Pro-Oxidant Effect of Resveratrol on Human Breast Cancer MCF-7 Cells is Associated with CK2 Inhibition

References

• Green AK, Aviki EM, Matsoukas K, Patil S, Korenstein D, Blinder V. Racial disparities in chemotherapy administration for early-stage breast cancer: a systematic review and meta-analysis. Breast Cancer Res Treat. 2018;172(2):247–63. doi:10.1007/s10549-018-4909-5
   PubMed Web of Science ®Google Scholar
• Ahmed SH. Safety of neoadjuvant chemotherapy for the treatment of breast cancer. Expert Opin Drug Saf. 2019;18(9):817–27. doi:10.1080/14740338.2019.1644318
   PubMed Web of Science ®Google Scholar
• Yun CW, Kim HJ, Lee SH. Therapeutic application of diverse marine-derived natural products in cancer therapy. Anticancer Res. 2019;39(10):5261–84. doi:10.21873/anticanres.13721
   PubMed Web of Science ®Google Scholar
• Efferth T . Editorial: Chemoprevention of cancer by natural products. Cancer Lett. 2019;459:13–4. doi:10.1016/j.canlet.2019.05.022
   PubMed Web of Science ®Google Scholar
• Newman DJ, Cragg GM. Natural products as sources of new drugs over the nearly four decades from 01/1981 to 09/2019. J Nat Prod. 2020;83(3):770–803. doi:10.1021/acs.jnatprod.9b01285
   PubMed Web of Science ®Google Scholar
• Atanasov AG, Zotchev SB, Dirsch VM, Supuran CT, the International Natural Product Sciences Taskforce. Natural products in drug discovery: advances and opportunities. Nat Rev Drug Discov. 2021;20(3):200–16. doi:10.1038/s41573-020-00114-z
   PubMed Web of Science ®Google Scholar
• Vervandier-Fasseur D, Latruffe N. The potential use of resveratrol for cancer prevention. Molecules. 2019;24(24):4506. doi:10.3390/molecules24244506
   PubMed Web of Science ®Google Scholar
• Shaito A, Posadino AM, Younes N, Hasan H, Halabi S, Alhababi D, Al-Mohannadi A, Abdel-Rahman WM, Eid AH, Nasrallah GK, et al. Potential adverse effects of resveratrol: a literature review. Int J Mol Sci. 2020;21(6):2084. doi:10.3390/ijms21062084
   PubMed Web of Science ®Google Scholar
• Elshaer M, Chen Y, Wang XJ, Tang X. Resveratrol: an overview of its anti-cancer mechanisms. Life Sci. 2018;207:340–9. doi:10.1016/j.lfs.2018.06.028
   PubMed Web of Science ®Google Scholar
• Ferraz da Costa DC, Fialho E, Silva JL. Cancer chemoprevention by resveratrol: The P53 tumor suppressor protein as a promising molecular target. Molecules. 2017;22:1014. doi:10.3390/molecules22061014
   PubMed Web of Science ®Google Scholar
• Chang LC, Yu YL. Dietary components as epigenetic-regulating agents against cancer. Biomedicine (Taipei). 2016;6(1):2–8. doi:10.7603/s40681-016-0002-8
   PubMedGoogle Scholar
• Alamolhodaei NS, Tsatsakis AM, Ramezani M, Hayes AW, Karimi G. Resveratrol as MDR reversion molecule in breast cancer: an overview. Food Chem Toxicol. 2017;103:223–32. doi:10.1016/j.fct.2017.03.024
   PubMed Web of Science ®Google Scholar
• Sinha D, Sarkar N, Biswas J, Bishayee A. Resveratrol for breast cancer prevention and therapy: preclinical evidence and molecular mechanisms. Semin Cancer Biol. 2016;40-41:209–32. doi:10.1016/j.semcancer.2015.11.001
   PubMed Web of Science ®Google Scholar
• Sun Y, Zhou QM, Lu YY, Zhang H, Chen Q-L, Zhao M, Su S-B. Resveratrol inhibits the migration and metastasis of MDA-MB-231 human breast cancer by reversing TGF-β1-induced epithelial-mesenchymal transition. Molecules. 2019;24(6):1131. doi:10.3390/molecules24061131
   PubMed Web of Science ®Google Scholar
• Silva-Pavez E, Tapia JC. Protein kinase CK2 in cancer energetics. Front Oncol. 2020;10:893. doi:10.3389/fonc.2020.00893
   PubMed Web of Science ®Google Scholar
• Borgo C, Ruzzene M. Role of protein kinase CK2 in antitumor drug resistance. J Exp Clin Cancer Res. 2019;38(1):287. doi:10.1186/s13046-019-1292-y
   PubMed Web of Science ®Google Scholar
• Trembley JH, Chen Z, Unger G, Slaton J, Kren BT, Waes CV, Ahmed K. Emergence of protein kinase CK2 as a key target in cancer therapy. Biofactors. 2010;36(3):187–95. doi:10.1002/biof.96
   PubMed Web of Science ®Google Scholar
• Li D, Chen L, Hu Z, Li H, Li J, Wei C, Huang Y, Song H, Fang L. Alterations of microRNAs are associated with impaired growth of MCF-7 breast cancer cells induced by inhibition of casein kinase 2. Int J Clin Exp Pathol. 2014;7(7):4008–15.
   PubMed Web of Science ®Google Scholar
• de Sales NFF, da Costa LS, Carneiro TIA, Mizuno DA, Oliveira FL, Cabral LMC, Torres AG, El-Bacha T. Anthocyanin-rich grape pomace extract (Vitis vinifera L.) from wine industry affects mitochondrial bioenergetics and glucose metabolism in human hepatocarcinoma HepG2 cells. Molecules. 2018;23(3):611. doi:10.3390/molecules23030611
   PubMed Web of Science ®Google Scholar
• Gnaiger E . Capacity of oxidative phosphorylation in human skeletal muscle: new perspectives of mitochondrial physiology. Int J Biochem Cell Biol. 2009;41(10):1837–45. doi:10.1016/j.biocel.2009.03.013
   PubMed Web of Science ®Google Scholar
• Gomes L, Sorgine M, Passos CLA, Ferreira C, de Andrade IR, Silva JL, Atella GC, Mermelstein C, Fialho E. Increase in fatty acids and flotillins upon resveratrol treatment of human breast cancer cells. Sci Rep. 2019;9(1):13960. doi:10.1038/s41598-019-50416-5
   PubMed Web of Science ®Google Scholar
• Hu C, Liu Y, Teng M, Jiao K, Zhen J, Wu M, Li Z. Resveratrol inhibits the proliferation of estrogen receptor-positive breast cancer cells by suppressing EZH2 through the modulation of ERK1/2 signaling. Cell Biol Toxicol. 2019;35(5):445–56. doi:10.1007/s10565-019-09471-x
   PubMed Web of Science ®Google Scholar
• Baek SH, Ko JH, Lee H, Jung J, Kong M, Lee JW, Lee J, Chinnathambi A, Zayed ME, Alharbi SA, et al. Resveratrol inhibits STAT3 signaling pathway through the induction of SOCS-1: Role in apoptosis induction and radiosensitization in head and neck tumor cells. Phytomedicine. 2016;23(5):566–77. : doi:10.1016/j.phymed.2016.02.011
   PubMed Web of Science ®Google Scholar
• Ferraz da Costa DC, Campos NPC, Santos RA, Guedes-da-Silva FH, Martins-Dinis MMDC, Zanphorlin L, Ramos CHI, Rangel LP, Silva JL. Resveratrol prevents p53 aggregation in vitro and in breast cancer cells. Oncotarget. 2018;9(49):29112–22. doi:10.18632/oncotarget.25631
   PubMedGoogle Scholar
• Lee WL, Huang JY, Shyur LF. Phytoagents for cancer management: regulation of nucleic acid oxidation, ROS, and related mechanisms. Oxid Med Cell Longev. 2013;2013:925804. doi:10.1155/2013/925804
   PubMed Web of Science ®Google Scholar
• Farhan M, Oves M, Chibber S, Hadi SM, Ahmad A. Mobilization of nuclear copper by green tea polyphenol epicatechin-3-gallate and subsequent prooxidant breakage of cellular DNA: implications for cancer chemotherapy. Int J Mol Sci. 2016;18(1):34. doi:10.3390/ijms18010034
   PubMed Web of Science ®Google Scholar
• Khan HY, Zubair H, Faisal M, Ullah MF, Farhan M, Sarkar FH, Ahmad A, Hadi SM. Plant polyphenol induced cell death in human cancer cells involves mobilization of intracellular copper ions and reactive oxygen species generation: a mechanism for cancer chemopreventive action. Mol Nutr Food Res. 2014;58(3):437–46. doi:10.1002/mnfr.201300417
   PubMed Web of Science ®Google Scholar
• Li W, Ma J, Ma Q, Li B, Han L, Liu J, Xu Q, Duan W, Yu S, Wang F, et al. Resveratrol inhibits the epithelial-mesenchymal transition of pancreatic cancer cells via suppression of the PI-3K/Akt/NF-κB pathway. Curr Med Chem. 2013;20(33):4185–94. : doi:10.2174/09298673113209990251
   PubMed Web of Science ®Google Scholar
• Kumar B, Iqbal MA, Singh RK, Bamezai RNK. Resveratrol inhibits TIGAR to promote ROS induced apoptosis and autophagy. Biochimie. 2015;118:26–35. doi:10.1016/j.biochi.2015.07.016
   PubMed Web of Science ®Google Scholar
• Cheng L, Yan B, Chen K, Jiang Z, Zhou C, Cao J, Qian W, Li J, Sun L, Ma J, et al. Resveratrol-Induced Downregulation of NAF-1 Enhances the Sensitivity of Pancreatic Cancer Cells to Gemcitabine via the ROS/Nrf2 Signaling Pathways. Oxid Med Cell Longev. 2018;2018:9482018. doi:10.1155/2018/9482018
   PubMed Web of Science ®Google Scholar
• Luo H, Yang A, Schulte BA, Wargovich MJ, Wang GY. Resveratrol induces premature senescence in lung cancer cells via ROS-mediated DNA damage. PLoS One. 2013;8(3):e60065. doi:10.1371/journal.pone.0060065
   PubMed Web of Science ®Google Scholar
• Kirtonia A, Sethi G, Garg M. The multifaceted role of reactive oxygen species in tumorigenesis. Cell Mol Life Sci. 2020;77(22):4459–83. doi:10.1007/s00018-020-03536-5
   PubMed Web of Science ®Google Scholar
• NavaneethaKrishnan S, Rosales JL, Lee KY. ROS-mediated cancer cell killing through dietary phytochemicals. Oxid Med Cell Longev. 2019;2019:9051542. doi:10.1155/2019/9051542
   PubMed Web of Science ®Google Scholar
• Zhou C, Ding J, Wu Y . Resveratrol induces apoptosis of bladder cancer cells via miR‑21 regulation of the Akt/Bcl‑2 signaling pathway . Mol Med Rep. 2014;9(4):1467–73. doi:10.3892/mmr.2014.1950
   PubMed Web of Science ®Google Scholar
• Sabharwal SS, Schumacker PT. Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles’ heel?Nat Rev Cancer. 2014;14(11):709–21. doi:10.1038/nrc3803
   PubMed Web of Science ®Google Scholar
• Qaiser F, Trembley JH, Kren BT, Wu JJ, Naveed AK, Ahmed K. Protein kinase CK2 inhibition induces cell death via early impact on mitochondrial function. J Cell Biochem. 2014;115(12):2103–15. doi:10.1002/jcb.24887
   PubMed Web of Science ®Google Scholar
• Bestgen B, Kufareva I, Seetoh W, Abell C, Hartmann RW, Abagyan R, Le Borgne M, Filhol O, Cochet C, Lomberget T, et al. 2-Aminothiazole derivatives as selective allosteric modulators of the protein kinase CK2. 2. structure-based optimization and investigation of effects specific to the allosteric mode of action. J Med Chem. 2019;62(4):1817–36. doi:10.1021/acs.jmedchem.8b01765
   PubMed Web of Science ®Google Scholar
• Hanif IM, Ahmad KA, Ahmed K, Pervaiz S. Involvement of reactive oxygen species in apoptosis induced by pharmacological inhibition of protein kinase CK2. Ann N Y Acad Sci. 2009;1171:591–9. doi:10.1111/j.1749-6632.2009.04916.x
   PubMed Web of Science ®Google Scholar
• Schneider CC, Hessenauer A, Götz C, Montenarh M. Montenarh: DMAT, an inhibitor of protein kinase CK2 induces reactive oxygen species and DNA double strand breaks. Oncol Rep. 2009;21(6):1593–7. doi:10.3892/or_00000392
   PubMed Web of Science ®Google Scholar
• Blanquer-Rosselló MD, Hernández-López R, Roca P, Oliver J, Valle A. Resveratrol induces mitochondrial respiration and apoptosis in SW620 colon cancer cells. Biochim Biophys Acta Gen Subj. 2017;1861(2):431–40. doi:10.1016/j.bbagen.2016.10.009
   PubMed Web of Science ®Google Scholar