References
- Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. doi:https://doi.org/10.3322/caac.21492
- INCA: Estimativa 2018 - incidência de câncer no brasil. Rio de Janeiro: Instituto Nacional do Câncer José Alencar Gomes da Silva, Ministério da Saúde. p. 130. 2018.
- Zur Hausen H. Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer. 2002;2(5):342–50. doi:https://doi.org/10.1038/nrc798
- IOC ICoHaC: Brazil, Human Papillomavirus and related cancers, fact sheet 2017. Barcelona, Espanha: Institut Català d’Oncologia, 2017.
- Miranda PM, Pitol BCV, Moran MS, Silva NNT, Felix PM, Lima-Filho JL, Carneiro CM, Silva IDCG, Carvalho RF, Lima AA, et al. Human papillomavirus infection in brazilian women with normal cervical cytology. Genet Mol Res. 2012;11(2):1752–61.: doi:https://doi.org/10.4238/2012.June.29.8
- Burd EM. Human papillomavirus and cervical cancer. Clin Microbiol Rev. 2003;16(1):1–17. doi:https://doi.org/10.1128/CMR.16.1.1-17.2003
- Bahrami A, Hasanzadeh M, Shahidsales S, Farazestanian M, Hassanian SM, Moetamani Ahmadi M, Maftouh M, Gharib M, Yousefi Z, Kadkhodayan S, et al. Genetic susceptibility in cervical cancer: from bench to bedside. J Cell Physiol. 2018;233(3):1929–39. doi:https://doi.org/10.1002/jcp.26019
- Koshiyama M. The effects of the dietary and nutrient intake on gynecologic cancers. Healthcare (Basel). 2019;7(3):1–23. doi:https://doi.org/10.3390/healthcare7030088
- Choi SW, Mason JB. Folate and carcinogenesis: an integrated scheme. J Nutr. 2000;130(2):129–32. doi:https://doi.org/10.1093/jn/130.2.129
- Tomita LY, D′Almeida V, Villa LL, Franco EL, Cardoso MA, for the BRINCA Study Group. Polymorphisms in genes involved in folate metabolism modify the association of dietary and circulating folate and vitamin B-6 with cervical neoplasia. J Nutr. 2013;143(12):2007–14. doi:https://doi.org/10.3945/jn.113.182212
- Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJ, den Heijer M, Kluijtmans LA, van den Heuvel LP, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet. 1995;10(1):111–3. doi:https://doi.org/10.1038/ng0595-111
- van der Put NM, van der Molen EF, Kluijtmans LA, Heil SG, Trijbels JM, Eskes TK, Van Oppenraaij-Emmerzaal D, Banerjee R, Blom HJ. Sequence analysis of the coding region of human methionine synthase: relevance to hyperhomocysteinaemia in neural-tube defects and vascular disease. QJM. 1997;90(8):511–7. doi:https://doi.org/10.1093/qjmed/90.8.511
- Leclerc D, Wilson A, Dumas R, Gafuik C, Song D, Watkins D, Heng HH, Rommens JM, Scherer SW, Rosenblatt DS, et al. Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria. Proc Natl Acad Sci USA. 1998;95(6):3059–64. doi:https://doi.org/10.1073/pnas.95.6.3059
- Wang P, Li S, Wang M, He J, Xi S. Association of MTRR A66G polymorphism with cancer susceptibility: evidence from 85 studies. J Cancer. 2017;8(2):266–77. doi:https://doi.org/10.7150/jca.17379
- Zhou J-Y, Shi R, Yu H-L, Zeng Y, Zheng W-L, Ma W-L. The association between two polymorphisms in the ts gene and risk of cancer: a systematic review and pooled analysis. Int J Cancer. 2012;131(9):2103–16. doi:https://doi.org/10.1002/ijc.27465
- Voeller D, Rahman L, Zajac-Kaye M. Elevated levels of thymidylate synthase linked to neoplastic transformation of mammalian cells. Cell Cycle. 2004;3(8):1005–7.
- Iida M, Banno K, Yanokura M, Nakamura K, Adachi M, Nogami Y, Umene K, Masuda K, Kisu I, Iwata T, et al. Candidate biomarkers for cervical cancer treatment: potential for clinical practice (review). Mol Clin Oncol. 2014;2(5):647–55. doi:https://doi.org/10.3892/mco.2014.324
- Silva NNT, Santos ACS, Nogueira VM, Carneiro CM, Lima AA. 3’UTR polymorphism of thymidylate synthase gene increased the risk of persistence of pre-neoplastic cervical lesions. BMC Cancer. 2020;20(1):323. doi:https://doi.org/10.1186/s12885-020-06811-7
- Flatley JE, Sargent A, Kitchener HC, Russell JM, Powers HJ. Tumour suppressor gene methylation and cervical cell folate concentration are determinants of high-risk Human Papillomavirus persistence: a nested case control study. BMC Cancer. 2014;14(1):803. doi:https://doi.org/10.1186/1471-2407-14-803
- Silva NNT, Santos ACS, Carneiro CM, Lima AA. Association of serum folate and vitamin B12 with pre-neoplastic cervical lesions. Clin Nutr Espen. 2020;38:223–8. doi:https://doi.org/10.1016/j.clnesp.2020.04.007
- Miranda PM, Silva NNT, Pitol BCV, Silva IDCG, Lima-Filho JL, Carvalho RF, Stocco RC, Beçak W, Lima AA. Persistence or clearance of Human Papillomavirus infections in women in Ouro Preto, Brazil. Biomed Res Int. 2013;2013:578276. doi:https://doi.org/10.1155/2013/578276
- Rousset F. Genepop’007: a complete re-implementation of the genepop software for windows and linux. Mol Ecol Resour. 2008;8(1):103–6. doi:https://doi.org/10.1111/j.1471-8286.2007.01931.x
- Rodriguez S, Gaunt TR, Day IN. Hardy-weinberg equilibrium testing of biological ascertainment for mendelian randomization studies. Am J Epidemiol. 2009;169(4):505–14. doi:https://doi.org/10.1093/aje/kwn359
- Henao OL, Piyathilake CJ, Waterbor JW, Funkhouser E, Johanning GL, Heimburger DC, Partridge EE. Women with polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (ms) are less likely to have cervical intraepithelial neoplasia (cin) 2 or 3. Int J Cancer. 2005;113(6):991–7. doi:https://doi.org/10.1002/ijc.20695
- Zhu J, Wu L, Kohlmeier M, Ye F, Cai W. Association between MTHFR C677T, MTHFR A1298C and MS A2756G polymorphisms and risk of cervical intraepithelial neoplasia II/III and cervical cancer: a meta-analysis. Mol Med Rep. 2013;8(3):919–27. doi:https://doi.org/10.3892/mmr.2013.1589
- Wu CY, Yang M, Lin M, Li LP, Wen XZ. MTHFR C677T polymorphism was an ethnicity-dependent risk factor for cervical cancer development: evidence based on a meta-analysis. Arch Gynecol Obstet. 2013;288(3):595–605. doi:https://doi.org/10.1007/s00404-013-2721-3
- Silva NNT, Sabino AP, Tafuri A, Lima AA. Lack of association between methylenetetrahydrofolate reductase C677T polymorphism, HPV infection and cervical intraepithelial neoplasia in Brazilian women. BMC Med Genet. 2019;20(1):100. doi:https://doi.org/10.1186/s12881-019-0831-x
- Badiga S, Johanning GL, Macaluso M, Azuero A, Chambers MM, Siddiqui NR, Piyathilake CJ. A lower degree of PBMC L1 methylation in women with lower folate status may explain the MTHFR C677T polymorphism associated higher risk of cin in the us post folic acid fortification era. PLoS One. 2014;9(10):e110093. doi:https://doi.org/10.1371/journal.pone.0110093
- Delgado-Enciso I, Martínez-Garza SG, Rojas-Martínez A, Espinoza-Gómez F, Canseco-Avila LM, et al. The effect of MTHFR polymorphisms, pregnancy and first intercourse on cervical cancer in a population from the northeastern Mexico. Rev Invest Clin. 2006;58(5):462–9.
- Mostowska A, Myka M, Lianeri M, Roszak A, Jagodziński PP. Folate and choline metabolism gene variants and development of uterine cervical carcinoma. Clin Biochem. 2011;44(8–9):596–600. doi:https://doi.org/10.1016/j.clinbiochem.2011.02.007
- Paz MF, Avila S, Fraga MF, Pollan M, Capella G, Peinado MA, Sanchez-Cespedes M, Herman JG, Esteller M. Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors. Cancer Res. 2002;62(15):4519–24.
- Mandola MV, Stoehlmacher J, Zhang W, Groshen S, Mc Y, et al. A 6 bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels. Pharmacogenetics. 2004;14(5):319–27.
- Ulrich CM, Bigler J, Velicer CM, Greene EA, Farin FM, Potter JD. Searching expressed sequence tag databases: discovery and confirmation of a common polymorphism in the thymidylate synthase gene. Cancer Epidemiol Biomarkers Prev. 2000;9(12):1381–5.
- Gao C-M, Ding J-H, Li S-P, Liu Y-T, Cao H-X, Wu J-Z, Tajima K. Polymorphisms in the thymidylate synthase gene and risk of colorectal cancer. Asian Pac J Cancer Prev. 2012;13(8):4087–91. doi:https://doi.org/10.7314/apjcp.2012.13.8.4087
- Araújo MD, Borges BN, Rodrigues-Antunes S, Burbano RM, Harada ML. Thymidylate synthase and methylenetetrahy-drofolate reductase gene polymorphisms and gastric cancer susceptibility in a population of northern Brazil. Genet Mol Res. 2015;14(3):10001–6. doi:https://doi.org/10.4238/2015.August.21.6
- Xiao S, Tang Y-S, Kusumanchi P, Stabler SP, Zhang Y, Antony AC. Folate deficiency facilitates genomic integration of Human Papillomavirus type 16 DNA in vivo in a novel mouse model for rapid oncogenic transformation of human keratinocytes. J Nutr. 2018;148(3):389–400. doi:https://doi.org/10.1093/jn/nxx060
- Cummings D, Dowling K, Silverstein N, Tanner A, Eryilmaz H, Smoller J, Roffman J. A cross-sectional study of dietary and genetic predictors of blood folate levels in healthy young adults. Nutrients. 2017;9(9):994. doi:https://doi.org/10.3390/nu9090994
- Liu C, Ding L, Bai L, Chen X, Kang H, Hou L, Wang J. Folate receptor alpha is associated with cervical carcinogenesis and regulates cervical cancer cells growth by activating erk1/2/c-fos/c-jun. Biochem Biophys Res Commun. 2017;491(4):1083–91. doi:https://doi.org/10.1016/j.bbrc.2017.08.015
- Yang J, Yang A, Wang Z, Wang W, Wang Z, Wang Y, Wang J, Song J, Li L, Lv W, et al. Interactions between serum folate and Human Papillomavirus with cervical intraepithelial neoplasia risk in a chinese population-based study. Am J Clin Nutr. 2018;108(5):1034–42. doi:https://doi.org/10.1093/ajcn/nqy160
- Zhao Y, Li M, Li Y, Lv Q, Chen F, Li B, Zhang Z, Guo H, Lu D, Wang F, et al. Evaluation of folate receptor-mediated cervical dyeing as a method for detection of cervical lesions. J Low Genit Tract Dis. 2019;23(2):133–7. doi:https://doi.org/10.1097/LGT.0000000000000411