166
- Ibrahim MA, Ashour OM, Ibrahim YF, EL-Bitar HI, Gomaa W, Abdel-Rahim SR. Angiotensin-converting enzyme inhibition and angiotensin AT1-receptor antagonism equally improve doxorubicin-induced cardiotoxicity and nephrotoxicity. Pharmacol Res. 2009;60(5):373–381. doi:https://doi.org/10.1016/j.phrs.2009.05.007
- Rizk HA, Masoud MA, Maher OW. Prophylactic effects of ellagic acid and rosmarinic acid on doxorubicin‐induced neurotoxicity in rats. J Biochem Mol Toxicol. 2017;31(12):e21977. doi:https://doi.org/10.1002/jbt.21977
- Zych M, Wojnar W, Borymski S, Szałabska K, Bramora P, Kaczmarczyk-Sedlak I. Effect of rosmarinic acid and sinapic acid on oxidative stress parameters in the cardiac tissue and serum of type 2 diabetic female rats. Antioxidants. 2019;8(12):579. doi:https://doi.org/10.3390/antiox8120579
- Chae CU, Albert CM, Moorthy M, Lee I-M, Buring JE. Vitamin E supplementation and the risk of heart failure in women. Circ Heart Fail. 2012;5(2):176–182. doi:https://doi.org/10.1161/CIRCHEARTFAILURE.111.963793
- Sharma G, Tyagi AK, Singh RP, Chan DC, Agarwal R. Synergistic anti-cancer effects of grape seed extract and conventional cytotoxic agent doxorubicin against human breast carcinoma cells. Breast Cancer Res Treat. 2004;85(1):1–12. doi:https://doi.org/10.1023/B:BREA.0000020991.55659.59
- Wang X, Teng Z, Wang H, Wang C, Liu Y, et al. Increasing the cytotoxicity of doxorubicin in breast cancer MCF-7 cells with multidrug resistance using a mesoporous silica nanoparticle drug delivery system. Int J Clin Exp Pathol. 2014;7:1337.
- Ramanauskiene K, Raudonis R, Majiene D. Rosmarinic acid and Melissa officinalis extracts differently affect glioblastoma cells. Oxid Med Cell Longev. 2016;2016:1–9. doi:https://doi.org/10.1155/2016/1564257