References
- Longley DB, Harkin DP, Johnston PG. 5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer. 2003;3(5):330–8. doi:https://doi.org/10.1038/nrc1074
- Rashid S, Ali N, Nafees S, Hasan SK, Sultana S. Mitigation of 5-Fluorouracil induced renal toxicity by chrysin via targeting oxidative stress and apoptosis in wistar rats. Food Chem Toxicol. 2014;66:185–93. doi:https://doi.org/10.1016/j.fct.2014.01.026
- Polk A, Vistisen K, Vaage-Nilsen M, Nielsen DL. A systematic review of the pathophysiology of 5-fluorouracil-induced cardiotoxicity. BMC Pharmacol Toxicol. 2014;15:47. doi:https://doi.org/10.1186/2050-6511-15-47
- Al-Asmari AK, Al-Zahrani AM, Khan AQ, Al-Shahrani HM, Ali Al Amri M. Taurine ameliorates 5-flourouracil-induced intestinal mucositis, hepatorenal and reproductive organ damage in Wistar rats: A biochemical and histological study. Hum Exp Toxicol. 2016;35(1):10–20. doi:https://doi.org/10.1177/0960327115573597
- King PD, Perry MC. Hepatotoxicity of chemotherapy. Oncologist. 2001;6(2):162–76. doi:https://doi.org/10.1634/theoncologist.6-2-162
- Moertel CG, Fleming TR, Macdonald JS, Haller DG, Laurie JA. Hepatic toxicity associated with fluorouracil plus levamisole adjuvant therapy. J Clin Oncol. 1993;11(12):2386–90. doi:https://doi.org/10.1200/JCO.1993.11.12.2386
- Gelen V, Şengül E, Yıldırım S, Atila G. The protective effects of naringin against 5-fluorouracil-induced hepatotoxicity and nephrotoxicity in rats. Iran J Basic Med Sci. 2018;21(4):404–10.
- Conklin KA. Chemotherapy-associated oxidative stress: impact on chemotherapeutic effectiveness. Integr Cancer Ther. 2004;3(4):294–300. doi:https://doi.org/10.1177/1534735404270335
- Al-Asmari AK, Khan AQ, Al-Masri N. Mitigation of 5-fluorouracil-induced liver damage in rats by vitamin C via targeting redox-sensitive transcription factors. Hum Exp Toxicol. 2016;35(11):1203–13. doi:https://doi.org/10.1177/0960327115626583
- Al-Ghamdi MS. The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa. J Ethnopharmacol. 2001;76(1):45–8. doi:https://doi.org/10.1016/s0378-8741(01)00216-1
- Ambati RR, Ramadan MF. Nigella sativa seed extracts in functional foods and nutraceutical applications. Black cumin (Nigella sativa) seeds: chemistry, technology, functionality. and applications. Springer; 2021. p. 501–20.
- Farag MA, Saad HH, Hegazi NM. Rediscovering Nigella seeds bioactives chemical composition using metabolomics technologies. Black cumin (Nigella sativa) seeds: chemistry, technology, functionality, and applications. Springer; 2021. p. 131–51.
- Tavakkoli A, Ahmadi A, Razavi BM, Hosseinzadeh H. Black Seed. Iran J Pharm Res. 2017;16(Suppl):2–23.
- Harzallah HJ, Grayaa R, Kharoubi W, Maaloul A, Hammami M, Mahjoub T. Thymoquinone, the Nigella sativa bioactive compound, prevents circulatory oxidative stress caused by 1,2-dimethylhydrazine in erythrocyte during colon postinitiation carcinogenesis. Oxid Med Cell Longev. 2012;2012:854065.
- Imran M, Rauf A, Khan IA, Shahbaz M, Qaisrani TB, Fatmawati S, Abu-Izneid T, Imran A, Rahman KU, Gondal TA. Thymoquinone: a novel strategy to combat cancer: A review. Biomed Pharmacother. 2018;106:390–402. doi:https://doi.org/10.1016/j.biopha.2018.06.159
- Ahmad A, Husain A, Mujeeb M, Khan SA, Najmi AK, Siddique NA, Damanhouri ZA, Anwar F. A review on therapeutic potential of Nigella sativa: a miracle herb. Asian Pac J Trop Biomed. 2013;3(5):337–52. doi:https://doi.org/10.1016/S2221-1691(13)60075-1
- Mansour MA, Nagi MN, El-Khatib AS, Al-Bekairi AM. Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase in different tissues of mice: a possible mechanism of action. Cell Biochem Funct. 2002;20(2):143–51. doi:https://doi.org/10.1002/cbf.968
- Alhmied F, Alammar A, Alsultan B, Alshehri M, Pottoo FH. Molecular mechanisms of thymoquinone as anticancer agent. CCHTS. 2021;24(10):1644–53. doi:https://doi.org/10.2174/1386207323999201027225305
- Kart A, Aydın E. Health promoting activities of Nigella sativa seed extracts. Black cumin (Nigella sativa) seeds: chemistry, technology, functionality, and applications. Springer; 2021. p. 521–37.
- Ola-Mudathir KF, Suru SM, Fafunso MA, Obioha UE, Faremi TY. Protective roles of onion and garlic extracts on cadmium-induced changes in sperm characteristics and testicular oxidative damage in rats. Food Chem Toxicol. 2008;46(12):3604–11. doi:https://doi.org/10.1016/j.fct.2008.09.004
- Slimestad R, Fossen T, Vågen IM. Onions: a source of unique dietary flavonoids. J Agric Food Chem. 2007;55(25):10067–80. doi:https://doi.org/10.1021/jf0712503
- Rohn S, Buchner N, Driemel G, Rauser M, Kroh LW. Thermal degradation of onion quercetin glucosides under roasting conditions. J Agric Food Chem. 2007;55(4):1568–73. doi:https://doi.org/10.1021/jf063221i
- Gorinstein S, Leontowicz H, Leontowicz M, Namiesnik J, Najman K, Drzewiecki J, Cvikrová M, Martincová O, Katrich E, Trakhtenberg S, et al. Comparison of the main bioactive compounds and antioxidant activities in garlic and white and red onions after treatment protocols. J Agric Food Chem. 2008;56(12):4418–26. doi:https://doi.org/10.1021/jf800038h
- Dorsch W, Schneider E, Bayer T, Breu W, Wagner H. Anti-inflammatory effects of onions: inhibition of chemotaxis of human polymorphonuclear leukocytes by thiosulfinates and cepaenes. Int Arch Allergy Appl Immunol. 1990;92(1):39–42. doi:https://doi.org/10.1159/000235221
- Park J, Kim J, Kim MK. Onion flesh and onion peel enhance antioxidant status in aged rats. J Nutr Sci Vitaminol. 2007;53(1):21–9. doi:https://doi.org/10.3177/jnsv.53.21
- Erlund I. Review of the flavonoids quercetin, hesperetin, and naringenin. Dietary sources, bioactivities, bioavailability, and epidemiology. Nutr Res. 2004;24(10):851–74. doi:https://doi.org/10.1016/j.nutres.2004.07.005
- Chien S-Y, Wu Y-C, Chung J-G, Yang J-S, Lu H-F, Tsou M-F, Wood WG, Kuo S-J, Chen D-R. Quercetin-induced apoptosis acts through mitochondrial- and caspase-3-dependent pathways in human breast cancer MDA-MB-231 cells. Hum Exp Toxicol. 2009;28(8):493–503. doi:https://doi.org/10.1177/0960327109107002
- Kumar S, Pandey AK. Chemistry and biological activities of flavonoids: an overview. The Scientific World Journal. 2013;2013:1–16. doi:https://doi.org/10.1155/2013/162750
- Ong CS, Tran E, Nguyen TTT, Ong CK, Lee SK, Lee JJ, Ng CP, Leong C, Huynh H. Quercetin-induced growth inhibition and cell death in nasopharyngeal carcinoma cells are associated with increase in Bad and hypophosphorylated retinoblastoma expressions. Oncol Rep. 2004;11(3):727–33. doi:https://doi.org/10.3892/or.11.3.727
- Lautraite S, Musonda A, Doehmer J, Edwards G, Chipman J. Flavonoids inhibit genetic toxicity produced by carcinogens in cells expressing CYP1A2 and CYP1A1. Mutagenesis. 2002;17(1):45–53. doi:https://doi.org/10.1093/mutage/17.1.45
- Vijayababu M, Arunkumar A, Kanagaraj P, Venkataraman P, Krishnamoorthy G, Arunakaran J. Quercetin downregulates matrix metalloproteinases 2 and 9 proteins expression in prostate cancer cells (PC-3). Mol Cell Biochem. 2006;287(1-2):109–16. doi:https://doi.org/10.1007/s11010-005-9085-3
- Tan W-f, Lin L-p, Li M-h, Zhang Y-X, Tong Y-g, Xiao D, Ding J. Quercetin, a dietary-derived flavonoid, possesses antiangiogenic potential. Eur J Pharmacol. 2003;459(2-3):255–62. doi:https://doi.org/10.1016/s0014-2999(02)02848-0
- Chen X. Protective effects of quercetin on liver injury induced by ethanol. Pharmacogn Mag. 2010;6(22):135–41. doi:https://doi.org/10.4103/0973-1296.62900
- Mashtoub S, Feo B, Whittaker AL, Lymn KA, Martinez-Puig D, Howarth GS. Oral Nucleotides only minimally improve 5-fluorouracil-induced mucositis in rats. Nutr Cancer. 2015;67(6):994–1000. doi:https://doi.org/10.1080/01635581.2015.1062118
- Thomson M, Alnaqeeb MA, Bordia T, Al-Hassan JM, Afzal M, Ali M. Effects of aqueous extract of onion on the liver and lung of rats. J Ethnopharmacol. 1998;61(2):91–9. doi:https://doi.org/10.1016/s0378-8741(98)00004-x
- Dollah MA, Parhizkar S, Izwan M. Effect of Nigella sativa on the kidney function in rats. Avicenna J Phytomed. 2013;3(2):152–8.
- Sheehan DC, Hrapchak BB. Theory and practice of histotechnology. 2nd ed. St. Louis: Mosby; 1980. p. xiii, 481.
- Hayat MA. Principles and techniques of electron microscopy: biological applications. 4th ed. New York: Cambridge University Press; 2000.
- Tipple TE, Rogers LK. Methods for the determination of plasma or tissue glutathione levels. Methods Mol Biol. 2012;889:315–24. doi:https://doi.org/10.1007/978-1-61779-867-2_20
- Liu Z, Wang X, Li L, Wei G, Zhao M. Hydrogen sulfide protects against paraquat-induced acute liver injury in rats by regulating oxidative stress, mitochondrial function, and inflammation. Oxid Med Cell Longev. 2020;2020:6325378. doi:https://doi.org/10.1155/2020/6325378
- Alisik M, Neselioglu S, Erel O. A colorimetric method to measure oxidized, reduced and total glutathione levels in erythrocytes. J Laboratory Med. 2019;43(5):269–77. doi:https://doi.org/10.1515/labmed-2019-0098
- Weydert CJ, Cullen JJ. Measurement of superoxide dismutase, catalase and glutathione peroxidase in cultured cells and tissue. Nat Protoc. 2010;5(1):51–66. doi:https://doi.org/10.1038/nprot.2009.197
- Devlin TM. Textbook of biochemistry: with clinical correlations. 7th ed. Hoboken, NJ: John Wiley & Sons; 2011. p. xxxii, 1204.
- Ozer J, Ratner M, Shaw M, Bailey W, Schomaker S. The current state of serum biomarkers of hepatotoxicity. Toxicology. 2008;245(3):194–205. doi:https://doi.org/10.1016/j.tox.2007.11.021
- Ramaiah SK. A toxicologist guide to the diagnostic interpretation of hepatic biochemical parameters. Food Chem Toxicol. 2007;45(9):1551–7. doi:https://doi.org/10.1016/j.fct.2007.06.007
- Dhouib H, Jallouli M, Draief M, Bouraoui S, El-Fazâa S. Oxidative damage and histopathological changes in lung of rat chronically exposed to nicotine alone or associated to ethanol. Pathol Biol (Paris). 2015;63(6):258–67. doi:https://doi.org/10.1016/j.patbio.2015.10.001
- Brunt EM, Tiniakos DG. Pathological features of NASH. Front Biosci. 2005;10:1475–84.
- Panasiuk A, Dzieciol J, Panasiuk B, Prokopowicz D. Expression of p53, Bax and Bcl-2 proteins in hepatocytes in non-alcoholic fatty liver disease. WJG. 2006;12(38):6198–202. doi:https://doi.org/10.3748/wjg.v12.i38.6198
- Birben E, Sahiner UM, Sackesen C, Erzurum S, Kalayci O. Oxidative stress and antioxidant defense. World Allergy Organ J. 2012;5(1):9–19. doi:https://doi.org/10.1097/WOX.0b013e3182439613
- Akindele AJ, Ezenwanebe KO, Anunobi CC, Adeyemi OO. Hepatoprotective and in vivo antioxidant effects of Byrsocarpus coccineus Schum. and Thonn. (Connaraceae). J Ethnopharmacol. 2010;129(1):46–52. doi:https://doi.org/10.1016/j.jep.2010.02.024
- Halliwell B, Gutteridge JM. Free radicals and antioxidant protection: mechanisms and significance in toxicology and disease. Hum Toxicol. 1988;7(1):7–13. doi:https://doi.org/10.1177/096032718800700102
- McCord JM. Human disease, free radicals, and the oxidant/antioxidant balance. Clin Biochem. 1993;26(5):351–7. doi:https://doi.org/10.1016/0009-9120(93)90111-I
- Petri S, Körner S, Kiaei M. Nrf2/ARE signaling pathway: key mediator in oxidative stress and potential therapeutic target in ALS. Neurol Res Int. 2012;2012:878030. doi:https://doi.org/10.1155/2012/878030
- Zhong H, Yin H. Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: focusing on mitochondria. Redox Biol. 2015;4:193–9. doi:https://doi.org/10.1016/j.redox.2014.12.011
- Hoque R, Farooq A, Mehal WZ. Sterile inflammation in the liver and pancreas. J Gastroenterol Hepatol. 2013;28 Suppl 1 (Suppl 1):61–7. doi:https://doi.org/10.1111/jgh.12018
- Kubes P, Mehal WZ. Sterile inflammation in the liver. Gastroenterology. 2012;143(5):1158–72. doi:https://doi.org/10.1053/j.gastro.2012.09.008
- Kurt A, Tumkaya L, Turut H, Cure MC, Cure E, Kalkan Y, Sehitoglu I, Acipayam A. Protective Effects of Infliximab on Lung Injury Induced by Methotrexate. Arch Bronconeumol. 2015;51(11):551–7. doi:https://doi.org/10.1016/j.arbres.2015.03.018
- Karin M, Ben-Neriah Y. Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu Rev Immunol. 2000;18(1):621–63. doi:https://doi.org/10.1146/annurev.immunol.18.1.621
- Nair MP, Mahajan S, Reynolds JL, Aalinkeel R, Nair H, Schwartz SA, Kandaswami C. The flavonoid quercetin inhibits proinflammatory cytokine (tumor necrosis factor alpha) gene expression in normal peripheral blood mononuclear cells via modulation of the NF-kappa beta system. Clin Vaccine Immunol. 2006;13(3):319–28. doi:https://doi.org/10.1128/CVI.13.3.319-328.2006
- Mitsiades CS, Mitsiades N, Poulaki V, Schlossman R, Akiyama M, Chauhan D, Hideshima T, Treon SP, Munshi NC, Richardson PG, et al. Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications. Oncogene. 2002;21(37):5673–83. doi:https://doi.org/10.1038/sj.onc.1205664
- Dejardin E, Droin NM, Delhase M, Haas E, Cao Y, Makris C, Li Z-W, Karin M, Ware CF, Green DR, et al. The lymphotoxin-β receptor induces different patterns of gene expression via two NF-κB pathways. Immunity. 2002;17(4):525–35. doi:https://doi.org/10.1016/S1074-7613(02)00423-5
- Lisanti A, Formica V, Ianni F, Albertini B, Marinozzi M, Sardella R, Natalini B. Antioxidant activity of phenolic extracts from different cultivars of Italian onion (Allium cepa) and relative human immune cell proliferative induction. Pharm Biol. 2016;54(5):799–806. doi:https://doi.org/10.3109/13880209.2015.1080733
- Darakhshan S, Bidmeshki Pour A, Hosseinzadeh Colagar A, Sisakhtnezhad S. Thymoquinone and its therapeutic potentials. Pharmacol Res. 2015;95-96:138–58. doi:https://doi.org/10.1016/j.phrs.2015.03.011
- Owen JB, Butterfield DA. Measurement of oxidized/reduced glutathione ratio. In Protein misfolding and cellular stress in disease and aging. Springer; 2010. p. 269–77.
- Giustarini D, Colombo G, Garavaglia ML, Astori E, Portinaro NM, Reggiani F, Badalamenti S, Aloisi AM, Santucci A, Rossi R, et al. Assessment of glutathione/glutathione disulphide ratio and S-glutathionylated proteins in human blood, solid tissues, and cultured cells. Free Radic Biol Med. 2017;112:360–75. doi:https://doi.org/10.1016/j.freeradbiomed.2017.08.008
- Li HY, Wu SY, Ma Q, Shi N. The pesticide deltamethrin increases free radical production and promotes nuclear translocation of the stress response transcription factor Nrf2 in rat brain. Toxicol Ind Health. 2011;27(7):579–90. doi:https://doi.org/10.1177/0748233710393400
- Mohammadi H, Ghassemi-Barghi N, Malakshah O, Ashari S. Pyrethroid exposure and neurotoxicity: a mechanistic approach. Arh Hig Rada Toksikol. 2019;70(2):74–89. doi:https://doi.org/10.2478/aiht-2019-70-3263
- Yan W, Wang H-D, Hu Z-G, Wang Q-F, Yin H-X. Activation of Nrf2-ARE pathway in brain after traumatic brain injury. Neurosci Lett. 2008;431(2):150–4. doi:https://doi.org/10.1016/j.neulet.2007.11.060
- Hosseinzadeh H, Parvardeh S, Asl MN, Sadeghnia HR, Ziaee T. Effect of thymoquinone and Nigella sativa seeds oil on lipid peroxidation level during global cerebral ischemia-reperfusion injury in rat hippocampus. Phytomedicine. 2007;14(9):621–7. doi:https://doi.org/10.1016/j.phymed.2006.12.005
- Majdalawieh AF, Fayyad MW. Immunomodulatory and anti-inflammatory action of Nigella sativa and thymoquinone: A comprehensive review. Int Immunopharmacol. 2015;28(1):295–304. doi:https://doi.org/10.1016/j.intimp.2015.06.023
- Aydin E, Kart A. Health Promoting Activities of Nigella sativa Seeds. In Black Cumin (Nigella sativa) Seeds: chemistry, technology, functionality, and applications. 2021;153–77.
- Ikhsan M, Hiedayati N, Maeyama K, Nurwidya F. Nigella sativa as an anti-inflammatory agent in asthma. BMC Res Notes. 2018;11(1):744. doi:https://doi.org/10.1186/s13104-018-3858-8
- Putnik P, Gabrić D, Roohinejad S, Barba FJ, Granato D, Mallikarjunan K, Lorenzo JM, Bursać Kovačević D. An overview of organosulfur compounds from Allium spp.: from processing and preservation to evaluation of their bioavailability, antimicrobial, and anti-inflammatory properties. Food Chem. 2019;276:680–91. doi:https://doi.org/10.1016/j.foodchem.2018.10.068
- Hu Y, Duan M, Liang S, Wang Y, Feng Y. Senkyunolide I protects rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3. Brain Res. 2015;1605:39–48. doi:https://doi.org/10.1016/j.brainres.2015.02.015